Date: Sunday, November 7, 2021
Session Type: Poster Session B
Session Time: 8:30AM-10:30AM
Background/Purpose: Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index (SLICC-FI) is a novel health measure in systemic lupus erythematosus (SLE) and was reported to have impact on outcomes including mortality. The objective of the study was to evaluate the association of depression and frailty in SLE patients.
Methods: SLE patients who fulfilled 1997 American College of Rheumatology (ACR) classification criteria were enrolled from five teaching hospitals in Korea and the participants filled out questionnaires at outpatient clinic. Electronic medical records were reviewed for laboratory results, disease activity at enrollment, medications and damage index score and SLICC-FI was calculated. To assess the severity of depression, patient health questionnaire-9 (PHQ-9) was used. Logistic regression analysis was used to evaluate the factors associated with frailty in SLE patients
Results: In total, 247 patients were recruited. Mean (standard deviation, SD) age of the cohort was 50.5 (1.6) and 91.9% of the cohort was female. The mean (SD) of SLE disease activity index-2000 (SLEDAI-2K) was 3.5 (4.0). According to SLICC-FI, 36 (14.6%) patients were classified as frail. Mild depression (PHQ-9 score ≥ 5) was observed in 97.2% of frail patients and 54.5% of not-frail patients. Severe depression (PHQ-9 ≥ 20) was observed in 22.2% of frail patients and 1.4% of not-frail patients. In multivariable logistic regression analysis, age (1.09), ESR (1.03), SLEDAI-2K (1.18), PHQ-9 score (1.27) and SLICC/ACR damage index (3.22) were associated with frailty (odds ratio in parenthesis).
Conclusion: Depression in SLE patients was associated with frailty. Rheumatologists should pay attention to early detection and intervention of depression in SLE patients to improve outcomes.
To cite this abstract in AMA style:Shin K, Choi I, Lee E, CHOI S, Yeo J, Lee Y, Yoo S, Hahm B, Park J, Lee J, Song Y, Kim J. Depression Is Associated with Frailty in Systemic Lupus Erythematosus Patients: Multicenter Retrospective Analysis Using Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/depression-is-associated-with-frailty-in-systemic-lupus-erythematosus-patients-multicenter-retrospective-analysis-using-systemic-lupus-erythematosus-international-collaborating-clinics-frailty-index/. Accessed January 27, 2023.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/depression-is-associated-with-frailty-in-systemic-lupus-erythematosus-patients-multicenter-retrospective-analysis-using-systemic-lupus-erythematosus-international-collaborating-clinics-frailty-index/