ACR Meeting Abstracts

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Abstracts tagged "SLE"

  • Abstract Number: 604 • 2013 ACR/ARHP Annual Meeting

    Mycophenolate Mofetil Is Not Associated With Reduced Cardiovascular Or Lupus Damage Accumulation In a Cross-Sectional Lupus Cohort Study

    Maureen A. McMahon1, Maria Dall'era2, Eliza Chakravarty3, Joseph E. Craft4, Gary S. Gilkeson5, Kenneth C. Kalunian6, R. John Looney7, Gerald McGwin Jr.8 and Meggan Mackay9, 1Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Yale University School of Medicine, Internal Medicine, Section of Rheumatology, New Haven, CT, 5Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 6UCSD School of Medicine, La Jolla, CA, 7Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 8Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 9Autoimmune & Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Mycophenolate mofetil (MMF) is frequently used for the treatment of lupus.  The immune-modulating effects of MMF extend beyond effects on lymphocyte proliferation, and include…
  • Abstract Number: 34 • 2013 ACR/ARHP Annual Meeting

    Dichotomous Responses Of Human Systemic Lupus Erythematosus B Cell Subsets To B Cell Receptor Stimulation

    Franziska Matzkies1, Anthony DeFranco2, Andrew J. Gross3, Maria Dall'era4 and Michelle Hermiston5, 1Medicine- Rheumatology, University of California, San Francisco, San Francisco, CA, 2Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, 3Medicine, University of California, San Francisco, San Francisco, CA, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5Pediatrics, Hematology/Oncology, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Autoantibody production is a hallmark of Systemic Lupus Erythematosus (SLE), supporting a central role for B cells in disease pathogenesis. Prior studies have demonstrated…
  • Abstract Number: 2722 • 2013 ACR/ARHP Annual Meeting

    In Vivo Administration Of MiR-146a Protects C57BL/6 Mice From Pristane-Induced Pulmonary Hemorrhage Via Suppressing Type I Interferon Response

    Dong Liang1, Shiyu Zhou2, Zheng Liu3, Zhengyuan Shan1, Philip Brohawn3, Yihong Yao3, John B. Harley4,5 and Nan Shen1,2,6, 1Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 4Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5US Department of Veterans Affairs Medical Center, Cincinnati, OH, 6Shanghai Institute of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Background/Purpose: miR-146a as an endogenous regulator plays a critical role in resolving acute inflammation. The risk-associated genetic variant in miR-146a promoter was linked to reduced…
  • Abstract Number: 1636 • 2013 ACR/ARHP Annual Meeting

    Pro-Inflammatory HDL and Subclinical Atherosclerosis Are Associated With Altered Expression Of Epigenetic and Oxidative Stress-Related Gene Transcripts In SLE

    Brian Skaggs1, Bevra H. Hahn2, Jennifer M. Grossman3, Elaine Lourenco1, Isao Matsuura4, Lori Sahakian5 and Maureen A. McMahon6, 1Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 3Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, 4UCLA David Geffen School of Medicine, Los Angeles, CA, 5Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, 6Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Premature atherosclerosis is widely recognized as a significant co-morbid condition of systemic lupus erythematosus (SLE), but exact mechanisms are unknown.  Although traditional cardiovascular risk…
  • Abstract Number: 1061 • 2013 ACR/ARHP Annual Meeting

    Clinical Phenotypes and Disease Burden Of Discoid Lupus Erythematosus In a Sample Of Systemic Lupus Erythematosus Patients In The Southeastern United States

    Leslie Anne Cassidy1, Gaobin Bao2, Charmayne M. Dunlop-Thomas3, S. Sam Lim4 and Cristina Drenkard5,6, 1Department of Medicine, Division of Rheumatology, Emory University, Atlanta, GA, 2Medicine, Emory University, Atlanta, GA, 3Medicine Rheumatology, Emory University, Atlanta, GA, 4Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, 5Department of Medicine, Emory University, Atlanta, GA, 6Epidemiology, Emory Rollins School of Public Health, Atlanta, GA

    Background/Purpose: The rash of discoid lupus erythematosus (DLE) has been reported in 10-25% of patients with systemic lupus erythematosus (SLE). Prior reports suggest that DLE…
  • Abstract Number: 605 • 2013 ACR/ARHP Annual Meeting

    Childhood Lupus Nephritis: Long Term Outcome Of 91biopsy Proven Cases From India

    Puja Srivastava1, Bonnie Abujam2, Ramnath Misra1, Able Lawrence1, Vikas Agarwal1 and Amita Aggarwal1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Background/Purpose: Childhood SLE has a higher prevalence of lupus nephritis (LN) as well as proliferative LN than adults. There is ethnic variation in response to…
  • Abstract Number: 2724 • 2013 ACR/ARHP Annual Meeting

    cAMP Responsive Element Modulator (CREM)α Governs CD8 Expression and Contributes to the Generation of CD3+CD4–CD8– T Cells in Lupus

    Christian M. Hedrich1, José C. Crispín1, Thomas Rauen1, Christina Ioannidis1, Tomohiro Koga2, Noe Rodriguez Rodriguez2, Sokratis A. Apostolidis3, Vasileios C. Kyttaris2 and George C. Tsokos1, 1Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, 2Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: CD3+CD4-CD8- "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T…
  • Abstract Number: 1637 • 2013 ACR/ARHP Annual Meeting

    IKZF1 Modulates PP2Ac Expression Through An Intronic Binding Site

    Kamalpreet Nagpal1, Katsue S. Watanabe2 and George C. Tsokos3, 1Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    IKZF1 modulates PP2Ac expression through an intronic binding siteKamalpreet Nagpal1, Katsue Sunahori2, George C. Tsokos11Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center,…
  • Abstract Number: 1062 • 2013 ACR/ARHP Annual Meeting

    The Brief Index Of Lupus Damage As a Predictor Of Mortality In a Cohort Of Patients With Systemic Lupus Erythematosus

    Stephanie Rush1, Laura Trupin2, Jinoos Yazdany2 and Patricia P. Katz2, 1University of California, San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, San Francisco, CA

    The Brief Index of Lupus Damage as a Predictor of Mortality in a Cohort of Patients with Systemic Lupus Erythematosus Background/Purpose: To examine whether a…
  • Abstract Number: 607 • 2013 ACR/ARHP Annual Meeting

    Venous Thromboembolic Disease Is Associated With Increased Length Of Stay and In-Hospital Mortality In Hospitalized SLE Patients: A Multi-State, Population-Based Study

    Matthew Cascino1, Laura Trupin1, Sara Murray1, Mary Margaretten2, Edward H. Yelin3 and Jinoos Yazdany1, 1Medicine, University of California, San Francisco, San Francisco, CA, 2Rheumatology, University of California, San Francisco, San Francisco, CA, 3Arthritis Research Group, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Individuals with systemic lupus erythematosus (SLE) are at increased risk for venous thromboembolism (VTE). However, there is limited population-based data on outcomes associated with…
  • Abstract Number: 2701 • 2013 ACR/ARHP Annual Meeting

    Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus T Cell Signaling

    Alexandros P. Grammatikos1, Debjani Ghosh2 and Vasileios C. Kyttaris1, 1Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Department of Microbiology and Immunology, The Brody School of Medicine, East Carolina University, Greenville, NC

    Background/Purpose: Systemic Lupus Erythematosus (SLE) T cells display an aberrant response to CD3/ TCR stimulation. The CD3/TCR complex in SLE is characterized by the substitution…
  • Abstract Number: 1639 • 2013 ACR/ARHP Annual Meeting

    GWAS In Hispanic and Latin American Individuals Enriched For Amerindian Ancestry Identifies a New Locus Associated With Systemic Lupus Erythematosus

    Marta Eugenia Alarcon Riquelme1, Julie T. Ziegler2, Mary E. Comeau3, Elena Sanchez4, Bernado Pons-Estel5, Eduardo Acevedo6, Jorge Mariano Cucho6, Ignacio Garcia de la Torre7, Mario H. Cardiel8, Pedro Miranda9, Luis Cattogio10, Marco Maradiaga11, Jorge Esquivel-Valerio12, Jose F Moctezuma13, Mercedes Garcia14, Guillermo Berbotto15, Alejandra Babini16, Hugo Scherbarth17, Sergio Toloza18, Judith A James19, Teresa Tusie-Luna20, John B Harley21, Raphael Zidovetski22, Carl Langefeldt2 and Chaim O. Jacob23, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Wake Forest University Health Sciences, Winston-Salem, NC, 4King's College London, London, United Kingdom, 5Hospital Provincial de Rosario, Rosario, Argentina, 6Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru, 7Hospital General de Occidente, Zapopan, Mexico, 8Centro de Investigacion Clinica de Morelia, Morelia, Mexico, 9Universidad de Chile and Centro de Estudios Reumatologicos, Santiago de Chile, Chile, 10Hospital Italiano, Buenos Aires, Argentina, 11Hospital General de Culiacán, Culiacan, Sinaloa, Mexico, 12Hospital Universitario Dr. José Eleuterio González, Universidad Autonoma de Nuevo León, Nuevo Leon, Mexico, 13Hospital General de Mexico, Mexico, Mexico, 14Hospital San Martin, La Plata, Argentina, 15Hospital Eva Peron, Granadero Baigorria, Argentina, 16Hospital Privado de Cordoba, Cordoba, Argentina, 17H.I.G.A. Oscar E. Alende, Mar del Plata, Argentina, 18Hospital San Juan Bautista, Catamarca, Argentina, 19Oklahoma Medical Research Foundation, Oklahoma City, OK, 20Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México, and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, 21Childrens Hospital, Cincinnati, OH, 22University of Southern California, Los Angeles, CA, 23Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA

    Background/Purpose: Systemic lupus erythematosus (SLE), a chronic autoimmune disease with a strong genetic component, exhibits a 9:1 female to male ratio and disproportionate impact on…
  • Abstract Number: 1066 • 2013 ACR/ARHP Annual Meeting

    Depression Screening In Patients With Systemic Lupus Erythematosus From The Southeastern United States: Missing Opportunities For Early Diagnosis and Treatment

    Cristina Drenkard1, Charmayne M. Dunlop-Thomas2, Gaobin Bao3 and S. Sam Lim4, 1Department of Medicine, Emory University, Atlanta, GA, 2Medicine Rheumatology, Emory University, Atlanta, GA, 3Medicine, Emory University, Atlanta, GA, 4Emory University School of Medicine, Division of Rheumatology, Atlanta, GA

    Background/Purpose: Depression can be found in 20-60% of SLE patients and has substantial impact on quality of life, disease outcomes and health care costs. Although…
  • Abstract Number: 610 • 2013 ACR/ARHP Annual Meeting

    Disease Specific Quality Of Life Domains Are Impaired In Patients With Lupus Nephritis?

    Meenakshi Jolly1, Zineb Aouhab2, Sergio Toloza3, Ana M. Bertoli4, Ivana Blazevik5, Luis M. Vila6, Ioana Moldovan7, Karina Marianne D. Torralba8, Arif Kaya9, Berna Goker10, Mehmet E. Tezcan11, Seminur Haznedaroglu12, Josiane Bourré-Tessier13, Ann E. Clarke14, D.J. Wallace15, Michael H. Weisman16 and Graciela S. Alarcon17, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Medicine, John H Stroger Hospital, Chicago, IL, 3Hospital San Juan Bautista, Catamarca, Argentina, 4Instituto Reumatológico Strusberg, Cordoba, Cordoba, Argentina, 5University of Buenos Aires, Buenos Aries, Argentina, 6Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 7Loma Linda Univ Medical Center, Loma Linda, CA, 8Rheumatology/Int Med, USC Keck Schl of Medicine, Los Angeles, CA, 9Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, 10Internal Medicine-Rheumatology, Gazi University, Ankara, Turkey, 11Rheumatology, Dr. Lutfi Kirdar Kartal EA Hastanesi, Istanbul, Turkey, 12Internal Medicine-Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 13Rheumatology, McGill University, Montréal, QC, Canada, 14Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, 15Cedars-Sinai Medical Center, Los Angeles, CA, 16Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 17Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Often systemic Lupus Erythematosus (SLE) patients with Lupus Nephritis (LN) require frequent visits with their health care providers, follow up, and exposure to immunosuppressive…
  • Abstract Number: 2703 • 2013 ACR/ARHP Annual Meeting

    An Intronic CR2 Polymorphism Associated With Systemic Lupus Erythematosus Alters CTCF Binding and CR1 Expression

    Jian Zhao1, Brendan M. Giles2, Rhonda L. Taylor3, Gabriel A. Yette2, Kara M. Lough2, Lawrence J. Abraham3, Hui Wu4, Patrick M. Gaffney5, Jennifer A. Kelly6, Kenneth M. Kaufman7,8, John B. Harley9,10, Carl D. Langefeld11, Elizabeth E. Brown12, Jeffrey C. Edberg13, Robert P. Kimberly14, Daniela Ulgiati3, Betty P. Tsao1 and Susan A. Boackle15, 1Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, 2University of Colorado School of Medicine, Aurora, CO, 3University of Western Australia, Perth, Western Australia, Australia, 4Rheumatology, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7U.S. Department of Veterans Affairs Medical Center, Cincinnati, OH, 81Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, 9Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10US Department of Veterans Affairs Medical Center, Cincinnati, OH, 11Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 12University of Alabama at Birmingham, Birmingham, AL, 13Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 14Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 15Medicine/Rheumatology, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by the production of antibodies to nuclear antigens, which form immune complexes that deposit in tissues and cause…
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