Abstracts tagged "skin fibrosis and systemic sclerosis"

Abstract Number: 3248 • 2016 ACR/ARHP Annual Meeting
Efficacy of Mycophenolate Mofetil and Oral Cyclophosphamide on Skin Thickness: Post-Hoc Analyses from the Scleroderma Lung Study I and II
Rajaie Namas^1,2, Donald P. Tashkin³, Holly Wilhalme⁴, Daniel E. Furst⁵, Chi-hong Tseng⁶, Michael Roth⁶, Suzanne Kafaja⁷, Elizabeth R. Volkmann⁴, Philip J. Clements⁶ and Dinesh Khanna⁸, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, ³David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ⁴University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵UCLA, Los Angeles, CA, ⁶Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁸University of Michigan, Ann Arbor, MI
Efficacy of mycophenolate mofetil and oral cyclophosphamide on skin thickness: post-hoc analyses from the Scleroderma Lung Study I and II. Background/Purpose: Assess the efficacy of…
Abstract Number: 803 • 2016 ACR/ARHP Annual Meeting
Multi-Organ RNA-Sequencing of Systemic Sclerosis (SSc) Patients Shows Reproducible Gene Expression Profiles Across Organ Systems
Bhaven K. Mehta¹, Michael E. Johnson¹, Kimberly A. Archambault¹, Tammara A. Wood², Antonia Valenzuela³, Amanda Crawford⁴, David Fiorentino⁵, Nielsen Fernandez-Becker⁶, Laren Becker⁶, Linda Nguyen⁶, Francesco Boin⁷, Paul Wolters⁸, Lorinda Chung⁹ and Michael Whitfield², ¹Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Dermatology, Stanford University, Redwood City, CA, ⁵Dermatology, Stanford University, Stanford, CA, ⁶Gastroenterology & Hepatology, Stanford University School of Medicine, Palo Alto, CA, ⁷Rheumatology, University California San Francisco, San Francisco, CA, ⁸Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁹Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: While a hallmark of systemic sclerosis (SSc) is skin fibrosis, internal organ involvement is the primary cause of mortality. Pulmonary Arterial Hypertension (PAH), Interstitial…
Abstract Number: 970 • 2016 ACR/ARHP Annual Meeting
The Serotonin Receptor 2 Inhibitor Terguride Has Beneficial Effects on Skin Fibrosis: Results from a Phase 2 Proof of Concept Study
Oliver Distler¹, Britta Maurer¹, Serena Vettori², Sandra Blumhardt³, Diana Frey⁴, Alfiya Distler⁵, Christian Beyer⁶ and Joerg HW Distler⁷, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ³rheumatology, USZ, zurich, Switzerland, ⁴USZ, Zurich, Switzerland, ⁵Dept Int Med 3, Univ Erlangen, Erlangen, Germany, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Circumstantial evidence from preclinical studies indicates a key role of serotonin (5-HT) signaling via the 5-HT-2B receptor in the development of fibrosis. Terguride is…
Abstract Number: 1850 • 2016 ACR/ARHP Annual Meeting
Optimization of a Murine Model to Recapitulate Dermal and Pulmonary Features of SSc
Tomoya Watanabe¹, Tetsuya Nishimoto², Jonathan Heywood³, Stanley Hoffman⁴, Logan Mlakar⁴ and Carol A. Feghali-Bostwick⁵, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. Traditionally, daily subcutaneous injections of BLM for 4-6…
Abstract Number: 1873 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of Modified Rodnan Skin Score in Systemic Sclerosis Using Group-Based Trajectory Modelling
Emmanuel Ledoult^1,2, Vincent Sobanski^1,3,4,5, Luc Mouthon^6,7,8, Hélène Béhal⁹, Christian Agard¹⁰, Jean-Christophe Lega¹¹, Patrick Jego¹², Yves-Michel Frances¹³, Gilles Kaplanski^14,15, Jean-Robert Harle¹⁶, Sabine Berthier¹⁷, Boris Bienvenu¹⁸, Olivier Fain¹⁹, Arsene Mekinian²⁰, Elisabeth Diot²¹, Robin Dhote²², Alain Le Quellec²³, Zahir Amoura^24,25, Noemie Le Gouellec²⁶, Jean-Emmanuel Kahn²⁷, Nadine Magy²⁸, Marie-Hélène Balquet²⁹, Grégory Pugnet³⁰, Thomas Papo³¹, Pierre Kieffer³², Viviane Queyrel³³, Jean-Baptiste Gaultier³⁴, Denis Wahl³⁵, Francois Maurier³⁶, Emmanuel Chatelus³⁷, Jean-Louis Pennaforte³⁸, Olivier Aumaître³⁹, Olivier Lidove⁴⁰, Cristina Belizna⁴¹, Carine Boulon⁴², Marie-Elise Truchetet⁴³, Jacques Pouchot⁴⁴, Eric Auxenfants⁴⁵, Anne-Laure Fauchais⁴⁶, Bernard Imbert⁴⁷, Eric Hachulla^1,48,49,50, David Launay^3,4,5,51 and the French Autoimmune and Autoinflammatory Rare Diseases Network (FAI2R), ¹CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, ²CHU Lille, Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique), F-59000 Lille, France, ³CHU Lille, Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique), F-59000 Lille, France, Lille, France, ⁴Inserm, U995, F-59000 Lille, France, Lille, France, ⁵Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France, Lille, France, ⁶Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ⁹Maison Régionale de la Recherche Clinique. CHU de Lille. F- 59000 Lille, France, Lille, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, University of Lyon, Lyon, France, ¹²CHU de Rennes - Internal Medicine, Rennes, France, ¹³Médecine gériatrique - Hôpital Nord - F-13000 Marseilles, Marseilles, France, ¹⁴Aix-Marseille Université - Internal Medicine hopital conception - F-13000 Marseilles, Marseille, France, ¹⁵INSERM U608, Marseille, France, ¹⁶Service de médecine interne et immunologie clinique / Hôpital de la Timone, Marseilles, France, ¹⁷Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ¹⁸Caen University Hospital, Caen, France, ¹⁹Service de médecine interne. Hôpital Saint-Antoine., Paris, France, ²⁰Internal Medicine, DHUi2B Saint Antoine Hospital, paris, France, ²¹Pôle médecine interne et gériatrique, pneumologie CHRU de Tours - Hôpital Bretonneau, Tours, France, ²²Service de médecine interne. Hôpital Avicenne, Paris, France, ²³Division of internal Medicine, Hôpital Saint-Eloi, Centre Hospitalier Universitaire de Montpellier, Montpellier, Montpellier, France, ²⁴Internal Medecine - Centre de Référence National pour les Lupus et et le Syndrome des Antiphospholipides, Internal Medecine - Centre de Référence National pour les Lupus et et le Syndrome des Antiphospholipides, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ²⁵Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ²⁶Internal Medicine, Lille, France, ²⁷Internal Medicine, Foch Hospital, Suresnes, France, ²⁸Médecine Interne. CHU Besancon, Besancon, France, ²⁹Médecine Interne - CH Lens, Lens, France, ³⁰Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, ³¹Bichat University Hospital - Internal Medicine, Paris, France, ³²Hopital Emile Muller - Medecine Interne, Mulhouse Cedex 1, France, ³³Service de médecine interne - CHU de Nice. Hopital de l'Archet., Nice, France, ³⁴Pole de Gériatrie et Médecine interne - CHU Saint-Etienne, Saint-Etienne, France, ³⁵CHU de Nancy - Service de médecine interne - Unité de Médecine vasculaire Institut lorrain du coeur et des vaisseaux Louis Mathieu, Nancy, France, ³⁶Centre de Compétences des Maladies Systémiques Rares - CHU Metz, metz, France, ³⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ³⁸Service de médecine interne Pôle Médecines CHU de Reims - Hôpital Robert Debré, Reims, France, ³⁹CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁴⁰Service de Médecine Interne-Rhumatologie Hôpital de la Croix St Simo, Paris, France, ⁴¹Angers University hospital - Internal Medicine, Angers, France, ⁴²Service de médecine interne et vasculaire - CHU Bordeaux, Bordeaux, France, ⁴³CHU de Bordeaux - Service de médecine interne, Bordeaux, France, ⁴⁴Internal Medicine Department, European Hospital Georges Pompidou, Paris, France, ⁴⁵CH Roubaix - Médecine interne, Roubaix, France, ⁴⁶Department of Internal Medicine, CHU de Limoges, Limoges, France, ⁴⁷CHU, Grenoble, Grenoble, France, ⁴⁸CHU Lille, Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique), F-59000, France, ⁴⁹Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France, ⁵⁰Inserm, U995, F-59000 Lille, France, ⁵¹CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France
Background/Purpose: The modified Rodnan skin score (mRSS) is a clinical evaluation score of the extent of cutaneous fibrosis in systemic sclerosis (SSc). mRSS has been…
Abstract Number: 1080 • 2015 ACR/ARHP Annual Meeting
Modified Rodnan Skin Score Thresholds for the Optimization of Cohort Enrichment in Clinical Trials in Skin Fibrosis in Patients with Diffuse Cutaneous Systemic Sclerosis
Rucsandra Dobrota¹, Britta Maurer¹, Nicole Graf², Suzana Jordan³, Carmen Marina Mihai⁴, Otylia Kowal-Bielecka⁵, Yannick Allanore⁶, Oliver Distler¹ and EUSTAR co-authors, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²graf biostatistics, Winterthur, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Internal Medicine and Rheumatology, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁵Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ⁶Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose: The modified Rodnan skin score (mRSS) is the major outcome measure for skin fibrosis in clinical trials (CT) in diffuse cutaneous scleroderma (dcSSc). Traditionally,…
Abstract Number: 1873 • 2015 ACR/ARHP Annual Meeting
Inter and Intrarater Reliability of the Modified Rodnan Skin Score in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰ and Dinesh Khanna¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Modified Rodnan Skin Score (MRSS) is a semiquantitative assessment of skin thickness which is a commonly used outcome measure in Systemic Sclerosis (SSc)…
Abstract Number: 1896 • 2015 ACR/ARHP Annual Meeting
Early Signs, Symptoms and Auto-Antibodies to Predict Diffuse Cutaneous or Limited Cutaneous Systemic Sclerosis at First Presentation
WMT van den Hombergh¹, HKA Knaapen-Hans¹, Patricia E. Carreira^2,3, FHJ van den Hoogen¹, Jaap Fransen¹ and MC Vonk¹, ¹Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³Rheumatology Unit, Hospital 12 de Octubre, Hospital 12 de Octubre, Madrid, Spain
ABSTRACT Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with a poorer prognosis compared to limited cutaneous SSc (lcSSc), due to earlier and more severe…
Abstract Number: 1905 • 2015 ACR/ARHP Annual Meeting
Stimulators of Soluble Guanylate Cyclase (sGC) Inhibit Experimental Skin Fibrosis of Different Aetiologies
Peter Sandner^1,2, Clara Dees³, Joerg H. W. Distler³, Christian Beyer³, Alfiya Distler³, Yun Zhang⁴, Katrin Palumbo-Zerr⁴, Georg A. Schett⁵, Alina Soare^3,6, Oliver Distler⁷ and Emanuel Haasbach⁸, ¹Bayer Health Care, Global Drug Discovery, Bayer Pharma AG, Wuppertal, Germany, ²Institute of Pharmacology, Hannover Medical School, Hannover, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology, Cantacuzino Hospital, Bucharest, Romania, ⁷Research of Systemic Autoimmune Diseases, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸Bayer HealthCare, Bayer Pharma AG, Wuppertal, Germany
Background/Purpose: Systemic sclerosis (SSc) is characterised by fibrosis and vascular alterations, both of which account for the high morbidity and mortality of SSc. Although several…
Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting
High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis
Khalil I. Bourji¹, Alain Meyer^2,3, Emmanuel Chatelus², Erika Pigatto¹, François Singh³, Bernard Geny³, Leonardo Punzi¹, Jacques-Eric Gottenberg², Franco Cozzi¹ and Jean Sibilia², ¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ³Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, France
Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
Abstract Number: 1698 • 2014 ACR/ARHP Annual Meeting
Peripheral Blood Eosinophil Counts Increase in Patients with Systemic Sclerosis and Associated with Its Disease Severity
Tamao Nakashita¹, Shinji Motojima², Katsutoshi Ando³ and Akira Dibatake⁴, ¹Department of Rheumatology and Allergy, Kameda Medical Center, Kamogawa City, Japan, ²[email protected], Kameda Medical Center, Kamogawa City, Japan, ³Depertment of Respiratoly Medicine, Juntendo university, tokyo, Japan, ⁴Rheumatology and Allergy, Kameda Medical Center, Kamogawa city, Japan
Background/Purpose : Increased levels of serum pro-fibrotic cytokines such as IL-4 and IL-13 and plasma CXCL4 have been previously reported in patients with systemic sclerosis…
Abstract Number: 751 • 2014 ACR/ARHP Annual Meeting
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis
Shervin Assassi¹, William Swindell², Minghua Wu¹, Filemon K. Tan¹, Dinesh Khanna³, Daniel E. Furst⁴, Donald Tashkin⁵, Richard Jahan-Tigh⁶, Maureen D Mayes¹, Johann Gudjonsson² and Jeffrey T. Chang⁶, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Dermatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴University of California at Los Angeles, Los Angeles, CA, ⁵Medicine, University of California at Los Angeles, Los Angeles, CA, ⁶University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: To examine the heterogeneity of global transcriptome patterns in systemic sclerosis (SSc) skin from a large cohort of patients and controls. Methods: Skin biopsies…
Abstract Number: 722 • 2014 ACR/ARHP Annual Meeting
Prediction of Improvement in Skin Fibrosis in Diffuse Cutaneous Systemic Sclerosis
Rucsandra Dobrota^1,2, Britta Maurer¹, Nicole Graf³, Carina Mihai², Otylia Kowal-Bielecka⁴, Yannick Allanore⁵ and Oliver Distler on behalf of the EUSTAR investigators and co-authors¹, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ³graf biostatistics, Winterthur, Switzerland, ⁴Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ⁵Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose Improvement of skin fibrosis over time is part of the “natural history” of patients with diffuse cutaneous systemic sclerosis (dcSSc). However, in the individual…

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