Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 1250 • ACR Convergence 2024
Qualitative Study on Patient-Reported Outcome Measures in Patients with Sjögren’s Disease
Suzanne Arends¹, Jiyoon C. Choi², Brandon Becker², Teresa Edwards³, Antoine Sreih⁴, Antonia Christodoulou⁴ and Vibeke Strand⁵, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Bristol Myers Squibb, Princeton, ³RTI International, Research Triangle Park, NC, ⁴Bristol Myers Squibb, Princeton, NJ, ⁵Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA
Background/Purpose: Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease characterized by lymphocytic infiltration of the endocrine glands. Globally, SjD affects between 0.01% and 0.05%…
Abstract Number: 1422 • ACR Convergence 2024
Evaluation of Salivary Gland Focus Score in Sjogren’s Disease Using Deep Learning: A Step Towards Tissue Biomarker Discovery
Konstantinos Panagiotopoulos¹, Nikos Tsiknakis², Dimitrios Zaridis³, Athanasios Tzioufas⁴, Dimitrios I. Fotiadis⁵ and Andreas Goules⁶, ¹Pathophysiology Department, National and Kapodistrian University of Athens, Athens, Greece, ²Karolinska Institutet, Department of Oncology-Pathology, Computational BioMedicine Laboratory, Foundation for Research and Technology Hellas, Stockholm, Sweden, ³School of Electrical & Computer Engineering and Biomedical Research Institute National Technical University of Athens and FORTH, Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, Ioannina, Greece, ⁴LAIKO HOSPITAL, Athens, Greece, ⁵Unit of Medical Technology and Intelligent Information Systems, University of Ioannina & FORTH, Ioannina, Greece, ⁶GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece
Background/Purpose: Sjogren's Disease (SjD) is characterized by focal sieladenitis in minor salivary gland biopsies (mSGB), which is evaluated using the Focus Score (FS). FS ≥…
Abstract Number: 1909 • ACR Convergence 2024
Racial Disparities in Ocular Complications of Systemic Rheumatic Diseases: A Retrospective Cross-Sectional Study
Insa Mannstadt¹, Yiyuan Wu² and Bella Mehta³, ¹Columbia University VP&S, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: While systemic rheumatic diseases, including Sjogren's syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and spondyloarthropathies, are known to have severe ophthalmologic manifestations, there…
Abstract Number: 2300 • ACR Convergence 2024
Activation of Tissue-Resident T Cells in Sjögren’s Disease with Human Salivary Organoids
Brandon Law¹, Rahmatullah Rahmati² and Andrew Luster³, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts Eye & Ear, Boston, MA, ³Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, particularly the salivary glands. These focal lymphocytic infiltrates are…
Abstract Number: 2630 • ACR Convergence 2024
Identification of Molecular Biomarkers for Sjögren’s Disease Stratification via a Deep Learning Foundation Model Dedicated to Immune-Mediated and Inflammatory Disease
Aygalic Jara-Mikolajczak¹, Zachary Abessera¹, Martin Rethoret-Pasty¹, Elisa Mazuir¹, Apolline Bruley¹, Wan Fai Ng², Marta Alarcon-Riquelme³, Michele Bombardieri⁴, Simon Bowman⁵, Elena Pontarini⁶, Jacques-Eric Gottenberg⁷, Xavier Mariette⁸, Laurence LAIGLE⁹, Julien Duquesne¹, Philippe Moigeon¹⁰ and Vincent Bouget¹¹, and NECESSITY Consortium, ¹Scienta Lab, Paris, France, ²Department of Rheumatology, Newcastle University, & HRB Clinical Research Facility, University College Cork, Newcastle upon Tyne, United Kingdom, ³Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ⁴Centre for Experimental Medicine and Rheumatology, The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ⁵Department of Rheumatology, University Hospital Birmingham, Birmingham, United Kingdom, ⁶William Harvey Research Institute, London, United Kingdom, ⁷Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, ⁸Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, ⁹Servier Laboratories, France, SURESNES, France, ¹⁰Servier Laboratories, France, Gif sur Yvette, France, ¹¹Scienta Lab, Gif-sur-Yvette, France
Background/Purpose: Sjögren’s Disease (SjD) exhibits heterogeneity in clinical manifestations and underlying biology. This heterogeneity complicates drug development, with no targeted therapy approved to date. Identifying…
Abstract Number: 1406 • ACR Convergence 2024
Development and Functional Characterization of Salivary Gland Organoids to Investigate Sjögren’s Disease
Negaar Goudarzi¹, Loïc Meudec², Juliette Pascaud², Fanny Jaulin³, Quentin Pascal⁴, Thierry Lazure⁵, Sacha E Silva Saffar², Xavier Mariette⁶ and Gaetane Nocturne⁶, ¹University Paris-Saclay, Le Kremlin Bicêtre, France, ²University Paris Saclay, Le Kremlin Bicetre, France, ³Institut Gustave Roussy, Villejuif, France, ⁴CEA, Fontenay aux roses, France, ⁵APHP. Université Paris-Saclay, Hôpital Bicêtre, Anatomie et cytologie pathologiques, Paris, France, ⁶Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France
Background/Purpose: Sjögren’s disease (SjD) is a systemic autoimmune disease that manifests as glandular dryness and systemic symptoms. Salivary gland epithelial cells (SGEC) are pivotal in…
Abstract Number: 1423 • ACR Convergence 2024
An Observational Analytical Study on HCV Patients with Sicca Manifestations Before and After Direct-Acting Antivirals in Comparison with Sjogren’s Disease; Infection versus Autoimmunity
Mohamed Tharwat Hegazy¹, Amina Maher², Tareq Algarf², Manar Abdul-Aziz², Osama Ashraf Wafa Mohamed³, Luca Quartuccio⁴, Naguib Zoheir², Salvatore De Vita⁵ and Gaafar Ragab⁶, ¹Faculty of Medicine, Cairo University, Cairo, Egypt, ²Cairo University, Cairo, Egypt, ³Newgiza University, Cairo, Egypt, ⁴Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, ⁵Udine University, Udine, Italy, ⁶Cairo University, Egypt, Cairo, Egypt
Background/Purpose: Hepatitis C virus (HCV) is often associated with autoimmune features and extra-hepatic manifestations. Sicca symptoms are reported in about 30% of the cases. Both…
Abstract Number: 1961 • ACR Convergence 2024
Salivary and Lacrimal Glands Ultrasonography in Systemic Lupus Erythematosus Patients
Mohammadrafi Damirchi¹, Nafiseh Abdolahi², Fatemeh Hosseini³, Mohadeseh Mohammadi³, Mina Khosravi⁴, Zahra Niakan¹ and Siavash Abbasi³, ¹Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Gorgan, Iran, ²Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Melbourne, Australia, ³Department of Radiology, Golestan University of Medical Sciences, Gorgan, Iran, Gorgan, Iran, ⁴Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran, Tehran, Iran
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition that can manifest in various ways, such as oral and eye-related symptoms, which may overlap…
Abstract Number: 2301 • ACR Convergence 2024
The Added Value of anti-Ro52 Antibody Titer in the Diagnosis of Sjögren’s Disease
Silvia Fonzetti¹, Caterina Porciani², Valentina Donati³, Davide Testa⁴, Giovanni Fulvio¹, Gaetano La Rocca¹, Inmaculada Conception Navarro García¹, Francesco Ferro⁵, Marta Mosca¹, Paola Migliorini⁶ and Chiara Baldini¹, ¹University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, ²University of Pisa, Department of Clinical and Experimental Medicine - Immmunology and Allergology Unit, Pisa, Italy, ³Azienda Ospedaliero-Universitaria Pisana, Unit of Pathological Anatomy 2, Pisa, Italy, ⁴Immunology Unit, University of Pisa, Pisa, ⁵Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, ⁶Immunology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Isolated anti-Ro52 antibodies (anti-Ro52) influence the ACR/EULAR 2016 classification criteria of Sjögren’s Disease (SD), meaning that patients with isolated anti-Ro52 positivity and abnormal salivary…
Abstract Number: 2631 • ACR Convergence 2024
Risk of Atherosclerotic Cardiovascular Events and Venous Thromboembolism in People with Primary Sjögren’s Syndrome: A Danish Cohort Study
Pierre Loiseau¹, Aurélie Mailhac², Pierre Duhaut¹, Henrik Toft Sørensen² and Reimar W Thomsen², ¹Department of Internal Medicine and RECIF, Amiens-Picardie University Hospital, Amiens, France, ²Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: There is evidence of an increased risk of cardiovascular disease in several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In primary…
Abstract Number: 1408 • ACR Convergence 2024
Color Doppler Ultrasound Is a Reliable Method for Imaging the Lacrimal Glands in Patients with Suspected Sjögren’s Disease
Ting Yang¹, Neils Sluijpers¹, Jolien van Nimwegen¹, Alja Stel¹, Adriaan Coumou¹, Frans Kroese², Hendrika Bootsma³, Konstantina Delli¹ and Sarah Pringle², ¹UMCG, Groningen, Netherlands, ²University Medical Center Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands
Background/Purpose: As a widely available, non-invasive and repeatable technique, ultrasound has already been used for the examination of irregularities of the major salivary glands. However,…
Abstract Number: 1424 • ACR Convergence 2024
Associations of Human Leukocyte Antigens (HLA) Class II with Interstitial Lung Disease (ILD) in Patients with Systemic Autoimmune Rheumatic Diseases (SARDs). A Prospective Study in Sequential Patients with SARD-ILD
Panagiotis Panagopoulos¹, Loukas chatzis², Vasiliki Kitsiou³, Katerina Tarassi³, Eirini Chatzinikita⁴, Katerina Malagari⁵, Theodoros Vassilakopoulos⁴, Alexandra Tsirogianni³, Andreas Goules⁶ and Athanasios Tzioufas⁷, ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ²Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, ³Immunology and Histocompatibility Department, Evangelismos General Hospital, Athens, Greece, ⁴Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁵2nd Department of Radiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁶GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, ⁷LAIKO HOSPITAL, Athens, Greece
Background/Purpose: Genetic studies in various systemic autoimmune rheumatic diseases (SARDs) support that human leukocyte antigen (HLA) class II alleles are associated with specific autoimmune disorders…
Abstract Number: 1972 • ACR Convergence 2024
Quantifying Sjogren’s Disease Burden: UHFUS Evaluation of the Number and Severity of Involved Exocrine Gland
Giovanni Fulvio¹, Rossana Izzetti², Valentina Donati³, Caterina Porciani⁴, Silvia Fonzetti¹, Gaetano La Rocca¹, Inmaculada Conception Navarro García¹, Francesco Ferro⁵, Chiara Baldini¹ and Marta Mosca¹, ¹University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, ²University of Pisa, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine - Unit of Dentistry and Oral Surgery, Pisa, ³Azienda Ospedaliero-Universitaria Pisana, Unit of Pathological Anatomy 2, Pisa, Italy, ⁴University of Pisa, Department of Clinical and Experimental Medicine - Immmunology and Allergology Unit, Pisa, Italy, ⁵Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy
Background/Purpose: Ultra-high frequency ultrasound (UHFUS) has emerged as a promising tool for evaluating small superficial exocrine glands including lachrymal (LGs) and labial salivary glands (LSGs)…
Abstract Number: 2302 • ACR Convergence 2024
A Specific Molecular Profiling of Secreted Rheumatoid Factors in Sjögren’ S Disease Patients with Lymphoma
Jing Jing Wang¹, Bridie Armour¹, Alexander Troelnikov¹, Tim Chataway¹, Veronique LE GUERN², Eric Hachulla³, Alain SARAUX⁴, Claire Larroche⁵, Jacques-Eric Gottenberg⁶, Xavier Mariette⁷ and Gaetane Nocturne⁷, ¹Flinders University, Adeleide, Australia, ²Cochin hospital, Paris, France, ³University of Lille, LILLE, France, ⁴CHU Brest, Brest, France, ⁵Avicenne University Hospital, Avicenne, France, ⁶Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, ⁷Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France
Background/Purpose: Sjogren’s disease (SjD) is characterized by an increased risk of lymphoma (x 10-15 compared to the general population). We and others have previously demonstrated…
Abstract Number: 2632 • ACR Convergence 2024
Genetically-engineered Ro-specific Regulatory T Cells to Treat Primary Sjögren’s Disease
Zhi Feng sherman Lim¹, Yi Tian Ting¹, Fabien Vincent², Maureen Rischmueller³, Eric Morand⁴ and Joshua Ooi¹, ¹Monash University-T Cell Therapies Research Group, Clayton, Victoria, Australia, ²Monash University, Clayton, Victoria, Australia, ³RheumatologySA, Adelaide, Australia, ⁴School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia
Background/Purpose: Autoantigen-specific regulatory T cells (Tregs) are potent, and specific, suppressors of pathogenic autoimmunity, and can be harnessed to treat autoimmune disease. In primary Sjögren’s…

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