ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 2688 • 2016 ACR/ARHP Annual Meeting

    Characteristics, Treatment and Outcome of Joint Involvement with Synovitis in Primary SjöGren’s Syndrome: French Multicentric Retrospective Case-Control Study

    Adrien Mirouse1, raphaèle seror2, Xavier Mariette3, Maxime Dougados4, Anne-Laure Fauchais5, Alban Deroux6, Nathalie Costedoat-Chalumeau7, Jeremie Sellam8, Jean-Benoit Arlet9, Christian Lavigne10, Dominique Fischer-Dumont11, Arsène Mékinian12 and Olivier Fain12, 1Service de médecine interne, Hôpital Saint-Antoine, Paris, France, 2INSERM U1184, Paris Sud University, Le Kremlin Bicetre, France, 3INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France, 4Paris Descartes University, Paris, France, 5Department of Internal Medicine, CHU de Limoges, Limoges, France, 6Internal Medicine, CHU Grenoble, Grenoble, France, 7Internal Medicine, Cochin University Hospital, Paris, France, 8Rheumatology, Saint-Antoine Hospital, Paris, France, 9Service de médecine interne, Hopital Européen Georges Pompidou, Paris, France, 10CHU Angers, department of Internal Medicine, Angers, France, 11Service de rhumatologie, Hôpital Avicenne, Bobigny, France, 12Service de médecine interne. Hôpital Saint-Antoine., Paris, France

    Background/Purpose: primary Sjogren’s syndrome (pSS) articular manifestations include often tender joints and more rarely synovitis. The main objective of this study was to describe characteristics,…
  • Abstract Number: 662 • 2016 ACR/ARHP Annual Meeting

    The Unusual Cross-Reactivity of Anti Muscarinic Receptor 3 Monclonal Antibodies Derived from Salivary Glands of Sjögren’s Syndrome Patients to Ro Peptides

    Syed M.S. Quadri1, Kristi A. Koelsch2, Biji T Kurien3, Valerie M Harris4 and R. Hal Scofield2, 1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjogrens syndrome (SS) is a chronic autoimmune inflammatory disease the characterisitic features of which includes hypofunction of exocrine glands leading to decrease in salivation…
  • Abstract Number: 2661 • 2016 ACR/ARHP Annual Meeting

    Performance of the Proposed ACR-EULAR Criteria for Sjogren’s Syndrome in a Prospective Multidisciplinary Diagnostic Cohort from Daily Clinical Practice

    Jolien F. van Nimwegen1, Martha S. van Ginkel1, Suzanne Arends1, Gwenny M. Verstappen1, Erlin A. Haacke1,2, Bert van der Vegt3, Nicole Sillevis Smitt-Kamminga4, Fred K.L. Spijkervet5, Frans G.M. Kroese1, Arjan Vissink6 and Hendrika Bootsma1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Opthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 6Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Sjögren’s syndrome (SS) is a systemic auto-immune disease with a heterogeneous clinical presentation. Recently, ACR-EULAR criteria were proposed for classification of SS, which combine…
  • Abstract Number: 2693 • 2016 ACR/ARHP Annual Meeting

    Evolution of Disease Activity over a 5-Year Period in the  395 Patients with Primary SjöGren’s Syndrome of the Assess Prospective Cohort

    Jacques-Eric Gottenberg1, Raphaele Seror2, Alain Saraux3, Valerie Devauchelle4, Emmanuelle Dernis Labous5, Philippe Dieudé6, Jean-Jacques Dubost7, Anne Laure Fauchais8, Vincent Goeb9, Claire Larroche10, Véronique Le-Guern11, Eric Hachulla12, Pierre Yves Hatron13, Jacques Morel14, Aleth Perdriger15, Stephanie Rist Bouillon16, Damien Sène17, Olivier Vittecoq18, Jean Sibilia19, Philippe Ravaud20 and Xavier Mariette21, 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, 3Rheumatology, Brest University Hospital, Brest, France, 4Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, 5Le Mans Hospital, Le Mans, France, 6Rheumatology, Hôpital Bichat, Paris, France, 7Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 8Rheumatology, Limoges, France, 9Rhumatologie, CHU Amiens, Amiens, France, 10Internal Medicine, Paris, France, 11service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 12Internal Medicine, Lille University Hospital, Lille, France, 13Internal Medicine, Lille, France, 14Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, 15C.H.R. Hôpital Sud, Rennes, France, 16Rhumatologie, Hopital La Source, La Source, France, 17Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, 18Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, 19Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 20Epidemiologist, PARIS, France, 21Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France

    Background/Purpose: Little is known about the natural history of primary Sjögren’s syndrome due to the limited number of prospective cohorts followed up in a yearly…
  • Abstract Number: 663 • 2016 ACR/ARHP Annual Meeting

    Cytokine and Chemokine Levels in Serum and Tears As Disease Activity Biomarkers in Patients with Primary Sjögren´s Syndrome

    Angel Alejandro Castillo-Ortiz1, Rosa Elda Barbosa-Cobos2, Lizbeth Becerril-Mendoza3, Gustavo Lugo-Zamudio4, Virgilio Lima-Gómez4, Adan Moreno-Eutimio5, Nayeli Nieto-Velázquez5 and Angel Tzec-Pérez5, 1Rheumatology, Hospital Juárez de México, Mérida, Mexico, 2Rheumatology, Hospital Juárez de México, Mexico, Mexico, 3Hospital Juárez de México, Mexico, Mexico, 4Hospital Juárez de México, México city, Mexico, 5Hospital Juárez de México, Mexico city, Mexico

    Background/Purpose: Evidence suggests that levels of different cytokines in primary Sjögren´s syndrome (pSS) are associated with cell infiltration degree within lacrimal and salivary glands and…
  • Abstract Number: 2662 • 2016 ACR/ARHP Annual Meeting

    Effect of Tobacco Smoking on the Clinical, Histopathological, and Serological Manifestations of SjöGren’s Syndrome

    Astrid Rasmussen1, Donald U. Stone2, Dustin Fife3, Michael Brown4, Keith Earley5, Lida Radfar6, C. Erick Kaufman7, David M. Lewis8, Nelson L. Rhodus9, Barbara M. Segal10, Daniel J Wallace11, Michael Weisman12, Swamy Venuturupalli13, Michael T. Brennan14, Christopher J Lessard3, Courtney G. Montgomery15, R. Hal Scofield15 and Kathy L. Sivils15, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 2King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Pfizer Inc., Groton, CT, 559th Medical Wing, US Air Force, San Antonio, TX, 6Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 8Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 9Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 10Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, 11Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 12Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 13Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, 14Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: To assess the prevalence of smoking in patients with Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca), and the association of smoking habits with…
  • Abstract Number: 2806 • 2016 ACR/ARHP Annual Meeting

    A Type-I Interferon Signature Is Associated with Autoantibody Profiles in Connective Tissue Diseases: Results from the Lupus Extended Autoimmune Phenotype (LEAP) Study

    John A. Reynolds1,2, Mumtaz Khan3, Tracy A. Briggs4, Gillian Rice5, Yanick Crow5, Ben Parker6 and Ian N. Bruce1,7, 1NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 3Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 4Institute of Human Development, University of Manchester, Manchester, United Kingdom, 5Manchester Academic Health Science Centre, Institute of Human Development, University of Manchester, Manchester, United Kingdom, 6Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 7Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

    Background/Purpose: Type I interferon has been implicated in the pathogenesis of systemic lupus erythematosus (SLE), but much less is known about its role in other…
  • Abstract Number: 665 • 2016 ACR/ARHP Annual Meeting

    Salivary Gland Secretome: A Novel Tool to Identify Biomarkers of Dryness and Immunopathology in Primary Sjogren’s Syndrome and Non-Autoimmune Sicca Patients

    Sofie L.M. Blokland1,2, Maarten R. Hillen1,2, Aike A. Kruize3, Timothy R.D.J. Radstake1,2 and Joel A.G. van Roon1,2, 1Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, 3Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Salivary gland biopsy is essential in primary Sjögren’s syndrome (pSS) diagnostics. However, tissue analysis using the traditional method has several limitations including inaccuracy of quantification of lymphocytic infiltration and poor correlation with dryness.…
  • Abstract Number: 2663 • 2016 ACR/ARHP Annual Meeting

    Antimalarials Protect Against Damage Accrual in Primary SjöGren’s Syndrome

    Gabriela Hernandez-Molina1, Valeria Valim2, Yemil Atisha-Fregoso3, Anastasia Secco4, Emmanuel Guerra5, Marianela Adrover5, Anna Julha Lage Santos6 and Antonio Catalan Pellet4, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 2Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 4Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 5Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 6Universidade Federal do Espírito Santo, Vitória, Brazil

    Background/Purpose: Antimalarials are frequently used in patients with primary Sjögren’s syndrome (SS). The aim of this study was to assess their impact on damage accrual…
  • Abstract Number: 2826 • 2016 ACR/ARHP Annual Meeting

    Clinical Utility of Circulating Anti-N-Methyl-D-Aspartate Receptor Subunits NR2A/B Antibody for the Diagnosis of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Sjogren’s Syndrome: An Updated Meta-Analysis

    Sen Hee Tay1, Anna-Marie Fairhurst2 and Anselm Mak1, 1Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, Singapore, 2Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

    Background/Purpose: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and…
  • Abstract Number: 11L • 2015 ACR/ARHP Annual Meeting

    Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome

    Simon Bowman1, Colin Everett2, Michele Bombardieri3, Robert Busch4, Paul Emery5, Frances Hall6, Colin T. Pease7, Costantino Pitzalis8, Elizabeth Price9, Luke Dawson10, Peter Smith11, Nurhan Sutcliffe3, Wan-Fai Ng12, Catherine Fernandez13, Sharon Ruddock13, Linda Sharples13, Catherine Reynolds13 and Sue Pavitt14, 1Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, 2Leeds Institute for Clinical Trials Research, University of Leeds, LEEDS, United Kingdom, 3Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 4Department of Life Sciences, University of Roehampton, London, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds Gen Infirmary, Leeds, United Kingdom, 6School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom, 7Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 8Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, 9Rheumatology Department, Great Western Hospital, Swindon, United Kingdom, 10School of Dental Sciences, University of Liverpool,, Liverpool, United Kingdom, 11School of Dental Sciences,, University of Liverpool, Liverpool, United Kingdom, 12NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 13Leeds Institute for Clinical Trials Research, University of Leeds, Leeds, United Kingdom, 14Division of Applied Health & Clinical Translation , School of Dentistry, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Evidence from open-label and observational studies support anti-B-cell therapy in patients with primary Sjogren’s Syndrome (PSS). The TRACTISS trial aimed to determine the extent…
  • Abstract Number: 627 • 2015 ACR/ARHP Annual Meeting

    Clinical Subsets and Presenting Features in Primary Sjögren’s Syndrome: Results from a Single Center Inception Cohort Study

    Chiara Baldini1, Francesco Ferro1, Nicoletta Luciano1, Rosaria Talarico1, Leonardo Lorenzini1, Daniela Martini1, Marta Mosca2 and Stefano Bombardieri1, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2University of Pisa, Pisa, Italy

    Background/Purpose: Aim of the study was to characterize the spectrum of presenting clinical features in a single-centre inception cohort of  patients  with primary Sjögren’s syndrome…
  • Abstract Number: 1051 • 2015 ACR/ARHP Annual Meeting

    Serum Calprotectin As Biomarker of Carotid Atherosclerosis in Patients with Primary Sjögren’s Syndrome

    Gabriela Moreira Balarini1, Eliana Zandonade2, leandro tanure3, gilda Aparecida ferreira3, Wildner Mardegan Sardenberg4, Érica Vieira Serrano4, Cléia Coelho Dias5, Túlio Pinho Navarro3, João Felipe Tonini4, Hilde H Nordal6, Piotr Mydel7, Johan Gorgas Brun8, Karl Albert Brokstad9, Eva Gerdts8, Roland Jonsson10,11 and Valeria Valim4,12, 1Department of Medical Clinic, Federal University of Espírito Santo (UFES), Brazil., cachoeiro de itapemirim, Brazil, 2Department of Statistic, Federal University of Espírito Santo (UFES), Brazil., vitória, Brazil, 3Department of Locomotor System, Federal University of Minas Gerais, Brazil., belo horizonte, Brazil, 4Department of Medical Clinic, Federal University of Espírito Santo (UFES), Brazil., vitória, Brazil, 5Department of Medical Clinic, Federal University of Espírito Santo (UFES), Brazil., vila velha, Brazil, 6Broegelmann Research Laboratory/University of Bergen, Norway, bergen, Norway, 7Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, 8Department of Clinical Science, University of Bergen, Norway, bergen, Norway, 9Department of Clinical Science, University of Bergen, Norway., bergen, Norway, 10Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 11Broegelmann research laboratory, Bergen, Norway, 12Rheumatology, Universidade Federal do Espírito Santo, Vitória, Brazil

    Background/Purpose: The relationship between atherosclerosis, traditional risk factors, disease activity and biomarkers is not well explored. We aimed to identify the association of carotid atherosclerosis…
  • Abstract Number: 2517 • 2015 ACR/ARHP Annual Meeting

    Primary Sjögren’s Syndrome and Pregnancy: Evolution of Thyroid Function, Xerostomia, Xerophthalmia and Salivary Test for Dental Caries Risk

    Elisa Trujillo1, Maria del Mar Trujillo2, Erica Padron3, Maria Garcia-Gonzalez4, Lorena Exposito5, Hiurma Sanchez5 and Sandra Garcia6, 1Hospital Universitario de Canarias, Servicio de Reumatologia, Tenerife, Spain, 2Servicio Canario de Salud., Servicio de Evaluación de tecnología Sanitaria, santa cruz de Tenerife, Spain, 3Hospital Universitario de Canarias, Servicio de Ginecología y Obstetricia., santa cruz de Tenerife, Spain, 4Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 5Hospital Universitario de Canarias, Servicio de Reumatologia, santa cruz de Tenerife, Spain, 6Bow lane dental Group, Dentist, London, England

    Background/Purpose: 1. To study the effect of pregnancy in PSS patients on oral and ocular dryness and the salivary test for dental caries activity. 2.…
  • Abstract Number: 3202 • 2015 ACR/ARHP Annual Meeting

    Functional Anti-Muscarinic Receptor-3 Monoclonal Antibodies Derived from Salivary Gland in Patients of Sjögren’s Syndrome

    Syed M.S. Quadri1,2, Kristi A. Koelsch3, Valerie Harris4, Biji T Kurien5 and R. Hal Scofield6, 1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren's syndrome (SS) is a chronic autoimmune inflammatory disease characterized by bilateral hypofunction of lacrimal and salivary glands leading to keratoconjuctivitis and xerostomia. The…
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