ACR Meeting Abstracts

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Abstracts tagged "skin"

  • Abstract Number: L09 • ACR Convergence 2020

    A Phase 2a Randomized, Double-blind, Placebo-controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis (NOVESA)

    Dinesh Khanna1, Christopher Denton2, Daniel Furst3, Maureen Mayes4, Marco Matucci-Cerinic5, Vanessa Smith6, Dick de Vries7, Liesbeth Deberdt8, Pieter‑Jan Stiers8, Niyati Prasad8 and Sohail Ahmed9, 1University of Michigan, Ann Arbor, MI, 2Royal Free Hospital, University College London, London, United Kingdom, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, 4University of Texas Health Science Center at Houston, Houston, TX, 5Università degli Studi di Firenze, Firenze, Italy, 6Ghent University Hospital, Ghent, Belgium, 7Galapagos BV, Leiden, Netherlands, 8Galapagos NV, Mechelen, Belgium, 9Ahmed Science Medicine, Basel, Switzerland

    Background/Purpose: There is a high unmet need for systemic sclerosis (SSc) treatments. Ziritaxestat (ziri; GLPG1690) is an autotaxin inhibitor with a novel mechanism of action.…
  • Abstract Number: L10 • ACR Convergence 2020

    Targeting Plasmacytoid Dendritic Cells Improves Cutaneous Lupus Erythematosus Skin Lesions and Reduces Type I Interferon Levels: Results of a Phase 1 Study of VIB7734

    Victoria Werth1, Jodi Karnell2, William Rees2, Nanette Mittereder3, Li Yan2, Yanping Wu3, Jorn Drappa2, Gabor Illei2 and John Ratchford2, 1University of Pennsylvania, Philadelphia, PA, 2Viela Bio, Gaithersburg, MD, 3Viela Bio, Gaithersburg

    Background/Purpose: Plasmacytoid dendritic cells (pDCs) secrete large amounts of type I interferon (IFN) and other cytokines upon activation. pDCs migrate to sites of active disease…
  • Abstract Number: 0946 • ACR Convergence 2020

    ENPP1 Regulates UV Light Triggered Type I Interferon Response in the Skin

    Sladjana Skopelja-Gardner1, Joyce Tai2, Xizhang Sun2 and Keith Elkon2, 1University of Washington, Seattle, WA, 2University of Washington, Seattle

    Background/Purpose: Systemic lupus erythematosus (SLE) patients have a prominent type I interferon (IFN-I) signature in both the lesional and non-lesional skin. We recently showed that…
  • Abstract Number: 0956 • ACR Convergence 2020

    An IL-18-Containing Five-Gene Signature Distinguishes Histologically Identical Dermatomyositis and Lupus Erythematosus Skin Lesions

    Alex Tsoi1, Mehrnaz Gharaee-Kermani2, Celine Berthier1, Tori Nault3, Grace Hile2, Shannon Estadt4, Matthew Patrick1, Rachael Wasikowski1, Allison Billi1, Lori Lowe1, Tamra Reed1, Johann Gudjonsson5 and J. Michelle Kahlenberg6, 1University of Michigan, Ann Arbor, 2University of Michigan, Ann Arbor, MI, 3University of Michigan, Canton, MI, 4University of Michigan, Ypsilanti, MI, 5University of Michigan, Ann ArborUniversity of Michigan, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Skin lesions in dermatomyositis (DM) patients are common, frequently refractory, and have prognostic significance.  Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE)…
  • Abstract Number: 1172 • ACR Convergence 2020

    Cardiovascular involvement as a clue for diagnosis of Juvenile Systemic Sclerosis sine scleroderma

    Gloria Lanzoni1, Giorgia Martini1, Alessandra Meneghel1, Fabio Vittadello2, Biagio Castaldi1, Elisabetta Zanatta3 and Francesco Zulian1, 1Department of Woman's and Child's Health, University of Padova, Padua, Italy, 2Centro Studi Statistici Explora, Padua, Italy, 3Department of Medicine-DIMED, University of Padova, Padua, Italy

    Background/Purpose: Juvenile Systemic Sclerosis (JSSc) is a rare condition in childhood and its variety with no skin involvement, systemic sclerosis sine scleroderma (JSSSS) is anecdotal…
  • Abstract Number: 1373 • ACR Convergence 2020

    IL-23 Skin and Joint Profiling in Psoriatic Arthritis: Novel Perspectives in Understanding Clinical Responses to IL-23 Inhibitors

    Alessandra Nerviani1, Marie-Astrid Boutet1, Wang Sin Gina Tan1, Katriona Goldmann1, Nirupam Purkayastha1, Tamas Lajtos1, Rebecca Hands1, Myles Lewis1, Stephen Kelly2 and Costantino Pitzalis3, 1Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 2Mile End Hospital, Barts Health NHS Trust, London, United Kingdom, 3Queen Mary University of London, London, United Kingdom

    Background/Purpose: PsA is a chronic heterogeneous inflammatory condition affecting up to 30% of patients with skin and/or nail psoriasis and the IL-23/IL-17 axis is believed…
  • Abstract Number: 1397 • ACR Convergence 2020

    Clinical and Demographic Features of Morphea Patients with Mucocutaneous Involvement: A Cross Sectional Study from the Morphea of Adults and Children Cohort

    Smriti Prasad1, Samantha Black2, Shivani Sharma3 and Heidi Jacobe1, 1University of Texas Southwestern Medical Center, Dallas, TX, 2The University of Texas Southwestern Medical Center, Dallas, TX, 3University of Texas Southwestern, Dallas, TX

    Background/Purpose: Morphea is an autoimmune skin condition that produces skin and soft tissue sclerosis. While clinical manifestations of morphea have been well-described, mucocutaneous findings such…
  • Abstract Number: 1610 • ACR Convergence 2020

    Cutaneous Side Effects of Hydroxychloroquine in Rheumatic Diseases –Combination of “Traditional” Multivariate Analysis for Risk Factors AndClassification Model Development Using Supervised Machine Learning –Single Centre Retrospective Cohort Study in India

    Sandeep Surendran1, Mithun CB1, Arun Tiwari2, Vishal Marwaha1 and Sekhar Easwar1, 1Amrita Institute of Medical Sciences, Kochi, Kerala, India., Kochi, Kerala, India, 2Amrita Institute of Medical Sciences, Kochi, Kerala, India., Kochi, India

    Background/Purpose: Hydroxychloroquine (HCQ) is associated with varied cutaneous side effects but only few studies in literature characterizing the risk factors for this. Recently machine learning…
  • Abstract Number: 0076 • ACR Convergence 2020

    The Role of Interferon Kappa in Psoriasis

    Mehrnaz Gharaee-Kermani1, Shannon Estadt2, Sonya Wolf-Fortune1, Jianhua Liu1, Tamra Reed3, Johann Gudjonsson4 and J. Michelle Kahlenberg5, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Ypsilanti, MI, 3University of Michigan, Ann Arbor, 4University of Michigan, Ann ArborUniversity of Michigan, 5Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Psoriasis is a common, chronic inflammatory autoimmune skin diseases characterized by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of inflammatory cells. Early infiltration…
  • Abstract Number: 1631 • ACR Convergence 2020

    No Increased Risk of Liver Dysfunction from Tildrakizumab Treatment: Post Hoc Analyses of the Tildrakizumab Psoriasis Clinical Program

    Mark Lebwohl1, Darren West2, Alan Mendelsohn3, Stephen Rozzo3 and Giampiero Girolomoni4, 1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Spectrum Dermatology, Scottsdale, AZ, 3Sun Pharmaceutical Industries, Inc., Princeton, NJ, 4Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy

    Background/Purpose: Tildrakizumab (TIL) is a high‐affinity, humanized, immunoglobulin G1κ, anti–interleukin-23p19 monoclonal antibody approved for the treatment of moderate to severe plaque psoriasis. We evaluated adverse…
  • Abstract Number: 0263 • ACR Convergence 2020

    Factors Associated with Disease Activity Remission and Recurrence in Cutaneous Lupus Erythematosus

    Stephanie Florez-Pollack1, Syed Rizvi2, Benjamin Chong2 and Linda Hynan2, 1University of Pennsylvania, PHILADELPHIA, PA, 2University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Cutaneous lupus erythematosus (CLE) is a photosensitive skin disorder that can occur with systemic lupus erythematosus. As CLE often fluctuates in disease activity, little…
  • Abstract Number: 1802 • ACR Convergence 2020

    Vitamin D Level: Predictor of SLE Disease Activity in AA Cohort with CLE?

    Ileannette Robledo-Vega1, John Scheinuk2, Emmanuel Pardo2, Ansley Pratt2, Soham Mahato3, Andrew G. Chapple2 and Myriam Guevara4, 1Louisiana State University Health Sciences Center, New Orlenas, LA, 2Louisiana State University, New Orleans, LA, 3LSUHSC School of Public Health, New Orleans, LA, 4Lousiana State University Health Sciences Center, New Orleans, LA

    Background/Purpose: There are few predominant African American (AA) epidemiological studies in Cutaneous Lupus Erythematosus (CLE). The Gilliam classification divides CLE into lupus specific, acute cutaneous…
  • Abstract Number: 0283 • ACR Convergence 2020

    Genome-wide DNA Methylation Analysis in Lupus Keratinocytes Identifies Differential Methylation of Genes That Regulate Apoptosis

    Grace Hile1, Patrick Coit1, Chang Zeng1, Rachael Wasikowski2, Alex Tsoi2, Allison Billi2, Johann Gudjonsson3, Amr Sawalha4 and J. Michelle Kahlenberg5, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann ARbor, 3University of Michigan, Ann ArborUniversity of Michigan, 4University of Pittsburgh, Pittsburgh, 5Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus erythematous (CLE) is a disfiguring manifestation of systemic LE (SLE), and the pathogenesis remains unclear. However, epidermal regulation of skin inflammation and…
  • Abstract Number: 1906 • ACR Convergence 2020

    Hsp90 Inhibition Effectively Prevents Progression of Dermal Fibrosis and Induces Regression of Established Bleomycin-Induced Dermal Fibrosis

    Hana Storkanova1, Lenka Storkanova2, Sabina Oreska3, Maja Spiritovic4, Barbora Hermankova5, Radim Becvar1, Karel Pavelka6, Jiří Vencovský6, Jörg HW Distler7, Ladislav Šenolt6 and Michal Tomcik1, 1Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha 2, Czech Republic, 4Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic,, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Our previous study demonstrated that Heat shock protein 90 (Hsp90) is overexpressed in the skin of patients with systemic sclerosis (SSc), in cultured SSc…
  • Abstract Number: 0284 • ACR Convergence 2020

    Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-induced Lupus Model

    Gantsetseg Tumurkhuu1, Shuang Chen2, Erica Montano1, Malcolm Lane2, Michifumi Yamashita2, Janet Markman2, Luz Blanco3, Mariana Kaplan4, Kenichi Shimada2, Timothy Crother2, Mariko Ishimori2, Daniel J Wallace1, Caroline Jefferies5 and Moshe Arditi2, 1Cedars-Sinai Medical Center, Los Angeles, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centreville, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 5Cedars-Sinai Medical Center, West Hollywood, CA

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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