Abstracts tagged "Synovitis"

Abstract Number: LB23 • ACR Convergence 2025
A Phase 1 Study of Autologous CAR-Treg Cells in Refractory Rheumatoid Arthritis: Interim Report of Safety and Efficacy
Minna Kohler¹, Sally Arai², Fawad Aslam³, Gregory Challener⁴, Matthew Frigault⁴, Melissa Griffith⁵, Tamiko Katsumoto⁶, Elena Massarotti⁷, Larry Moreland⁸, Allison Rosenthal⁹, Jeffrey Sparks⁷, Janeth Yinh⁴, Sarah Baxter¹⁰, Ari Bitton¹¹, Jason Dubovsky¹², Victor Yuan¹³, Mindy Jensen¹⁴, Andrew Clauw¹⁵, Gabrielle Furman⁴, Rita Gyurko⁷, Megan Hall⁹, Anna McIntyre⁴, Jennifer Seifert¹⁶, Emma Stainton², Michelle Blake¹⁰, Sabrina Fox-Bosetti¹³, Herve Lebrec¹³, Amanda Pace¹⁰, Yuanyuan Xiao¹⁷, Mei-Lun Wang¹⁸, Joe Arron¹³ and Jeffrey Bluestone¹⁹, ¹Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, ²Stanford, Palo Alto, California, ³Mayo Clinic, Arizona, Scottsdale, Arizona, ⁴Massachusetts General Hospital, Boston, Massachusetts, ⁵University of Colorado Anschutz Medical Campus, Aurora, Colorado, ⁶Stanford University, Millbrae, California, ⁷Brigham and Women's Hospital, Boston, Massachusetts, ⁸University of Colorado, Denver, Colorado, ⁹Mayo Clinic, Phoenix, Arizona, ¹⁰Sonoma Biotherapeutics, Seattle, Washington, ¹¹Sonoma Biotherapeutics, San Diego, California, ¹²Sonoma Biotherapeutics, Thousand Oaks, California, ¹³Sonoma Biotherapeutics, South San Francisco, California, ¹⁴Sonoma Bio, Seattle, Washington, ¹⁵University of Colorado, Aurora, Colorado, ¹⁶University of Colorado and Oklahoma Medical Research Foundation, Aurora, Colorado, ¹⁷Sonoma Biotherapeutics, Los Altos, California, ¹⁸Sonoma Biotherapeutics, San Francisco, California, ¹⁹Sonoma Biotherapeutics Inc, South San Francisco, California
Background/Purpose: Regulatory T cells (Tregs) modulate inflammation, maintain self-tolerance, promote tissue repair, and hold promise as a versatile therapeutic. Autologous polyclonal Tregs have a favorable…
Abstract Number: 1942 • ACR Convergence 2025
An Agnostic Evaluation of Serum Proteins Discriminates the Severity of Ultrasound Arthritis in SLE Patients
Robert Clancy¹, Philip Carlucci², Alberto Nordmann-Gomes³, Leila Khalili⁴, Wei Tang⁵, Giovanna Rosas Chavez⁴, Stephen Suh⁶, Laura Geraldino-Pardilla¹, Yevgeniya Gartshteyn⁷, Joel Guthridge⁸, Judith James⁸ and Anca Askanase⁴, ¹Columbia University, New York, NY, ²New York University School of Medicine, New York, NY, ³Columbia University Irving Medical Center, New York, NY, ⁴Columbia University Medical Center, New York, NY, ⁵Westchester Medical Center, Valhalla, NY, ⁶Columbia University Irving Medical Center, New York City, NY, ⁷Columbia University Medical Center, Glen Rock, NJ, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Inflammatory arthritis occurs in up to 90% of patients and is a main cause of SLE work-related disability. SLE arthritis is difficult to evaluate…
Abstract Number: 0917 • ACR Convergence 2025
Synovial Tissue Neutrophils are Associated with Disease Activity and Early Remission in Rheumatoid Arthritis
Annabelle Small¹, Vincent Wong², Christopher Altmann¹, Helen Weedon³, Malcolm Smith⁴, Susanna Proudman⁵ and Mihir Wechalekar⁶, ¹Flinders University, Bedford Park, South Australia, Australia, ²College of Medicine and Public Health, Bedford Park, South Australia, Australia, ³Flinders University of South Australia, Bedford Park, South Australia, Australia, ⁴Flinders University, Adelaide, South Australia, Australia, ⁵Royal Adelaide Hospital and University of Adelaide, Medindie, South Australia, Australia, ⁶Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia
Background/Purpose: Neutrophils drive local pathology of rheumatoid arthritis (RA) in the synovial tissue (ST) through local production inflammatory mediators, cytokines, and extracellular traps. However, despite…
Abstract Number: 1801 • ACR Convergence 2025
Matrikine Activation of Synovial Fibroblasts Promotes Monocyte Migration and Stimulates an OA Chondrocyte Phenotype
Richard Loeser¹, Jorge Fernandez Davila¹, Philip Coryell², Susan Chubinskaya³ and Doug Phanstiel⁴, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina-Chapel Hill, Chapel Hill, NC, ³University of Texas Medical Branch, Galveston, TX, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Protease cleavage of matrix proteins generates matrix fragments including fibronectin fragments (FN-f) found in OA cartilage and synovial fluid. Matrix fragments or “matrikines” activate…
Abstract Number: 0629 • ACR Convergence 2025
Characterizing Arthritis Subtypes in SLE: Prevalence, Clinical Features, and the Role of Type I Interferon Signatures
Pankti Mehta¹, Fadi Kharouf², Virginia Carrizo Abarza³, Qixuan Li⁴, Dafna D. Gladman⁵, Zahi Touma⁶ and Laura Whitall Garcia⁷, ¹University of Toronto, Gladman Krembil Psoriatic Arthritis Research Program, Toronto, ON, Canada, ²University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³University of Toronto, Toronto, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, ⁶University of Toronto, Toronto, ON, Canada, ⁷University Health Network, Toronto, ON, Canada
Background/Purpose: We aimed to study the prevalence of subtypes of lupus arthritis and determine their association with clinical features, serology, and type I interferon signature.Methods:…
Abstract Number: 1789 • ACR Convergence 2025
Spatial Analysis of Advanced Osteoarthritis Synovial Tissue
jacob Dickman¹, Stephanie Ruzicka¹, Holub Meaghan², Jutras Brandon³, Adam Edelstein³ and Robert Lochhead⁴, ¹Medical College of Wisconsin, Milwaukee, WI, ²Central Michigan University College of Medicine, Mount Pleasant, MI, ³Northwestern University, Chicago, IL, ⁴Medical College of Wisconsin, GERMANTOWN, WI
Background/Purpose: Osteoarthritis (OA) is a joint pathology involving joint cartilage destruction and synovial inflammation. Severe knee OA is often surgically treated with total knee arthroplasty…
Abstract Number: 0890 • ACR Convergence 2025
Granzyme K+ CD8 T cells colocalize with myeloid cells and activate them through several pathways
Julia Nicole Zeid¹, Kaitlyn Arce², Nanxi Guo¹, Kartik Bhamidipati³, Kevin Wei⁴, Larry Moreland⁵, Fan Zhang⁶ and Anna Helena Jonsson², ¹University of Colorado School of Medicine, Aurora, ²University of Colorado School of Medicine, Aurora, CO, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁵University of Colorado, Denver, CO, ⁶The University of Colorado, Aurora, CO
Background/Purpose: Granzyme K (GZMK)-expressing CD8 T cells have recently been detected in tissues from an increasing number of autoimmune conditions, but their role in disease…
Abstract Number: 1783 • ACR Convergence 2025
Nerve Growth Factor Causes Sensitization, Nociceptor Sprouting, Synovitis, And Osteophyte Formation In Naïve Murine Joints
alia obeidat¹, michael Newton², Jun Li¹, Baofeng Hu³, Shingo Ishihara⁴, Lindsey Lammlin², Lucas Junginger², Easton Farrell², Frank Ko¹, Richard Miller⁵, Carla Scanzello⁶, Tristan Maerz⁷, Rachel Miller⁸ and Anne-Marie Malfait⁹, ¹Rush University Medical Center, Chicago, ²University Of Michigan, Ann Arbor, ³University of Pennsylvania, Wynnewood, PA, ⁴Rush University, Chicago, ⁵Northwestern University, Chicago, ⁶University of Pennsylvania, Philadelphia, ⁷University of Michigan, Ann Arbor, MI, ⁸Rush University Medical Center, Chicago, IL, ⁹rush university, CHICAGO, IL
Background/Purpose: The neurotrophin, nerve growth factor (NGF), a key mediator of pain and inflammation, is increased in joints with osteoarthritis (OA). Neutralizing NGF with monoclonal…
Abstract Number: 0807 • ACR Convergence 2025
Deciphering Synovitis in Systemic Sclerosis
Celina Geiss¹, Miranda Houtman¹, Camino Calvo Cebrian¹, Raphael Micheroli², Melpomeni Toitou¹, Yannis Djeffal³, Alexandra Khmelevskaya¹, Mojca Frank-Bertoncelj¹, Sam Edalat¹, Thomas Rauer⁴, Kristina Bürki⁵, Chantal Pauli⁶, Michael Bonelli⁷, Thomas Karonitsch⁸, Oliver Distler⁹, Caroline Ospelt¹ and Muriel Elhai¹⁰, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, ²University Hospital Zurich, Zurich, Switzerland, ³INSERM, IMRB, Université Paris Est Créteil, Paris, France, ⁴³Department of Traumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, ⁶Institute for Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, ⁷Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Wien, Austria, ⁸Department of Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁹Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, ¹⁰University Hospital zurich, Zürich, Switzerland
Background/Purpose: Synovitis is a common manifestation of systemic sclerosis (SSc), driving disability and predicting disease progression and mortality. Current immunosuppressive strategies, largely extrapolated from rheumatoid…
Abstract Number: 1782 • ACR Convergence 2025
Mapping The Synovial Innervation Of The Human Knee Joint
alia obeidat¹, Jun Li¹, Spencer Fullam², Roderick Carter², Merissa Olmer³, Bella Mehta⁴, Miguel Otero⁵, Daniel Ramirez⁶, Richard Miller⁷, Dana Orange⁸, Martin Lotz⁹, Rachel Miller¹⁰ and Anne-Marie Malfait², ¹Rush University Medical Center, Chicago, ²rush university, CHICAGO, IL, ³Scripps Research Institute, La Jolla, CA, ⁴Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ, ⁵Hospital For Special Surgery, New York, ⁶Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁷Northwestern University, Chicago, ⁸Rockefeller University, New York, ⁹Scripps Research, La Jolla, CA, ¹⁰Rush University Medical Center, Chicago, IL
Background/Purpose: Knee joints are densely innervated by sensory neurons, predominantly nociceptors. Knowledge about innervation of healthy human synovium and the changes that accompany osteoarthritis (OA)…
Abstract Number: 0798 • ACR Convergence 2025
Inhibition of Wnt Signaling Attenuates Inflammatory Arthritis Severity
Alisa Mueller¹, Angela Zou², Lucy-Jayne Marsh³, Samuel Kemble³, Saba Nayar³, Gerald Watts⁴, Cassandra Murphy⁵, Emily Taylor³, Triin Major³, David Gardner⁶, Christopher Buckley⁷, Kevin Wei⁸, Soumya Raychaudhuri⁵, ilya Korsunsky⁵, Andrew Filer⁹, Adam Croft¹⁰ and Michael Brenner¹¹, ¹Stanford University and VA Palo Alto Health Care System, Stanford, CA, ²Harvard Medical School, Boston, MA, ³University of Birmingham, Birmingham, United Kingdom, ⁴Harvard Medical School, Brookline, MA, ⁵Brigham and Women's Hospital, Boston, MA, ⁶University of Birmingham, Havelock North, New Zealand, ⁷University of Oxford, Oxford, United Kingdom, ⁸Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁹The University of Birmingham, Birmingham, United Kingdom, ¹⁰University of Birmingham, Hagley, Stourbridge, United Kingdom, ¹¹Brigham and Women's Hospital, Harvard Medical School, Newton, MA
Background/Purpose: Fibroblasts are critical in promoting pathogenic synovial inflammation and bone erosion in rheumatoid arthritis (RA). Moreover, recent studies have pointed to their potential contribution…
Abstract Number: 1780 • ACR Convergence 2025
Modeling Osteoarthritis Knee Joint in a Compartmentalized Microfluidic System using IPSC-derived Sensory Neurons and human Synovial Fibroblasts
Abdelhak Belmadani¹, Dongjun Ren¹, Daniel Hoffman², Nirupa Jayraj¹, Paola Pacifico¹, Vince Truong³, Patrick Walsh³, Daniela Menichella¹, Anna Rapp⁴, Carla Scanzello⁵, Rachel Miller⁶, Richard Miller⁷ and Anne-Marie Malfait⁸, ¹Northwestern University Chicago, Chicago, IL, ²Rush University, Chicago, IL, ³Anatomic Inc, Minneapolis, MN, ⁴University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, ⁶Rush University Medical Center, Chicago, IL, ⁷Northwestern University, Chicago, ⁸Rush University Medical Center, Chicago
Background/Purpose: Joint pain is one of the most significant clinical hallmarks of knee osteoarthritis (OA). Knee OA is a chronic degenerative disease of the joints…
Abstract Number: 0481 • ACR Convergence 2025
Intracellular Methotrexate Polyglutamate Profiles Do Not Correlate with Early Clinical Response in Treatment-Naïve Rheumatoid Arthritis: A Prospective Study
Chandrashekara MN¹, AASTHA KHULLAR², Bidyalaxmi Leishangthem³, Shankar Naidu⁴, Varun Dhir⁵ and Sanjay Jain⁴, ¹PGIMER, Chandigarh, Chandigarh, India, ²Postgraduate Institute of Medical Education and Research, CHANDIGARH, Chandigarh, India, ³PGIMER, Chandigarh, India, Chandigarh, Chandigarh, India, ⁴Post graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, Chandigarh, India, ⁵PGIMER, CHD, INDIA, CHANDIGARH, Chandigarh, India
Background/Purpose: Methotrexate (MTX) polyglutamates (MTX-PGs), the intracellular active forms of MTX, are hypothesized to reflect cumulative exposure and potentially predict therapeutic efficacy in rheumatoid arthritis…
Abstract Number: 1757 • ACR Convergence 2025
Skin-to-Joint Immune Cell Migration and Synovial Reprogramming in Psoriatic Arthritis Onset
Maria Gabriella Raimondo¹, Hashem Mohammadian², Mario Angeli², Vladyslav Fedorchenko², Kaiyue Huang³, Yi-Nan Li⁴, Raphael Micheroli⁵, Jörg Distler⁶, Ursula Fearon⁷, Juergen Rech², Francesco Ciccia⁸, Juan Cañete⁹, Adam Croft¹⁰, Mariola Kurowska-Stolarska¹¹, Stefano Alivernini¹², Maria Antonietta D'Agostino¹³, Georg Schett², Simon Rauber¹⁴ and Andreas Ramming¹⁵, ¹Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ²Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, ³Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, ⁴University Hospital of Düsseldorf, Düsseldorf, Germany, ⁵University Hospital Zurich, Zurich, Switzerland, ⁶University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ⁷Trinity College Dublin, Dublin, Dublin, Ireland, ⁸Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy, Naples, Italy, ⁹Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ¹⁰University of Birmingham, Hagley, Stourbridge, United Kingdom, ¹¹University of Glasgow, Glasgow, ¹²Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ¹³Division of Rheumatology and Clinical Immunology - Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ¹⁴Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Bayern, Germany, ¹⁵Department of Internal Medicine ³, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) & Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: Psoriatic arthritis (PsA) develops in about 30% of individuals with psoriasis (PsO), highlighting a critical connection between skin and joint inflammation. However, the mechanisms…
Abstract Number: 0464 • ACR Convergence 2025
Synovial Inflammation is not Associated With Reoperation in Patients With Rheumatoid Arthritis Undergoing Total Hip or Knee Arthroplasty
Solana Cushing¹, Kelsey Gripp², Edward DiCarlo³, Deanna Jannat-Khah¹, Yoshimi Endo³, Jose Rodriguez³, Mark Figgie³, Bella Mehta⁴ and Susan Goodman³, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ
Background/Purpose: Reoperations following arthroplasty are a significant burden to patients and surgeons. In patients with RA who receive total hip (THA) or knee (TKA) arthroplasty,…

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