SLE Archives - Page 16 of 38 - ACR Meeting Abstracts

Abstract Number: 1919 • 2017 ACR/ARHP Annual Meeting
The SLE-Key Test Detects an SLE Serologic Signature That Persists over Time and Is Independent of Disease Activity
Chaim Putterman¹, Michelle Petri², Roberto Caricchio³, Jim C. Oates⁴, Pennina Safer⁵, Keren Jakobi-Brook⁵, Rachel Sorek⁵, Ilana Gluzman⁵, Steve Wallace⁶ and Irun R. Cohen^5,7, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, ²Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ³Temple Lupus Clinic, Temple University, Philadelphia, PA, USA, Philadelphia, PA, ⁴Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁵ImmunArray Ltd., Rehovot, Israel, Rehovot, Israel, ⁶ImmunArray Inc., VA, USA, Richmond, VA, ⁷Weizmann Institute of Science, Rehovot, Israel, Rehovot, Israel
Background/Purpose: We have developed the iCHIP1,2 to profile repertoires of serum autoantibodies. The first iCHIP application was the SLE-key RuleOut test3,4 , to rule out…
Abstract Number: 2637 • 2017 ACR/ARHP Annual Meeting
A Novel Regulatory Antigen Presenting B Cell and Memory Regulatory T Cell Subsets Are Enriched during the Quiescent Phase of Childhood Onset Systemic Lupus Erythematosus
Joo Guan Yeo^1,2, Thaschawee Arkachaisri^1,3, Lena Das¹, Justin Hung Tiong Tan¹, Jing Yao Leong², Yun June Angela Tan⁴, Liyun Lai⁵, Loshinidevi D/O Thana Bathi², Phyllis Chen², Seck Choon Elene Lee¹, Yun Xin Book¹ and Salvatore Albani^5,6, ¹Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, ²Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ³Duke-NUS Medical School, Singapore, Singapore, ⁴Department of Paediatric Anaesthesia, KK Women's and Children's Hospital, Singapore, Singapore, ⁵SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ⁶KK Women's and Children's Hospital, Singapore, Singapore
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-factorial disease and the conventional oligo-dimensional investigative approach involving one or a few cell subsets at a time…
Abstract Number: 833 • 2017 ACR/ARHP Annual Meeting
Chronic Cutaneous Lupus Erythematosus Patients Have a Breakdown in Autoreactive VH4.34 Antibody Tolerance While Maintaining Tolerance to dsDNA and Chromatin
Scott Jenks¹, Regina Bugrovsky¹, Xiaoqian Wang^1,2, Aisha Hill³, Chungwen Wei⁴, S. Sam Lim⁵, Ignacio Sanz⁶ and Cristina Drenkard⁵, ¹Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ²Division of Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, atlanta, GA, ⁴Medicine, Emory University School of Medicine, Atlanta, GA, ⁵Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁶Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA
Background/Purpose: While the contribution of humoral immunity to SLE is well established, the role it plays in chronic cutaneous lupus erythematosus (CCLE) is less clear.…
Abstract Number: 1633 • 2017 ACR/ARHP Annual Meeting
Use of Emergency Department (ED) and Resulting Hospitalization By Patients with Systemic Lupus Erythematosus (SLE) in a Predominantly Afro-Caribbean Inner-City Cohort
Maushmi Savjani¹, Justin Levinson² and Ellen M. Ginzler³, ¹Internal Medicine, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ²Medicine, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ³Rheumatology, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: Given the complexity, chronicity and associated co-morbidities, management of SLE poses a challenge. Despite established care in private and fellow/resident clinics, our patients often…
Abstract Number: 2559 • 2017 ACR/ARHP Annual Meeting
KZR-616, a Selective Inhibitor of the Immunoproteasome, Blocks the Disease Progression in Multiple Models of Systemic Lupus Erythematosus (SLE)
Tony Muchamuel¹, Janet Anderl², R Andrea Fan², Henry W. B. Johnson³, Christopher J Kirk⁴ and Eric Lowe², ¹Pharmacology and Toxicology, Kezar Life Sciences, South San Francisco, CA, ²Biology, Kezar Life Sciences, South San Francisco, CA, ³Medicinal Chemistry, Kezar Life Sciences, South San Francisco, CA, ⁴Kezar Life Sciences, South San Francisco, CA
Background/Purpose: The proteasome inhibitor bortezomib has been used successfully to treat patients with SLE. The immunoproteasome is a distinct class of proteasome found predominantly in…
Abstract Number: 2638 • 2017 ACR/ARHP Annual Meeting
Inducible cAMP Early Repressor Promotes Glycolysis By Inhibiting the Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 in Th17 Cells
Michihito Kono, Nobuya Yoshida, Nicole E. Skinner and George C. Tsokos, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Th17 cells are key players in SLE. Because Th17 cells use mainly glycolysis, blocking glycolysis can inhibit Th17 cell differentiation and treatment of lupus-prone…
Abstract Number: 930 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Modified-Release Prednisone in Managing Moderate Activity SLE during Pregnancy: An Implemented Case-Control Study
Marianna Meroni¹, Véronique Laure Ramoni², Massimiliano Parodi³, Paolo Stobbione³ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, ²Division of Rheumatology, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, ³Rheumatology Unit, Internal Medicine Department, A.O. S.S. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy, Alessandria, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genoa, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) can affect young women and pregnancy still represents a challenge. Prednisone is safely used, at low doses (<7.5 mg daily),…
Abstract Number: 1655 • 2017 ACR/ARHP Annual Meeting
Interferon b Blockade Rescues Human BM-MSC Osteoblastogenesis Defects in Systemic Lupus Erythematosus
Lin Gao¹, Jennifer H. Anolik² and R. John Looney³, ¹medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³University of Rochester Medical Center, Rochester, NY
Background/Purpose: Bone marrow mesenchymal stromal cells (BM-MSCs) are multipotent stem cells that can differentiate into chondrocytes, osteoblasts and adipocytes. SLE has been implicated as a…
Abstract Number: 2563 • 2017 ACR/ARHP Annual Meeting
SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice
Akiko Nagasu¹, Tomoyuki Mukai¹, Masanori Iseki², Hajime Nagasu³, Shunichi Fujita¹, Takafumi Mito¹, Shoko Kodama¹, Yumi Sasae⁴, Naoki Kashihara³, Katsuhiko Ishihara², Yasuyoshi Ueki⁵ and Yoshitaka Morita¹, ¹Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, ²Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ³Department of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Rheumatology, Kawasaki Medical School, Kurashiki Okayama, Japan, ⁵Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Missouri-Kansas City, MO
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, leading to multiple organ dysfunction. SH3BP2 (Src homology domain 3…
Abstract Number: 2645 • 2017 ACR/ARHP Annual Meeting
The Internalization of DNA-Antibodies By Podocytes during Lupus Nephritis
Anja Römer-Hillmann¹, Elisabeth Jung², Annika Engbers¹, Marcel Reinhardt¹, Hedda Wardemann³, Thomas Pap⁴ and Annett Jacobi⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Department of Internal Medicine D, Rheumatology, University Hospital Muenster, Muenster, Germany, ³Deutsches Krebsforschungszentrum, Heidelberg, Germany, ⁴Institute for Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁵Internal Medicine, Ruppiner Kliniken GmbH, Neuruppin, Germany
Background/Purpose: Podocytes are postmitotic visceral epithelial cells, located at the Bowmans capsule of the kidney building up the slit diaphragm with their foot processes to…
Abstract Number: 149 • 2017 Pediatric Rheumatology Symposium
Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB1*15 and HLA-DRB1*03 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent
Stacy Ardoin¹, Pinar Ozge Avar Aydin², Lai Hin Kimi Chan³, Katherine Lintner⁴, Yee Ling Wu^5,6, Rabheh Aziz¹, Anjali Patwardhan^7,8, Evan Mulvihill¹, Gakit Yu⁹, Bi Zhou¹⁰, Emeli Lundstrom¹¹, Leonid Padyukov¹², Kyla Driest¹³, Cagri Yildirim-Toruner¹³, Sharon Bout-Tabaku¹³, Charles Spencer¹⁴, Gloria Higgins¹, Sampath Prahalad¹⁵, Hermine Brunner¹⁶ and Chack-Yung Yu^10,17, ¹Pediatrics and Rheumatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ²Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁴Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁵The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁷Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ⁸Pediatric Rheumatology, Nationwide Children's Hospital, Columbia, MO, ⁹Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ¹⁰Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ¹¹Rheumatology, Karolinska Institute, Stockholm, Switzerland, ¹²Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ¹³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ¹⁴Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ¹⁵Pediatrics, Emory Children's Center, Atlanta, GA, ¹⁶Rheumatology, PRCSG, Cincinnati, OH, ¹⁷Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: A complete genetic deficiency of complement C4 almost always leads to the pathogenesis of systemic lupus erythematosus (SLE) with childhood onset, although its prevalence…
Abstract Number: 91 • 2017 Pediatric Rheumatology Symposium
Peri-pubertal Onset of Systemic Lupus Erythematosus is Associated with Shorter than Expected Adult Height
Merav Heshin-Bekenstein¹, Aimee O. Hersh², Emily von Scheven³ and Erica Lawson¹, ¹Pediatric Rheumatology, University of California San Francisco, San Francisco, CA, ²Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, ³Division of Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA
Background/Purpose: Patients with childhood-onset SLE (cSLE) have a higher incidence of renal disease and may receive more intensive immunosuppression as compared to individuals with adult-onset…
Abstract Number: 13L • 2016 ACR/ARHP Annual Meeting
Low-Dose IL-2 Therapy in Refractory SLE: Results from Single Center Phase I/IIa Clinical Trial
Jens Humrich¹, Caroline von Spee-Mayer², Elise Siegert³, Angelika Rose², Martina Bertolo⁴, Philipp Enghard⁵, Falk Hiepe⁶, Tobias Alexander⁷, Eugen Feist⁸, Andreas Radbruch⁹, Gerd R. Burmester¹⁰ and Gabriela Riemekasten¹¹, ¹Department of Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ²Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Department of Rheumatology, Charité – University Medicine Berlin, Berlin, Germany, ⁵Department of Nephrology, Charité – University Medicine Berlin, Berlin, Germany, ⁶Charité – Universitätsmedizin, Berlin, Germany, ⁷Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁸Charité-Universitätsmedizin Berlin, Berlin, Germany, ⁹Deutsches Rheumaforschungszentrum, Berlin, Germany, ¹⁰Charité – University Medicine Berlin, Berlin, Germany, ¹¹Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany

Background/Purpose: Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…
Abstract Number: 931 • 2016 ACR/ARHP Annual Meeting
Rates of Lipid Testing and Statin Prescriptions Among SLE and Diabetes Mellitus Patients in a Nationwide Medicaid Cohort
Sarah K. Chen¹, Medha Barbhaiya², Michael A. Fischer³, Hongshu Guan⁴, Tzu-Chieh Lin², Candace H. Feldman⁵, Brendan M. Everett⁶ and Karen H. Costenbader², ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, ⁶Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: We have recently found that rates of myocardial infarction (MI) are similar among individuals with SLE and those with diabetes mellitus (DM) in a…
Abstract Number: 1379 • 2016 ACR/ARHP Annual Meeting
Evaluation of S100 Proteins As Potential Biomarkers of Global and Renal-Specific Disease Activity in Childhood-Onset Systemic Lupus Erythematosus
Jessica Turnier¹, Ndate Fall², Sherry Thornton², Alexei Grom^2,3 and Hermine I. Brunner^4,5, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³PRCSG, Cincinnati, OH, ⁴Cincinnati Children's Hospital Medical Center, PRCSG, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is a heterogeneous disease with differing levels of disease activity and organ-specific disease manifestations in each individual. In particular,…

Abstracts tagged "SLE"

The SLE-Key Test Detects an SLE Serologic Signature That Persists over Time and Is Independent of Disease Activity

A Novel Regulatory Antigen Presenting B Cell and Memory Regulatory T Cell Subsets Are Enriched during the Quiescent Phase of Childhood Onset Systemic Lupus Erythematosus

Chronic Cutaneous Lupus Erythematosus Patients Have a Breakdown in Autoreactive VH4.34 Antibody Tolerance While Maintaining Tolerance to dsDNA and Chromatin

Use of Emergency Department (ED) and Resulting Hospitalization By Patients with Systemic Lupus Erythematosus (SLE) in a Predominantly Afro-Caribbean Inner-City Cohort

KZR-616, a Selective Inhibitor of the Immunoproteasome, Blocks the Disease Progression in Multiple Models of Systemic Lupus Erythematosus (SLE)

Inducible cAMP Early Repressor Promotes Glycolysis By Inhibiting the Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2 in Th17 Cells

Efficacy and Safety of Modified-Release Prednisone in Managing Moderate Activity SLE during Pregnancy: An Implemented Case-Control Study

Interferon b Blockade Rescues Human BM-MSC Osteoblastogenesis Defects in Systemic Lupus Erythematosus

SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice

The Internalization of DNA-Antibodies By Podocytes during Lupus Nephritis

Deficiency of Complement C4A or Low Copy Number of Total C4 Genes, HLA-DRB115 and HLA-DRB103 Are Strong Genetic Risk Factors for Pediatric SLE of European Descent

Peri-pubertal Onset of Systemic Lupus Erythematosus is Associated with Shorter than Expected Adult Height

Low-Dose IL-2 Therapy in Refractory SLE: Results from Single Center Phase I/IIa Clinical Trial

Rates of Lipid Testing and Statin Prescriptions Among SLE and Diabetes Mellitus Patients in a Nationwide Medicaid Cohort

Evaluation of S100 Proteins As Potential Biomarkers of Global and Renal-Specific Disease Activity in Childhood-Onset Systemic Lupus Erythematosus