ACR Meeting Abstracts

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Abstracts tagged "skin"

  • Abstract Number: 1537 • ACR Convergence 2022

    Proteomic Profiling of Plasma Microvesicles Isolated from Patients with Systemic Sclerosis

    Line Iversen1, Ole Østergaard2, Tina Friis3, susanne Ullman4, Søren Jacobsen5 and Jesper Olsen2, 1Department of Dermatology, Odense University Hospital., Odense, Denmark, 2Novo Nordisk Foundation Center for Protein Research, Copenhagen University, Copenhagen, Denmark, 3Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, 4Department of Dermatology, Bispebjerg, Copenhagen University Hospitals, Copenhagen, Denmark, 5Department of Rheumatology, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark

    Background/Purpose: In the current work, we used a mass spectrometry based proteomics workflow to analyze isolated plasma microvesicles from systemic sclerosis (SSc) patients and from…
  • Abstract Number: 0556 • ACR Convergence 2022

    Immune Checkpoint VISTA Regulates Type I Interferon (IFN-I) Production and Controls UV Light Triggered Skin IFN-I Response

    Zachary Peters1, Lindsay Mendyka1, Sicong Shan1, Angelique Cortez1, William Rigby2, Christopher Burns1, Randolph Noelle3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Hitchcock Medical Center, Lebanon, PA, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Most lupus patients chronically exhibit higher IFN-I scores in the skin, peripheral blood, and kidneys that is exacerbated by ultraviolet (UV) light. In normal…
  • Abstract Number: 1559 • ACR Convergence 2022

    Long Term Clinical Effects of Apremilast on Behcet’s Disease and Changes in Serum Cytokines

    Yusuke Ushio1, Risa Wakiya2, Kiyo Ueeda3, Tomohiro Kameda2, shusaku nakashima4, Hiromi Shimada2, Mikiya Kato2, taichi miyagi5, Rina Mino6, Kanako Chujo7 and Hiroaki Dobashi8, 1Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, 2Kagawa University, Kagawa, Japan, 3Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 4Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 5Kagawa University, Kidagun, Japan, 6Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Miki-cho, Kita-gun, Japan, 7Kagawa University, Miki, Kita District, Kagawa, Japan, 8Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Kagawa, Japan

    Background/Purpose: Apremilast, the small-molecule phosphodiesterase -4 inhibitor, was approved for the treatment of recurrent oral ulcers associated with Behcet's disease (BD) in Japan from September…
  • Abstract Number: 0567 • ACR Convergence 2022

    Gain-of-Function Mutations in Lyn Kinase Cause a Novel Autoinflammatory Disease with Small Vessel Vasculitis and Liver Fibrosis

    Adriana Almeida de Jesus1, Guibin Chen2, Dan Yang2, Tomas Brdicka3, Natasha Ruth4, David Bennin5, Dita Cebecauerova6, Hana Malcova7, Helen Freeman8, Neil Martin9, Karel Svojgr6, Murray Passo4, Farzana Bhuyan10, Sara Alehashemi11, Andre Rastegar12, Kat Uss12, Lela Kardova12, Iris Duric3, Ebun Omoyinmi13, Petra Peldova6, Chyi-Chia Richard Lee14, David Kleiner14, Colleen Hadigan15, Stephen Hewitt14, Stefania Pittaluga14, Carmelo Carmona-Rivera16, Katherine R. Calvo15, Nirali Shah14, Miroslava Balascakova6, Danielle Fink17, Radana Kotalova6, Zuzana Parackova6, Lucie Peterkova6, Daniela Kuzilkova6, Vit Campr6, Lucie Sramkova6, Stephen Brooks16, Eric Meffre18, Rebecca Harper2, Hyesun Kuehn15, Mariana Kaplan16, Paul Brogan19, Sergio Rosenzweig15, Zuoming Deng16, Anna Huttenlocher5, Susan Moir12, Douglas Kuhns17, Manfred Boehm2, Karolina Skvarova Kramarzova20 and Raphaela Goldbach-Mansky21, 1NIAID, NIH, Silver Spring, MD, 2National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 3Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Academy of Sciences of Czech Republic (ASCR), Prague, Czech Republic, 4Medical University of South Carolina, Charleston, SC, 5Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 6Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic, 7Second Faculty of Medicine, Charles University/University Hospital Motol, Praha, Czech Republic, 8Raigmore Hospital, Inverness, Scotland, United Kingdom, 9Royal Hospital for Children, Glasgow, Scotland, United Kingdom, 10National Institutes of Health, Bethesda, MD, 11NIH/NIAID/TADS, Clarksville, MD, 12National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 13Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 14National Cancer Institute, National Institutes of Health, Bethesda, MD, 15Clinical Center, National Institutes of Health, Bethesda, MD, 16National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 17National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, 18Yale University, New Haven, CT, 19UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 20Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, 21NIH/NIAID, Potomac, MD

    Background/Purpose: Lyn kinase is a member of the Src family of tyrosine kinases that regulates innate and adaptive immune responses. Lyn C-terminal tail tyrosine residue,…
  • Abstract Number: 1577 • ACR Convergence 2022

    Impact of Cutaneous Vasculitis on Health-Related Quality-of-Life

    Sarah Mann1, Aamir Hussain2, Anisha Dua3, Angelina Patrone4, Kalen Larson5, Peter Merkel6 and Robert Micheletti7, 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology, Georgetown University, Washington, DC, 3Northwestern University, Chicago, IL, 4Patient Partner, Philadelphia, PA, 5Vasculitis Foundation, Kansas City, MO, 6University of Pennsylvania, Philadelphia, PA, 7Departments of Dermatology and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Cutaneous manifestations of vasculitis can cause pruritus, pain, and ulceration, and their psychosocial impacts may be significant. However, the quality-of-life (QoL) impact of skin…
  • Abstract Number: 0654 • ACR Convergence 2022

    Lymphatic Dysfunction and Immune Activation in Lupus

    william ambler1, Madhavi Somaraju1, JiHyun Sim1, Ethan Seltzer1, Noa Schwartz2, Ecem Sevim3, Doruk Erkan1, Jinyeon Shin4, Rahgu Kataru4, Babak Mehrara5 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Albert Einstein College of Medicine, New York, NY, 3Montefiore Medical Center - Wakefield Campus, New York, NY, 4Memorial Sloan Kettering, New York, NY, 5Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY

    Background/Purpose: Systemic lupus erythematosus is a prototypic autoimmune disease in which patients frequently have photosensitivity. Exposure to ultraviolet radiation (UVR) causes the eruption of cutaneous…
  • Abstract Number: 1657 • ACR Convergence 2022

    Extreme Phenotype Approach Identifies Rare Variants in Systemic Sclerosis and Dermatomyositis Patients with Severe Calcinosis

    Srijana Davuluri1, Urvashi Kaundal2, Christian Lood3, Puneet Kapoor1, Yumeko Kawano4, Stefania Dell'Orso5, Zuoming Deng6, Zsuzsanna McMahan7, Ami Shah7, Laura Hummers8, Daniel Kastner9, Fredrick Wigley10, David Fiorentino11, Pravitt Gourh12 and Lorinda Chung11, 1Stanford University School of Medicine, Palo Alto, CA, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 3Division of Rheumatology, University of Washington, Seattle, WA, 4Brigham and Women's Hospital, Boston, MA, 5NIH, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Johns Hopkins Rheumatology, Baltimore, MD, 8Johns Hopkins Univerisity, Baltimore, MD, 9National Human Genome Research Institute, Bethesda, MD, 10Johns Hopkins University, Baltimore, MD, 11Stanford University, Stanford, CA, 12National Institutes of Health, Bethesda, MD

    Background/Purpose: Calcinosis, deposition of insoluble calcium salts in skin and subcutaneous tissues, affects up to 40% of systemic sclerosis (SSc) patients, and up to 20%…
  • Abstract Number: 0667 • ACR Convergence 2022

    Correlation Matrices Visualize Differential Degree of Cell and Pathway Heterogeneity in Skin of Cutaneous Lupus Erythematosus Treatment Subgroups

    Felix Chin1, Thomas Vazquez2, Josh Dan3, DeAnna Diaz4, Grant Sprow5, Jay Patel6, Nilesh Kodali7, Rui Feng8 and Victoria Werth9, 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2FIU Wertheim College of Medicine, Virginia Beach, VA, 3Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 4Philadelphia College of Medicine, Philadelphia, PA, 5Albert Einstein College of Medicine, Philadelphia, PA, 6Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PN, 7New Jersey Medical School, Coppell, TX, 8University of Pennsylvania, Philadelphia, 9University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Background/Purpose: First-line treatment for cutaneous lupus erythematosus involves the use of antimalarials. Treatment response is highly variable with some patients responding well to hydroxychloroquine (HCQ),…
  • Abstract Number: 1662 • ACR Convergence 2022

    Nationwide Distribution of Other Connective Tissue Disease (OCTD) and Systemic Sclerosis (SSc) in Areas of Environmental Concern

    Noelle Kosarek1, Megan Romano2, Robert Simms3, Angeline Andrew4, Erika Moen4, Patricia pioli4 and Michael Whitfield5, 1Dartmouth Geisel School of Medicine, Lebanon, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Lebanon, NH, 5Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and internal organs, vascular abnormalities, and autoantibody formation. The etiology…
  • Abstract Number: 0752 • ACR Convergence 2022

    A Phase I Clinical Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Immunogenicity of Ebdarokimab in Patients with Moderate to Severe Plaque Psoriasis

    Rui Chen1, Yu Xia2, Baiyong Li2, Xiang Ni2, Guoqin Wang2, Cui Zhang2, Benchao Chen2, Li Wang2 and Hongzhong Jin3, 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Akeso Biopharma, Inc., Zhongshan, China, 3Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Disease, Beijing, China

    Background/Purpose: Interleukin-12 (IL-12) and interleukin-23 (IL-23) are two essential cytokins involved in the immune-mediated inflammatory disorders of psoriasis. Anti-IL-12/IL-23 therapy has been developed for the…
  • Abstract Number: 1694 • ACR Convergence 2022

    Skin Exposure to UV Light Triggers Podocyte and Distal Tubular Injury, in the Presence of CD177+ Neutrophil Cell Cluster

    Angelique Cortez1, Lindsay Mendyka1, Fred Kolling2 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Sensitivity to ultraviolet (UV) light affects ~ 80% of systemic lupus erythematosus (SLE) patients. UV light exposure of lupus skin leads to local and…
  • Abstract Number: 1759 • ACR Convergence 2021

    An Analysis of Medication Responsiveness Based on Subtype and Race Within a Cohort of Cutaneous Lupus Erythematosus Patients

    Emily Keyes1, Anisha Jobanputra2, Madison Grinnell3, Rui Feng4, Thomas Vazquez5, DeAnna Diaz6 and Victoria Werth7, 1Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, 2Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, OMAHA, NE, 4University of Pennsylvania Department of Biostatistics, Philadelphia, PA, 5FIU Wertheim College of Medicine, Virginia Beach, VA, 6Philadelphia College of Medicine, Philadelphia, PA, 7Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Cutaneous lupus erythematosus (CLE) can present in association with or without concomitant SLE, and with skin manifestations varying by subtype – acute CLE, subacute…
  • Abstract Number: 1784 • ACR Convergence 2021

    Characterizing Musculoskeletal Disease Burden in Mild to Moderate Psoriasis Patients Suggestive of Comorbid PsA: Analysis of CorEvitas’ Psoriasis Registry

    Alexis Ogdie-Beatty1, Bruce Strober2, Mark Lebwohl3, Angel Cronin4, Tin-chi Lin4, Hyung-Joo Kang4, Nicole Middaugh4, Jacqueline O’Brien4, Shauna Jardon5, Sven Richter6, Yuri Klyachkin7 and Philip Mease8, 1University of Pennsylvania, Philadelphia, PA, 2Yale University, New Haven, CT, 3Icahn School of Medicine at Mount Sinai, New York, NY, 4CorEvitas, LLC, Waltham, MA, 5Amgen Inc., Gilbert, AZ, 6Amgen Inc., Thousand Oaks, CA, 7Amgen Inc., Lexington, KY, 8Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA

    Background/Purpose: Patients (pts) with mild to moderate psoriasis (PsO) and musculoskeletal disease burden may be diagnosed with PsA upon referral to a rheumatologist. Early intervention…
  • Abstract Number: 1857 • ACR Convergence 2021

    Ultra-High Frequency Ultrasound Compared to Durometry and Skin Score for Cutaneous Assessment in Systemic Sclerosis

    Marco Di Battista1, Saverio Vitali2, Simone Barsotti3, Alessandra Della Rossa4, Valentina Dini5, Marco Romanelli5 and Marta Mosca3, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Radiology Unit - University of Pisa, Pisa, Italy, 3Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 4Rheumatology Unit - University of Pisa, Pisa, Italy, 5Dermatology Unit - University of Pisa, Pisa, Italy

    Background/Purpose: To assess skin involvement in a cohort of patients with systemic sclerosis (SSc) comparing results obtained from modified Rodnan skin score (mRSS), durometry and…
  • Abstract Number: 0046 • ACR Convergence 2021

    Psoriatic Arthritis Skin Is Transcriptionally Different to Psoriasis Skin and Enriched in Immunoglobulin Transcripts

    Hanna Johnsson1, John Cole1, Stefan Siebert1, Iain McInnes2 and Gerard Graham1, 1University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, School of Medicine, Glasgow, Scotland, United Kingdom

    Background/Purpose: Up to 30% of patients with psoriasis develop psoriatic arthritis (PsA). The traditional assumption is that the skin disease is the same in both…
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