Abstracts tagged "SLE"

Abstract Number: 2103 • 2018 ACR/ARHP Annual Meeting
Using a Drosophila Model to Unravel the Genetic Complexity of Systemic Lupus Erythematosus
Nathan Mortimer, Mary Fischer, Ashley Waring and Victoria DeMichel, School of Biological Sciences, Illinois State University, Normal, IL
Background/Purpose: The objective of our research is to understand the genetic architecture and molecular mechanisms that contribute to the development and progression of the autoimmune…
Abstract Number: 2655 • 2018 ACR/ARHP Annual Meeting
SLE-Key® Ruleout Testing in Support of Patient Triage in the Clinical Rheumatology Setting
Steve Wallace¹, Giovani Geslani², Joanna Geslani², Michael Strachan³, Don Thomas⁴, Korey Ullrich⁵, Alvin F. Wells⁶, Emileigh Wong¹, Maggie Barton¹ and Pennina Safer⁷, ¹ImmunArray Inc., Richmond, VA, ²Rheumatology Associates Arlington, Arlington, TX, ³Premier Healthcare Associates, Richmond, VA, ⁴Arthritis & Pain Associates of P. G. County, Greenbelt, MD, ⁵Rheumatology Associates of South Florida, Boca Raton, FL, ⁶Rheumatology and Immunotherapy Center, Franklin, WI, ⁷ImmunArray Ltd., Rehovot, Israel, Rehovot, Israel
Background/Purpose: SLE diagnosis and classification can be challenging. The low incidence of SLE limits primary care physician experience with the disease, but the impact of…
Abstract Number: 348 • 2018 ACR/ARHP Annual Meeting
Psychometric Validation of the Arthritis Helplessness Index in Systemic Lupus Erythematosus
Shadi Gholizadeh¹, Desiree R Azizoddin², Sarah D. Mills³, Geraldine Zamora Racaza⁴, Hi'Ilani Mary Kala'aukahi Potemra⁵, Daniel J. Wallace⁶, Michael Weisman⁷ and Perry M. Nicassio⁸, ¹SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, ²Department of Anesthesiology, Stanford University School of Medicine, Palo Alto, CA, ³Medicine, Lineberger Comprehensive Cancer Center University of North Carolina, Durham, NC, ⁴Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵University of California, Los Angeles, Los Angeles, CA, ⁶Geffen School of Medicine at UCLA, West Hollywood, CA, ⁷Harbor UCLA Medical Center, Los Angeles, CA, ⁸Cousins Center for PNI, UCLA, LA, CA
Background/Purpose: Helplessness is a relevant construct in systemic lupus erythematosus (SLE), an unpredictable chronic illness with no known cure characterized by relapsing and remitting features.…
Abstract Number: 779 • 2018 ACR/ARHP Annual Meeting
Cerebrospinal Fluid Biomarkers for Diagnosing Neuropsychiatric SLE: A Systematic Review and Meta-Analysis
Seyed-Foad Ahmadi¹, Golara Zahmatkesh², Masoud Majed³ and Sheetal Desai⁴, ¹Department of Medicine, University of California Irvine, Orange, CA, ²Department of Psychiatry, University of New Mexico, Albuquerque, NM, ³Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Medicine/Rheumatology, Unviersity of California, Irvine, Orange, CA
Cerebrospinal Fluid Biomarkers for Diagnosing Neuropsychiatric SLE: A Systematic Review and Meta-analysis Background/Purpose: Current guidelines recommend that in suspected neuropsychiatric SLE (NPSLE), the initial diagnostic workup…
Abstract Number: 1666 • 2018 ACR/ARHP Annual Meeting
The Use of Patient-Reported Outcome Measures to Assess Clinical Features of Fibromyalgia in SLE
Jennifer Rogers¹, Amanda M. Eudy², Lisa Criscione-Schreiber², David Pisetsky³, Kai Sun⁴, Jay Doss⁴ and Megan E. B. Clowse², ¹Medicine, Divison of Rheumatology, Duke University, Durham, NC, ²Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, ³Department of Medicine, Duke University, Durham, NC, ⁴Division of Rheumatology & Immunology, Duke University, Durham, NC
Background/Purpose: Patient-reported outcome measures (PROs) in SLE can capture patient specific information and the patient perspective, but clinical use can be challenging due to confounding…
Abstract Number: 2105 • 2018 ACR/ARHP Annual Meeting
Genetic Analysis of a Drosophila Systemic Lupus Erythematosus Model Reveals Lupus Susceptibility Genes
Pooja KR, Brooklynne Thielen, Xavier Hernandez and Nathan Mortimer, School of Biological Sciences, Illinois State University, Normal, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with various immunological abnormalities and a diverse range of clinical symptoms. In contrast to the…
Abstract Number: 2664 • 2018 ACR/ARHP Annual Meeting
Long-Term Clinical Outcomes in a Cohort of Adults with Childhood-Onset Systemic Lupus Erythematosus
Noortje Groot¹, Y.K. Onno Teng², Karina de Leeuw³, Marc Bijl⁴, Radboud J. E. M. Dolhain⁵, Els J. Zirkzee⁶, Ruth D.E. Fritsch-Stork⁷, Irene E.M. Bultink⁸ and Sylvia S.M. Kamphuis⁹, ¹Pediatric Rheumatology, Sophia Children's Hospital – Erasmus University Medical Centre, Rotterdam, Netherlands, ²Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴Internal Medicine and Rheumatology, Martini Hospital, Groningen, Netherlands, ⁵Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, ⁶Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ⁷Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁹Pediatric Rheumatology, Sophia Children's Hospital – Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Childhood-onset SLE (cSLE) is a severe lifelong multisystem autoimmune disease. Long-term outcome data are limited. Here, we report for the first time on the…
Abstract Number: 395 • 2018 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus (SLE) with Inflammatory Myositis
Nicole Bitencourt, Elizabeth (Blair) Solow and Bonnie L. Bermas, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: The goal of this study was to identify specific clinical features of patients with SLE who have inflammatory myositis. Methods: A retrospective chart review…
Abstract Number: 916 • 2018 ACR/ARHP Annual Meeting
Integrative Analysis of Multi-Omics Data in an Ethnically Diverse Lupus Cohort Identifies Distinct Molecular Subtypes of SLE
Cristina Lanata¹, Ishan Paranjpe², Joanne Nitiham³, Kimberly Taylor⁴, Brooke Rhead⁵, Milena Gianfrancesco⁶, Lisa Barcellos⁷, Louise Murphy⁸, Patricia Katz⁹, Laura Trupin⁶, Jinoos Yazdany², Maria Dall'Era², Marina Sirota¹⁰ and Lindsey A. Criswell⁹, ¹Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁵University of California, Berkeley, Berkeley, CA, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷School of Public Health, UC Berkeley, Berkeley, CA, ⁸Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ⁹University of California San Francisco, San Francisco, CA, ¹⁰Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease with heterogeneous disease manifestations and outcomes. We aimed to define how molecular differences underlie this…
Abstract Number: 1672 • 2018 ACR/ARHP Annual Meeting
Poor Sleep Quality Predicts Worsening SLE Disease Activity
Philip Chu¹, Alicia M. Hinze², Noor Al-Hammadi³, Lacey Feigl⁴, Nancy Mathis⁴, Deepali Sen⁵, Seth Eisen⁴, Yo-El Ju⁶ and Alfred Kim⁷, ¹Internal Medicine, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, ⁴Rheumatology, Washington University School of Medicine, Saint Louis, MO, ⁵Rheumatology, Washington University School of Medicine, St. Louis, MO, ⁶Neurology, Washington University School of Medicine, Saint Louis, MO, ⁷Medicine/Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Poor sleep quality is commonly observed in patients with SLE. We hypothesize that poor sleep contributes to worsening SLE. The aims of this study…
Abstract Number: 2107 • 2018 ACR/ARHP Annual Meeting
Lupus-Prone SLE1.2.3. Mice Exhibit Loss of Thymus-Derived CD4+CD25+Helios+ Tregs
Nick Huang¹, Zhi-Wei Lai¹, Gourav Choudhary², Thomas Winans³, Ryan Kelly⁴, Katalin Banki⁵, Laurence Morel⁶ and Andras Perl¹, ¹Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, ³SUNY Upstate Medical University, Syracuse, NY, ⁴SUNY, Syracuse, NY, ⁵Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, ⁶Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is characterized by the production of autoantibodies against nuclear antigens (ANA) and phospholipids…
Abstract Number: 2671 • 2018 ACR/ARHP Annual Meeting
Development and First-in-Human Characterization of an ICOSL and BAFF Bispecific Inhibitor AMG 570 for SLE Treatment
Laurence E Cheng¹, Hailing Hsu², Martin Kankam³, Nicholas Siebers⁴, Randall Stoltz⁵, Lubna Abuqayyas², Bella Ertik⁶, Barbara Sullivan², Lei Zhou² and Jane R Parnes², ¹Amgen Inc., South San Francisco, CA, ²Amgen Inc., Thousand Oaks, CA, ³Vince and Associates Clinical Research, Inc.,, Overland Park, KS, ⁴Covance, Madison, WI, ⁵Covance, Evansville, IN, ⁶Amgen Inc, Boston, MA
Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), are associated with dysregulated T cell and B cell responses. AMG 570 is a bispecific molecule targeting…
Abstract Number: 9L • 2017 ACR/ARHP Annual Meeting
Circulating Type I, II and III Interferons (IFNs) Associate with IFN-Scores, but Define Distinct Subsets of Active SLE
Vilija Oke¹, Iva Gunnarsson¹, Jessica M. Dorschner², Agneta Zickert¹, Timothy B. Niewold³ and Elisabet Svenungsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Colton Center for Autoimmunity, New York University, New York, NY

Background/Purpose: Serum induced IFN gene expression (IFN-score) is considered a golden standard to assess IFN activity in SLE. So far, IFN-scores have not been compared…
Abstract Number: 331 • 2017 ACR/ARHP Annual Meeting
Case Series: Comparison of Repository Corticotropin Injection (H.P. Acthar Gel) Versus Glucocorticoids on Bone Density in SLE Patients
Anny T. Wu¹ and Joshua June², ¹Rheumatology, Franciscan Alliance, Munster, IN, ²3394 E Jolly Rd Ste C, Great Lakes Center of Rheumatology, Lansing, MI
Background/Purpose: Repository Corticotropin Injection (RCI) is an adrenocorticotropin hormone in 16% gelatin with a prolonged release after intramuscular (IM) or subcutaneous injection. Adverse effects of…
Abstract Number: 1269 • 2017 ACR/ARHP Annual Meeting
Investigating Time Trends in Incident Pediatric Lupus across Ethnic Groups in Toronto, Canada—a Large, Multiethnic Metropolitan Area
Laura Y Feldman¹, Patrick Brown², Linda T Hiraki^1,3 and Earl Silverman³, ¹Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ²Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Lupus incidence rates are known to differ by ethnicity among children and adults, with African ancestry as a risk factor for incident lupus, compared…

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