Abstracts tagged "SLE"

Abstract Number: 331 • 2017 ACR/ARHP Annual Meeting
Case Series: Comparison of Repository Corticotropin Injection (H.P. Acthar Gel) Versus Glucocorticoids on Bone Density in SLE Patients
Anny T. Wu¹ and Joshua June², ¹Rheumatology, Franciscan Alliance, Munster, IN, ²3394 E Jolly Rd Ste C, Great Lakes Center of Rheumatology, Lansing, MI
Background/Purpose: Repository Corticotropin Injection (RCI) is an adrenocorticotropin hormone in 16% gelatin with a prolonged release after intramuscular (IM) or subcutaneous injection. Adverse effects of…
Abstract Number: 1269 • 2017 ACR/ARHP Annual Meeting
Investigating Time Trends in Incident Pediatric Lupus across Ethnic Groups in Toronto, Canada—a Large, Multiethnic Metropolitan Area
Laura Y Feldman¹, Patrick Brown², Linda T Hiraki^1,3 and Earl Silverman³, ¹Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Lupus incidence rates are known to differ by ethnicity among children and adults, with African ancestry as a risk factor for incident lupus, compared…
Abstract Number: 1671 • 2017 ACR/ARHP Annual Meeting
Complement C4 Gene Copy Number Variations Bestow Large Ranges of Serum C4 Protein Levels in Chinese Patients with Systemic Lupus Erythematosus (SLE) and Contribute to Organ and Cardiovascular Damages over Time
Chi Chiu Mok¹, Emily King², Bi Zhou³, Gakit Yu⁴, Yee Ling Wu⁵ and CHACK-YUNG Yu⁶, ¹Rheumatology, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Pediatrics, Nationwide Children's Hospital, Columbus, OH, ³Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁵Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: Human SLE is characterized by fluctuating serum levels of complement proteins. There are frequent copy number variations (CNVs) of complement C4A and C4B genes…
Abstract Number: 2583 • 2017 ACR/ARHP Annual Meeting
Effects of Mycophenolate Mofetil (MMF) on Immunogenicity of Ppsv-23 Vaccine in Patients with Systemic Lupus Erythematosus and Other Autoimmune Diseases
Priya Prakash¹, Mark Tratenberg², Slavica Bobic³, Rui Zhang⁴, Kirk Sperber⁵, Amy Wasserman⁶ and Julia Ash⁷, ¹Medicine-Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY, ²New York Medical College / Westchester Medical Center, valhalla, NY, ³Medicine-Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, ⁴Medicine -Rheumatology, New York Medical College / Westchester Medical Center, valhalla, NY, ⁵New York Medical College / Westchester Medical Center, Valhalla, NY, ⁶Medicine - Rheumatology, New York Medical College / Westchester Medical Center, VALHALLA, NY, ⁷Medicine -Rheumatology, New York Medical College / Westchester Medical Center, Valhalla, NY
Background/Purpose: MMF suppresses immune function by inhibiting T cell dependent and independent humoral immune responses. This study investigates the humoral immune response to the PPSV23…
Abstract Number: 2920 • 2017 ACR/ARHP Annual Meeting
Comparative Rates of Osteoporotic Fractures Among U.S. Medicaid Enrollees with and without Systemic Lupus Erythematosus
Sara K. Tedeschi¹, Beatrice Pan¹, Hongshu Guan¹, Seoyoung C. Kim², Daniel H. Solomon¹ and Karen H. Costenbader¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Pharmacoepidemiology and Pharmocoeconomics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Fractures are potentially avoidable and highly morbid. We studied non-vertebral fracture rates among SLE patients enrolled in Medicaid, the U.S. health insurance program for…
Abstract Number: 669 • 2017 ACR/ARHP Annual Meeting
Unbiased Screening of Urinary Protein Biomarkers for Glomerular Filtration Rate Normalization
Sanam Soomro¹, Samantha Stanley², Ramesh Saxena³, Michelle Petri⁴ and Chandra Mohan¹, ¹Biomedical Engineering, University of Houston, Houston, TX, ²Biomedical Engineering Department, University of Houston, Houston, TX, ³Internal Medicine/Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD
Background/Purpose: To account for glomerular filtration rate, urinary creatinine is routinely used for the normalization of urine biomarkers related to disease. Because of the small…
Abstract Number: 1272 • 2017 ACR/ARHP Annual Meeting
Cluster Analysis of Autoantibodies and Their Relationship with Demographic and Clinical Features in Pediatric Systemic Lupus Erythematosus in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
Ginger Janow¹, Uptej Khalsa² and Tracy Andrews³, ¹Pediatric Rheumatology, Joseph M Sanzari Children’s Hospital, Hackensack Meridian Health Network, Hackensack, NJ, ²Pediatrics, Newark Beth Israel Medical Center, Children's Hospital of New Jersey, Newark, NJ, ³Research, Hackensack University Medical Center, Hackensack Meridian Health, Hackensack, NJ
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic, heterogeneous, multisystem autoimmune disease characterized, in part, by the presence of autoantibodies. The spectrum of disease presents…
Abstract Number: 1675 • 2017 ACR/ARHP Annual Meeting
SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations
Lina Marcela Diaz Gallo¹, Emeli Lundström¹, Vilija Oke¹, Kerstin Elvin², Yee Ling Wu³, Johanna Gustafsson¹, Andreas Jönsen⁴, Dag Leonard⁵, Agneta Zickert⁶, Gunnel Nordmark⁷, Anders A. Bengtsson⁴, Johanna K Sandling⁷, Lars Rönnblom⁸, Iva Gunnarsson¹, CHACK-YUNG Yu⁹, Leonid Padyukov¹⁰ and Elisabet Svenungsson¹⁰, ¹Department of Medicine, Rheumatology Unit, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Dept. of Clinical Immunology and Transfusion Medicine, Unit of Clinical Immunology, Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ³The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁵Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁷Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ⁸Medical Sciences, Rheumatology clinic, Uppsala, Sweden, ⁹Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ¹⁰Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: SLE is a remarkably heterogeneous disease including diverging clinical symptoms, autoantibodies and genetic susceptibility. Hitherto unrecognized patterns may define sub-phenotypes with different pathogenesis and…
Abstract Number: 2587 • 2017 ACR/ARHP Annual Meeting
KZR-616, a Selective Inhibitor of the Immunoproteasome, Shows a Promising Safety and Target Inhibition Profile in a Phase I, Double-Blind, Single (SAD) and Multiple Ascending Dose (MAD) Study in Healthy Volunteers
Jason Lickliter¹, Janet Anderl², Christopher J Kirk³, Jinhai Wang⁴ and Darrin Bomba⁵, ¹Nucleus Network, Melbourne, Australia, ²Biology, Kezar Life Sciences, South San Francisco, CA, ³Kezar Life Sciences, South San Francisco, CA, ⁴DMPK, Kezar Life Sciences, South San Francisco, CA, ⁵Clinical Operations, Kezar Life Sciences, South San Francisco, CA
Background/Purpose: Proteasome inhibition is a standard of care for plasma cell malignancies. The first-generation inhibitor, bortezomib (BTZ), targets the constitutive proteasome and immunoproteasome and has…
Abstract Number: 2974 • 2017 ACR/ARHP Annual Meeting
B Cell Binding Autoreactive VH4.34 Antibodies Are Specific to Lupus, Consist of Diverse Isotypes, and Are Associated with High Disease Activity and Lupus Nephritis
Scott Jenks¹, Joseph Marcus², Kevin Cashman¹ and Ignacio Sanz³, ¹Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ²San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, ³Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA
Background/Purpose: SLE is characterized by the dysregulation of humoral immunity including high levels of autoreactive IgG VH4.34 antibodies recognized by the rat anti-human idiotypic antibody…
Abstract Number: 676 • 2017 ACR/ARHP Annual Meeting
Immunosignature Autoantibody Profiles Provide Mechanistic Insight into Systemic Lupus Erythematosus and Differentiation from Symptomatically Overlapping Diseases
Theodore M. Tarasow¹, Robert Gerwien¹, Jonathan Melnick¹, Scott A. Melville¹ and Chaim Putterman², ¹HealthTell, Inc., San Ramon, CA, ²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Diagnosis and monitoring of patients with SLE usually requires careful evaluation by a rheumatologist. However, difficulties in accurately quantifing disease and treatment response can…
Abstract Number: 1293 • 2017 ACR/ARHP Annual Meeting
Indications for Cesarean Delivery in Systemic Lupus Erythematosus Pregnancies
Evelyne Vinet¹, Paul R. Fortin², Stéphanie Roberge³, Emmanuel Bujold⁴ and Nils Chaillet⁵, ¹Divisions of Rheymatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Infectious Diseases and Immunity Research Division, CHU de Québec-Université Laval Research Center, Québec, QC, Canada, ³Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada, ⁴Reproduction, mother and youth health, Centre Hospitalier de l'Université Laval (CHUL), Québec, QC, Canada, ⁵Département d’obstétrique et gynécologie et département de Médecine de famille et médecine d’urgence, Université de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: Pregnant SLE women are at increased risk of cesarean delivery compared to pregnant women from the general population. Yet, to date, no one has…
Abstract Number: 1786 • 2017 ACR/ARHP Annual Meeting
Lupus Nephritis Is Linked to Immunity to an Intestinal Commensal Lachnospiracaea Species
Gregg J. Silverman¹, Doua F. Azzouz², Hanane El Bannoudi², Aidana Omarbekova³, Brad H. Rovin⁴, Roberto Caricchio⁵, Alexander Alekseyenko⁶ and Jill P. Buyon², ¹Department of Medicine, New York University School of Medicine, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Ohio State University Medical Center, Columbus, OH, ⁵Medicine/Rheumatology, Temple University, Philadelphia, PA, ⁶Medical University of South Carolina, Charleston, SC
Background/Purpose: A transmissible agent has long been suspected in the pathogenesis of SLE, yet the potential contribution of members of the intestinal microbiome to the…
Abstract Number: 2600 • 2017 ACR/ARHP Annual Meeting
Plasma Cell and T-Cell Activity Downregulation during MMF Therapy in SLE May be Necessary for Successful Immunosuppression
Cristina Arriens¹, Rufei Lu², Teresa Aberle², Stan Kamp², Wade DeJager², Melissa E. Munroe², Eliza Chakravarty¹, Katherine Thanou², Joan T. Merrill³, Joel M. Guthridge⁴ and Judith A. James³, ¹Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK
Background/Purpose: MMF is a key therapy for moderate to severe SLE. MMF inhibits inosine monophosphate dehydrogenase, an enzyme needed in nucleotide synthesis required for lymphocyte…
Abstract Number: 2979 • 2017 ACR/ARHP Annual Meeting
The Expression of Mitochondrial Molecules in Microparticle Immune Complexes in the Blood of Patients with Systemic Lupus Erythematosus
Fariborz Mobarrez¹, Enrico Fuzzi¹, Iva Gunnarsson¹, David Pisetsky² and Elisabet Svenungsson¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medicine, Duke University Medical Center, Durham, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complexes, especially those with nuclear molecules bound by antinuclear antibodies. Although the…

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