Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2812 • 2016 ACR/ARHP Annual Meeting
Clinical Trial Simulation Identifies Factors for Patient Engagement in Systemic Lupus Erythematosus and Lupus Nephritis Trials By African-Americans
S. Sam Lim¹, Doug McKinnell², M Edward Pierson³ and Faye O'Brien³, ¹Medicine, Emory University School of Medicine, Atlanta, GA, ²Deloitte UK Life Sciences Advisory, London, United Kingdom, ³AstraZeneca, Gaithersburg, MD
Background/Purpose: Clinical trials of patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN) can be confounded by difficulties in engaging patients. Identifying factors of…
Abstract Number: 1383 • 2016 ACR/ARHP Annual Meeting
ANTI-RO/SSA and/or ANTI-La/SSB Antibodies: Association with Mild LUPUS Manifestations in 645 Childhood-Onset Systemic LUPUS Erythematosus
Glaucia V. Novak¹, Mariana Marques², Verena Balbi², Natali W. Gormezano², Katia T. Kozu², Ana Paula Sakamoto³, Rosa M R Pereira⁴, Maria Teresa Terreri³, Claudia S. Magalhães⁵, Silvana B. Sacchetti Sr.⁶, Adriana M E Sallum², Roberto Marini Sr.⁷, Virgínia Ferriani⁸, Cássia M. Barbosa⁹, Tânia C M Castro¹⁰, Valéria C. Ramos¹¹, Eloisa Bonfá¹² and Clovis A Silva¹³, ¹Pediatric Rheumatology Unit,, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, ³Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil, ⁴Rheumatology, University of São Paulo, São Paulo, Brazil, ⁵Pediatric Rheumatology Division, São Paulo State University (UNESP), Botucatu, Brazil, ⁶Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁸Department of Pediatrics School of Medicine of Ribeirão Preto, University of São Paulo (USP-RP), Ribeirão Preto, Brazil, ⁹Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, ¹⁰Pediatric Rheumatology Unit, Hospital Menino Jesus, São Paulo, Brazil, ¹¹Pediatric Rheumatology Unit, Pontifical Catholic University of Sorocaba, São Paulo, Brazil, ¹²Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ¹³Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Anti-Ro/SSA and anti-La/SSB antibodies were reported in 30-50% and 10-30% of adult SLE patients, associated mainly with cutaneous manifestations. However, to our knowledge there…
Abstract Number: 1386 • 2016 ACR/ARHP Annual Meeting
Outcome of 847 Childhood-Onset Systemic LUPUS Erythematousus Patients in Three Age Groups
Sandra R M Lopes¹, Natali W. Gormezano², Roberta C. Gomes Sr.³, Nadia E Aikawa⁴, Rosa M R Pereira⁵, Maria Teresa Terreri⁶, Claudia S. Magalhães⁷, Eunice M. Okuda⁸, Ana Paula Sakamoto⁶, Adriana M E Sallum², Simone Appenzeller⁹, Virgínia Ferriani¹⁰, Cássia M. Barbosa¹¹, Simone Lotufo¹², Adriana A. Jesus^13,14, Luis E C Andrade¹⁵, Lucia M A Campos⁴, Eloisa Bonfa¹⁶ and Clovis A Silva³, ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, ³Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology Division, Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ⁶Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Division, São Paulo State University (UNESP), Botucatu, Brazil, ⁸Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, ⁹Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, ¹⁰Department of Pediatrics School of Medicine of Ribeirão Preto, University of São Paulo (USP-RP), Ribeirão Preto, Brazil, ¹¹Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, ¹²Pediatric Rheumatology Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil, ¹³Pediatrics Department, Universidade de São Paulo, São Paulo, Brazil, ¹⁴Pediatrics, Instituto da Criança da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil, ¹⁵Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ¹⁶Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: A recent large study comparing childhood systemic lupus erythematosus (cSLE) with adult-onset SLE revealed a more aggressive and worse outcome in the former group.…
Abstract Number: 737 • 2015 ACR/ARHP Annual Meeting
A Paper Patient-Based Flare Study in SLE
Joanna Sturgess¹, Elizabeth Allan¹, David A. Isenberg², Cynthia Aranow³, Martin Aringer⁴, Anca Askanase⁵, Sang-Cheol Bae⁶, Sasha R Bernatsky⁷, Ian N. Bruce⁸, Jill P. Buyon⁹, Ricard Cervera¹⁰, Ann Clarke¹¹, Mary Anne Dooley¹², Paul R. Fortin¹³, Ian Giles², Ellen M. Ginzler¹⁴, Dafna Gladman¹⁵, Caroline Gordon¹⁶, Bridget Griffiths¹⁷, John G. Hanly¹⁸, Murat Inanc¹⁹, Søren Jacobsen²⁰, Diane L. Kamen²¹, Munther Khamashta²², Peter Lanyon²³, S. Sam Lim²⁴, Susan Manzi²⁵, Marta Mosca²⁶, Ola Nived²⁷, Christine A. Peschken²⁸, Michelle Petri²⁹, Kenneth C. Kalunian³⁰, Anisur Rahman³¹, Rosalind Ramsey-Goldman³², Guillermo Ruiz-Irastorza³³, Jorge Sánchez-Guerrero³⁴, Matteus Schneider³⁵, Kristján Steinsson³⁶, Gunnar K. Sturfelt³⁷, Murray Urowitz^38,39, Ronald F. van Vollenhoven⁴⁰, Carlos Vasconcelos⁴¹, Daniel J Wallace⁴², Asad Zoma⁴³, Joan T. Merrill⁴⁴, Eric Morand⁴⁵, Sharon Chambers⁴⁶, Nathalie Costedoat-Chalumeau⁴⁷ and Sara Croca², ¹Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom, ²Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ³Feinstein Institute for Medical Research, Mahasset, NY, ⁴Rheumatology, Universitatsklinikum, Dresden, Germany, ⁵Columbia University College of Physicians & Surgeons, New York, NY, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁷Division of Rheumatolog, McGill Unversity Health Cener, Montreal, QC, Canada, ⁸Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ⁹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ¹⁰Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain, ¹¹Division of Rheumatology, Department of Medicine, University of Calgary, Calgary, AB, Canada, ¹²UNC Kidney Centre, Chapel Hill, NC, ¹³Université Laval, CHU de Québec, Québec, QC, Canada, ¹⁴Medicine/Box 42, SUNY-Downstate, Brooklyn, NY, ¹⁵Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹⁶Rheumatology (East Wing), Medical School, Birmingham, United Kingdom, ¹⁷Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, ¹⁸Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ¹⁹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²⁰Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ²¹Medicine, Medical University of South Carolina, Charleston, SC, ²²Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ²³Rheumatology, Queens Medical Centre Nottingham, Nottingham, United Kingdom, ²⁴Emory University School of Medicine, Atlanta, GA, ²⁵Rheumatology, Allegheny Health Network, Pittsburgh, PA, ²⁶University of Pisa, Pisa, Italy, ²⁷Rheumatology, Inst of Clinical sciences, Lund, Sweden, ²⁸Rheumatology, Univ of Manitoba, Winnipeg, MB, Canada, ²⁹Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ³⁰Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, ³¹Academic Centre for Rheumatology, University College London, London, United Kingdom, ³²Northwestern University Feinberg School of Medicine, Chicago, IL, ³³Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, ³⁴Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada, ³⁵MNR-Klinik, Heinrich-Heine-Univ Dusseldorf, Dusseldorf, Germany, ³⁶Rheumatology, Univ. Hospital, Reykjavik, Iceland, ³⁷Department of Rheumatology, Univ Hospital Lund, Lund, Sweden, ³⁸University of Toronto, Toronto, ON, Canada, ³⁹Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴⁰Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁴¹Medicina Interna, Unidade de Imunologia Clínica - Hospital Santo António, Oporto, Portugal, ⁴²Cedars-Sinai Medical Center, West Hollywood, CA, ⁴³Rheumatology, Hairmyres Hospital, East Kilbride, United Kingdom, ⁴⁴Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴⁵Medicine, Monash University, Clayton, Australia, ⁴⁶TrinCay Medical Services, Camana Bay, Cayman Islands, ⁴⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France
ACR Abstract – A Paper Patient-Based Flare Study in Systemic Lupus Erythematosus (SLE) Isenberg D, Sturgess J, Allan E, Aranow C, Aringer M, Askanase A,…
Abstract Number: 747 • 2015 ACR/ARHP Annual Meeting
Depletion of Serum Soluble CD40L Characterizes the Association Between Systemic Lupus Erythematosus and Thrombotic Thrombocytopenic Purpura: Longitudinal, Single-Center Study
Javier Merayo-Chalico¹, Ana Barrera-Vargas², Jorge Alcocer-Varela² and Diana Gómez-Martín², ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a higher incidence of thrombotic thrombocytopenic purpura (TTP). Differentiating TTP from SLE activity may represent a challenge…
Abstract Number: 780 • 2015 ACR/ARHP Annual Meeting
Long-Term Prognosis and Factors Associated with Damage Accrual in Japanese Patients with Systemic Lupus Erythematosus
Yoko Wada¹, Hisashi Hasegawa², Takeshi Kuroda³, Masaaki Nakano⁴ and Ichiei Narita¹, ¹Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Division of Clinical Nephrology and Rheumatology, Niigata City General Hospital, Niigata, Japan, ³Health Administration Center, Niigata University, Niigata, Japan, ⁴Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by fluctuating disease activity over periods of years. The estimated 5-year survival rate of…
Abstract Number: 1107 • 2015 ACR/ARHP Annual Meeting
Inhibition of B Cell Activation and Plasma Cell Differentiation By Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22
Natalia V. Giltiay¹, Geraldine L. Shu², Anthony Shock³ and Edward A. Clark^1,2, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Department of Immunology, University of Washington, Seattle, WA, ³UCB Pharma, Slough, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by B cell hyperactivity and production of autoantibodies. Treatment of patients with moderate-to-severe SLE with epratuzumab, a humanized…
Abstract Number: 2935 • 2015 ACR/ARHP Annual Meeting
Disease Evolution in Late Onset and Early Onset Systemic Lupus Erythematosus (SLE)
Roa'a Al Johani¹, Dafna Gladman², Jiandong Su² and Murray Urowitz^2,3, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: To compare clinical features, disease activity and outcome in late onset versus early onset SLE over 5 years of follow up. Methods: Patients with…
Abstract Number: 2953 • 2015 ACR/ARHP Annual Meeting
The Emergency Room and SLE: What Characteristics Are Associated with Increased Emergency Room Utilization in Lupus Patients?
Kimberly Trotter¹, Kichul Ko¹, Gabrielle Liu¹ and Tammy Utset², ¹Medicine, University of Chicago, Chicago, IL, ²University of Chicago, Chicago, IL
Background/Purpose: There is sparse data examining the characteristics of SLE patients who frequent the emergency room (ER). Data suggest that lupus patients with certain sociodemographic…
Abstract Number: 3218 • 2015 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study of the Efficacy and Safety of Belimumab Administered Subcutaneously Plus Standard Care to Patients with Systemic Lupus Erythematosus (SLE)
William Stohl¹, Andreas Schwarting², Masato Okada³, Morton Scheinberg⁴, Andrea Doria⁵, Anne Hammer⁶, Christi Kleoudis⁷, Damon Bass⁸, James Groark⁹, Norma Lynn Fox¹⁰, David Roth¹¹ and David Gordon¹¹, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²ACURA Kliniken, Bad Kreuznach, Germany, ³Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ⁴Rheumatology Hospital Abreu Sodre Pesquisa Clínica, São Paulo, Brazil, ⁵Division of Rheumatology, University of Padova, Padova, Italy, ⁶GlaxoSmithKline, Research Triangle Park, NC, ⁷Parexel, Durham, NC, ⁸Immuno-Inflammation, GlaxoSmithKline, King of Prussia, PA, ⁹GlaxoSmithKline, Philadelphia, NC, ¹⁰GlaxoSmithKline, Washington, MD, ¹¹GlaxoSmithKline, Philadelphia, PA
Background/Purpose: To assess the efficacy and safety of belimumab (BEL) administered subcutaneously plus standard SLE care (SoC) in patients with active SLE.Methods: BLISS-SC (BEL112341; NCT01484496)…
Abstract Number: 1320 • 2014 ACR/ARHP Annual Meeting
Analysis of Risk Factors for Thrombosis in Pediatric Patients with Systemic Lupus Erythematosus
Kyla D. Driest¹, Mollie S. Sturm², Sarah H. O'Brien³, Charles H. Spencer⁴ and Stacy P. Ardoin⁵, ¹Rheumatology, OSU Pediatrics, Nationwide Children's Hospital, Columbus, OH, ²Nationwide Children's Hospital, Columbus, OH, ³Hematology, Nationwide Children's Hospital, Columbus, OH, ⁴Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ⁵Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a higher thrombotic risk compared to the general population, and arterial and venous thromboses impart substantial morbidity…
Abstract Number: 1079 • 2014 ACR/ARHP Annual Meeting
Prevalence of Cardiac Arrhythmias in Systemic Lupus Erythematosus
Gihyun Myung¹, Lindsy J. Forbess², Mariko L. Ishimori², Sumeet Chugh¹, Daniel Wallace¹ and Michael H. Weisman¹, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose Cardiovascular disease is a major cause of death among systemic lupus erythematosus (SLE) patients. Although the prevalence of atrial fibrillation (0.5-1%) and QT prolongation…
Abstract Number: 873 • 2014 ACR/ARHP Annual Meeting
The Second Messenger, Cyclic GMP-AMP Dinucleotide (cGAMP) and the Enzyme, Cyclic GMP-AMP Synthase (cGAS), Are Expressed in Systemic Lupus Erythematosus
Jie An¹, Joshua Woodward², Reynold Karr³, Thomas H. Teal⁴ and Keith B. Elkon¹, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Microbiology, University of Washington, Seattle, WA, ³Department of Medicine, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA
Background/Purpose: The type I IFNs (IFN-I), are strongly associated with Systemic Lupus Erythematosus (SLE). It is generally considered that IFN-I is induced by immune complexes…
Abstract Number: 700 • 2014 ACR/ARHP Annual Meeting
Decreased Lung Diffusion Capacity in Asymptomatic Patients with Systemic Lupus Erythematosus Does Not Predict Future Lung Disease
Ofir Elalouf¹, Elizabeth Fireman², David Levartovsky¹, Ilana Kaufman¹, Ori Rogovski³, Ori Elkayam¹, Dan Caspi¹ and Daphna Paran¹, ¹Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ²Pulmonary and Allergic diseases, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ³Internal Medicine ward, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Background/Purpose In a previous study, performed 9±3.6 years ago 74 asymptomatic patients with systemic lupus erythematosus (SLE) and or antiphospholipid syndrome (APS) who fulfilled the…
Abstract Number: 697 • 2014 ACR/ARHP Annual Meeting
Venous and Arterial Thrombosis in SLE: Differences in Natural History
Katharine Hickman¹, Laurence S. Magder² and Michelle Petri³, ¹University College London, London, United Kingdom, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Thrombosis is increased in SLE due to disease activity and co-morbid factors including antiphospholipid antibodies. We separately investigated the natural history of venous vs.…

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