Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2550 • 2014 ACR/ARHP Annual Meeting
Impaired Speckle Tracking As a Marker of Subclinical Left Ventricular Dysfunction in Patients Affected By Primary Sjögren’s Syndrome
Fabiola Atzeni¹, Stefano Galaverna², Chiara Colombo², Luigi Gianturco², Laura Boccassini¹, Piercarlo Sarzi-Puttini¹ and Maurizio Turiel², ¹Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Cardiology Unit, IRCCS-Galeazzi Orthopedic Institute,, Milan, Italy
Background/Purpose Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease that particularly affects the salivary and lachrymal glands, and leads to dry eyes and…
Abstract Number: 534 • 2014 ACR/ARHP Annual Meeting
Serum Biomarkers of Inflammation and Fibrosis in Advancing Diagnosis, Prognosis and Treatment of Anti-Ro Associated Congenital Heart Block
Amit Saxena¹, Peter M. Izmirly², Sung Won Han³, Andrew Markham⁴, Robert M. Clancy⁵ and Jill P. Buyon⁵, ¹Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Department of Population Health, New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose Women with Sjogren’s Syndrome (SS) and anti-Ro antibodies face the risk of a pregnancy complicated by fetal congenital heart block (CHB). Identification of maternal…
Abstract Number: 2979 • 2014 ACR/ARHP Annual Meeting
Nucleic Acid Sensing Receptors TLR7, RIG-I and MDA5 Collaborate in Driving the Systemic IFN Signature and Amplify the Pathogenic Loop: Potential New Targets for Therapy in Primary Sjogrens Syndrome
Naomi I Maria¹, Cornelia G. van Helden-Meeuwsen¹, Eline C. Steenwijk¹, Arne S. IJpma², Wouter Beumer¹, Zana Brkic¹, Virgil A. Dalm¹, Paul L. van Daele¹, P. Martin van Hagen¹, Peter J. van der Spek², Hemmo A. Drexhage¹ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Erasmus Medical Center, Bioinformatics, Rotterdam, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by autoantibodies targeting RNA-associated antigens, anti-SSA/SSB. The IFN-signature is present in over half of…
Abstract Number: 2546 • 2014 ACR/ARHP Annual Meeting
Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome
Lakshmanan Suresh¹, Julian Ambrus², Long Shen³ and Sahana Vishwanath⁴, ¹60 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, ²100 High St., University Of Buffalo, Buffalo, NY, ³Department of Medicine, SUNY at Buffalo, Buffalo, NY, ⁴Medicine, SUNY- Buffalo, buffalo, NY
Background/Purpose Sjogren’s syndrome (SS) is a complex disorder involving both the innate and immune system. Fatigue is a common feature of the disease. Mitochondrial dysfunction…
Abstract Number: 533 • 2014 ACR/ARHP Annual Meeting
Predictive Significance of CCL21 and CXCL13 Levels in the Minor Salivary Glands of Patients with Sjögren’s Syndrome
Kyung-Eun Lee¹, Dong-Jin Park¹ and Shin-Seok Lee², ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose Chemokines, which control inflammatory cell migration, have been shown to play important roles in the inflammatory processes associated with Sjögren’s Syndrome (SS). CCL21 and…
Abstract Number: 2981 • 2014 ACR/ARHP Annual Meeting
Prognostic Value of the Complex P2X7 Receptor-Inflammasome in Patients with Primary Sjögren’s Syndrome at Lymphoma Risk
Chiara Baldini¹, Eleonora Santini², Chiara Rossi², Francesca Sernissi¹, Daniela Martini¹, Alessia Gallo³, Valentina Donati², Nicoletta Luciano¹, Francesco Ferro¹, Illias Alevizos⁴, Anna Solini² and Stefano Bombardieri⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Sjogren's Clinic, NIDCR, Bethesda, MD, ⁴NIDCR, Bethesda, MD, ⁵Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Pro-inflammatory P2X7-receptor has been recently implicated in the pathogenesis of primary Sjögren’s syndrome (pSS), suggesting that it may be involved in the initiation and…
Abstract Number: 2544 • 2014 ACR/ARHP Annual Meeting
How Does a Younger Age at the Onset of Sjögren’s Syndrome (pSS) Influence the Clinical Presentation and the Clinical Course of the Disease?
Chiara Baldini¹, Luca Quartuccio², Elena Bartoloni-Bocci³, Roberta Priori⁴, Francesco Carubbi⁵, Alessia Alunno³, Roberto Gerli³, Guido Valesini⁴, Salvatore De Vita² and Stefano Bombardieri⁶, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ³Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, ⁴Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ⁵Rheumatology Clinic, University of L'Aquila, L'Aquila, Italy, ⁶Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: (1) To analyze the clinical presentation and the clinical course of Sjögren’s Syndrome (pSS) in Caucasian patients with an “early-onset” pSS and (2) to compare…
Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting
Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs
Kathrine Skarstein^1,2, Lara Adnan Aqrawi³, Roland Jonsson^4,5 and Janicke Cecilie Liaaen Jensen⁶, ¹Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ²Department of Pathology, Haukeland University Hospital, Bergen, Norway, ³Department of Clinical Science, University of Bergen, Bergen, Norway, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁶Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
Abstract Number: 2775 • 2013 ACR/ARHP Annual Meeting
Adenosine A2b Receptor Agonist Bay60-6583 Restores Salivary Gland Function In a Mouse Model For Sjögren’s Syndrome
Barbara Szczerba¹, Paulina Rybakowska¹, Paromita Dey¹, Harini Bagavant¹ and Umesh Deshmukh², ¹Department of Medicine, University of Virginia, Charlottesville, VA, ²Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder mainly affecting the exocrine glands. However, it is now clear that both immune and non-immune…
Abstract Number: 506 • 2013 ACR/ARHP Annual Meeting
Hospitalization In Patients With Primary Sjögren’s Syndrome
Yemil Atisha-Fregoso¹, Yahaira Rivera² and Gabriela Hernandez-Molina², ¹Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, Mexico
Background/Purpose: There is scant information on the frequency, main causes and associated risk factors of hospitalization in patients with primary Sjögren syndrome (PSS).We aimed to…
Abstract Number: 2032 • 2013 ACR/ARHP Annual Meeting
How Does Age At Onset Influence Autoimmune Rheumatic Diseases?
Jenny Amaya-Amaya¹, Juan-Camilo Sarmiento-Monroy², Nicolás Molano-González¹, Mónica Rodríguez-Jiménez¹, Rubén-Darío Mantilla², Adriana Rojas-Villarraga¹ and Juan-Manuel Anaya², ¹Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ²School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia
Background/Purpose: Age at onset of disease (AOD) refers to the time period at which a patient experiences the first sign (s) and symptom(s). AOD varies…
Abstract Number: 507 • 2013 ACR/ARHP Annual Meeting
Level Of Agreement Of The AECG 2002 and ACR 2012 Classification Criteria For Sjögren’s Syndrome In The Brittany Cohort: Clues To Understand Discrepancies
Divi Cornec¹, Alain Saraux², Jacques-Olivier Pers³, Sandrine Jousse-Joulin⁴, Yves Renaudineau³, Beatrice Cochener⁵, Thierry Marhadour⁶ and Valerie Devauchelle-Pensec⁷, ¹Department of rheumatology, Brest Occidentale University, Brest, France, ²Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ³Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ⁴Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ⁵Department of ophtalmology, Brest Occidentale University, Brest, France, ⁶Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁷Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: New classification criteria for primary Sjögren’s syndrome (pSS) have been proposed in 2012 and approved by the ACR. They differ substantially from the currently…
Abstract Number: 1844 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis, Sjogren’s Syndrome and Systemic Lupus Erythematosus Patients Have a Distinct Spectrum Of Serum Anticytokine Autoantibodies
Sarthak Gupta^1,2, Ioanna P. Tatouli³, Lindsey B. Rosen², Sarfaraz A. Hasni¹, Richard M. Siegel¹, Steven M. Holland², Haralampos M. Moutsopopoulos³ and Sarah K. Browne², ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ³School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Anticytokine autoantibodies are pathogenic in many hematologic, pulmonary and infectious diseases. However, the prevalence and significance of anticytokine autoantibodies in rheumatic conditions is poorly…
Abstract Number: 508 • 2013 ACR/ARHP Annual Meeting
Is Ultrasonography Of Salivary Gland a Validate Tool In Sjögren Syndrome? Study 1: Interobserver Reliability Between International Group Of Experts
Sandrine Jousse-Joulin¹, Vera Milic², Elke Theander³, Malin V. Jonsson⁴, Wan-Fai Ng⁵, Chiara Baldini⁶, Marina Carotti⁷, Alan N. Baer⁸, Joel Fradin⁹, Pascale Rachele¹⁰, Hendrika Bootsma¹¹, Jacqueline Brown¹², Nicoletta Luciano⁶, S Bombardieri¹³, Roland Jonsson¹⁴, Salvatore De Vita¹⁵, Alojzija Hocevar¹⁶, Matija Tomsic^17,18, Alain Saraux¹⁹, Emmanuel Nowak²⁰, Alessandro Ciapetti Sr.²¹, Arjan Vissink²², John Rout²³, Thomas Mandl²⁴, Simon J. Bowman²⁵ and Valerie Devauchelle-Pensec²⁶, ¹Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ²rheumatology, belgrade university, belgrade, Serbia, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ⁵Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁶University of Pisa, Rheumatology Unit, Pisa, Italy, ⁷Rheumatology and radiology, Ospedali Riuniti, Ancona, Italy, ⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁰radiology, university of Pisa, Pisa, Italy, ¹¹Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ¹²dental division, Tower Wing Guy's hospital, london, United Kingdom, ¹³Department of Clinical and Experimental Medicine, Department of Rheumatology, University of Pisa, Pisa, Pisa, Italy, ¹⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹⁵Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ¹⁶Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹⁷Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia, ¹⁸Faculty of Medicine, Unversity Ljubljana, Ljubljana, Slovenia, ¹⁹Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France, ²⁰CIC, CHU Brest, Brest, France, ²¹Department of Rheumatology, Politechnic University of the Marche, Ancona, Ancona, Italy, ²²Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²³Birmingham Dental Hospital, Birmingham, United Kingdom, ²⁴Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden, ²⁵Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, ²⁶Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France
Background/Purpose: Ultrasonography (US) of salivary glands is a relatively new test to diagnose primary Sjögren syndrome (pSS)1-6. In 2012, an international group of interest was…
Abstract Number: 1656 • 2013 ACR/ARHP Annual Meeting
Interferon Type I and T Helper 17: A Dangerous Liaison In Primary Sjögren’s Syndrome?
Zana Brkic¹, Sandra M.J. Paulissen², Cornelia G. van Helden-Meeuwsen³, Naomi I. Maria³, Odilia B.J. Corneth⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Martin van Hagen³, Erik Lubberts⁶ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome…

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