Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2664 • 2016 ACR/ARHP Annual Meeting
Evaluation of Thyroid Autoimmune Disease in Primary SjöGren’s Syndrome and Its Association with Disease Phenotype
Mario Giron-Pillado¹, Yemil Atisha-Fregoso¹, Ivette Cruz-Bautista¹, Miguel Astudillo-Angel¹ and Gabriela Hernandez-Molina², ¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico
Background/Purpose:
Abstract Number: 2875 • 2016 ACR/ARHP Annual Meeting
Depressed Serum IgM Levels in SLE Are Restricted to Defined Subgroups
Caroline Grönwall¹, Uta Hardt¹, Iva Gunnarsson², Gregg J. Silverman³ and Elisabet Svenungsson¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Natural IgM autoantibodies have been proposed to have protective properties, and decreased levels of IgM to phosphorylcholine (PC) in SLE are associated with higher…
Abstract Number: 669 • 2016 ACR/ARHP Annual Meeting
RNA-Sequencing Reveals Sjogren’s Syndrome Anti-Ro Negative Patients Share Similar Pathways to Multiple Sclerosis Patients
Indra Adrianto¹, John Ice¹, Astrid Rasmussen², Courtney Montgomery¹, R. Hal Scofield¹, Gabriel Pardo¹, Kathy Sivils¹, Robert Axtell¹ and Christopher Lessard¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by autoantibodies to Ro and/or La proteins and lymphocytic infiltration into exocrine glands. Multiple sclerosis (MS)…
Abstract Number: 2668 • 2016 ACR/ARHP Annual Meeting
Real Time Sonoelastography in Primary Sjögren’s Syndrome Correlates with Morphological Ultrasonographic Features and Glandular Activity but Not with Glandular Fibrosis
Gabriela Hernandez-Molina¹, Luis Azpeitia², Sergio Criales-Vera³, Carlos Pacheco⁴, Edgardo Reyes⁵, Guadualupe Lima⁴, Luis Llorente⁶ and Eric Kimura-Hayama³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, ²Radiology, Instituto Nacional de Cardiologia, Mexico City, Mexico, ³Radiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Salivary gland ultrasonography is a highly specific tool for the diagnosis of primary Sjögren´s syndrome (PSS). Real time sonoelastography (RTS) is a novel imaging…
Abstract Number: 3029 • 2016 ACR/ARHP Annual Meeting
Ultrasonography of Major Salivary Glands in Patients Suspected with Primary Sjögren’s Syndrome: Comparison with Salivary Gland Biopsy and Classification Criteria
Esther Mossel¹, Konstantina Delli², Jolien F. van Nimwegen³, Alja J. Stel³, Erlin A. Haacke⁴, Fred K.L. Spijkervet⁵, Frans G.M. Kroese³, Arjan Vissink², Hendrika Bootsma⁶ and Suzanne Arends³, ¹University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: Ultrasonography of major salivary glands (sUS) is applied in the diagnostic work-up of primary Sjögren's syndrome (pSS). This study aims to assess (i) the…
Abstract Number: 672 • 2016 ACR/ARHP Annual Meeting
Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)
Pilar Brito-Zerón^1,2, Soledad Retamozo³, Margit Zeher⁴, Astrid Rasmussen⁵, Raphaele Seror⁶, Elke Theander⁷, Xiaomei Li⁸, Chiara Baldini⁹, Jacques-Eric Gottenberg¹⁰, Debashish Danda¹¹, Luca Quartuccio¹², Roberta Priori^13,14, Gabriela Hernandez-Molina¹⁵, Aike A. Kruize¹⁶, Valeria Valim¹⁷, Marika Kvarnström¹⁸, Damien Sene¹⁹, Roberto Gerli²⁰, Sonja Praprotnik²¹, David A. Isenberg²², Roser Solans²³, Maureen Rischmueller²⁴, Seung-Ki Kwok²⁵, Gunnel Nordmark²⁶, Yasunori Suzuki²⁷, Roberto Giacomelli²⁸, Valerie Devauchelle²⁹, Michele Bombardieri³⁰, Benedikt Hofauer³¹, Hendrika Bootsma³², Johan G. Brun³³, Guadalupe Fraile³⁴, Steven E. Carsons³⁵, Tamer Gheita³⁶, Jacques Morel³⁷, Cristina F. Vollenweider³⁸, Fabiola Atzeni³⁹, Nihan Acar-Denizli⁴⁰, Ildike-Fanny Horvath⁴, Kathy Sivils⁵, Thomas Mandl⁴¹, Pulukool Sandhya¹¹, Salvatore De Vita⁴², Jorge Sánchez-Guerrero⁴³, Eefje van der Heijden¹⁶, Virginia Moça Trevisano⁴⁴, Marie Wahren-Herlenius¹⁸, Xavier Mariette⁶, Manuel Ramos-Casals^1,45,46 and EULAR-SS Task Force Big Data Consortium (ASSES, GEAS-SEMI, EULAR), ¹Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, ³Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, ⁴Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Debrecen, Hungary, ⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ⁶Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ⁷Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, ⁸Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, China, Hefei, Anhui, China, ⁹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ¹⁰Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France, Strasbourg, France, ¹¹Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ¹²Rheumatology Clinic, DSMB, University of Udine, Udine, Italy, Udine, Italy, ¹³Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ¹⁴Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ¹⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, ¹⁶Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Utrecht, Netherlands, ¹⁷Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, ¹⁸Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ¹⁹Service de Médecine Interne 2, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, 2, Paris, France, Paris, France, ²⁰Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Italy, Perugia, Italy, ²¹Department of Rheumatology, University Medical Centre Ljubljana, Slovenia, Ljubljana, Slovenia, ²²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ²³Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain, Barcelona, Spain, ²⁴Department of Rheumatology, School of Medicine, The University of Western Australia, Crawley, Australia, Crawley, Australia, ²⁵Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea, ²⁶Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ²⁷Division of Rheumatology, Kanazawa University Graduate School of Medicine, Ishikawa, Japan, Kanazawa, Japan, ²⁸Clinical Unit of Rheumatology, University of l'Aquila, School of Medicine, L'Aquila, Italy, L'Aquila, Italy, ²⁹Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ³⁰Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, UK, London, United Kingdom, ³¹Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, München, Germany, München, Germany, ³²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands, ³³Department of Clinical Science, University of Bergen. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, ³⁴Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, ³⁵Division of Rheumatology, Allergy and Immunology Winthrop-University Hospital, Stony Brook University School of Medicine, NY, USA, Mineola, NY, ³⁶Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ³⁷Department of Rheumatology, Teaching hospital and University of Montpellier, France, Montpellier, France, ³⁸Rheumatology, German Hospital, Buenos Aires, Argentina, Buenos Aires, Argentina, ³⁹IRCCS Galeazzi Orthopedic Institute, Milan, Italy, Milan, Italy, ⁴⁰Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Turkey, Istabul, Turkey, ⁴¹Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Rheumatology, Malmö, Sweden, Malmö, Sweden, ⁴²Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital "Santa Maria della Misericordia", Udine, Italy, Udine, Italy, ⁴³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico, ⁴⁴Federal University of São Paulo, Sao Paulo, Brazil, San Paulo, Brazil, ⁴⁵Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, ⁴⁶Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain
Background/Purpose: To analyse the influence of geolocation (North-to-South gradient) on the clinical presentation of primary Sjögren syndrome (SjS) at diagnosis. Methods: The Big Data Sjögren…
Abstract Number: 2670 • 2016 ACR/ARHP Annual Meeting
Work Disability in Newly Diagnosed Patients with Primary SjöGren’s Syndrome – a Population-Based Cohort Study
Thomas Mandl¹, Tanja Schjødt Jørgensen², Marie Skougaard Nielsen², Peter Olsson¹ and Lars Erik Kristensen³, ¹Dept of Rheumatology, Skane University Hospital Malmö, Lund University, Malmo, Sweden, ²The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ³The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
Background/Purpose: To study long-term work disability (WD) and possible predictors in newly diagnosed patients with primary Sjögren’s syndrome (pSS). Methods: 51 pSS patients…
Abstract Number: 3031 • 2016 ACR/ARHP Annual Meeting
Rethinking Primary Sjögren’s Syndrome: Stratification By Clinical Phenotypes to Improve Understanding of Disease Pathogenesis, Trial Design, Clinical Management and Prospective Health Gains?
Dennis Lendrem¹, Nadia Howard Tripp^2,3, Xavier Mariette⁴, Svein Joar A. Johnsen⁵, Jessica Tarn⁶, Katie Hackett⁶, Bridget Griffiths⁷, Sheryl Mitchell⁸, Alain Saraux⁹, Valerie Devauchelle¹⁰, Katrine Norheim¹¹, John D. Isaacs¹², Peter McMeekin^13,14, Simon Bowman¹⁵, Roald Omdal¹⁶, Jacques-Eric Gottenberg¹⁷ and Wan-Fai Ng¹⁸, ¹Newcastle upon Tyne, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ³Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom, ⁴Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁵Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁶Newcastle University, Newcastle-upon-Tyne, United Kingdom, ⁷Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, ⁸Freeman Hospital, Newcastle upon Tyne, United Kingdom, ⁹Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹⁰Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ¹¹Stavanger University Hospital, Stavanger, Norway, ¹²Newcastle University and the Freeman Hospital, Newcastle-upon-Tyne, United Kingdom, ¹³Institute of Health and Society, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ¹⁴Northumbria University, Newcastle-upon-Tyne, United Kingdom, ¹⁵Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ¹⁶University of Bergen, Bergen, Norway, ¹⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹⁸Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose: Primary SjšgrenÕs Syndrome (pSS) is a chronic autoimmune rheumatic disease causing a wide-range of symptoms including dryness, pain and fatigue. Individual patient experiences of…
Abstract Number: 674 • 2016 ACR/ARHP Annual Meeting
Targeting Glandular IL-21-Production in Primary Sjogren′s Syndrome Patients By Immunomodulatory Treatment
Gwenny M. Verstappen¹, Hendrik L.F. Broekman¹, Erlin A. Haacke², Petra M. Meiners³, Fred K.L. Spijkervet³, Arjan Vissink⁴, Hendrika Bootsma⁵ and Frans G.M. Kroese¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: Interleukin-21 plays a central role in plasma cell differentiation and germinal center (GC) formation and is likely involved in the pathogenesis of primary Sjögren’s…
Abstract Number: 2671 • 2016 ACR/ARHP Annual Meeting
Impaired Bone Health in Patients with Primary Sjogren’s Syndrome
Zaiying Hu¹, Shanglin Zhu², Zetao Liao³ and Baiyu Zhang², ¹Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China
Background/Purpose: Patients were all Chinese from the outpatient and inpatient clinic of our hospital (Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China). Primary SS…
Abstract Number: 3032 • 2016 ACR/ARHP Annual Meeting
Abnormalities in the Biological or Haematological Domain of the Essdai Predict an Increase in Systemic Disease Activity the Year after: 5-Year Data from the Prospective Multicenter Assess Cohort
Jacques-Eric Gottenberg¹, Raphaele Seror², Alain Saraux³, Valerie Devauchelle⁴, Emmanuelle Dernis⁵, Philippe Dieudé⁶, Jean-Jacques Dubost⁷, Anne Laure Fauchais⁸, Vincent Goeb⁹, Claire Larroche¹⁰, Véronique Le-Guern¹¹, Eric Hachulla¹², Pierre Yves Hatron¹³, Jacques Morel¹⁴, Aleth Perdriger¹⁵, Stephanie Rist Bouillon¹⁶, Damien Sène¹⁷, Olivier Vittecoq¹⁸, Jean Sibilia¹⁹, Philippe Ravaud²⁰ and Xavier Mariette²¹, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, ³Rheumatology, Brest University Hospital, Brest, France, ⁴Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ⁵Service de Rhumatologie, Centre Hospitalier, Le Mans, France, ⁶Rheumatology, Hôpital Bichat, Paris, France, ⁷Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ⁸Rheumatology, Limoges, France, ⁹Rhumatologie, CHU Amiens, Amiens, France, ¹⁰Internal Medicine, Paris, France, ¹¹service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹²Internal Medicine, Lille University Hospital, Lille, France, ¹³Internal Medicine, Lille, France, ¹⁴Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, ¹⁵C.H.R. Hôpital Sud, Rennes, France, ¹⁶Rhumatologie, Hopital La Source, La Source, France, ¹⁷Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁸Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, ¹⁹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁰Epidemiologist, PARIS, France, ²¹Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France
Background/Purpose: Very limited data is available regarding predictors of systemic disease activity in primary Sjögren’s syndrome. The ESSDAI, the international systemic disease activity score of…
Abstract Number: 11L • 2015 ACR/ARHP Annual Meeting
Preliminary Results of a Double-Blind Randomised Trial of Rituximab Anti-B-Cell Therapy in Patients with Primary Sjogrens Syndrome
Simon Bowman¹, Colin Everett², Michele Bombardieri³, Robert Busch⁴, Paul Emery⁵, Frances Hall⁶, Colin T. Pease⁷, Costantino Pitzalis⁸, Elizabeth Price⁹, Luke Dawson¹⁰, Peter Smith¹¹, Nurhan Sutcliffe³, Wan-Fai Ng¹², Catherine Fernandez¹³, Sharon Ruddock¹³, Linda Sharples¹³, Catherine Reynolds¹³ and Sue Pavitt¹⁴, ¹Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ²Leeds Institute for Clinical Trials Research, University of Leeds, LEEDS, United Kingdom, ³Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ⁴Department of Life Sciences, University of Roehampton, London, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds Gen Infirmary, Leeds, United Kingdom, ⁶School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom, ⁷Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁸Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁹Rheumatology Department, Great Western Hospital, Swindon, United Kingdom, ¹⁰School of Dental Sciences, University of Liverpool,, Liverpool, United Kingdom, ¹¹School of Dental Sciences,, University of Liverpool, Liverpool, United Kingdom, ¹²NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, ¹³Leeds Institute for Clinical Trials Research, University of Leeds, Leeds, United Kingdom, ¹⁴Division of Applied Health & Clinical Translation , School of Dentistry, University of Leeds, Leeds, United Kingdom
Background/Purpose: Evidence from open-label and observational studies support anti-B-cell therapy in patients with primary Sjogren’s Syndrome (PSS). The TRACTISS trial aimed to determine the extent…
Abstract Number: 632 • 2015 ACR/ARHP Annual Meeting
Isolated Atrioventricular Block of Unknown Origin in the Adult and Autoimmunity: Diagnostic and Therapeutic Considerations Exemplified By Three Anti-Ro/SSA-Associated Cases
Antonio Brucato¹, Pietro Enea Lazzerini², Pier Leopoldo Capecchi³, Anna Valenti⁴, Lucia Baldi⁵, Maria Romana Bacarelli³, Claudia Nucci⁵, Valentina Moscadelli³, Gabriella Morozzi³, Mohamed Butjdir^6,7,8 and Franco Laghi Pasini³, ¹Internal Medicine, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy, ²Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ³Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ⁴Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁵Cardiology, University of Siena, Siena, Italy, ⁶Medicine, Cell Biology and Pharmacology, State University of New York at Downstate Medical Center, New York, NY, ⁷NYU School of Medicine, New York, NY, ⁸Research Department, VA New York Harbor Healthcare System, New York, NY
Background/Purpose: Circulating anti-Ro/SSA antibodies may rarely affect the adult conduction-system. A direct autoantibody-mediated electrophysiological inhibition of cardiomyocyte calcium-channels (acquired form) or an ante-natal subclinical injury…
Abstract Number: 1056 • 2015 ACR/ARHP Annual Meeting
Aquaporin Gene Therapy Corrects Bone Morphogenetic Protein 6 Associated Exocrine Gland Dysfunction in Mouse Model of Sjögren’s Syndrome
Hongen Yin¹, Zhennan Lai², Javier Cabrera-Perez³, Patricia Glenton⁴, Ankur Patel⁵, William Swaim⁵, Changyu Zheng⁵, Maria Guimaro⁵, Sandra Afione⁶, Cuong Nguyen⁵, Fred Nyberg⁷ and John A. Chiorini², ¹NIDCR, NIH, Bethesda, MD, ²Mptb, NIH/NIDCR, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Bethesda, MD, ⁴Department of Pathology and Infectious Diseases, University of Florida, Gaineville, FL, ⁵Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁶National Institute of Dental and Craniofacial Research, Bethesda, MD, ⁷Department of Pharmaceutical Bioscience, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, MD, Sweden
Background/Purpose: Loss of secretory epithelial function is a hallmark of primary Sjögren’s syndrome (pSS). Previously we reported that bone morphogenetic protein 6 (BMP-6) inhibits cell volume…
Abstract Number: 2794 • 2015 ACR/ARHP Annual Meeting
A New Scoring System for Ultrasonographic Evaluation of Salivary Gland in Sjogren: Multireader Reliability
Sandrine Jousse-Joulin¹, Malin V. Jonsson², Nicoletta Luciano³, Elke Theander⁴, Vera Milic⁵, Alojzija Hocevar⁶, Jacqueline Brown⁷, Andrew Carr⁸, Divi Cornec⁹, Marina Carotti¹⁰, Benjamin A. Fisher¹¹, Joel Fradin¹², John Rout¹³, Alain Saraux¹⁴, Alja Stel¹⁵, Arjan Vissink¹⁶, Simon Bowman¹⁷, Alan N. Baer¹⁸, Matija Tomšič⁶, Wan-Fai Ng¹⁹, Chiara Baldini³ and Valerie Devauchelle²⁰, ¹Rheumatology, CHu La cavle Blanche, Brest, France, ²Department of Clinical Dentistry, Section for Oral and Maxillofacial Radiology,, University of Bergen, Bergen, Norway, ³Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ⁴Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ⁵rheumatology, belgrade university, belgrade, Serbia, ⁶Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁷dental division, Tower Wing Guy's hospital, london, United Kingdom, ⁸departement of radiology, University of Newcastle, New castle, United Kingdom, ⁹Department of rheumatology, Brest Occidentale University, Brest, France, ¹⁰Istituto di Radiologia, Ospedali Riuniti di Ancona, Ancona, Italy, ¹¹Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom, ¹²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ¹³Birmingham Dental Hospital, Birmingham, United Kingdom, ¹⁴Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹⁵Hanzeplein 1, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ¹⁶Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ¹⁷Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ¹⁸Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁰Service de Rhumatologie, CHU Brest, Brest, France
Background/Purpose: A new consensual scoring system for Ultrasonography (US) of the salivary gland in pSS is required and endorsed by an international group of experts…

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