Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 1813 • 2016 ACR/ARHP Annual Meeting
Prevalence and Incidence of Systemic Lupus Erythematosus in Tucuman -Argentina
Luciana Gonzalez Lucero¹, Raul Sueldo², Alberto Ives Torres³, Alexia Cristofari³, Ana Lucía Barbaglia³, Ana Olea³, Ana Quinteros⁴, Gladys Seleme³, Francisco Colombres³, Dora Lia Vásquez³, Gustavo Arquez³, Gustavo Alberto Carrizo³, Hector Lazaro³, Maria Josefina Molina³, Laura Juarez³, Maria Constanza Bertolaccini⁵, Maria Olga Leal⁶, María Silvia Yacuzzi², Mariana Espindola Echazu³, Norma Robles De Garrone³, Rodolfo Orlando Dip³, Olga Romano³, Oscar Pera³, Silvia Paz³, Veronica Bellomio⁷, Maximiliano Machado Escobar², Silvia Rengel⁸, Liliana Galindo⁷, Mirta Santana² and Eleonora Lucero², ¹Rheumatology Unit, Hospital Padilla, Tucumán, Tucumán, Argentina, ²Hospital Angel Cruz Padilla, Tucumán, Argentina, ³Sociedad de Reumatología de Tucumán, tucuman, Argentina, ⁴Centro Integral Reumatológico, Tucuman, Argentina, ⁵Rheumatology, Hospital Angel Cruz Padilla, Tucumán, Argentina, ⁶Centro Integral De Reumatologia, Tucumán, Argentina, ⁷Hospital Ángel Cruz Padilla, Tucuman, Argentina, ⁸Hospital Centro de Salud, Tucuman, Argentina
Background/Purpose: Systemic Lupus Erythematosus (SLE) is the paradigm of the autoimmune diseases that primarily affects women in a ratio of 9: 1. In England and…
Abstract Number: 1814 • 2016 ACR/ARHP Annual Meeting
Epidemiology and Microbiology of Pneumonia in Systemic Lupus Erythematosus (SLE)
Gabriela García-Guevara¹, Ricardo Ríos-Corzo², Hilda Fragoso-Loyo³, Juan Jakez-Ocampo⁴, John Hernandez-Flores², Mariana Lopez-Lopez⁵, Eduardo Carrillo-Maravilla⁶, Jose Sifuentes-Osornio² and Yemil Atisha-Fregoso⁷, ¹Internal Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Mexico, ²Internal Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁶Medicina Interna, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ⁷Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Background/Purpose: Pneumonia, remains as a main cause of mortality in patients with SLE. There are not specific guidelines for the empiric treatment in these patients.…
Abstract Number: 1842 • 2016 ACR/ARHP Annual Meeting
Pentraxin 3 Level Positively Correlated with Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus Patients
Yifang Mei, Xiaoping Sun, Yuxia Shao, Huanhuan Zhan and Zhiyi Zhang, Department of Rheumatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a kind of chronic and autoimmune disease with variable multi-system involvement of unknown causes, which is characterized by periods…
Abstract Number: 737 • 2015 ACR/ARHP Annual Meeting
A Paper Patient-Based Flare Study in SLE
Joanna Sturgess¹, Elizabeth Allan¹, David A. Isenberg², Cynthia Aranow³, Martin Aringer⁴, Anca Askanase⁵, Sang-Cheol Bae⁶, Sasha R Bernatsky⁷, Ian N. Bruce⁸, Jill P. Buyon⁹, Ricard Cervera¹⁰, Ann Clarke¹¹, Mary Anne Dooley¹², Paul R. Fortin¹³, Ian Giles², Ellen M. Ginzler¹⁴, Dafna Gladman¹⁵, Caroline Gordon¹⁶, Bridget Griffiths¹⁷, John G. Hanly¹⁸, Murat Inanc¹⁹, Søren Jacobsen²⁰, Diane L. Kamen²¹, Munther Khamashta²², Peter Lanyon²³, S. Sam Lim²⁴, Susan Manzi²⁵, Marta Mosca²⁶, Ola Nived²⁷, Christine A. Peschken²⁸, Michelle Petri²⁹, Kenneth C. Kalunian³⁰, Anisur Rahman³¹, Rosalind Ramsey-Goldman³², Guillermo Ruiz-Irastorza³³, Jorge Sánchez-Guerrero³⁴, Matteus Schneider³⁵, Kristján Steinsson³⁶, Gunnar K. Sturfelt³⁷, Murray Urowitz^38,39, Ronald F. van Vollenhoven⁴⁰, Carlos Vasconcelos⁴¹, Daniel J Wallace⁴², Asad Zoma⁴³, Joan T. Merrill⁴⁴, Eric Morand⁴⁵, Sharon Chambers⁴⁶, Nathalie Costedoat-Chalumeau⁴⁷ and Sara Croca², ¹Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom, ²Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ³Feinstein Institute for Medical Research, Mahasset, NY, ⁴Rheumatology, Universitatsklinikum, Dresden, Germany, ⁵Columbia University College of Physicians & Surgeons, New York, NY, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁷Division of Rheumatolog, McGill Unversity Health Cener, Montreal, QC, Canada, ⁸Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ⁹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ¹⁰Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain, ¹¹Division of Rheumatology, Department of Medicine, University of Calgary, Calgary, AB, Canada, ¹²UNC Kidney Centre, Chapel Hill, NC, ¹³Université Laval, CHU de Québec, Québec, QC, Canada, ¹⁴Medicine/Box 42, SUNY-Downstate, Brooklyn, NY, ¹⁵Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹⁶Rheumatology (East Wing), Medical School, Birmingham, United Kingdom, ¹⁷Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, ¹⁸Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ¹⁹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²⁰Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ²¹Medicine, Medical University of South Carolina, Charleston, SC, ²²Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ²³Rheumatology, Queens Medical Centre Nottingham, Nottingham, United Kingdom, ²⁴Emory University School of Medicine, Atlanta, GA, ²⁵Rheumatology, Allegheny Health Network, Pittsburgh, PA, ²⁶University of Pisa, Pisa, Italy, ²⁷Rheumatology, Inst of Clinical sciences, Lund, Sweden, ²⁸Rheumatology, Univ of Manitoba, Winnipeg, MB, Canada, ²⁹Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ³⁰Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, ³¹Academic Centre for Rheumatology, University College London, London, United Kingdom, ³²Northwestern University Feinberg School of Medicine, Chicago, IL, ³³Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, ³⁴Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada, ³⁵MNR-Klinik, Heinrich-Heine-Univ Dusseldorf, Dusseldorf, Germany, ³⁶Rheumatology, Univ. Hospital, Reykjavik, Iceland, ³⁷Department of Rheumatology, Univ Hospital Lund, Lund, Sweden, ³⁸University of Toronto, Toronto, ON, Canada, ³⁹Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴⁰Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁴¹Medicina Interna, Unidade de Imunologia Clínica - Hospital Santo António, Oporto, Portugal, ⁴²Cedars-Sinai Medical Center, West Hollywood, CA, ⁴³Rheumatology, Hairmyres Hospital, East Kilbride, United Kingdom, ⁴⁴Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴⁵Medicine, Monash University, Clayton, Australia, ⁴⁶TrinCay Medical Services, Camana Bay, Cayman Islands, ⁴⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France
ACR Abstract – A Paper Patient-Based Flare Study in Systemic Lupus Erythematosus (SLE) Isenberg D, Sturgess J, Allan E, Aranow C, Aringer M, Askanase A,…
Abstract Number: 747 • 2015 ACR/ARHP Annual Meeting
Depletion of Serum Soluble CD40L Characterizes the Association Between Systemic Lupus Erythematosus and Thrombotic Thrombocytopenic Purpura: Longitudinal, Single-Center Study
Javier Merayo-Chalico¹, Ana Barrera-Vargas², Jorge Alcocer-Varela² and Diana Gómez-Martín², ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a higher incidence of thrombotic thrombocytopenic purpura (TTP). Differentiating TTP from SLE activity may represent a challenge…
Abstract Number: 780 • 2015 ACR/ARHP Annual Meeting
Long-Term Prognosis and Factors Associated with Damage Accrual in Japanese Patients with Systemic Lupus Erythematosus
Yoko Wada¹, Hisashi Hasegawa², Takeshi Kuroda³, Masaaki Nakano⁴ and Ichiei Narita¹, ¹Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Division of Clinical Nephrology and Rheumatology, Niigata City General Hospital, Niigata, Japan, ³Health Administration Center, Niigata University, Niigata, Japan, ⁴Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by fluctuating disease activity over periods of years. The estimated 5-year survival rate of…
Abstract Number: 1107 • 2015 ACR/ARHP Annual Meeting
Inhibition of B Cell Activation and Plasma Cell Differentiation By Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22
Natalia V. Giltiay¹, Geraldine L. Shu², Anthony Shock³ and Edward A. Clark^1,2, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Department of Immunology, University of Washington, Seattle, WA, ³UCB Pharma, Slough, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by B cell hyperactivity and production of autoantibodies. Treatment of patients with moderate-to-severe SLE with epratuzumab, a humanized…
Abstract Number: 2935 • 2015 ACR/ARHP Annual Meeting
Disease Evolution in Late Onset and Early Onset Systemic Lupus Erythematosus (SLE)
Roa'a Al Johani¹, Dafna Gladman², Jiandong Su² and Murray Urowitz^2,3, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: To compare clinical features, disease activity and outcome in late onset versus early onset SLE over 5 years of follow up. Methods: Patients with…
Abstract Number: 2953 • 2015 ACR/ARHP Annual Meeting
The Emergency Room and SLE: What Characteristics Are Associated with Increased Emergency Room Utilization in Lupus Patients?
Kimberly Trotter¹, Kichul Ko¹, Gabrielle Liu¹ and Tammy Utset², ¹Medicine, University of Chicago, Chicago, IL, ²University of Chicago, Chicago, IL
Background/Purpose: There is sparse data examining the characteristics of SLE patients who frequent the emergency room (ER). Data suggest that lupus patients with certain sociodemographic…
Abstract Number: 3218 • 2015 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study of the Efficacy and Safety of Belimumab Administered Subcutaneously Plus Standard Care to Patients with Systemic Lupus Erythematosus (SLE)
William Stohl¹, Andreas Schwarting², Masato Okada³, Morton Scheinberg⁴, Andrea Doria⁵, Anne Hammer⁶, Christi Kleoudis⁷, Damon Bass⁸, James Groark⁹, Norma Lynn Fox¹⁰, David Roth¹¹ and David Gordon¹¹, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²ACURA Kliniken, Bad Kreuznach, Germany, ³Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ⁴Rheumatology Hospital Abreu Sodre Pesquisa Clínica, São Paulo, Brazil, ⁵Division of Rheumatology, University of Padova, Padova, Italy, ⁶GlaxoSmithKline, Research Triangle Park, NC, ⁷Parexel, Durham, NC, ⁸Immuno-Inflammation, GlaxoSmithKline, King of Prussia, PA, ⁹GlaxoSmithKline, Philadelphia, NC, ¹⁰GlaxoSmithKline, Washington, MD, ¹¹GlaxoSmithKline, Philadelphia, PA
Background/Purpose: To assess the efficacy and safety of belimumab (BEL) administered subcutaneously plus standard SLE care (SoC) in patients with active SLE.Methods: BLISS-SC (BEL112341; NCT01484496)…
Abstract Number: 697 • 2014 ACR/ARHP Annual Meeting
Venous and Arterial Thrombosis in SLE: Differences in Natural History
Katharine Hickman¹, Laurence S. Magder² and Michelle Petri³, ¹University College London, London, United Kingdom, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Thrombosis is increased in SLE due to disease activity and co-morbid factors including antiphospholipid antibodies. We separately investigated the natural history of venous vs.…
Abstract Number: 689 • 2014 ACR/ARHP Annual Meeting
Prednisone, Disease Activity and Hypertension Independently Predict Cataracts in Systemic Lupus Erythematosus (SLE)
Khaled Alderaan¹, Vuk Sekicki², Laurence S. Magder³ and Michelle Petri⁴, ¹King Fahad Specilaist Hospital, Dammam, Saudi Arabia, ²Medicine, Saint Agnes Hospital, Baltimore, MD, ³Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Cataract is the most common ocular damage in SLE. It is the second most frequent item in the SLICC/ACR Damage Index. Apart from cumulative…
Abstract Number: 2675 • 2014 ACR/ARHP Annual Meeting
The Selective Loss of SLAMF4⁺ CD8⁺ T Cells Contributes to the Decreased Cytotoxic Capacity Observed in Systemic Lupus Erythematosus
Katalin Kis-Toth¹, Denis Comte¹, Maria Karampetsou¹, Lakshmi Kannan² and George C. Tsokos¹, ¹Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, ²Rheumtology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose Signaling lymphocytic activation molecule family member 4 (SLAMF4) engagement by its ligand SLAMF2 can mediate the cytotoxicity of CD8+ T cells and natural killer…
Abstract Number: 677 • 2014 ACR/ARHP Annual Meeting
Pharmacokinetics, Safety, and Biological Activity of Intravenously or Subcutaneously Administered Tabalumab in Subjects with Rheumatoid Arthritis or Systemic Lupus Erythematosus
Jennifer Witcher¹, Ryan Hansen¹, Leijun Hu¹, David Radtke¹, James Voelker¹ and Juliet McColm², ¹Eli Lilly and Company, Indianapolis, IN, ²Eli Lilly and Company, Windlesham, United Kingdom
Background/Purpose : B-cell activating factor (BAFF) promotes B-cell survival and maturation, and increased serum levels are associated with autoimmune disease and disease activity in systemic…
Abstract Number: 2674 • 2014 ACR/ARHP Annual Meeting
The Effect and Mechanisms of Icaritin on Regulating Foxp3/IL17a Expression in CD4⁺ T Cells from SLE
Jieyue Liao¹, Yu Liu², Ming Zhao³, hai Jing Wu⁴ and Qianjin Lu⁵, ¹Department of Dermatology, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Second Xiangya Hospital, Central South University, shangcha, China, ³Department of Dermatology, Second Xiangya Hospital, Central South University, changsha, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, sahngsha, China, ⁵Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose : Systemic lupus erythematosus (SLE) is a female predominant autoimmune disease characterized by overproduction of autoantibodies. The pathogenesis of SLE is complex. Several studies…

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