ACR Meeting Abstracts

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Abstracts tagged "synovial cells"

  • Abstract Number: 1 • 2019 ACR/ARP Annual Meeting

    Interleukin-6 Promotes Osteoclast-like Phenotype in Human Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh1, Mahamudul Haque 1, Bhanupriya Madarampalli 2 and Salahuddin Ahmed 3, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, Spokane, WA, 2University of Washington, Seattle, WA, 3Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and joint destruction caused by pro-inflammatory cytokines. Progressive joint damage is also an…
  • Abstract Number: 16 • 2019 ACR/ARP Annual Meeting

    Monoclonal ACPA Promote Synovial Fibroblasts Migration Through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Bence Rethi 1, Akilan Krishnamurthy 2, Vijay Joshua 3, Alexandra Circiumaru 1, Aase Hensvold 1, Marianne Engström 4, Sergiu-Bogdan Catrina 5, Johanna Steen 6, Vivianne Malmström 3, Caroline Grönwall 3, Lars Klareskog 7, Heidi Wähämaa 1 and Anca Catrina 7, 1Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, 2Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, 4Karolinska Institutet and Karolinska University Hospital, Stockholm, 5Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 6Stockholm University, Stockholm, 7Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) play an important role in rheumatoid arthritis (RA) pathogenesis. ACPAs have different amino acid motif recognition patterns and show cross-reactivity…
  • Abstract Number: 816 • 2019 ACR/ARP Annual Meeting

    The Long Non-coding RNA HOTAIR Regulates BMP2 and Wnt Pathways in Synovial Fibroblasts

    Muriel Elhai1, Raphael Micheroli 1, Mojca Frank-Bertoncelj 2, Kerstin Klein 1, Oliver Distler 3 and Caroline Ospelt 2, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Zürich, Switzerland, 2University Hospital Zürich, Zürich, Switzerland, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Mechanisms involved in joint patterning of rheumatic diseases remain unknown. The long non-coding RNA HOTAIR is exclusively expressed in synovial fibroblasts (SF) from lower…
  • Abstract Number: 819 • 2019 ACR/ARP Annual Meeting

    The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts

    Mojca Frank-Bertoncelj 1, Tadeja Kuret2, Ana Županič 3, Snezna Sodin-Semrl 4, Oliver Distler 5 and Caroline Ospelt 1, 1University Hospital Zürich, Zürich, Switzerland, 2University Hospital Zürich, Zurich, Tajikistan, 3University Hospital Zürich, Zurich, Switzerland, 4University Medical Center Ljubljana, Ljubljana, Slovenia, 5Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
  • Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting

    Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis

    Ricardo Grieshaber-Bouyer1, Till Kämmerer 2, Nils Rosshirt 2, Philipp Koniezke 2, Sebastien Hagmann 2, Elena Tripel 2, Johannes Kirsch 2, Tobias Gotterbarm 2 and Babak Moradi 2, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, 2Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany

    Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
  • Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting

    An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium

    Anna Helena Jonsson1, Fan Zhang 2, Gerald Watts 2, Kevin Wei 1, Deepak Rao 2, Soumya Raychaudhuri 2 and Michael Brenner 3, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital:, Boston

    Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
  • Abstract Number: 1229 • 2018 ACR/ARHP Annual Meeting

    Diagnosing Prosthetic Joint Infections in Patients with Inflammatory Arthritis

    Serene Z. Mirza1, Shawn Richardson2, Cynthia Kahlenberg2, Jason Blevins2, Michelle Demetres3, Lily Martin3, Jackie Szymonifka2, Peter K. Sculco4, Mark P. Figgie5 and Susan M. Goodman2, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Weill Cornell Medicine, New York, NY, 4Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY

    Background/Purpose: Patients with inflammatory arthritis (IA) are at increased risk of prosthetic joint infections, yet differentiating between septic and aseptic failure is a  challenge in…
  • Abstract Number: 2034 • 2018 ACR/ARHP Annual Meeting

    Increased Invasive Capacity and Metabolic Activity in Synovial Fibroblasts from Children with Downs Arthropathy Compared to Juvenile Idiopathic Arthritis

    Sharon Ansboro1, Charlene Foley2, Monika Biniecka3, Emma MacDermott4, Douglas J. Veale5, Ronan Mullan6, Orla G Killeen7 and Ursula Fearon8, 1Molecular Rheumatology, Trinty College Dublin, Dublin, Ireland, 2Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland, 3Department of Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 4Our Lady's Children's Hospital, Crumlin, Dublin, Ireland, 5Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, 6Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, 7National Centre for Paediatric Rheumatology, Dublin, Ireland, 8Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Downs Arthropathy (DA) is an inflammatory joint condition affecting children with Down syndrome, which is under-recognised, has a delayed diagnoses, resulting in chronic disability.…
  • Abstract Number: 1407 • 2017 ACR/ARHP Annual Meeting

    Huntingtin Interactin Protein 1 (HIP1) Regulates Invasiveness, Actin Filament and Lamellipodia Formation in Rheumatoid Arthritis Fibroblast-like Synoviocytes (FLS)

    Teresina Laragione, Carolyn Harris, Erjing Gao and Percio S. Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is an arthritis severity and joint damage gene recently discovered in rodent models of arthritis. Hip1 regulates fibroblast-like synoviocytes (FLS)…
  • Abstract Number: 1408 • 2017 ACR/ARHP Annual Meeting

    The Cation Channel TRPV2 Decreases Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness By Inhibiting RhoA Activation, Cell Adhesion and Actin Cytoskeleton Changes

    Teresina Laragione, Carolyn Harris, Erjing Gao and Percio S. Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: We have recently identified the non-selective cation channel TRPV2 (transient receptor potential vanilloid subfamily, type 2 channel) as a new central mediator of arthritis…
  • Abstract Number: 1456 • 2017 ACR/ARHP Annual Meeting

    Synergistic Reversal of Arthritis By Synoviocyte-Targeted Therapy and TNF Immunomodulation

    Christian Secchi1,2,3, Karen M. Doody2, Mattias N. D. Svensson2,4, Frances Humby5, Rebecca Hands5, Eugenio Santelli1,2, Cristiano Sacchetti2,6, Kuninobu Wakabayashi7, Dennis J. Wu8, Ardita Aliko9, Piotr Mydel9,10, Tsuyoshi Kasama7, David L. Boyle11, Francesco Galimi12, Michel L. Tremblay13, Gary S. Firestein6, Costantino Pitzalis5, Stephanie Standford8,14 and Nunzio Bottini2,4, 1Medicine, University of California San Diego, San Diego, CA, 2Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 3Medicine, National Institute of Biostructures and Biosystems, University of Sassari Medical School, Sassari, Italy, 4Department of Medicine, University of California San Diego, La Jolla, CA, 5Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 6Medicine, University of California San Diego, La Jolla, CA, 7Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, 8University of California San Diego, San Diego, CA, 9University of Bergen, Bergen, Norway, 10Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, 11University of California San Diego, La Jolla, CA, 12National Institute of Biostructures and Biosystems, University of Sassari Medical School, Sassari, Italy, 13Goodman Cancer Centre, McGill University, Montréal, QC, Canada, 14La Jolla Institute for Allergy and Immunology, La Jolla, CA

    Background/Purpose: Despite the availability of immunosuppressive disease-modifying anti-rheumatic agents (DMARDs), many rheumatoid arthritis (RA) patients still fail to achieve remission. Fibroblast-like synoviocytes (FLS) are non-immunological…
  • Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting

    Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis

    Aurélie Najm1,2, Benoît Le Goff MD PhD2,3, Frédéric Blanchard1, Jérome Amiaud4, Céline Charrier5 and Veit Krenn6, 1INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, 2Rheumatology, Nantes University Hospital, Nantes, France, 3UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 4UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 5UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 6Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany

    Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
  • Abstract Number: 2801 • 2017 ACR/ARHP Annual Meeting

    Effects of Anti-IL17 Blockade with Secukinumab on Systemic and Local Immune Responses: A Mechanism-of-Action Study in Peripheral Spondyloarthritis

    Leonieke van Mens1, Marleen van de Sande2, Silvia Menegatti3, Iris Blijdorp1, Jet de Jong2, Inka Fluri4, Talia Latuhihin1, Arno van Kuijk5, Nataliya Yeremenko4 and Dominique Baeten1, 1AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, 2Clinical Immunology and Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, 4Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, 5Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands

    Background/Purpose: IL-17A blockade is an effective therapy for AS and PsA, the prototypical forms of spondyloarthritis(SpA). How IL-17A blockade affects the systemic and local immune…
  • Abstract Number: 3071 • 2016 ACR/ARHP Annual Meeting

    Recombinant Human Proteoglycan-4 (rhPRG4) Inhibits Monosodium Urate (MSU) Crystal Phagocytosis By Human Macrophages and Resultant Inflammatory Response

    Marwa Qadri1, Tannin Schmidt2, Khaled Elsaid3 and Gregory Jay4, 1Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, 2Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, 3Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 4Emergency Medicine, Brown University, Providence, RI

    Background/Purpose:   Gout is an inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in synovial joints. MSU crystals interact with resident macrophages that…
  • Abstract Number: 577 • 2016 ACR/ARHP Annual Meeting

    TCZ Modulates the Production of Ccfdna Derived from RA Synovial Cells

    Naonori Hashimoto1, Kohsuke Yoshida1, Teppei Hashimoto2, Ayako Nakai1, Kenta Kaneshiro1, Kohjin Suzuki1, Yoshiko Kawasaki2, Nao Shibanuma3, Natsuko Nakagawa4, Yoshitada Sakai5 and Akira Hashiramoto6, 1Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 3Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 4Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, 5Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose:   DNA is fragmented and released into blood circulation as a circulating cell-free DNA (ccfDNA) because of damage or death of cells. Although the…
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