Abstracts tagged "SLE"

Abstract Number: 27 • 2018 ACR/ARHP Annual Meeting
Top-Down Proteomics Coupled with Antibody Sequencing from Single B Cells Reveals a Monoclonal Anti-Sm Clone Present in the Serum of an SLE Patient over Three Years
Zhe Wang¹, Jennifer Muther², Judith A. James³, Si Wu¹ and Kenneth Smith², ¹Chemistry and Biochemistry, University of Oklahoma, Norman, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Proteomics is becoming an increasingly powerful tool to study autoantibodies. Current bottom-up approaches are yielding a plethora of knowledge about public clonotypes and clonal…
Abstract Number: 728 • 2018 ACR/ARHP Annual Meeting
A Higher Activity Index at Initial Renal Biopsy Is Associated with Rapid Progression to Renal Failure in Patients with Refractory Lupus Nephritis
Shuwei Wang¹, Stacy Tanner², Teja Kapoor³, Thania Perez⁴, Vivette D D'Agati⁵, Anca Askanase⁴, Robert Winchester³ and Laura Geraldino-Pardilla³, ¹Rheumatology, Columbia University, College of Physicians & Surgeons, New York City, NY, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, Winnipeg, DC, Canada, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, College of Physicians & Surgeons, New York, NY, ⁵Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, New York City, NY
Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality affecting ~50% of systemic lupus erythematosus (SLE) patients. Up to 30% of patients…
Abstract Number: 1091 • 2018 ACR/ARHP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Is Essential for T Lymphocyte Homeostasis and Decreased Levels of SRSF1 Correlate with Lymphopenia in SLE Patients
Takayuki Katsuyama¹, Kotaro Iida² and Vaishali R. Moulton¹, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Rheumatology, Department of Medicine, Boston, MA
Background/Purpose: Lymphopenia is one of the most common clinical features in patients with systemic lupus erythematosus (SLE), and associates with severe disease and comorbidities such…
Abstract Number: 1943 • 2018 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Poor Renal Outcomes, Damage Accrual, and Death: A Prospective Ghanaian SLE Cohort
Ashira Blazer¹, Ida Dzifa Dey², Margaret Reynolds³, Festus Ankrah³, Nancyanne Schmidt⁴, Robert M. Clancy⁵ and Jill P. Buyon⁶, ¹Internal Medicine Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Rheumatology Unit, School of Medicine and Dentistry,University of Ghana, Accra, Ghana, ³Internal Medicine, The University of Ghana, Accra, Ghana, ⁴Internal Medicine, New York University School of Medicine, New York, NY, ⁵NYU School of Medicine, New York, NY, ⁶Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, are enriched in ancestrally African populations due to a conferred superior resistance to Trypanosoma…
Abstract Number: 2170 • 2018 ACR/ARHP Annual Meeting
Relationship between Short- and Long-Term Periods of Self-Reported Physical Activity Patterns in Individuals with SLE
Gizem Irem Kinikli¹, Susanne Pettersson², Iva Gunnarsson³, Elisabet Svenungsson³ and Carina Boström⁴, ¹Physiotherapy and Rehabilitation, Hacettepe University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara/TURKEY, Ankara, Turkey, ²Neurobiology, care sciences and society, Karolinska Institutet, Department of Neurobiology, care sciences and society, Karolinska University Hospital, Stockholm/SWEDEN, Stockholm, Sweden, ³Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁴Karolinska University Hospital, Karolinska Institutet, Department of Neurobiology, care sciences and society, Karolinska University Hospital, Stockholm/SWEDEN, Stockholm, Sweden
Background/Purpose: Physical inactivity is prevalent in Systemic Lupus Erythematosus (SLE). Assessment of physical activity (PA) is vital to manage cardiovascular risk factors in SLE. The…
Abstract Number: 2895 • 2018 ACR/ARHP Annual Meeting
Effect of Vitamin D on Serum Markers of Bone Turnover in SLE in a Randomized Controlled Trial
Sara K. Tedeschi¹, Cynthia Aranow², Diane L. Kamen³, Meryl S. LeBoff⁴, Betty Diamond² and Karen Costenbader⁵, ¹Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²The Feinstein Institute for Medical Research, Manhasset, NY, ³Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁴Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Bone health in SLE is adversely affected by vitamin D deficiency, inflammatory cytokines including interferon (IFN)-α, and glucocorticoid use. We tested the hypothesis that…
Abstract Number: 93 • 2018 ACR/ARHP Annual Meeting
Biomarkers Associating Endothelial Function in Systemic Lupus Erythematous
Wan-Fang Lee¹, Chao-Yi Wu², Huang-Yu Yang³ and Jing-Long Huang^2,4, ¹Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ²Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ³Department of Nephrology,, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ⁴Medicine, Chang-Gung University, Taoyuan city, Taiwan
Background/Purpose: The endothelium is a key element in the regulation of vascular homeostasis and its alteration is a precursor of vascular disease. Considering SLE is…
Abstract Number: 749 • 2018 ACR/ARHP Annual Meeting
Is Lupus Nephritis Onset Delayed in Older Caucasian Females with Less Aggressive Pathology?
Cristina Arriens¹, Sixia Chen², David Karp³, Ramesh Saxena⁴, Joan T. Merrill¹ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁴Nephrology Division, UT Southwestern Medical Center, Dallas, TX, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Lupus Nephritis (LN) usually presents within 5 years of SLE diagnosis, however the minority of patients with late-occurring nephritis are poorly characterized. Factors associated…
Abstract Number: 1095 • 2018 ACR/ARHP Annual Meeting
IFN Gene Expression Correlates with Frequency of Circulating Switched Memory B-Cells in Patients with Incomplete Systemic Lupus Erythematosus
Wietske Lambers¹, Geert Lanting¹, Wayel H. Abdulahad², Hendrika Bootsma², Johanna Westra² and Karina de Leeuw³, ¹Rheumatology/Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Incomplete systemic lupus erythematosus (iSLE) includes patients with typical features of SLE, who do not meet classification criteria. Still, up to 50% will develop…
Abstract Number: 2019 • 2018 ACR/ARHP Annual Meeting
Investigating Urine S100A4 and Podocyte Proteins As Biomarkers of Lupus Nephritis Activity
Jessica Turnier¹, Jianghong Deng², Pinar Ozge Avar Aydin³, David Witte⁴, Prasad Devarajan⁵, Matthew Fenchel⁶, Michael Bennett⁷ and Hermine I. Brunner⁸, ¹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Beijing Children’s Hospital and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁶Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: We lack accurate clinical tools to identify the degree of active renal inflammation in childhood-onset SLE (cSLE). In this study, we investigated urine S100A4…
Abstract Number: 2184 • 2018 ACR/ARHP Annual Meeting
An Economic Evaluation on the Impact of Earlier Systemic Lupus Erythematosus (SLE) Diagnosis Using Complement C4d Activation Products in a Multivariate Assay Panel (MAP)
Ann E. Clarke¹, Tom Goss², Andrew Piscitello³, Tarun Chandra³, Tyler O'Malley⁴, Thierry Dervieux⁴ and Tami Powell⁵, ¹Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ²Health Economics Outcomes Research, Boston Healthcare, Boston, MA, ³EmpiriQA LLC, Long Grove, IL, ⁴Exagen Diagnostics, Inc., Vista, CA, ⁵Corporate Payer Strategy & Reimbursement, Exagen Diagnostics, Inc., vista, CA
Background/Purpose: Diagnosis (dx) of systemic lupus erythematosus (SLE) is made via a combination of clinical and laboratory examinations; the sensitivity and specificity (S&S) of standard…
Abstract Number: 2971 • 2018 ACR/ARHP Annual Meeting
Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease: Long Term Outcomes
Joanna Tieu^1,2, Seerapani Gopaluni^3,4, Rona Smith¹ and David Jayne¹, ¹Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²Department of Medicine, University of Adelaide, Adelaide, Australia, ³Medicine, University of Cambridge, Cambridge, United Kingdom, ⁴Vasculitis and Lupus, Addenbrooke’s Hospital, Cambridge, United Kingdom
Background/Purpose: Despite a low incidence of hypogammaglobulinemia (HG) in clinical trials using rituximab (RTX), HG occurs in follow-up of patients with autoimmune disease. Immunoglobulin replacement…
Abstract Number: 9L • 2017 ACR/ARHP Annual Meeting
Circulating Type I, II and III Interferons (IFNs) Associate with IFN-Scores, but Define Distinct Subsets of Active SLE
Vilija Oke¹, Iva Gunnarsson¹, Jessica M. Dorschner², Agneta Zickert¹, Timothy B. Niewold³ and Elisabet Svenungsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Colton Center for Autoimmunity, New York University, New York, NY

Background/Purpose: Serum induced IFN gene expression (IFN-score) is considered a golden standard to assess IFN activity in SLE. So far, IFN-scores have not been compared…
Abstract Number: 722 • 2017 ACR/ARHP Annual Meeting
Differential Diagnosis of Autoimmune Diseases, Outlier Detection Plus Subgrouping in Clinical Trials By High Content Autoantibody Profiling
Peter Schulz-Knappe, Petra Budde and Hans-Dieter Zucht, Protagen AG, Dortmund, Germany
Background/Purpose: Early diagnosis as well as initiation of successful treatment are two big challenges in the management of patients with autoimmune diseases (AID). Overlap of…
Abstract Number: 1625 • 2017 ACR/ARHP Annual Meeting
Incidence and Outcomes of Venous Thromboembolism in Hospitalized Patients with Systemic Lupus Erythematosus: Results from Nationwide Inpatient Sample Database 2003-2011
Shweta Kishore¹, Varun Mittal², Shradha Ahuja³ and Vikas Majithia^1,4, ¹Division of Rheumatology, University of Mississippi, Jackson, MS, ²Division of Hematology and Oncology, Albert Einstein Healthcare Network, Philadelphia, PA, ³Division of Hospital Medicine, University of Mississippi, Jackson, MS, ⁴Jackson VA Medical Center and University of Mississippi, Jackson, MS
Background/Purpose: Venous thromboembolism (VTE) is a major cause of mortality and morbidity in hospitalized patients. Hospitalized patients with autoimmune disorders are particularly at risk of…

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