Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: To assess the prevalence of smoking in patients with Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca), and the association of smoking habits with the clinical, serological, and histopathological manifestations of SS.
Methods: Cross-sectional case-control study of 1288 patients with sicca symptoms (587 SS and 701 non-SS sicca) evaluated in a multi-disciplinary research clinic. Smoking patterns were obtained from questionnaire data and disease-related clinical and laboratory data were compared between current, past, ever, and never smokers.
Results: Current smoking rates were 4.6% for SS patients compared to 14.1% in non-SS sicca (p=5.17x10E-09), 18% in a local lupus cohort (p=1.13x10E-14) and 16.8% in the community (p=4.12x10E-15). Current smoking was protective against SS classification (OR 0.35, 95%CI 0.22-0.56, FDR q=1.35E10-05), focus score ≥1 (OR 0.22, 95%CI 0.13-0.39, FDR q= 6.78x10E-08), and anti-Ro/SSA(+) (OR 0.35, 95%CI 0.2-0.63, FDR q=0.0009); ever smoking was protective against the same features and against anti-La/SSB(+) (OR 0.52, 95%CI 0.39-0.70, FDR q=0.001). Duration of smoking was inversely correlated with SS even after controlling for socioeconomic status, BMI, alcohol and caffeine consumption.
Conclusion: Current tobacco smoking is negatively and independently associated with SS, protecting against disease-associated humoral and cellular autoimmunity. The overall smoking rate amongst SS patients is significantly lower than in matched populations and the effects of smoking are proportional to exposure duration.In spite of the protective effects of tobacco on SS manifestations, it is associated with other serious comorbidities such as lung disease, cardiovascular risk and malignancy, and should thus be strongly discouraged in patients with sicca.
To cite this abstract in AMA style:Rasmussen A, Stone DU, Fife D, Brown M, Earley K, Radfar L, Kaufman CE, Lewis DM, Rhodus NL, Segal BM, Wallace DJ, Weisman M, Venuturupalli S, Brennan MT, Lessard CJ, Montgomery CG, Scofield RH, Sivils KL. Effect of Tobacco Smoking on the Clinical, Histopathological, and Serological Manifestations of SjöGren’s Syndrome [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/effect-of-tobacco-smoking-on-the-clinical-histopathological-and-serological-manifestations-of-sjogrens-syndrome/. Accessed March 20, 2019.
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