Abstracts tagged "spondyloarthritis"

Abstract Number: 2032 • ACR Convergence 2020
Treatment Response to Biological Disease-modifying Anti-rheumatic Drugs Is Associated with Favorable Changes of the Body Composition in Patients with Ankylosing Spondylitis
Valeria Rios Rodriguez¹, Mikhail Protopopov¹, Fabian Proft¹, Judith Rademacher¹, Burkhard Muche¹, Anne-Katrin Weber¹, Susanne Lüders¹, Hildrun Haibel¹, Maryna Verba¹, Joachim Sieper¹ and Denis Poddubnyy², ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: There is few data available regarding differences in body composition and its possible changes in patients with ankylosing spondylitis (AS) treated with biological disease-modifying…
Abstract Number: 0363 • ACR Convergence 2020
Efficacy of Ixekizumab on Disease Activity and Quality of Life in Patients with Active Nonradiographic Axial Spondyloarthritis and Objective Signs of Inflammation, Stratified by Baseline CRP/Sacroiliac Joint MRI Status
Walter Maksymowych¹, Helena Marzo-Ortega², Mikkel Ǿstergaard³, Lianne Gensler⁴, Joerg Ermann⁵, Atul Deodhar⁶, Denis Poddubnyy⁷, David Sandoval⁸, Rebecca Bolce⁸, Andris Kronbergs⁸, Soyi Liu-Leage⁹, Gabriel Doridot⁸, Vladimir Geneus⁸, Ann Leung¹⁰, David Adams⁹ and Martin Rudwaleit¹¹, ¹University of Alberta, Edmonton, AB, Canada, ²The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ³University of Copenhagen, Copenhagen, Denmark, ⁴University of California San Francisco, San Francisco, CA, ⁵Brigham and Women’s Hospital, Boston, ⁶Oregon Health & Science University, Portland, OR, ⁷Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁸Eli Lilly and Company, Indianapolis, ⁹Eli Lilly and Company, Indianapolis, IN, ¹⁰Syneos Health, Morrisville, ¹¹Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany
Background/Purpose: Ixekizumab (IXE), a high-affinity anti-interleukin-17A monoclonal antibody, is effective in patients (pts) with active non-radiographic axial spondyloarthritis (nr-axSpA), who had elevated C-reactive protein (CRP)…
Abstract Number: 0881 • ACR Convergence 2020
Reduction of Anterior Uveitis Flares in Patients with Axial Spondyloarthritis During Certolizumab Pegol Treatment: 96-Week Results from the C-VIEW Study
Irene van der Horst-Bruinsma¹, Rianne van Bentum¹, Frank Verbraak², Thomas Rath³, James Rosenbaum⁴, Bengt Hoepken⁵, Oscar Irvin-Sellers⁶, Thomas Kumke⁵, Lars Bauer⁵ and Martin Rudwaleit⁷, ¹Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ²Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ³St Franziskus-Hospital, Münster, Germany, ⁴Oregon Health & Science University, Portland, OR, ⁵UCB Pharma, Monheim am Rhein, Germany, ⁶UCB Pharma, Slough, United Kingdom, ⁷Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany
Background/Purpose: Acute anterior uveitis (AAU) is the most common extra-articular manifestation in axial spondyloarthritis (axSpA), affecting up to 40% of patients and causing significant burden.1…
Abstract Number: 1309 • ACR Convergence 2020
Prevalence of Undiagnosed Axial Spondyloarthritis Among Patients with Inflammatory Bowel Disease: A Secondary Care Cross-Sectional Study
Chong Seng Edwin Lim¹, Mark Tremelling¹, Louise Hamilton¹, Alexander MacGregor¹, Tom Turmezei¹, Matthew Kim¹ and Karl Gaffney², ¹Norfolk and Norwich University Hospital, Norwich, United Kingdom, ²Norfolk and Norwich University Hospital NHS Foundation Trust, Norfolk, United Kingdom
Background/Purpose: Axial spondyloarthritis (axSpA) is closely related to inflammatory bowel disease (IBD), however contemporary data on the burden of hidden disease in the IBD population…
Abstract Number: 1358 • ACR Convergence 2020
Certolizumab Pegol Efficacy in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and C-Reactive Protein Status
Atul Deodhar¹, Lianne Gensler², Stephen Hall³, Philip Robinson⁴, Bengt Hoepken⁵, Lars Bauer⁵, Thomas Kumke⁵ and Walter Maksymowych⁶, ¹Oregon Health & Science University, Portland, OR, ²University of California San Francisco, San Francisco, CA, ³Cabrini Medical Centre, Monash University and Emeritus Research, Malvern, Victoria, Australia, ⁴University of Queensland, Herston, Queensland, Australia, ⁵UCB Pharma, Monheim am Rhein, Germany, ⁶University of Alberta, Edmonton, AB, Canada
Background/Purpose: This post-hoc analysis from the phase 3 C-axSpAnd study aimed to evaluate whether the response to certolizumab pegol (CZP) in non-radiographic axial spondyloarthritis (nr-axSpA)…
Abstract Number: 1592 • ACR Convergence 2020
Improving Documentation of Smoking Cessation Counseling Among Spondyloarthropathy Smokers
Yusuf Chao¹, Jake Hutto², Elena Joerns², Rashmi Arora³, Una Makris¹ and Swathi Reddy³, ¹UT Southwestern Medical Center, Dallas, TX, ²Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, ³Veterans Affairs North Texas Healthcare System / UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Smoking is prevalent among patients with spondyloarthropathies (SpA) and is associated with higher disease activity, poorer quality of life, and dampened response to biologic…
Abstract Number: 1870 • ACR Convergence 2020
Development of Candidate Criteria for Axial Disease in Juvenile Spondyloarthritis: An International Collaboration
Pamela F. Weiss¹, Timothy G. Brandon², Amita Aggarwal³, Ruben Burgos-Vargas⁴, Robert Colbert⁵, Gerd Horneff⁶, Rik Joos⁷, Ronald Laxer⁸, Kirsten Minden⁹, Angelo Ravelli¹⁰, Nicolino Ruperto¹¹, Judith Smith¹², Matthew Stoll¹³, Shirley Tse¹⁴, Filip Van den Bosch¹⁵ and Raymond Naden¹⁶, ¹Children's Hospital of Philadelphia, Philadelphia, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ⁴Department of Rheumatology, General Hospital of Mexico, Ciudad de Mexico, Mexico, ⁵Pediatric Clinical Trials Unit and Office of Clinical Director, NIAMS, NIH, Bethesda, MD, ⁶Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, ⁷Ziekenhuis Netwerk Antwerpen, Basel, Switzerland, ⁸The Hospital for Sick Children, Toronto, ON, Canada, ⁹Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ¹⁰Università degli Studi di Genova, Genoa, Italy, ¹¹PRINTO, Istituto Giannina Gaslini, Genova, Italy, ¹²University of Wisconsin, Madison, WI, ¹³University of Alabama at Birmingham, Birmingham, AL, ¹⁴SickKids, Toronto, ON, Canada, ¹⁵Ghent University Hospital, Ghent, Belgium, ¹⁶Department of Medicine, Middlemore Hospital, Auckland, Auckland, New Zealand
Background/Purpose: The lack of pediatric classification criteria for axial disease is a major impediment to the conduct of clinical trials for juvenile spondyloarthritis (SpA). Classification…
Abstract Number: 1902 • ACR Convergence 2020
Determinants of Physician Global Assessment and Influence of Contextual Factors in Early Axial Spondyloarthritis
Fumio Hirano¹, Robert Landewé², Floris van Gaalen³, Désirée van der Heijde⁴, Cecile Gaujoux-Viala⁵ and Sofia Ramiro⁶, ¹Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands, ²Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ³Leiden University Medical Center (LUMC), Leiden, Netherlands, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, CHU Nîmes, University of Montpellier-Nîmes, France, EA2415, University of Montpellier, Montpellier, France, Nîmes, France, ⁶Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: In rheumatic and musculoskeletal diseases, physician global assessment (PhGA) is a major factor of treatment decision. However, it is not well-known which disease manifestations…
Abstract Number: 0364 • ACR Convergence 2020
Subcutaneous Secukinumab 150 Mg Provides Sustained Relief in Total and Nocturnal Back Pain, Morning Stiffness, Fatigue, and Low Disease Activity in Patients with Active Ankylosing Spondylitis: End-of-study (5-year) Data from the MEASURE 2 Trial
Helena Marzo-Ortega¹, Corinne Miceli-Richard², Sonja Gill³, Marina Magrey⁴, Paula Machado⁵, Abhijit Shete⁶, Jianyuan Wang⁶, Susanne Rohrer⁶ and Atul Deodhar⁷, ¹The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ²Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ³412 – 3075 Hospital Gate, Oakville, Canada, ⁴Case Western Reserve University School of Medicine, Cleveland, OH, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Oregon Health & Science University, Portland, OR
Background/Purpose: Patients (pts) with ankylosing spondylitis (AS) report pain (70–80%), stiffness (20–40%), and fatigue (50–60%) as the most troubling symptoms. Early diagnosis and sustained improvement…
Abstract Number: 0882 • ACR Convergence 2020
Efficacy and Safety of Secukinumab in Patients with Spondyloarthritis and Enthesitis at the Achilles Tendon: 52-weeks Results from a Randomized, Placebo-controlled Phase 3b Trial
Frank Behrens¹, Philipp Sewerin², Eugenio De Miguel³, Yusuf Patel⁴, Anastas Batalov⁵, Eva Dokoupilova⁶, Christine Kleinmond⁷, Effie Pournara⁸, Ankita Shekhawat⁹, Claudia Jentzsch¹⁰, Annette Wiedon¹¹ and Xenofon Baraliakos¹², ¹CIRI/Rheumatology & Fraunhofer TMP, Goethe University, Frankfurt, Germany, ²Department of Rheumatology & Hiller Research Unit, University Hospital Düsseldorf, Duesseldorf, Germany, ³Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, ⁴Hull University Teaching Hospitals, Hull East Yorkshire, United Kingdom, ⁵Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria, ⁶MEDICAL PLUS s.r.o., Uherske Hradiste, University of Veterinary and Pharmaceutical sciences, Faculty of Pharmacy, Department of Pharmaceutics, Uherské Hradiště, Czech Republic, ⁷ClinProject GmbH, Eurasburg, Germany, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Novartis Healthcare Private Limited, Hyderabad, Telangana, India, ¹⁰Novartis Pharma GmbH, Nuremberg, Germany, ¹¹Novartis Pharma GmbH, Nurnberg, Germany, ¹²Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany
Background/Purpose: Enthesitis is a key feature of all types of spondyloarthritis (SpA) that substantially contributes to the overall burden of disease. Inhibition of the key…
Abstract Number: 1310 • ACR Convergence 2020
Gut Microbiome Changes Are Different Between Ankylosing Spondylitis and Inflammatory Bowel Disease, and Correlate with Disease Activity in Both Diseases
Peter Sternes¹, Laurel Brett², Julie Phipps³, Francesco Ciccia⁴, Erika de Guzman³, Mark Morrison⁵, Gerald Holtmann⁶, Eva Klingberg⁷, Carolyn McIvor², Helena Forsblad-d'Elia⁸ and Matthew Brown⁹, ¹Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, Brisbane, Queensland, Australia, ²Department of Gastroenterology, Logan Hospital, Brisbane, Queensland, Australia, ³Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, ⁴Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Naples, Campania, Italy, ⁵University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, ⁶Department of Gastrenterology, Princess Alexandra Hospital, Brisbane, Queensland, Australia, ⁷Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Vastra Gotaland, Sweden, ⁸Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Vasterbottens Lan, Sweden, ⁹Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom
Background/Purpose: Multiple studies have confirmed that the gut and stool microbiome in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are distinct from healthy controls,…
Abstract Number: 1360 • ACR Convergence 2020
New-Onset Inflammatory Bowel Diseases Among IL-17 Inhibitors-Treated Patients: Results from the Case-Control MISSIL Study
Jean-Guillaume Letarouilly¹, Benjamin Pariente², Thao Pham³, Emilie Acquacalda⁴, Béatrice Banneville⁵, Sébastien Barbarot⁶, Elodie Bauer⁷, Pauline Baudart⁸, Pascal Claudepierre⁹, Arnaud Constantin¹⁰, Emmanuelle Dernis¹¹, Renaud Felten¹², Philippe Gaudin¹³, Céline Girard¹⁴, Bruno Gombert¹⁵, Philippe Goupille¹⁶, Xavier Guennoc¹⁷, Isabelle Henry-Desailly¹⁸, Denis Jullien¹⁹, Elena Karimova²⁰, Sylvain Lanot²¹, Loïc Le Dantec²², Tristan Pascart²³, Laurianne Plastaras²⁴, Nathalie Sultan-Bichat²⁵, Xavier Truchet²⁶, Stéphane Varin²⁷, Daniel Wendling²⁸, Lousie Gaboriau²⁹, Delphine Staumont-Sallé³⁰, Laurent Peyrin-Biroulet³¹ and René-Marc Flipo¹, ¹Univ-Lille, CHU Lille, department of rheumatology, Lille, France, ²Univ-Lille, CHU Lille, department of gastroenterology, Lille, France, ³Aix Marseille Univ, APHM, department of rheumatology, Marseille, France, ⁴CHPG, department of rheumatology, Monaco, Monaco, ⁵AP-HP, Hôpital Pitié-Salpêtrière, Service de Rhumatologie, Paris, 75013, Paris, France, ⁶CHU de Nantes, department of dermatology, Nantes, France, ⁷CHRU Nancy, department of rheumatology, VANDOEUVRE LES NANCY, Lorraine, France, ⁸CHU Caen, department of rheumatology, Caen, France, ⁹Hôpital Henri Mondor, Université Paris Est Créteil, EA 7379 EpiDermE, department of rheumatology, Créteil, France, ¹⁰Hospital Pierre Paul Riquet, Toulouse, France, ¹¹CH Le Mans, department of rheumatology, Le Mans, France, ¹²Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, ¹³CHU Grenoble, department of rheumatology, Grenoble, France, ¹⁴CHU Montpellier, department of rheumatology, Montpellier, France, ¹⁵CH La Rochelle, department of rheumatology, La Rochelle, France, ¹⁶CHU Tours, department of rheumatology, Tours, France, ¹⁷CH Saint-Brieuc, department of rheumatology, Saint-Brieuc, France, ¹⁸CHU Amiens, department of rheumatology, Amiens, France, ¹⁹CHU Lyon, department of dermatology, Lyon, France, ²⁰CH Lens, department of dermatology, Lens, France, ²¹CH Alençon, department of rheumatology, Alençon, France, ²²Ahnac, department of rheumatology, Hénin-Beaumont, France, ²³Ghicl, Hôpital Saint-Philibert, department of rheumatology, Lomme, France, ²⁴CH Colmar, department of gastroenterology, Colmar, France, ²⁵CH Ouest-Réunion, department of dermatology, Saint Paul, La Réunion, France, ²⁶HIA Sainte-Anne, department of gastroenterology, Toulon, France, ²⁷CHD Vendée, department of rheumatology, La Roche-sur-Yon, France, ²⁸CHU Besançon, department of rheumatology, Besancon, France, ²⁹Univ-Lille, CHU Lille, department of pharmacovigilance, Lille, France, ³⁰Univ-Lille, CHU Lille, department of dermatology, Lille, France, ³¹CHU Nancy, department of gastroenterology, VANDOEUVRE LES NANCY, Lorraine, France
Background/Purpose: A warning regarding safety of Interleukin 17 inhibitors (IL-17i) has been issued from data of randomized controlled trials (RCT) showing cases of new-onset inflammatory bowel…
Abstract Number: 1603 • ACR Convergence 2020
P4 Index Correlates with RAPID3 and Disease-Specific Indices in Rheumatoid Arthritis (RA) and Axial Spondyloarthritis (axSpA)
Abhijeet Danve¹, Betty Hsiao² and Phillip Zhang³, ¹Yale University, Rocky Hill, CT, ²Yale Rheumatology, New Haven, ³Yale University, New Haven, CT
Background/Purpose: RAPID3 scores correlate well with disease-specific indices, including the Clinical Disease Activity Index (CDAI) in RA and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)…
Abstract Number: 1871 • ACR Convergence 2020
Comparison of Work Productivity Outcomes Between Chronic Back Pain Patients with and Without a Diagnosis of Axial Spondyloarthritis After 2-Year Protocolised Follow-Up: Data from the Spondyloarthritis Caught Early Cohort
Anne Boel¹, Miranda van Lunteren², Karen Fagerli³, Roberta Ramonda⁴, Sofia Exarchou⁵, Marleen van de Sande⁶, Floris van Gaalen⁷ and Désirée van der Heijde⁸, ¹Leiden University Medical Centre, Hooge Zwaluwe, Netherlands, ²Leiden University Medical Centre, Weesp, Netherlands, ³Diakonhjemmet Hospital, Oslo, Norway, ⁴University of Padova, Padova, Italy, ⁵Rheumatology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden, Malmo, Sweden, ⁶Amsterdam UMC, AMC/University of Amsterdam, Department of Rheumatology and Clinical Immunology, Amsterdam Infection & Immunity Institute and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ⁷Leiden University Medical Center (LUMC), Leiden, Netherlands, ⁸Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The aim of this study was to compare work-productivity and activity impairment outcomes after two-year follow-up between chronic back pain (CBP) patients with and…
Abstract Number: 1903 • ACR Convergence 2020
Assessment of Global DNA Methylation in Peripheral Blood Cell Subpopulations of Patients with Axial Spondyloarthritis : Preliminary Results
Eric Toussirot¹, Sebastien Pasquereau², Charline Vauchy³, Zeina Nehme⁴, Daniel Wendling⁵, Jean Charles Balbalnc⁶, Caroline Laheurte⁷, Marc Puyraveau⁸ and Georges Herbein², ¹CIC biotherapies, Besançon University Hospital, Besançon, France, ²Pathogens & Inflammation/EPILAB Laboratory, UPRES EA 4266, Besancon, France, ³INSERM CIC-1431, Besancon, France, ⁴Pathogens & Inflammation/EPILAB Laboratory, UPRES EA 4266, Besancon, ⁵CHU Besançon, department of rheumatology, Besancon, France, ⁶Rhumatologie, Trevenans, France, ⁷Plateforme de biomonitring, Besancon, France, ⁸uMETh & INSERM CIC 1431, Besancon, France
Background/Purpose: Axial spondyloarthritis (ax-SpA) corresponds to a group of chronic inflammatory disease mainly affecting the axial skeleton. TNF and IL-17A have been identified as key…

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