Session Title: T-cell Biology in Autoimmune Diseases
Session Type: Abstract Submissions (ACR)
The T helper 17 (Th17) cell subset, which produces IL-17A, IL-17F, IL-22 and IL-21, has been implicated in the pathogenesis of primary Sjögren’s syndrome (pSS). The aim of this study was to elucidate a possible link between the Th17 system and another key-player in the pathogenesis of pSS ¯ Interferon (IFN) type I.
IFN type I signature was assessed by mRNA expression of IFN type I inducible genes. Th cell populations were analyzed by flow cytometry in peripheral blood of 12 pSS patients positive (IFN+) and 12 patients negative (IFN-) for the IFN type I signature and 12 healthy controls (HC). Cytokine expression by memory Th cells (CD4+CD45RO+) cells and memory CCR6+ Th cells (CD4+CD45RO+CCR6+) cells was assessed.
Th17 (defined as CD4+CD45RO+CCR6+CCR4+CXCR3-CCR10-) and Treg cell percentages were significantly increased in IFN+ patients compared with IFN- patients and HC. This was accompanied by a significant decrease in Th1 cells in IFN+ patients compared to HC. IL-22 and IL-21 production by memory Th cells and memory CCR6+ cells was higher in IFN+ patients. Interestingly, Th17 cell percentage was significantly correlated with presence of anti-SSA antibodies, hypergammagloblulinemia and elevated expression of monocyte B cell activating factor (BAFF) , all three previously found in IFN type I signature positive patients.
Here we show for the first time a relation between two key players of pSS pathogenesis − IFN type I and the Th17 pathway. This study brings new insights in the pathogenesis of pSS, having possible implications for future treatment.
S. M. J. Paulissen,
C. G. van Helden-Meeuwsen,
N. I. Maria,
O. B. J. Corneth,
J. P. van Hamburg,
P. L. Van Daele,
V. A. Dalm,
M. van Hagen,
M. A. Versnel,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/interferon-type-i-and-t-helper-17-a-dangerous-liaison-in-primary-sjogrens-syndrome/