Abstracts tagged "Synovitis"

Abstract Number: 2394 • 2015 ACR/ARHP Annual Meeting
B-Flow Imaging of Synovial Tissue in Osteoarthritis
Ralf G. Thiele¹, Allen P. Anandarajah² and Christopher T. Ritchlin³, ¹University of Rochester Medical Center, Rochester, NY, ²Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ³Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Development of disease modifying medication for osteoarthritis (OA) is desirable, but the target tissue of such treatment remains unclear. We have previously shown that…
Abstract Number: 2567 • 2015 ACR/ARHP Annual Meeting
SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis
Ryoji Fujii¹, Iwao Seki², Rie Komatsu¹, Tomomi Kohara², Miwa Takai², Tomoo Sato³, Koji Konomi², Hiroyuki Aono², Kazuo Yudoh¹, Kusuki Nishioka⁴ and Toshihiro Nakajima⁵, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ²Santen Pharmaceutical Co. Ltd., Nara, Japan, ³Molecular Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ⁴Institute of Medical Science, Tokyo Medical University, Tokyo, Japan, ⁵Department of Locomotor Science/Future Medical Science, Institute of Medical Science, integrated Gene Editing Section (iGES), Tokyo Medical University, Tokyo, Japan
Background/Purpose: SPACIA1/SAAL1 is a gene associated with abnormal synovial proliferation. We previously showed that SPACIA1/SAAL1 small interfering RNA inhibited the proliferation of rheumatoid arthritis synovial…
Abstract Number: 152 • 2014 ACR/ARHP Annual Meeting
Subclinical Synovial Inflammation in Gout
Priya Chowalloor^1,2, Patrick Cheah³ and Helen I. Keen^1,2, ¹Rheumatology, Royal Perth Hospital, Perth, Australia, ²School of Medicine and Pharmacology, The University of Western Australia, Crawley, Australia, ³Rheumatology, Sir Charles Gairdner Hospital, Nedlands, Australia
Background/Purpose Gout is poorly managed in the community. Long standing poorly controlled gout can lead into progressive destructive arthropathy, decreased quality of life and increased…
Abstract Number: 143 • 2014 ACR/ARHP Annual Meeting
Detailed Anatomical Distribution of Synovial Inflammation Revealed By Ultrasound in Patients with Blau Syndrome
Kei Ikeda¹, Naotomo Kambe², Syuji Takei^3,4, Taiji Nakano⁵, Yuzaburo Inoue⁵, Minako Tomiita⁶, Natsuko Oyake⁷, Takashi Satoh⁸, Tsuyoshi Yamatou³, Tomohiro Kubota³, Ikuo Okafuji⁹, Nobuo Kanazawa¹⁰, Ryuta Nishikomori¹¹, Naoki Shimojo⁵, Hiroyuki Matsue⁸ and Hiroshi Nakajima¹, ¹Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ²Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, ³Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, ⁴School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ⁵Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan, ⁶Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba, Japan, ⁷Department of Pediatrics, Hitachinaka General Hospital, Hitachinaka, Japan, ⁸Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, ⁹Department of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Japan, ¹⁰Department of Dermatology, Wakayama Medical University, Wakayama, Japan, ¹¹Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose Arthritis is the most frequent manifestation of Blau syndrome, an autoinflammatory disorder caused by the genetic mutation of NOD2. However, the detailed information on…
Abstract Number: 2126 • 2014 ACR/ARHP Annual Meeting
The Utility of Digital Activity Fluorescence Optical Imaging in Quantifying Hand and Wrist Inflammation in Rheumatic Diseases
Yogan Kisten¹, Noémi Györi¹, Hamed Rezaei^2,3, Adrian Levitsky⁴, Anna Karlsson¹, Erik af Klint³ and Ronald van Vollenhoven^3,5, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ²Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The rheumatology clinic of the Karolinska University Hospital, Stockholm, Sweden, ⁴The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ⁵Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden
Background/Purpose The objective detection and quantification of disease activity in its earliest pathophysiological stage is critical for achieving optimal therapy results. Fluorescence optical imaging (FOI)…
Abstract Number: 2419 • 2013 ACR/ARHP Annual Meeting
CDK6 Transcripts Expression Control By The Synoviocyte Proliferation Gene, SPACIA1
Rie Komatsu¹, Ryoji Fujii¹, Tomoo Sato¹, Yoshihisa Yamano¹, Kazuo Yudoh², Moroe Beppu³, Kusuki Nishioka⁴ and Toshihiro Nakajima^3,4,5, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ²Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ³St. Marianna University School of Medicine, Kanagawa, Japan, ⁴Tokyo Medical University, Tokyo, Japan, ⁵Misato Marine Hospital, Kohchi, Japan
SPACIA1ASFs) and . In the present study we investigated the mechanisms involved in the SPACIA1-related regulation of CDK6 gene expression in vitro.ASFs: Among the key…
Abstract Number: 1970 • 2013 ACR/ARHP Annual Meeting
The Utility Of Fluorescence Optical Imaging For Detecting Clinically Silent Synovitis Of The Hands and Wrists
Yogan Kisten¹, Noémi Györi², Hamed Rezaei³, Anna Karlsson¹, Carolina Romanus², Ronald van Vollenhoven⁴ and Erik af Klint⁵, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ²Unit for Clinical Therapy Research Inflammaroty Diseases (ClinTRID) Department of Medicine, the Karolinska Insitute, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁴Unit for Clinical Research Therapy. Inflammatory Diseases (ClinTrid), Karolinska Institute, Stockholm, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The rheumatology clinic of the Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: The detection of subclinical synovial inflammation (“silent synovitis”) would be of critical importance for the detection of rheumatoid arthritis (RA) in its earliest pathophysiological…
Abstract Number: 1944 • 2013 ACR/ARHP Annual Meeting
Ultrasound Characteristics Of Extensor Tendon Abnormalities and Peritendinous Fluid In Rheumatoid Arthritis
Laurie Ann Ramrattan¹ and Gurjit S. Kaeley², ¹Internal Medicine, University of Florida, Jacksonville, FL, ²College of Medicine, University of Florida, Jacksonville, FL
Background/Purpose: Rheumatoid arthritis (RA) is synonymous for involving synovial lined structures such as joints and tendon sheaths. Alterations in the extensor tendons overlying the metacarpophalangeal…

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