Abstracts tagged "Sjogren’s syndrome and salivary gland"

Abstract Number: 1473 • 2019 ACR/ARP Annual Meeting
Syndecan-1 Is a Potential Biomarker for Salivary Glandular Function and Disease Activity in Patients with Sjögren’s Syndrome
Gunwoo Kim¹, Min-Su Han ², Ju Hye Jeong ³, Man-Hoon Han ⁴, Sang Jin Lee ⁵ and Eon Jeong Nam ⁶, ¹Division of Rheumatology, Department of Internal medicine, Daegu Fatima Hospital, Daegu, Taegu-jikhalsi, Republic of Korea, ²Laboratory for arthritis and bone biology, Fatima Research Institute, Daegu Fatima Hospital, Daegu, Taegu-jikhalsi, Republic of Korea, ³Department of Nuclear medicine, Kyungpook National University Chilgok Hospital, 807, Hoguk-ro, Buk-gu, Daegu 41404, Taegu-jikhalsi, Republic of Korea, ⁴Department of Pathology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Taegu-jikhalsi, Republic of Korea, ⁵Division of Rheumatology, Kyungpook National University Hospital, Daegu, Republic of Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Kyungpook National University Chilgok Hospitalospital, 807, Hoguk-ro, Buk-gu, Daegu 41404, Taegu-jikhalsi, Republic of Korea
Background/Purpose: Sjögren’s syndrome (SS) is known as autoimmune epithelitis, because epithelial cells in the glands are the primary target of disease and play a major…
Abstract Number: 7 • 2018 ACR/ARHP Annual Meeting
RNA Sequencing Detection of Gene Dysregulation in B Cells Sorted from Salivary Gland Tissue and from Peripheral Blood Reveals New Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology
Elodie Rivière^1,2, Nicolas Tchitchek¹, Gaetane Nocturne^1,3, Juliette Pascaud¹, Saida Boudaoud¹, Alice Thai⁴, Normand Allaire⁴, Bernd Jagla⁵, Michael Mingueneau⁴ and Xavier Mariette^1,3, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ²Arthritis Fondation Courtin, Paris, France, ³Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Immunology Research, Biogen, Cambridge, MA, ⁵Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic auto-immune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Chronic B cell activation, the…
Abstract Number: 1571 • 2018 ACR/ARHP Annual Meeting
RNA Sequencing Detection of Gene Dysregulation in Epithelial Cells Sorted from Salivary Gland Tissue Reveals Interesting Pathways Involved in Primary Sjögren’s Syndrome Pathophysiology
Elodie Rivière^1,2, Nicolas Tchitchek¹, Gaetane Nocturne^1,3, Juliette Pascaud¹, Alexandre Virone¹, Saida Boudaoud¹, Alice Thai⁴, Normand Allaire⁴, Bernd Jagla⁵, Michael Mingueneau⁴ and Xavier Mariette^1,3, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ²Arthritis Fondation Courtin, Paris, France, ³Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Immunology Research, Biogen, Cambridge, MA, ⁵Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique C3IB, Institut Pasteur, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary glands. Several lines of evidence support…
Abstract Number: 1576 • 2018 ACR/ARHP Annual Meeting
Soluble Semaphorin 4D/CD100 Is Increased in the Saliva of Sjögren’s Syndrome
Shin Eui Kang¹, Jeong Seok Lee², Ji Soo Park¹, Ji Hye Lee², Jeong Yeon Kim¹, Hyun Jung Yoo², Yun Jong Lee³, Eun Young Lee⁴, Eun Bong Lee² and Yeong Wook Song^1,5, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration in exocrine organs with dry mouth and dry eyes. Semaphorin 4D (SEMA4D) /…
Abstract Number: 2799 • 2018 ACR/ARHP Annual Meeting
Sjogren’s Syndrome Minor Salivary Gland CD4+ T Cells Associate with Oral Disease Features and Have a T Follicular Helper-like Transcriptional Profile
Michelle L. Joachims¹, Kerry M. Leehan¹, Mikhail Dozmorov^1,2, Zijian Pan¹, Astrid Rasmussen¹, Lida Radfar³, David M. Lewis⁴, Donald U. Stone^5,6, Kiely Grundahl⁷, R. Hal Scofield^1,8,9, Christopher J. Lessard¹, Jonathan Wren¹, Linda F. Thompson¹, Kathy L. Sivils¹⁰, Jacen Maier-Moore^1,11 and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Biostatistics, Virginia Commonwealth University, Richmond, VA, ³Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁸Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹¹Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX
Background/Purpose: The predominant salivary gland (SG) T cell types contributing to disease in Sjögren’s syndrome (SS) are unclear. This study assessed the frequency and number…
Abstract Number: 268 • 2017 ACR/ARHP Annual Meeting
Applications of Salivary Gland Ultrasonography in Sjögren Syndrome and Sicca Symptoms: A Single Center Experience
Yen-Po Tsao^1,2, Ming-Han Chen^3,4, Wei Sheng Chen^1,5, Chien Chih Lai^1,5 and Chang Youh Tsai^1,2, ¹National Yang-Ming University, Taipei, Taiwan, ²Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ³Division of Allergy- Immunology- Rheumatology, Department of Medicine, Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ⁴Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ⁵Department of medicine, division of allergy, immunology, rheumatology, Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Background/Purpose: Sjögren’s syndrome is an autoimmune disease that involves salivary and lacrimal gland, which influences life quality of patients. In the recent classification criteria declared…
Abstract Number: 558 • 2017 ACR/ARHP Annual Meeting
Salivary Syndecan-1 Levels Are Associated with Salivary Gland Dysfunction and Immune Dysregulation in Patients with Sjögren’s Syndrome
Eon Jeong Nam¹, Jong Wan Kang¹, Jung Su Eun¹, Na Ri Kim¹, Sang Jin Lee¹, Keum Hee Sa², Gi Bum Bae³ and Young Mo Kang⁴, ¹Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Kyungpook National University, Daegu, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Daegu, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea, Daegu, Korea, Republic of (South)
Background/Purpose: Sjögren’s syndrome (SJS) is a chronic autoimmune disorder with lymphocytic infiltration of exocrine and non-exocrine epithelia, in which epithelial cells play a critical role…
Abstract Number: 653 • 2016 ACR/ARHP Annual Meeting
Thrombospondin-1 Is Highly Expressed By Salivary Gland Epithelial Cells of Sjögren’s Syndrome Patients, Both Constitutively and upon Exposure to Necrotic Cells Debris
Aglaia G Vakrakou^1,2, Markos D Patsouras¹, Panagiotis G Vlachoyiannopoulos¹, Athanasios G Tzioufas¹ and Menelaos N Manoussakis^2,3, ¹Department of Pathophysiology, Department of Pathophysiology, School of Medicine, University of Athens, Greece, Athens, Greece, ²Hellenic Pasteur Institute, Athens, Greece., Hellenic Pasteur Institute, Athens, Greece, Athens, Greece, ³Department of Pathophysiology, School of Medicine, University of Athens, Greece, Department of Pathophysiology, School of Medicine, University of Athens, Greece, Athens, Greece
Background/Purpose: Sjögren’s syndrome (SS) patients manifest inflammation in salivary glands (SG) (lymphocytic infiltration of salivary and lachrymal glands) and evidence of intrinsic activation in the…
Abstract Number: 3075 • 2015 ACR/ARHP Annual Meeting
Salivary Gland FcRL4+ B-Cells Are a Potential Source of Progenitor Cells for MALT Lymphoma in Primary Sjögren’s Syndrome
Erlin A. Haacke¹, Frans G.M. Kroese², Philip Kluin³, Petra M. Meiners⁴, Annie Visser⁵, Fred K.L. Spijkervet⁶ and Hendrika Bootsma⁷, ¹Pathology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Pathology and Medical Biology, UMCG Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, UMC Groningen, Groningen, Netherlands, ⁶Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: Patients with primary Sjögren's Syndrome (pSS) have an increased risk of non-Hodgkin's lymphoma, predominantly of the Mucosa Associated Lymphoid Tissue (MALT) type, which commonly…
Abstract Number: 1257 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Signatures of Salivary Gland Inflammation in Sjögren’s Syndrome
Michael Cole¹, Diana Quach¹, Hong L. Quach¹, Lisa F. Barcellos¹ and Lindsey A. Criswell², ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Sjögren’s Syndrome (SS, OMIM #270150) is a chronic, multi-system autoimmune disease characterized by progressive destruction of the exocrine glands, with subsequent mucosal and conjunctival…
Abstract Number: 2094 • 2014 ACR/ARHP Annual Meeting
Deep Sequencing Reveals Differential RNA Expression during Malignant Transformation in Major Salivary Glands in a Mouse Model of Sjogren’s Syndrome
Kaiyu Jiang¹, Long Shen², Zihua Hu³, Julian Ambrus⁴ and James Jarvis⁵, ¹415 Carmen Road, Apt. 1, The University at Buffalo, Buffalo, NY, ²Department of Medicine, SUNY at Buffalo, Buffalo, NY, ³Center for Computational Research, University at Buffalo, Buffalo, NY, ⁴100 High St., University Of Buffalo, Buffalo, NY, ⁵Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose – Sjšgren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that targets salivary and lacrimal glands and may be accompanied bymultiorgan systemic manifestations. To further…