Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Sjögren’s syndrome is an autoimmune disease that involves salivary and lacrimal gland, which influences life quality of patients. In the recent classification criteria declared by ACR/EULAR in 2016, salivary gland biopsy remained one of the main diagnostic factors. Salivary gland ultrasonography (SGUS) has been evaluated recently for diagnosis Sjögren’s syndrome or detection the morphological change of the gland. SGUS offered a non-invasive, time-consuming way in elucidating the condition of salivary gland. Although SGUS had been used in detection autoimmune diseases, such as IgG4 disease or sarcoidosis, the usefulness and effectiveness in Sjögren syndrome remained controversial.
Total 74 patients were enrolled. SGUS was conducted by a 10MHz-13MHz linear probe at both parotid and submandibular glands. Each gland was scored from 0 to 4 according to the scoring scale proposed previously. The total maximum score was 16. Minor salivary gland biopsy results were examined by pathologist with Chisholm-Mason grade. Blood samplings and ESSPRI questionnaires were conducted after SGUS.
Total 47 patients with primary Sjögren’s Syndrome, 9 patients with secondary Sjögren’s Syndrome, and 18 patients with sicca symptoms were examined. SGUS score correlated with serum anti-Ro/SSA (p=0.012), anti-La/SSB (p=0.004), ESSPRI score (p<0.001), and Chisholm-Mason score of salivary gland biopsy (N=24, p=0.012). Furthermore, dryness scale and fatigue scale correlated with SGUS score (p=0.001 and 0.002, respectively), but not with pain scale (p=0.199). In patient with primary Sjögren syndrome, the correlations between ESSPRI and SGUS remained (p=0.024), but it did not exist in patient with secondary Sjögren syndrome (p=0.073) or sicca symptoms (p=0.074).
In our study, SGUS score correlated with patients’ self-reporting ESSPRI score and the microscopic biopsy result. It also correlated with serology markers such as anti-Ro/SSA and anti-La/SSB. SGUS may provide a direct evaluation tool for evaluation the severity of gland architecture as well as an alternative representative for histological change.
To cite this abstract in AMA style:Tsao YP, Chen MH, Chen WS, Lai CC, Tsai CY. Applications of Salivary Gland Ultrasonography in Sjögren Syndrome and Sicca Symptoms: A Single Center Experience [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/applications-of-salivary-gland-ultrasonography-in-sjogren-syndrome-and-sicca-symptoms-a-single-center-experience/. Accessed September 20, 2021.
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