ACR Meeting Abstracts

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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 1406 • ACR Convergence 2024

    Development and Functional Characterization of Salivary Gland Organoids to Investigate Sjögren’s Disease

    Negaar Goudarzi1, Loïc Meudec2, Juliette Pascaud2, Fanny Jaulin3, Quentin Pascal4, Thierry Lazure5, Sacha E Silva Saffar2, Xavier Mariette6 and Gaetane Nocturne6, 1University Paris-Saclay, Le Kremlin Bicêtre, France, 2University Paris Saclay, Le Kremlin Bicetre, France, 3Institut Gustave Roussy, Villejuif, France, 4CEA, Fontenay aux roses, France, 5APHP. Université Paris-Saclay, Hôpital Bicêtre, Anatomie et cytologie pathologiques, Paris, France, 6Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France

    Background/Purpose: Sjögren’s disease (SjD) is a systemic autoimmune disease that manifests as glandular dryness and systemic symptoms. Salivary gland epithelial cells (SGEC) are pivotal in…
  • Abstract Number: 1423 • ACR Convergence 2024

    An Observational Analytical Study on HCV Patients with Sicca Manifestations Before and After Direct-Acting Antivirals in Comparison with Sjogren’s Disease; Infection versus Autoimmunity

    Mohamed Tharwat Hegazy1, Amina Maher2, Tareq Algarf2, Manar Abdul-Aziz2, Osama Ashraf Wafa Mohamed3, Luca Quartuccio4, Naguib Zoheir2, Salvatore De Vita5 and Gaafar Ragab6, 1Faculty of Medicine, Cairo University, Cairo, Egypt, 2Cairo University, Cairo, Egypt, 3Newgiza University, Cairo, Egypt, 4Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, 5Udine University, Udine, Italy, 6Cairo University, Egypt, Cairo, Egypt

    Background/Purpose: Hepatitis C virus (HCV) is often associated with autoimmune features and extra-hepatic manifestations. Sicca symptoms are reported in about 30% of the cases. Both…
  • Abstract Number: 1961 • ACR Convergence 2024

    Salivary and Lacrimal Glands Ultrasonography in Systemic Lupus Erythematosus Patients

    Mohammadrafi Damirchi1, Nafiseh Abdolahi2, Fatemeh Hosseini3, Mohadeseh Mohammadi3, Mina Khosravi4, Zahra Niakan1 and Siavash Abbasi3, 1Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Gorgan, Iran, 2Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran, Melbourne, Australia, 3Department of Radiology, Golestan University of Medical Sciences, Gorgan, Iran, Gorgan, Iran, 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran, Tehran, Iran

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition that can manifest in various ways, such as oral and eye-related symptoms, which may overlap…
  • Abstract Number: 2301 • ACR Convergence 2024

    The Added Value of anti-Ro52 Antibody Titer in the Diagnosis of Sjögren’s Disease

    Silvia Fonzetti1, Caterina Porciani2, Valentina Donati3, Davide Testa4, Giovanni Fulvio1, Gaetano La Rocca1, Inmaculada Conception Navarro García1, Francesco Ferro5, Marta Mosca1, Paola Migliorini6 and Chiara Baldini1, 1University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, 2University of Pisa, Department of Clinical and Experimental Medicine - Immmunology and Allergology Unit, Pisa, Italy, 3Azienda Ospedaliero-Universitaria Pisana, Unit of Pathological Anatomy 2, Pisa, Italy, 4Immunology Unit, University of Pisa, Pisa, 5Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 6Immunology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Isolated anti-Ro52 antibodies (anti-Ro52) influence the ACR/EULAR 2016 classification criteria of Sjögren’s Disease (SD), meaning that patients with isolated anti-Ro52 positivity and abnormal salivary…
  • Abstract Number: 2631 • ACR Convergence 2024

    Risk of Atherosclerotic Cardiovascular Events and Venous Thromboembolism in People with Primary Sjögren’s Syndrome: A Danish Cohort Study

    Pierre Loiseau1, Aurélie Mailhac2, Pierre Duhaut1, Henrik Toft Sørensen2 and Reimar W Thomsen2, 1Department of Internal Medicine and RECIF, Amiens-Picardie University Hospital, Amiens, France, 2Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: There is evidence of an increased risk of cardiovascular disease in several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In primary…
  • Abstract Number: 1408 • ACR Convergence 2024

    Color Doppler Ultrasound Is a Reliable Method for Imaging the Lacrimal Glands in Patients with Suspected Sjögren’s Disease

    Ting Yang1, Neils Sluijpers1, Jolien van Nimwegen1, Alja Stel1, Adriaan Coumou1, Frans Kroese2, Hendrika Bootsma3, Konstantina Delli1 and Sarah Pringle2, 1UMCG, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands

    Background/Purpose: As a widely available, non-invasive and repeatable technique, ultrasound has already been used for the examination of irregularities of the major salivary glands. However,…
  • Abstract Number: 1424 • ACR Convergence 2024

    Associations of Human Leukocyte Antigens (HLA) Class II with Interstitial Lung Disease (ILD) in Patients with Systemic Autoimmune Rheumatic Diseases (SARDs). A Prospective Study in Sequential Patients with SARD-ILD

    Panagiotis Panagopoulos1, Loukas chatzis2, Vasiliki Kitsiou3, Katerina Tarassi3, Eirini Chatzinikita4, Katerina Malagari5, Theodoros Vassilakopoulos4, Alexandra Tsirogianni3, Andreas Goules6 and Athanasios Tzioufas7, 1Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 2Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 3Immunology and Histocompatibility Department, Evangelismos General Hospital, Athens, Greece, 4Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 52nd Department of Radiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 6GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 7LAIKO HOSPITAL, Athens, Greece

    Background/Purpose: Genetic studies in various systemic autoimmune rheumatic diseases (SARDs) support that human leukocyte antigen (HLA) class II alleles are associated with specific autoimmune disorders…
  • Abstract Number: 1972 • ACR Convergence 2024

    Quantifying Sjogren’s Disease Burden: UHFUS Evaluation of the Number and Severity of Involved Exocrine Gland

    Giovanni Fulvio1, Rossana Izzetti2, Valentina Donati3, Caterina Porciani4, Silvia Fonzetti1, Gaetano La Rocca1, Inmaculada Conception Navarro García1, Francesco Ferro5, Chiara Baldini1 and Marta Mosca1, 1University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, 2University of Pisa, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine - Unit of Dentistry and Oral Surgery, Pisa, 3Azienda Ospedaliero-Universitaria Pisana, Unit of Pathological Anatomy 2, Pisa, Italy, 4University of Pisa, Department of Clinical and Experimental Medicine - Immmunology and Allergology Unit, Pisa, Italy, 5Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy

    Background/Purpose: Ultra-high frequency ultrasound (UHFUS) has emerged as a promising tool for evaluating small superficial exocrine glands including lachrymal (LGs) and labial salivary glands (LSGs)…
  • Abstract Number: 2302 • ACR Convergence 2024

    A Specific Molecular Profiling of Secreted Rheumatoid Factors in Sjögren’ S Disease Patients with Lymphoma

    Jing Jing Wang1, Bridie Armour1, Alexander Troelnikov1, Tim Chataway1, Veronique LE GUERN2, Eric Hachulla3, Alain SARAUX4, Claire Larroche5, Jacques-Eric Gottenberg6, Xavier Mariette7 and Gaetane Nocturne7, 1Flinders University, Adeleide, Australia, 2Cochin hospital, Paris, France, 3University of Lille, LILLE, France, 4CHU Brest, Brest, France, 5Avicenne University Hospital, Avicenne, France, 6Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 7Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France

    Background/Purpose: Sjogren’s disease (SjD) is characterized by an increased risk of lymphoma (x 10-15 compared to the general population). We and others have previously demonstrated…
  • Abstract Number: 2632 • ACR Convergence 2024

    Genetically-engineered Ro-specific Regulatory T Cells to Treat Primary Sjögren’s Disease

    Zhi Feng sherman Lim1, Yi Tian Ting1, Fabien Vincent2, Maureen Rischmueller3, Eric Morand4 and Joshua Ooi1, 1Monash University-T Cell Therapies Research Group, Clayton, Victoria, Australia, 2Monash University, Clayton, Victoria, Australia, 3RheumatologySA, Adelaide, Australia, 4School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia

    Background/Purpose: Autoantigen-specific regulatory T cells (Tregs) are potent, and specific, suppressors of pathogenic autoimmunity, and can be harnessed to treat autoimmune disease. In primary Sjögren’s…
  • Abstract Number: 1409 • ACR Convergence 2024

    Salivary Organoids Contain More Diverse Epithelial and Less Mesenchymal Cells Than Adherent Cultures: Choose Your Sjögren’s Disease Research Tool Carefully

    Ting Yang1, Abel Soto Gamez1, Janneke Terpstra1, Hendrika Bootsma2, Arjan Vissink1, Frans Kroese3 and Sarah Pringle3, 1UMCG, Groningen, Netherlands, 2Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 3University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: The majority of the critical pieces of work probing the involvement of the salivary gland (SG) epithelium in Sjogren’s Disease (SjD) employ salivary gland…
  • Abstract Number: 1425 • ACR Convergence 2024

    Sjögren’s Syndrome and Interstitial Lung Disease: Experience in a Collaborative Rheumatology-Pulmonology Clinic

    Sonia Jiménez Barrios1, Sandra Garrote Corral2, Juan Rigual3, Carlos de La Puente Bujidos3, Maria Angeles Blazquez Canamero4 and Jesús Loarce3, 1Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain, 2Hospital Universitario Ramón y Cajal, Madrid, Spain, 3Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 4Hospital Ramon y Cajal, Madrid, Madrid, Spain

    Background/Purpose: Pulmonary lung disease represents the most prevalent extra-glandular manifestation in patients with Sjögren’s syndrome (SS). Notably, interstitial lung disease (ILD) stands out as the…
  • Abstract Number: 2287 • ACR Convergence 2024

    Hydroxychloroquine and the Risk of Lymphoma Progression in Sjogren’s Disease: A Retrospective Case Control Study

    Christine Xue1, Monica Guma2 and Katherine Nguyen2, 1UC San Diego, San Diego, CA, 2UC San Diego, San Diego

    Background/Purpose:  Sjogren's disease is an autoimmune disorder characterized by chronic lymphocytic inflammation of the salivary and lacrimal glands. Affected individuals are at heightened risk of…
  • Abstract Number: 2303 • ACR Convergence 2024

    Type I Interferon Signature Drives Phenotypic Clusters of Sjögren’s Disease and Can Predict Systemic Evolution Among the “B-cell Active with Low Symptoms” Subgroup

    Yann Nguyen1, Maxime Beydon2, Jacques-Eric Gottenberg3, Jacques MOREL4, Aleth Perdringer5, Emmanuelle Dernis6, Valerie Devauchelle7, Damien Sène8, Philippe Dieudé9, Marion couderc10, Anne-Laure Fauchais11, Claire Larroche12, Olivier Vittecoq13, Carine salliot14, Eric Hachulla15, Véronique Le Guern16, Xavier Mariette17, Raphaele Seror18 and Gaetane Nocturne17, 1Université Paris Saclay, Clichy, Ile-de-France, France, 2Université Paris Saclay, Kremlin Bicetre, 3Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 4CHU and University of Montpellier, Montpellier, France, 5CHU Rennes Univ Rennes, Rennes, France., Rennes, 6CH LE MANS, LE MANS, Pays de la Loire, France, 7UBO, Brest, France, 8Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, Ile-de-France, France, 9Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, 10CHU de Clermont-Ferrand, Clermont-Ferrand, 11University Hospital of Limoges, Limoges, 12Avicenne University Hospital, Avicenne, France, 13CHU and University of Rouen, Rouen, France, 14Department of Rheumatology, Centre Hospitalier Régional d'Orléans, Orléans, France., Orléans, 15Department of Internal Medicine and clinical immunology, North-West National Reference Center for Rare Systemic Autoimmune Diseases iques et Auto-Immunes Rares du Nord-Ouest, Hôpital Claude Huriez, Université de Lille, France, Lille, France, 16APHP, Hôpital Cochin, Paris, 17Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, 18Service de Rhumatologie, Hôpital Bicêtre, AP-HP, le Kremlin Bicetre, Ile-de-France, France

    Background/Purpose: Sjögren’s disease (SjD) is a heterogenous autoimmune disease, with a wide range of symptoms, from dryness, fatigue, pain, to systemic manifestations, and an increased…
  • Abstract Number: 2633 • ACR Convergence 2024

    Multicenter Validation of a Machine Learning Foundation Model to Diagnose Sjögren’s Disease and Identify Histological Biomarkers for Disease Stratification

    Julien Duquesne1, Charlotte Claye1, Louis Basseto1, Michael Barnes2, Elena Pontarini3, Amaya Syed2, Michele Bombardieri4, Benjamin A. Fisher5, SABA NAYAR5, Andreas Goules6, Athanasios Tzioufas7, Loukas chatzis8, Wan Fai Ng9, Bec Scane10, Matilde Bandeira11, Vasco C. Romão12, Thierry Lazure13, Clovis Adam14, Xavier Mariette15, Samuel Bitoun16 and Vincent Bouget17, and NECESSITY Consortium, 1Scienta Lab, Paris, France, 2William Harvey Research institute, Centre for Translational Bioinformatics, London, United Kingdom, 3William Harvey Research Institute, London, United Kingdom, 4Centre for Experimental Medicine and Rheumatology, The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 5University of Birmingham, Birmingham, United Kingdom, 6GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 7LAIKO HOSPITAL, Athens, Greece, 8Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 9Department of Rheumatology, Newcastle University, & HRB Clinical Research Facility, University College Cork, Newcastle upon Tyne, United Kingdom, 10Department of Rheumatology, Newcastle University, Athens, Greece, 11Centro Hospitalar Universitario Lisboa Norte, Lisboa, Portugal, 12Rheumatology Department, ULS Santa Maria & Rheumatology Research Unit, Instituto Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, 13APHP. Université Paris-Saclay, Hôpital Bicêtre, Anatomie et cytologie pathologiques, Paris, France, 14APHP. Université Paris-Saclay, Hôpital Bicêtre, Laboratoire de neuropathologie, Paris, France, 15Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, 16Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicetre, France, 17Scienta Lab, Gif-sur-Yvette, France

    Background/Purpose: Sjögren’s Disease (SjD) classification relies on the EULAR/ACR 2016 criteria: i) quantifying lymphocyte infiltration in labial salivary gland (LSG) biopsies, ii) autoantibody status and…
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