Abstracts tagged "SLE"

Abstract Number: 1070 • 2013 ACR/ARHP Annual Meeting
Characteristics and Medication Use Patterns Among Belimumab Users In a Commercially Insured Population With Systemic Lupus Erythematosus
Xuehua Ke¹, Jeetvan Patel², Hong Kan², Debra F Eisenberg¹ and Alan Oglesby², ¹HealthCore Inc, Wilmington, DE, ²GlaxoSmithKline, Research Triangle Park, NC
Background/Purpose: Belimumab is a B lymphocyte stimulator-specific inhibitor approved for treatment of systemic lupus erythematosus (SLE). The purpose of the study was to describe medication…
Abstract Number: 562 • 2013 ACR/ARHP Annual Meeting
The Knock-Out Of TWEAK Receptor/Fn14 Ameliorates Lupus Nephritis In MRL/Lpr Mice
Yumin Xia¹, Leal Herlitz², Simona Gindea¹, Jing Wen¹, Rahul Pawar¹, Alexander Misharin³, Harris R. Perlman⁴, Ping Wu⁵, Jennifer Michaelson⁵, Linda Burkly⁵ and Chaim Putterman⁶, ¹Albert Einstein College of Medicine, Bronx, NY, ²The Department of Pathology, Columbia University Medical Center, New York, NY, ³Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Northwestern University, Chicago, IL, ⁵Biogen Idec, Cambridge, MA, ⁶The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Renal mesangial cells, podocytes, and tubular cells express Fn14, the sole confirmed receptor for the tumor necrosis factor (TNF)-family member cytokine TWEAK (TNF-like weak…
Abstract Number: 2674 • 2013 ACR/ARHP Annual Meeting
Vitamin D Deficiency Is Common and Associated With Increased C-Reactive Protein In Children With Lupus: An Atherosclerosis Prevention In Pediatric Lupus Erythematosus Substudy
Angela B. Robinson¹, Vin Tangpricha², Eric Yow³, Reut Gurion⁴, Grace McComsey⁴ and Laura E. Schanberg⁵, ¹Pediatric Infectious Disease, Rheumatology and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ²Medicine, Emory University School of Medicine, Atlanta, GA, ³Biostatistics, Duke Clinical Research Institute, Durham, NC, ⁴Pediatric Infectious Diseases, Rheumatology, and Geographic Medicine, Rainbow Babies and Children's Hospital / Case Medical Center, Cleveland, OH, ⁵Pediatrics, Duke University Medical Center, Durham, NC
Background/Purpose: Epidemiologic associations suggest vitamin D may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements,…
Abstract Number: 1611 • 2013 ACR/ARHP Annual Meeting
Off-Label Use Of Rituximab For Systemic Lupus Erythematosus in Europe: Limited Use Mostly In Refractory Patients
Ronald F. van Vollenhoven¹, Melinda Mild², Andrea Doria³, T. Dörner⁴, Gianfranco Ferraccioli⁵, Frederic Houssiau⁶, T.W.J. Huizinga⁷, David A. Isenberg⁸, László Kovács⁹, Guillermo Ruiz-Irastorza¹⁰, Danilo Squatrito¹¹, Alexandre Voskuyl¹², Marta Mosca¹³, G D Sebastiani¹⁴, Murat Inanç¹⁵, Gabriella Szücs¹⁶, Søren Jacobsen¹⁷, A. Castro¹⁸ and for The IRBIS-EMA group¹⁹, ¹Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), the Karolinska Institute, Stockholm, Sweden, ²Department of medicine, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit - Department of Medicine, University of Padova, Padova, Italy, ⁴Charité University Medicine Berlin, Berlin, Germany, ⁵Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ⁶Department of Rheumatology, Université catholique de Louvain, Brussels, Belgium, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁹Department of Rheumatology, University of Szeged, Szeged, Hungary, ¹⁰Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain, ¹¹Center for Autoimmune Diseases, Department of Internal Medicine, Careggi Hospital- Florence, Florence, Italy, ¹²Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹³Rheumatology Unit, University of Pisa, Pisa, Italy, ¹⁴Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Rome, Italy, ¹⁵Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹⁶Department of Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary, ¹⁷Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ¹⁸Hospital Universitari de Reus, Spain, Reus, Spain, ¹⁹ClinTRID, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Rituximab (Rituxan, Mabthera; RTX) has not been approved for use in SLE, but uncontrolled observations have suggested efficacy in some patients and the medication…
Abstract Number: 1039 • 2013 ACR/ARHP Annual Meeting
Risk Of High-Grade Cervical Dysplasia In Women With Systemic Inflammatory Diseases
Seoyoung C. Kim¹, Robert J. Glynn², Edward Giovannucci³, Sonia Hernandez-diaz⁴, Jun Liu⁵, Sarah Feldman², Elizabeth W. Karlson⁶, Sebastian Schneeweiss⁷ and Daniel H. Solomon^8,9, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard School of Publich Health, Boston, MA, ⁴Harvard School of Public Health, Boston, MA, ⁵Division of Pharmaoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA, ⁸Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, ⁹Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Human papillomaviruses (HPV) are causes of high-grade cervical dysplasia and cervical cancer. Persistent HPV infection, the major risk factor for cervical cancer, is associated…
Abstract Number: 571 • 2013 ACR/ARHP Annual Meeting
Protective Effect Of Inducible Adeno-Associated Virus Mediated IL-2 Gene Therapy On Tissue Damages In Lupus-Prone Mice
Masayuki Mizui¹, Tomohiro Koga², Linda Lieberman³, Jessica Beltran³, Mark C. Johnson⁴, José C. Crispin², Roland Tisch⁴ and George C. Tsokos⁵, ¹Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-2 plays critical roles not only in immune responses but also in peripheral tolerance. Impairment of IL-2 production has been linked to the development…
Abstract Number: 2554 • 2013 ACR/ARHP Annual Meeting
In Vitro Fertilization In Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Series Of 82 Cycles
Pauline Orquevaux¹, Agathe Masseau², Véronique le Guern³, Vanessa Gayet⁴, Danièle Vauthier-Brouzes⁵, Du Boutin⁶, Bertrand Wechsler⁷, Nathalie Morel⁸, Jean Loup Pennaforte¹, Jean-Charles Piette⁹ and Nathalie Costedoat-Chalumeau¹⁰, ¹Hu Robert Debre, CHU Reims, Reims, France, ²Internal Medicine Department, Nantes University Hospital, Nantes, France, ³Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁴Cochin Hospital, Paris, France, ⁵gynecology obstetrical, Pitié Salpétrière Hospital, Paris, France, ⁶Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Internal Medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁸Internal Medicine, COCHIN, Paris, France, ⁹Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, ¹⁰Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) undergoing in vitro fertilization (IVF) are at increased risk of both hormone-associated flare and…
Abstract Number: 1618 • 2013 ACR/ARHP Annual Meeting
Chromatin Binding In SLE Patients Correlates With The Intensity Of Apoptotic Binding By 9G4+ B Cells
Asiya Seema Chida¹, Quan-Zhen Li², Chandra Mohan³, Youliang Wang¹, Scott Jenks⁴, Louise Hartson¹ and Ignacio Sanz⁵, ¹Medicine, Emory University Medical Center, Atlanta, GA, ²Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Houston, Houston, TX, ⁴Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁵Rheumatology, Emory University, Atlanta, GA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-organ autoimmune disease characterised by production of autoantibodies to multiple nuclear antigens, some of which are highly specific…
Abstract Number: 1007 • 2013 ACR/ARHP Annual Meeting
Dose Of Corticosteroid, Risk Of Adverse Events and Healthcare Resource Utilization In Systemic Lupus Erythematosus
Wei-Shi Yeh¹, Shih-Yin Chen², Kathleen McCarty³, Qian Li², Yuan-Chi Lee² and Nathalie Franchimont³, ¹Biogen Idec, Cambridge, MA, ²United BioSource Corporation, Lexington, MA, ³Biogen Idec Inc., Weston, MA
Background/Purpose: Gluco-corticosteroids (GCs) are frequently used to treat autoimmune disease and their chronic use has long been known to cause adverse events (AEs). The purpose…
Abstract Number: 573 • 2013 ACR/ARHP Annual Meeting
Absence Of Estrogen Receptor Alpha Reduces The Number and Function Of Bone Marrow Derived Plasmacytoid Dendritic Cells In Lupus Prone Mice
Jennifer Scott¹, Osama S. Naga², Melissa A. Cunningham³, Jena Wirth³, Jackie G. Eudaly² and Gary S. Gilkeson⁴, ¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Med/Rheumatology, MUSC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9:1 ratio compared to men. Previous work in our laboratory…
Abstract Number: 2551 • 2013 ACR/ARHP Annual Meeting
Pharmacodynamics and Predictive Biomarkers In Patients Treated With Atacicept: Data From The APRIL-SLE Trial
David A. Isenberg¹, David Wofsy², Yong Li³, Daiana Licu⁴, Stephen D. Wax⁵, Caroline Gordon⁶ and Claudia Pena Rossi⁴, ¹Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ²Rheumatology/Immunology, University of California San Francisco and NIAID Autoimmunity Centers of Excellence, San Francisco, CA, ³EMD Serono, Rockland, MA, ⁴Merck Serono S.A., Geneva, Switzerland, ⁵Global Clinical Development Center - Immunology, EMD Serono Inc, Rockland, MA, ⁶Rheumatology Research Group (East Wing), School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Atacicept is a fusion protein that inhibits B cell stimulating factors BLyS and APRIL. We examined the pharmacodynamic (PD) effects of atacicept in patients…
Abstract Number: 1621 • 2013 ACR/ARHP Annual Meeting
T Helper 17 Cells and Interferon Type I: Partners In Crime In SLE?
Odilia B.J. Corneth¹, Zana Brkic², Cornelia G. van Helden-Meeuwsen³, Radboud J.E.M. Dolhain⁴, Naomi I. Maria³, Sandra M.J. Paulissen⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm², Martin van Hagen³, Marjan A. Versnel² and Erik Lubberts⁶, ¹Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ²Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: A hallmark of systemic autoimmune diseases, such as systemic lupus erythematotsus (SLE), is the increased expression of interferon (IFN) type I inducible genes, the…
Abstract Number: 885 • 2013 ACR/ARHP Annual Meeting
Fatigue In SLE Is Associated With Upregulation Of Interferon- Alpha Related Gene Transcripts
Maureen A. McMahon¹, Jennifer M. Grossman², Bevra H. Hahn³, Lori Sahakian⁴, Isao Matsuura⁵, Elaine Lourenco⁶ and Brian Skaggs⁶, ¹Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵UCLA David Geffen School of Medicine, Los Angeles, CA, ⁶Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Fatigue is a major complaint in at least 80% of SLE patients, and is often listed as the most disabling symptom of the disease;…
Abstract Number: 578 • 2013 ACR/ARHP Annual Meeting
Ultrasonographic Findings and Inter-Observer Reliability In Danish Patients With Systemic Lupus Erythematosus – a Comparison With Clinical Examination Of Wrist and Hand Joints
Lene Dreyer¹, Søren Jacobsen², Lars Juul³ and Lene Terslev⁴, ¹Internal Medicine - Rheumatology Section, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ²Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ³Department of Rheumatology, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ⁴Copenhagen University Hospital at Glostrup, Copenhagen, Denmark
Background/Purpose: Patients with systemic lupus erythematosus (SLE) frequently encounter problems of musculoskeletal origin including arthralgia, tenosynovitis and arthritis in varying degrees of severity. Some patients…
Abstract Number: 2522 • 2013 ACR/ARHP Annual Meeting
Novel Autoantibody Against CAF-1 Is a Biomarker For CNS Manifestation in patients With SLE
Kentaro Doe¹, Kazuhisa Nozawa², Kaori Hiruma², Yusuke Yamada¹, Yuko Matsuki¹, Soichiro Nakano¹, Michihiro Ogasawara³ and Yoshinari Takasaki⁴, ¹Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of internal medicine and rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Proliferating cell nuclear antigen (PCNA) is known to be an autoantigen specifically recognized by antibodies in sera from patients with systemic lupus erythematosus (SLE). Although a prevalence of anti-PCNA…