Abstracts tagged "SLE"

Abstract Number: 1264 • 2016 ACR/ARHP Annual Meeting
Pilot Evaluation Points to Male Specific Educational Programming for Males with SLE
Dariana M. Pichardo¹, Jillian A. Rose², Priscilla Toral¹ and Roberta Horton¹, ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Methods: Results: Conclusion: Despite our small sample size, our pilot shows an unmet need for this population, which potentially impacts on…
Abstract Number: 1807 • 2016 ACR/ARHP Annual Meeting
Prevalence of Progressive Multifocal Leukoencephalopathy in Adults and Children with Systemic Lupus Erythematosus
Pooja Mahadeshwar¹, Teja Kapoor¹, Kayla Quinnies², Nicholas Tatonetti², Joyce Hui-Yuen³, Samantha Nguyen¹, Joan Bathon¹, Kayla Neville¹, James Miceli¹, Stacy Tanner⁴ and Anca Askanase¹, ¹Rheumatology, Columbia University Medical Center, New York, NY, ²Biomedical Informatics, Columbia University Medical Center, NY, NY, ³North Shore-Long Island Jewish Health System, Lake Success, NY, ⁴Rheumatology, Columbia University Medical Center, NY, NY
Background/Purpose: In the era of powerful immunosuppression, opportunistic infections are an increasing concern in Systemic Lupus Erythematosus (SLE). A potentially fatal opportunistic demyelinating disease of…
Abstract Number: 2804 • 2016 ACR/ARHP Annual Meeting
Predictors of Survival in Renal Transplantation for Lupus Nephritis – 40 Patients in 40 Years
Eleana Ntatsaki¹, Alba Velo Garcia², Borja del Carmelo Gracia Tello Sr.³, Alan D. Salama⁴ and David A. Isenberg⁵, ¹Centre for Rheumatology, University College London, London, United Kingdom, ²Internal Medicine Department, University Hospital Complex of Pontevedra, Pontevedra, Spain, ³Internal Medicina, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Zaragoza, Spain, ⁴Centre for Nephrology, University College London, London, United Kingdom, ⁵Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Lupus nephritis (LN) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), leading to end stage renal failure…
Abstract Number: 2880 • 2016 ACR/ARHP Annual Meeting
Distinct Metabolic Pathways Regulate Lipid Antigen Presentation By Monocytes and B Cells: Implications for SLE Patients with Pre-Clinical Atherosclerotic Plaque
Kirsty Waddington¹, Edward Smith², Sara Croca³, David A. Isenberg⁴, Anisur Rahman⁵, Ines Pineda Torra⁶ and Elizabeth Jury⁷, ¹Clinical Pharmacology and Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology Research, University College London, London, United Kingdom, ³Rheumatology, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, ⁵Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁶Clinical Pharmacology, University College London, London, United Kingdom, ⁷Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased risk of developing clinically apparent cardiovascular disease (CVD) and subclinical atherosclerotic plaque, detectable by vascular ultrasound…
Abstract Number: 931 • 2016 ACR/ARHP Annual Meeting
Rates of Lipid Testing and Statin Prescriptions Among SLE and Diabetes Mellitus Patients in a Nationwide Medicaid Cohort
Sarah K. Chen¹, Medha Barbhaiya², Michael A. Fischer³, Hongshu Guan⁴, Tzu-Chieh Lin², Candace H. Feldman⁵, Brendan M. Everett⁶ and Karen H. Costenbader², ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, ⁶Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: We have recently found that rates of myocardial infarction (MI) are similar among individuals with SLE and those with diabetes mellitus (DM) in a…
Abstract Number: 1379 • 2016 ACR/ARHP Annual Meeting
Evaluation of S100 Proteins As Potential Biomarkers of Global and Renal-Specific Disease Activity in Childhood-Onset Systemic Lupus Erythematosus
Jessica Turnier¹, Ndate Fall², Sherry Thornton², Alexei Grom^2,3 and Hermine I. Brunner^4,5, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³PRCSG, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is a heterogeneous disease with differing levels of disease activity and organ-specific disease manifestations in each individual. In particular,…
Abstract Number: 1816 • 2016 ACR/ARHP Annual Meeting
SLE and Uctd in the Rheumatology Informatics System for Effectiveness (RISE) Registry
Julia F Simard¹, Jim Oates², Jinoos Yazdany³, Nick Bansback⁴, Deborah Collier⁵, Karen Law⁶, Katherine Liao⁷, Kaleb Michaud⁸, Esi Morgan⁹, Catalina Orozco¹⁰, Andreas Reimold¹¹, Rachel Myslinski¹², Tracy Johansson¹³, Salahuddin Kazi¹⁴ and Megan E. B. Clowse¹⁵, ¹Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA, ²Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁴Population and Public Health, The University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Internal Medicine, Emory University School of Medicine, Atlanta, GA, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁸University of Nebraska Medical Center, Omaha, NE, ⁹Pediatric rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Rheumatology Associates, Dallas, TX, ¹¹Hospital of Southern Norway, Kristiansand, Norway, ¹²Governance & Ethics Specialist, Amer College of Rheumatology, Atlanta, GA, ¹³Practice, Advocacy & Quality, American College of Rheumatology, Atlanta, GA, ¹⁴Rheumatology, UT Southwestern Medical Center, Dallas, TX, ¹⁵Rheumatology, Duke University School of Medicine, Durham, NC
Background/Purpose: The ACR-sponsored RISE (Rheumatology Informatics System for Effectiveness) Registry is an electronic health record (EHR)-based national database of rheumatology clinical visits. De-identified patient data…
Abstract Number: 2810 • 2016 ACR/ARHP Annual Meeting
Correlates of Spontaneous Cytokine Production in Individuals Undergoing Interferon-Gamma Release Assay Testing
Grant Hughes¹, Christian Lood², Uche Obih¹ and David Koelle¹, ¹University of Washington, Seattle, WA, ²Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: The interferon gamma (IFN-G) release assay (IGRA) estimates probability of latent TB infection (LTBI) based on IFN-G released by whole blood after 18h exposure…
Abstract Number: 2936 • 2016 ACR/ARHP Annual Meeting
All-Trans Retinoic Acid Stabilizes Natural T Regulatory Cells Isolated from Patients with Systemic Lupus Erythematosus Under Inflammatory Conditions
Julie Wang¹, Zixuan Qiao², Feng Huang³, Ya Liu², Nancy J. Olsen⁴ and Song Guo Zheng⁵, ¹Medicine, Penn State Hershey Medical Center, Hershey, PA, ²Medicine, Xuzhou Medical University, Xuzhou, China, ³Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Hershey Medical Center, Hershey, PA
Background/Purpose: Recent studies have demonstrated that naturally occurring CD4+Foxp3+regulatory T cells (nTregs) are unstable and dysfunctional in the presence of pro-inflammatory cytokines. All-trans RA (atRA),…
Abstract Number: 121 • 2016 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus (SLE) Is a Salient Cause of Premature Mortality in the United States: A Sex-Based Exploration
Titilola Falasinnu¹ and Julia F Simard², ¹Health Research and Policy, Stanford University, Stanford, CA, ²Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA
Background/Purpose: The epidemiology of SLE has a complex gendered aspect, characterized by marked differences between the sexes in terms of the incidence, prevalence, and clinical…
Abstract Number: 965 • 2016 ACR/ARHP Annual Meeting
Clinical and Serologic Variables Associated with Renal Response Among Lupus Nephritis Phase III Trial Patients Treated with Standard of Care Immunosuppression
Matthew D. Cascino¹, Peter Lambert², Anna Decker², Tamiko Katsumoto², Jay Garg², Paul Brunetta², Maria Dall'Era¹ and Leonard L. Dragone², ¹Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²Genentech, Inc., South San Francisco, CA
Background/Purpose: Lupus nephritis (LN) is associated with high treatment failure rates and the development of new therapies for LN is limited by the lack of…
Abstract Number: 1384 • 2016 ACR/ARHP Annual Meeting
Comparison of the Systemic Lupus Collaborating Clinics-Damage Index Score with a Physician Global Assessment of Damage in an International Cohort of Patients with Childhood-Onset Systemic Lupus
Michael J. Holland¹, Jun Ying², Nicolino Ruperto^3,4, Kasha Wiley¹, Earl Silverman⁵ and Hermine I. Brunner¹, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center for Biostatistical Services, University of Cincinnati College of Medicine, Cincinnati, OH, ³Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ⁴Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genoa, Italy, ⁵Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease, which can affect any organ system. cSLE is associated with significant morbidity, including…
Abstract Number: 1817 • 2016 ACR/ARHP Annual Meeting
A Longitudinal Analysis of Change in Lupus Disease Activity Pattern in Hopkins Lupus Cohort Using a Multistate Markov Model Approach
Wei Fu¹ and Michelle Petri², ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-systemic inflammatory disease with extreme variability of its activity over time. We have described three main patterns: long…
Abstract Number: 2811 • 2016 ACR/ARHP Annual Meeting
Predictors of Persistent Disease Activity and Persistent Remission in Systemic Lupus Erythematosus – Results from the Hopkins Lupus Cohort
Ioanna Giannakou¹, Katerina Chatzidionysiou², Noémi Györi³, Laurence S Magder⁴, Ronald F. van Vollenhoven^5,6 and Michelle Petri⁷, ¹Department of Medicine, Karolinska Institute, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ³Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁴Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology Unit, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁶Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ⁷Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by a variability of disease expression, both between individuals and within individuals, over time. The aim of this…
Abstract Number: 2937 • 2016 ACR/ARHP Annual Meeting
Regulation of Follicular Helper T (TFH) Cells By ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
Woelsung Yi¹, Sanjay Gupta², Chien-Huan Weng³, Yurii Chinenov⁴, James K. Liao⁵ and Alessandra B. Pernis⁶, ¹Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Weill Cornell Medical College, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Cardiology Section, University of Chicago Medical Center, Chicago, IL, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Follicular helper T (TFH) cells promote humoral responses and serve as a limiting factor for the selection of high affinity germinal center B cells.…

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