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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 2686 • 2016 ACR/ARHP Annual Meeting

    Objective Improvement in Fatigue Scores for Primary Sjögren’s Patients Receiving a Tailored Multidisciplinary Fatigue Intervention in a Generic Fatigue Clinic

    Katie Hackett1,2, Robert Forder3, Dennis W Lendrem4, Ben Hargreaves5, Victoria Strassheim1,3, Zoe Gotts3, Vincent Deary1,6, Wan-Fai Ng7,8 and Julia Newton1,3, 1CRESTA Fatigue Clinic, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Newcastle University, Newcastle upon Tyne, United Kingdom, 4Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Musculoskeletal Directorate, Newcastle upon Tyne NHS Foundation Trust, Newcastle, United Kingdom, 6School of Health Psychology, Northumbia University, Newcastle upon Tyne, United Kingdom, 7Musculoskeletal Research Group Institute of Cellular Medicine, Newcastle University, Newcastle University, Newcastle, England, 8Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Primary Sjögren’s syndrome (PSS) is an autoimmune disease which targets secretary glands resulting in dry eyes and mouth. Approximately 70% of PSS patients experience…
  • Abstract Number: 661 • 2016 ACR/ARHP Annual Meeting

    Epitope Specificity and End-Organ Susceptibility Dictates Anti-Ro52 Mediated Salivary Gland Dysfunction

    Magdalena Sroka1, Indranil Biswas1, Brian Shepherd1, Dat C Truong2, Harini Bagavant1 and Umesh S Deshmukh1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma, Norman, OK

    Background/Purpose: Circulating autoantibodies reactive against Ro52 are detected in the sera of 70% of patients with Sjögren’s syndrome (SS), and their presence has been associated…
  • Abstract Number: 2660 • 2016 ACR/ARHP Annual Meeting

    Do Ultrasonographic Lesions of Salivary Glands Evolve in SjöGren Patients during Follow-up ?

    Alain Saraux1, Valerie Devauchelle2, Sandrine Jousse-Joulin3, Divi Cornec4, Pierre Gazeau5 and Dewi Guellec5, 1Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, 2Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, 3Rheumatology, CHu La cavle Blanche, Brest, France, 4Department of rheumatology, Brest Occidentale University, Brest, France, 5Rheumatology, CHU Brest, Brest, France

    Background/Purpose: to evaluate if the salivary glands ultrasonographic score (SGUS) is modified during follow-up in primitive Sjögren patients (pSS) and to compare pSS with idiopathic…
  • Abstract Number: 2688 • 2016 ACR/ARHP Annual Meeting

    Characteristics, Treatment and Outcome of Joint Involvement with Synovitis in Primary SjöGren’s Syndrome: French Multicentric Retrospective Case-Control Study

    Adrien Mirouse1, raphaèle seror2, Xavier Mariette3, Maxime Dougados4, Anne-Laure Fauchais5, Alban Deroux6, Nathalie Costedoat-Chalumeau7, Jeremie Sellam8, Jean-Benoit Arlet9, Christian Lavigne10, Dominique Fischer-Dumont11, Arsène Mékinian12 and Olivier Fain12, 1Service de médecine interne, Hôpital Saint-Antoine, Paris, France, 2INSERM U1184, Paris Sud University, Le Kremlin Bicetre, France, 3INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France, 4Paris Descartes University, Paris, France, 5Department of Internal Medicine, CHU de Limoges, Limoges, France, 6Internal Medicine, CHU Grenoble, Grenoble, France, 7Internal Medicine, Cochin University Hospital, Paris, France, 8Rheumatology, Saint-Antoine Hospital, Paris, France, 9Service de médecine interne, Hopital Européen Georges Pompidou, Paris, France, 10CHU Angers, department of Internal Medicine, Angers, France, 11Service de rhumatologie, Hôpital Avicenne, Bobigny, France, 12Service de médecine interne. Hôpital Saint-Antoine., Paris, France

    Background/Purpose: primary Sjogren’s syndrome (pSS) articular manifestations include often tender joints and more rarely synovitis. The main objective of this study was to describe characteristics,…
  • Abstract Number: 662 • 2016 ACR/ARHP Annual Meeting

    The Unusual Cross-Reactivity of Anti Muscarinic Receptor 3 Monclonal Antibodies Derived from Salivary Glands of Sjögren’s Syndrome Patients to Ro Peptides

    Syed M.S. Quadri1, Kristi A. Koelsch2, Biji T Kurien3, Valerie M Harris4 and R. Hal Scofield2, 1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjogrens syndrome (SS) is a chronic autoimmune inflammatory disease the characterisitic features of which includes hypofunction of exocrine glands leading to decrease in salivation…
  • Abstract Number: 2661 • 2016 ACR/ARHP Annual Meeting

    Performance of the Proposed ACR-EULAR Criteria for Sjogren’s Syndrome in a Prospective Multidisciplinary Diagnostic Cohort from Daily Clinical Practice

    Jolien F. van Nimwegen1, Martha S. van Ginkel1, Suzanne Arends1, Gwenny M. Verstappen1, Erlin A. Haacke1,2, Bert van der Vegt3, Nicole Sillevis Smitt-Kamminga4, Fred K.L. Spijkervet5, Frans G.M. Kroese1, Arjan Vissink6 and Hendrika Bootsma1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Opthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 6Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Sjögren’s syndrome (SS) is a systemic auto-immune disease with a heterogeneous clinical presentation. Recently, ACR-EULAR criteria were proposed for classification of SS, which combine…
  • Abstract Number: 2693 • 2016 ACR/ARHP Annual Meeting

    Evolution of Disease Activity over a 5-Year Period in the  395 Patients with Primary SjöGren’s Syndrome of the Assess Prospective Cohort

    Jacques-Eric Gottenberg1, Raphaele Seror2, Alain Saraux3, Valerie Devauchelle4, Emmanuelle Dernis Labous5, Philippe Dieudé6, Jean-Jacques Dubost7, Anne Laure Fauchais8, Vincent Goeb9, Claire Larroche10, Véronique Le-Guern11, Eric Hachulla12, Pierre Yves Hatron13, Jacques Morel14, Aleth Perdriger15, Stephanie Rist Bouillon16, Damien Sène17, Olivier Vittecoq18, Jean Sibilia19, Philippe Ravaud20 and Xavier Mariette21, 1Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 2Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, 3Rheumatology, Brest University Hospital, Brest, France, 4Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, 5Le Mans Hospital, Le Mans, France, 6Rheumatology, Hôpital Bichat, Paris, France, 7Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 8Rheumatology, Limoges, France, 9Rhumatologie, CHU Amiens, Amiens, France, 10Internal Medicine, Paris, France, 11service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 12Internal Medicine, Lille University Hospital, Lille, France, 13Internal Medicine, Lille, France, 14Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, 15C.H.R. Hôpital Sud, Rennes, France, 16Rhumatologie, Hopital La Source, La Source, France, 17Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, 18Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, 19Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 20Epidemiologist, PARIS, France, 21Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France

    Background/Purpose: Little is known about the natural history of primary Sjögren’s syndrome due to the limited number of prospective cohorts followed up in a yearly…
  • Abstract Number: 663 • 2016 ACR/ARHP Annual Meeting

    Cytokine and Chemokine Levels in Serum and Tears As Disease Activity Biomarkers in Patients with Primary Sjögren´s Syndrome

    Angel Alejandro Castillo-Ortiz1, Rosa Elda Barbosa-Cobos2, Lizbeth Becerril-Mendoza3, Gustavo Lugo-Zamudio4, Virgilio Lima-Gómez4, Adan Moreno-Eutimio5, Nayeli Nieto-Velázquez5 and Angel Tzec-Pérez5, 1Rheumatology, Hospital Juárez de México, Mérida, Mexico, 2Rheumatology, Hospital Juárez de México, Mexico, Mexico, 3Hospital Juárez de México, Mexico, Mexico, 4Hospital Juárez de México, México city, Mexico, 5Hospital Juárez de México, Mexico city, Mexico

    Background/Purpose: Evidence suggests that levels of different cytokines in primary Sjögren´s syndrome (pSS) are associated with cell infiltration degree within lacrimal and salivary glands and…
  • Abstract Number: 2662 • 2016 ACR/ARHP Annual Meeting

    Effect of Tobacco Smoking on the Clinical, Histopathological, and Serological Manifestations of SjöGren’s Syndrome

    Astrid Rasmussen1, Donald U. Stone2, Dustin Fife3, Michael Brown4, Keith Earley5, Lida Radfar6, C. Erick Kaufman7, David M. Lewis8, Nelson L. Rhodus9, Barbara M. Segal10, Daniel J Wallace11, Michael Weisman12, Swamy Venuturupalli13, Michael T. Brennan14, Christopher J Lessard3, Courtney G. Montgomery15, R. Hal Scofield15 and Kathy L. Sivils15, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 2King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Pfizer Inc., Groton, CT, 559th Medical Wing, US Air Force, San Antonio, TX, 6Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 8Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 9Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 10Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, 11Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 12Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 13Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, 14Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: To assess the prevalence of smoking in patients with Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca), and the association of smoking habits with…
  • Abstract Number: 2806 • 2016 ACR/ARHP Annual Meeting

    A Type-I Interferon Signature Is Associated with Autoantibody Profiles in Connective Tissue Diseases: Results from the Lupus Extended Autoimmune Phenotype (LEAP) Study

    John A. Reynolds1,2, Mumtaz Khan3, Tracy A. Briggs4, Gillian Rice5, Yanick Crow5, Ben Parker6 and Ian N. Bruce1,7, 1NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 2Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 3Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 4Institute of Human Development, University of Manchester, Manchester, United Kingdom, 5Manchester Academic Health Science Centre, Institute of Human Development, University of Manchester, Manchester, United Kingdom, 6Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 7Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

    Background/Purpose: Type I interferon has been implicated in the pathogenesis of systemic lupus erythematosus (SLE), but much less is known about its role in other…
  • Abstract Number: 665 • 2016 ACR/ARHP Annual Meeting

    Salivary Gland Secretome: A Novel Tool to Identify Biomarkers of Dryness and Immunopathology in Primary Sjogren’s Syndrome and Non-Autoimmune Sicca Patients

    Sofie L.M. Blokland1,2, Maarten R. Hillen1,2, Aike A. Kruize3, Timothy R.D.J. Radstake1,2 and Joel A.G. van Roon1,2, 1Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, 3Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Salivary gland biopsy is essential in primary Sjögren’s syndrome (pSS) diagnostics. However, tissue analysis using the traditional method has several limitations including inaccuracy of quantification of lymphocytic infiltration and poor correlation with dryness.…
  • Abstract Number: 2663 • 2016 ACR/ARHP Annual Meeting

    Antimalarials Protect Against Damage Accrual in Primary SjöGren’s Syndrome

    Gabriela Hernandez-Molina1, Valeria Valim2, Yemil Atisha-Fregoso3, Anastasia Secco4, Emmanuel Guerra5, Marianela Adrover5, Anna Julha Lage Santos6 and Antonio Catalan Pellet4, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, 2Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 4Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 5Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 6Universidade Federal do Espírito Santo, Vitória, Brazil

    Background/Purpose: Antimalarials are frequently used in patients with primary Sjögren’s syndrome (SS). The aim of this study was to assess their impact on damage accrual…
  • Abstract Number: 2826 • 2016 ACR/ARHP Annual Meeting

    Clinical Utility of Circulating Anti-N-Methyl-D-Aspartate Receptor Subunits NR2A/B Antibody for the Diagnosis of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Sjogren’s Syndrome: An Updated Meta-Analysis

    Sen Hee Tay1, Anna-Marie Fairhurst2 and Anselm Mak1, 1Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, Singapore, 2Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

    Background/Purpose: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and…
  • Abstract Number: 667 • 2016 ACR/ARHP Annual Meeting

    Cytokine and Chemokine Levels in Serum and Saliva As Disease Activity Biomarkers in Patients with Primary Sjögren’s Syndrome

    Angel Tzec-Pérez1, Rosa Elda Barbosa-Cobos2, Gustavo Esteban Lugo-Zamudio3 and Lizbeth Teresa Becerril-Mendoza2, 1Hospital Juárez de México, Mexico city, Mexico, 2Rheumatology, Hospital Juárez de México, Mexico, Mexico, 3Rheumatology, Hospital Juárez de México, México, Mexico

    Background/Purpose: Background Evidence suggests that levels of different cytokines in primary Sjögren's syndrome (pSS) are associated with cell infiltration degree within salivary and lacrimal glands…
  • Abstract Number: 2664 • 2016 ACR/ARHP Annual Meeting

    Evaluation of Thyroid Autoimmune Disease in Primary SjöGren’s Syndrome and Its Association with Disease Phenotype

    Mario Giron-Pillado1, Yemil Atisha-Fregoso1, Ivette Cruz-Bautista1, Miguel Astudillo-Angel1 and Gabriela Hernandez-Molina2, 1Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico

    Background/Purpose:  
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