Abstract Number: 1188 • 2019 ACR/ARP Annual Meeting
Novel PET-Coronary Flow Reserve Imaging to Assess for Coronary Microvascular Dysfunction in Systemic Lupus Erythematosus Compared to Subjects with Diabetes Mellitus and Controls
Background/Purpose: High risk of premature cardiovascular disease (CVD) among SLE patients is well documented, but the best means to detect the earliest stages of CVD…Abstract Number: 1586 • 2019 ACR/ARP Annual Meeting
All-cause Hospitalizations and Mortality in Systemic Lupus Erythematosus in the US- results from a National Inpatient Database
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disorder with variable presentation. While several studies have outlined the risk factors for hospitalization and…Abstract Number: 1624 • 2019 ACR/ARP Annual Meeting
Progression and Factors Associated with Damage Accrual in a SLE Inception Cohort of Hispanic Patients
Background/Purpose: The aims of our study were to determine the cumulative prevalence of damage at baseline, 5 years and 10 years of follow-up, to identify…Abstract Number: 1914 • 2019 ACR/ARP Annual Meeting
Increased Risk of Progression to Lupus Nephritis for Lupus Patients with Elevated Interferon Signature
Background/Purpose: The interferon (IFN) signature in SLE is well established, distinguishing lupus patients from healthy controls. Additionally, within lupus patients, higher levels of IFN-responsive gene…Abstract Number: 2127 • 2019 ACR/ARP Annual Meeting
Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics
Background/Purpose: Early diagnosis of inflammatory rheumatic diseases (IRD), as axial Spondyloarthritis (axSpA), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) represents in our days a…Abstract Number: 2528 • 2019 ACR/ARP Annual Meeting
Effect of Additional Administration of HCQ on Pro-inflammatory Cytokine Expression, Especially in Lupus Nephritis
Background/Purpose: Hydroxychloroquine(HCQ) is recommended for all patients with SLE in EULAR recommendation 2019, however, there are not enough data about the effect of additional HCQ…Abstract Number: 2563 • 2019 ACR/ARP Annual Meeting
PK/PD, Safety and Exploratory Efficacy of Subcutaneous Anifrolumab in SLE: A Phase-II Study in Interferon Type I High Patients with Active Skin Disease
Background/Purpose: Anifrolumab, a fully human anti–IFN Type I receptor mAb, is under investigation for the treatment of SLE at a dose of 300 mg intravenously…Abstract Number: 2812 • 2019 ACR/ARP Annual Meeting
A New Role for Selectins in Systemic Lupus Erythematosus
Background/Purpose: In systemic lupus erythematosus (SLE), blood platelets have an activated phenotype, and express high levels of CD40L and P-selectin. Our group demonstrated that SLE…Abstract Number: 82 • 2019 ACR/ARP Annual Meeting
Rab4A Increases Mitochondrial Oxidative Stress and Glutathione Disulfide Accumulation That Underlie Neurobehavioral Changes in Lupus-Prone Mice
Background/Purpose: Background/Purpose The human GTPase HRES-1/Rab4 has been identified as a susceptibility locus for systemic lupus erythematosus (SLE) and is overexpressed in T cells of…Abstract Number: 653 • 2019 ACR/ARP Annual Meeting
Newly Diagnosed Lupus Nephritis in Elderly Predicts Good Renal Outcome: A Distinct Disease Subset from Young-onset Lupus Nephritis
Background/Purpose: Elderly-onset SLE is recognized to be benign disease entity with a favorable nature course. Although late-onset lupus nephritis (LN), long interval between onset of…Abstract Number: 860 • 2019 ACR/ARP Annual Meeting
Efficacy of Belimumab in Patients of Black Race with Systemic Lupus Erythematosus and High Disease Activity or Renal Manifestations
Background/Purpose: Black patients have more severe SLE and more frequent lupus nephritis vs other racial groups. Efficacy and safety of intravenous (IV) belimumab was demonstrated…Abstract Number: 1031 • 2019 ACR/ARP Annual Meeting
Expanded Circulating Peripheral Helper T Cells Are Associated with B Cell Differentiation in Systemic Lupus Erythematosus
Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…Abstract Number: 1207 • 2019 ACR/ARP Annual Meeting
A Quality Improvement Intervention to Reduce 30-Day Hospital Readmission Rates Among Patients with Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic immune-mediated disease with significant morbidity and mortality that often requires inpatient hospitalization. SLE has one of the…Abstract Number: 1590 • 2019 ACR/ARP Annual Meeting
Clinical and Sociodemographic Associates of Depression and Anxiety in Systemic Lupus Erythematosus
Background/Purpose: In our recent systematic review, we have shown a high prevalence for depression (35%) and anxiety (25.8%) in Systemic Lupus Erythematosus (SLE)1. A better…Abstract Number: 1625 • 2019 ACR/ARP Annual Meeting
Severe Infection Prior to Diagnosis of Systemic Lupus Erythematosus (SLE) Is Associated with Disease-Specific Attributes and Long-Term Comorbidities
Background/Purpose: Lupus is a systemic autoimmune disease whose mechanism of development is largely unknown. Prior infection is a suspected sentinel event that may trigger disease…
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