ACR Meeting Abstracts

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Abstracts tagged "synovial cells"

  • Abstract Number: 1856 • 2013 ACR/ARHP Annual Meeting

    Potentiating Effects Of IL-17A, IL-17AF, IL-17F In Combination With TNF But Not With IL-1beta In Human Primary Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

    Christine Huppertz1, Marija Curcic Djuric1, Robert Hennze1, Friedrich Raulf1, Frank Kolbinger1, Anis Mir1 and David Lee2, 1Autoimmunity, Transplantation and Inflammatory Disease, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, SWITZERLAND, Basel, Switzerland, 2Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: The pro-inflammatory cytokine interleukin-17A (IL-17A) activates fibroblast-like synoviocytes (FLS) and other mesenchymal cells via the IL-17RA/RC receptor. FLS are a major source of inflammatory…
  • Abstract Number: 1374 • 2013 ACR/ARHP Annual Meeting

    NR1D1 Is a New Suppressor of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Invasion

    Teresina Laragione1,2 and Percio Gulko1,2, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune disease. Arthritis severity and joint damage predict clinical outcome and the risk for disability in…
  • Abstract Number: 951 • 2013 ACR/ARHP Annual Meeting

    The Anti-IL-17A Monoclonal Antibody Secukinumab (AIN457) Inhibits Pro-Inflammatory Mediator Release From Human Primary Synoviocytes Costimulated With IL-17 and TNF

    Christine Huppertz, Marija Curcic Djuric, Robert Hennze and Frank Kolbinger, Autoimmunity, Transplantation and Inflammatory Disease, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, SWITZERLAND, Basel, Switzerland

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are targets of the pro-inflammatory IL-17 cytokines and a major source of inflammatory mediators in the inflamed synovium in rheumatoid arthritis…
  • Abstract Number: 938 • 2013 ACR/ARHP Annual Meeting

    A Disintegrin and Metalloprotease-17 (ADAM-17) Is Expressed In Rheumatoid Arthritis and Mediates Monocyte Migration

    Takeo Isozaki1, Nao Oguro2, Shinya Seki1, Yoko Miura1, Sho Ishii1, Hiroyuki Tsukamoto1, Takahiro Tokunaga1, Masayu Umemura1, Hidekazu Furuya1, Ryo Yanai1, Sakiko Isojima1, Kuninobu Wakabayashi1, Nobuyuki Yajima1, Yusuke Miwa1 and Tsuyoshi Kasama1, 1Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, 2Div of Rhemuatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized byinflammation and joint destruction. Migration of monocytes/macrophages into the synovium is important in a variety…
  • Abstract Number: 772 • 2013 ACR/ARHP Annual Meeting

    Neovascularization and CD15s Influence Long Distance Migration Of Synovial Fibroblasts From Patients With Rheumatoid Arthritis

    Birgit Zimmermann1, Sina Köppert1, Stephanie Lefèvre1, Stefan Rehart2, Ulf Müller-Ladner1 and Elena Neumann3, 1Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 3Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany

    Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are central cells of cartilage destruction and neoangiogenesis. RASF show an increased migratory potential in the synovium towards…
  • Abstract Number: 428 • 2012 ACR/ARHP Annual Meeting

    TNFα Modulates the Expression of Circadian Clock Gene, Per2, Via D-Box Motif in the Promoter Region in Rheumatoid Synovial Cells

    Kohsuke Yoshida1, Akira Hashiramoto2, Takaichi Okano3, Nao Shibanuma4 and Shunichi Shiozawa5, 1Hyogo Prefectural Rehabilitation Center at Nishi-harima, Tatsuno, Japan, 2Department of Internal Medicine, Kobe University Graduate School of Medicine / The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, 3The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, 4The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 5Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
  • Abstract Number: 898 • 2012 ACR/ARHP Annual Meeting

    Nuclear Receptor Related 1 Induces Synovial Hyperplasia Via Transcriptional Regulation of Novel Target Genes

    Kimberlee S. Mix, Biological Sciences, Loyola University New Orleans, New Orleans, LA

    Background/Purpose: Nuclear receptor related 1 (NURR1 / NR4A2) is an orphan member of the nuclear receptor super-family that functions as a constitutively active transcription factor.…
  • Abstract Number: 895 • 2012 ACR/ARHP Annual Meeting

    Transcriptomics of Synovial Tissue of Early Human (CHECK) and Experimental OA Identify Pathways Associated with Cartilage Damage

    Arjen B. Blom1, Peter L.E.M. van Lent2, Martijn H. van den Bosch1, Hans Cats3, Peter M. van der Kraan1 and Wim B. van den Berg4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Many osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. Mechanisms through which synovial activation contributes to the joint pathology that…
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