Abstracts tagged "Synovitis"

Abstract Number: LB23 • ACR Convergence 2025
A Phase 1 Study of Autologous CAR-Treg Cells in Refractory Rheumatoid Arthritis: Interim Report of Safety and Efficacy
Minna Kohler¹, Sally Arai², Fawad Aslam³, Gregory Challener⁴, Matthew Frigault⁴, Melissa Griffith⁵, Tamiko Katsumoto⁶, Elena Massarotti⁷, Larry Moreland⁸, Allison Rosenthal⁹, Jeffrey Sparks⁷, Janeth Yinh⁴, Sarah Baxter¹⁰, Ari Bitton¹¹, Jason Dubovsky¹², Victor Yuan¹³, Mindy Jensen¹⁴, Andrew Clauw¹⁵, Gabrielle Furman⁴, Rita Gyurko⁷, Megan Hall⁹, Anna McIntyre⁴, Jennifer Seifert¹⁶, Emma Stainton², Michelle Blake¹⁰, Sabrina Fox-Bosetti¹³, Herve Lebrec¹³, Amanda Pace¹⁰, Yuanyuan Xiao¹⁷, Mei-Lun Wang¹⁸, Joe Arron¹³ and Jeffrey Bluestone¹⁹, ¹Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, ²Stanford, Palo Alto, California, ³Mayo Clinic, Arizona, Scottsdale, Arizona, ⁴Massachusetts General Hospital, Boston, Massachusetts, ⁵University of Colorado Anschutz Medical Campus, Aurora, Colorado, ⁶Stanford University, Millbrae, California, ⁷Brigham and Women's Hospital, Boston, Massachusetts, ⁸University of Colorado, Denver, Colorado, ⁹Mayo Clinic, Phoenix, Arizona, ¹⁰Sonoma Biotherapeutics, Seattle, Washington, ¹¹Sonoma Biotherapeutics, San Diego, California, ¹²Sonoma Biotherapeutics, Thousand Oaks, California, ¹³Sonoma Biotherapeutics, South San Francisco, California, ¹⁴Sonoma Bio, Seattle, Washington, ¹⁵University of Colorado, Aurora, Colorado, ¹⁶University of Colorado and Oklahoma Medical Research Foundation, Aurora, Colorado, ¹⁷Sonoma Biotherapeutics, Los Altos, California, ¹⁸Sonoma Biotherapeutics, San Francisco, California, ¹⁹Sonoma Biotherapeutics Inc, South San Francisco, California
Background/Purpose: Regulatory T cells (Tregs) modulate inflammation, maintain self-tolerance, promote tissue repair, and hold promise as a versatile therapeutic. Autologous polyclonal Tregs have a favorable…
Abstract Number: 2285 • ACR Convergence 2025
Synovium-on-a-chip – Development of a Humanized Rheumatoid Arthritis Model that Mimics Disease and Patient Biological Heterogeneity
Theresa Wampler Muskardin¹, Ruiqi Chen², Yeji Lee³, Azka Ali³, Andrra Nimoni³, Christele Felix³, Hattie Heiland³, Romy Kallas³, Daniel Ramirez⁴, David Mayman³, Timothy Niewold⁵ and Weiqiang Chen⁶, ¹Hospital for Special Surgery and Weill Cornell Medicine, New York, NY, ²New York University - Tandon School of Engineering, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery, New York, New York, ⁶New York University, Tandon School of Engineering, New York, NY
Background/Purpose: In rheumatoid arthritis (RA), reasons for treatment resistance and alternate strategies that would be more effective in treatment-resistant patients remain unknown. Accurate methodology to…
Abstract Number: 1133 • ACR Convergence 2025
A Proteomic Analysis Of Subclinical Synovial Inflammation Associated With Monosodium Urate Crystal Deposition
Mariano Andrés¹, María-Luisa Peral-Garrido², Samanta Ortuño³, Rocío Caño³, Silvia Gómez-Sabater³, Alejandra Bermúdez⁴, Teresa Lozano⁵, Miguel Perdiguero⁵, elena Caro-Martínez⁶, Ruth Sánchez-Ortiga⁵, Carolina Ruiz-García⁷, Eliseo Pascual⁸ and Rubén Francés⁸, ¹Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, ²Vinalopó University Hospital, Novelda, Spain, ³Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain, ⁴Rheumatology Department, Dr. Balmis General University Hospital, Alicante, Spain., Alicante, Spain, ⁵Dr Balmis General University Hospital, Alicante, Spain, ⁶HACLE San Vicente Hospital, San Vicente del Raspeig, Spain, ⁷Campoamor Health Center, Alicante, Spain, ⁸Miguel Hernandez University of Elche, Alicante, Spain
Background/Purpose: Persistent subclinical inflammation from monosodium urate (MSU) crystals is present in gout and asymptomatic hyperuricemia (AH). The underlying mechanism is poorly understood. This study…
Abstract Number: 0080 • ACR Convergence 2025
The Role of DICAM in Modulating Macrophage Differentiation and Inflammatory Responses via αvβ3 Integrin Signaling in Rheumatoid Arthritis
Hanna Lee¹, Youn-Kwan Jung², Sang-il Lee³, Yun-Hong Cheon⁴ and Hyunjin Lim⁴, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Changwon, Changwon-si, Kyongsang-namdo, Republic of Korea, ²Institute of Medical Science, Gyeongsang National University, Jinju, Jinju, Kyongsang-namdo, Republic of Korea, ³Department of Internal Medicine and Institute of Medical Science, College of Medicine, Gyeongsang National University and Hospital, Jinju, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Jinju, Kyongsang-namdo, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation, cartilage destruction, and bone erosion. Among the various immune cells involved…
Abstract Number: 1965 • ACR Convergence 2025
Two-Year Outcomes of Microwave Ablation for Recurrent Monoarthritis with Synovial Hypertrophy Resistant to Medical Treatment: Expanded Cohort and Long-Term Follow-Up Results
Rabia Deniz¹, Tevfik Güzelbey², İlhan Nahit Mutlu², Kübra Kalkan³, Özgür Kılıçkesmez² and Cemal Bes⁴, ¹University of Health Sciences Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey, ²University of Health Sciences Başakşehir Çam and Sakura City Hospital, Department of Radiology, Istanbul, Turkey, ³University of Health Sciences Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, Istanbul, Turkey, ⁴University of Health Sciences, Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey
Background/Purpose: Recurrent monoarthritis (RM) is a significant therapeutic challenge in rheumatology, often persisting despite NSAIDs, corticosteroids (CS), DMARDs, and biologic therapies. Local interventions like intra-articular…
Abstract Number: 0932 • ACR Convergence 2025
Compartment-specific NK-cell phenotypes reveal distinct maturation and activation states in inflammatory arthritis
Franca Sophie Deicher¹, Tarik Exner², Maren Claus³, Schayan Yousefian⁴, Lea Rodon⁵, sophie leonhardt⁶, Jörg Distler⁷, Carsten Watzl³, Hanns-Martin Lorenz⁸, Simon Haas⁴, Daniel Hübschmann⁹ and Wolfgang Merkt¹⁰, ¹Uniklinik Düsseldorf, Düsseldorf, Germany, ²University Hospital Heidelberg, Heidelberg, Germany, ³IfADo, Leibniz Institute Dortmund, Dortmund, Germany, ⁴Charite, Berlin, Berlin, Germany, ⁵University Hospital Heidelberg, Heidelberg, Hungary, ⁶Heidelberg University, Heidelberg, Germany, ⁷University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ⁸Universitétsklinikum Heidelberg, Heidelberg, Germany, ⁹Heidelberg University, Berlin, Germany, ¹⁰University Hospital Düsseldorf, Düsseldorf, Germany
Background/Purpose: Synovial natural killer (NK) cells contribute to inflammation in arthritis by secreting cytokines and modulating synovial fibroblast activation. The aim of this study is…
Abstract Number: 0061 • ACR Convergence 2025
IL-22 Contributes to Autoantibody-induced Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Inflamed Synovium of a Murine Model
Shinjiro Kaieda¹, Suzuna Sugi¹, Takuma Koga², Takashi Kinoshita¹ and Tomoaki Hoshino¹, ¹Kurume university School of Medicine, Kurume, Japan, ²Kurume Universty School of Medicine, Kurume, Japan
Background/Purpose: IL-22 is a key cytokine involved in modulating tissue responses during inflammation and is markedly upregulated in inflammatory diseases, such as psoriasis, inflammatory bowel…
Abstract Number: 1961 • ACR Convergence 2025
Clinical Utility and Patient Experience of Ultrasound-Guided Synovial Biopsy in Refractory Arthritis: A Case Series from a Secondary Care Center
Maria Beatriz Paredes Romero¹, Elisabet Castañeda Estévez², Martina Steiner³, Marco Algarra- San José³, Ana Valeria Acosta³, Tatiana Cobo-Ibáñez⁴, Isabel De la Cámara³, Ana Victoria Esteban Vázquez⁵, Patricia Richi³, Maria Liz Romero-Bogado³, Laura Trives⁵, Cristina Vergara-Dangond⁴, Jorge palomar-Ramos³ and Santiago Muñoz⁵, ¹Infanta Sofía University Hospital, Madrid, Spain, ²Hospital Universitario Infanta Sofía, Madrid, Spain, ³Infanta Sofía University Hospital, Madrid, Spain, ⁴Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, San Sebastian de Los Reyes, Madrid, Spain, ⁵Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, Madrid, Spain
Background/Purpose: Diagnosing arthritis remains challenging in a subset of patients despite advances in imaging, serological markers, and clinical scoring systems. Ultrasound-guided synovial biopsy (USG-SB) stands…
Abstract Number: 0925 • ACR Convergence 2025
Pathogenic role of SPP1+ macrophages in Rheumatoid Arthritis
Megan M. Hanlon¹, Catherine Manning¹, Kevin Wei¹, Ursula Fearon² and Ellen M. Gravallese³, ¹Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ²Trinity College Dublin, Dublin, Dublin, Ireland, ³Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Synovial tissue macrophages (STMs) represent a mixed population of cells contributing to the pathogenesis of rheumatoid arthritis (RA). We identified an enrichment of Secreted…
Abstract Number: 1943 • ACR Convergence 2025
Searching for subclinical synovitis and erosions in seropositive palindromic rheumatism: the added value of the ultrasonographic study of feet
Andrés Ponce¹, Cynthia Vanesa del Valle Rojas², nuria Sapena³, Georgina Novell³, anastasia Motcritcaia³, Beatriz Frade Sosa⁴, Juan Camilo Sarmiento-Monroy⁵, Vicenç Torrente-Segarra⁶, Julio Ramirez⁷, Virginia Ruiz-Esquide⁸, ana Belen Azuaga³, Francisco Vilchez³, Sandra Farietta³, Patricia Corzo⁹, Juan Cañete¹⁰, José Gomez-Puerta¹¹ and Raimon Sanmartí⁸, ¹Hospital Clinic, Barcelona, Spain, ²Consorci Sanitari Alt Penedès-Garraf, Barcelona, Catalonia, Spain, ³Hospital Clinic, Barcelona, Catalonia, Spain, ⁴Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain, ⁵Hospital Clínic Barcelona, Barcelona, Spain, ⁶Hospital Comarcal Alt Penedés Garraf, Vilafranca del Penedès, Spain, ⁷Clinic Barcelona Hospital Universitari, Barcelona, Catalonia, Spain, ⁸Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain, ⁹Rheumatology Department, Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁰Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ¹¹Rheumatology Department, Hospital Clinic, Barcelona, Spain, Barcelona, Spain
Background/Purpose: Palindromic rheumatism (PR) is characterized by intermittent episodes of arthritis or periarthritis, and it can progress to rheumatoid arthritis (RA), particularly in patients with…
Abstract Number: 0919 • ACR Convergence 2025
Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns
Stefanie Kurth¹, Andre Tiaden¹, Edveena Hanser¹, Simone Häner¹, Stavros Giaglis¹, Florian Geier¹, Dominik Burri¹, Katarzyna Buczak¹, Ute Heider², Stefan Wild², Yves Acklin¹, Christian Egloff¹ and Diego Kyburz³, ¹University of Basel, Basel, Switzerland, ²Miltenyi Biotec, Bergisch-Gladbach, Germany, ³University Hospital Basel, Basel, Switzerland
Background/Purpose: Extracellular vesicles (EVs) are secreted by virtually all cells and are known to carry bioactive cargo including proteins, RNA, DNA and metabolites. Analysis of…
Abstract Number: 1942 • ACR Convergence 2025
An Agnostic Evaluation of Serum Proteins Discriminates the Severity of Ultrasound Arthritis in SLE Patients
Robert Clancy¹, Philip Carlucci², Alberto Nordmann-Gomes³, Leila Khalili⁴, Wei Tang⁵, Giovanna Rosas Chavez⁴, Stephen Suh⁶, Laura Geraldino-Pardilla¹, Yevgeniya Gartshteyn⁷, Joel Guthridge⁸, Judith James⁸ and Anca Askanase⁴, ¹Columbia University, New York, NY, ²New York University School of Medicine, New York, NY, ³Columbia University Irving Medical Center, New York, NY, ⁴Columbia University Medical Center, New York, NY, ⁵Westchester Medical Center, Valhalla, NY, ⁶Columbia University Irving Medical Center, New York City, NY, ⁷Columbia University Medical Center, Glen Rock, NJ, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Inflammatory arthritis occurs in up to 90% of patients and is a main cause of SLE work-related disability. SLE arthritis is difficult to evaluate…
Abstract Number: 0917 • ACR Convergence 2025
Synovial Tissue Neutrophils are Associated with Disease Activity and Early Remission in Rheumatoid Arthritis
Annabelle Small¹, Vincent Wong², Christopher Altmann¹, Helen Weedon³, Malcolm Smith⁴, Susanna Proudman⁵ and Mihir Wechalekar⁶, ¹Flinders University, Bedford Park, South Australia, Australia, ²College of Medicine and Public Health, Bedford Park, South Australia, Australia, ³Flinders University of South Australia, Bedford Park, South Australia, Australia, ⁴Flinders University, Adelaide, South Australia, Australia, ⁵Royal Adelaide Hospital and University of Adelaide, Medindie, South Australia, Australia, ⁶Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
Background/Purpose: Neutrophils drive local pathology of rheumatoid arthritis (RA) in the synovial tissue (ST) through local production inflammatory mediators, cytokines, and extracellular traps. However, despite…
Abstract Number: 1801 • ACR Convergence 2025
Matrikine Activation of Synovial Fibroblasts Promotes Monocyte Migration and Stimulates an OA Chondrocyte Phenotype
Richard Loeser¹, Jorge Fernandez Davila¹, Philip Coryell², Susan Chubinskaya³ and Doug Phanstiel⁴, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina-Chapel Hill, Chapel Hill, NC, ³University of Texas Medical Branch, Galveston, TX, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Protease cleavage of matrix proteins generates matrix fragments including fibronectin fragments (FN-f) found in OA cartilage and synovial fluid. Matrix fragments or “matrikines” activate…
Abstract Number: 0629 • ACR Convergence 2025
Characterizing Arthritis Subtypes in SLE: Prevalence, Clinical Features, and the Role of Type I Interferon Signatures
Pankti Mehta¹, Fadi Kharouf², Virginia Carrizo Abarza³, Qixuan Li⁴, Dafna D. Gladman⁵, Zahi Touma⁶ and Laura Whitall Garcia⁷, ¹University of Toronto, Gladman Krembil Psoriatic Arthritis Research Program, Toronto, ON, Canada, ²University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³University of Toronto, Toronto, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, ⁶University of Toronto, Toronto, ON, Canada, ⁷University Health Network, Toronto, ON, Canada
Background/Purpose: We aimed to study the prevalence of subtypes of lupus arthritis and determine their association with clinical features, serology, and type I interferon signature.Methods:…

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