ACR Meeting Abstracts

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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 1048 • ACR Convergence 2024

    Self-Perception of Oral Health and Habits in Patients with Sjögren’s Syndrome, Rheumatoid Arthritis, and Systemic Lupus Erythematosus

    Karina Palomo-Arnaud1, Gabriel Figueroa-Parra2, Angel Kevin Garza-Elizondo1, Margarita Isabel Alarcon Jarquin3, Jesus Cardenas-de la Garza4, Dionicio Galarza-Delgado5 and Janett Riega Torres2, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico, 2Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 3Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, 4Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 5UANL Hospital Universitario, Monterrey, Nuevo León, Mexico

    Background/Purpose: Oral manifestations, especially periodontitis and tooth loss, are highly prevalent in patients with rheumatic diseases. Sjogren’s syndrome (SS), rheumatoid arthritis (RA), and systemic lupus…
  • Abstract Number: 1419 • ACR Convergence 2024

    Antiphospholipid Antibodies and Hypercoagulable Events in Patients with Sjogren’s Syndrome

    Katelyn Kaufman1 and Schartess Culpepper Pace2, 1University of Miami Holy Cross Hospital, Fort Lauderdale, FL, 2University of Miami, Pembroke Pines, FL

    Background/Purpose: The association between antiphospholipid antibodies (aPL) and autoimmune processes, such as systemic lupus erythematosus (SLE) is well documented, however, there are limited data on…
  • Abstract Number: 1861 • ACR Convergence 2024

    CD8T Cells Depletion Promotes Human Tph/Tfh Cells Proliferation and Sjogren Syndrome Like Symptoms Without Graft versus Host Diseases in PBMC Transferred-humanized Mice

    Yuzo Koda1, Piruzyan Mariam1, Sota Fujimori1, Ryota Sato2 and Sayuka Kato1, 1Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 2Mitsubishi Tanabe Pharma Corporation, Brighton, MA

    Background/Purpose: Peripheral helper T (Tph) and follicular helper T (Tfh) cells are known to play a central role in the interaction between T and B…
  • Abstract Number: 2297 • ACR Convergence 2024

    Mortality and Its Predictor Variables in Patients with Sjögren Disease: Data from SjögrenSER-Pros Prospective Registry

    Olga Rusinovich1, Zulema Plaza2, Mónica Fernández Castro3, José Rosas-Gómez de Salazar4, Victor Manuel Martinez Taboada5, Alejandro Olive6, Raúl Menor Almagro7, Belen Serrano Benavente8, Judit Font Urgelles9, Angel Garcia-Aparicio10, Sara Manrique-Arija11, Jesus A García-Vadillo12, Ruth Lopez Gonzalez13, Javier Narvaez-García14, Maria Beatriz Rodriguez15, Carlos Galisteo16, Jorge Gonzalez Martin17, Paloma Vela-Casasempere18, Cristina Bohorquez19, MARIA CELIA ERAUSQUIN ARRUABARRENA20, MARIA BEATRIZ PAREDES ROMERO21, ELENA Aurrecoechea22, Sheila Melchor Diaz23, José María Pego-Reigosa24, Sergi Heredia Martin25, Clara Moriano26, Maria Angeles Blazquez Canamero27, Paula Estrada-Alarcón28, enrique Judez29, Joaquin María Belzunegui:30, Consuelo Ramos31, Marta de la Puerta32, Fernando Sánchez-Alonso33 and Jose Luis Andreu34, 1Hospital Universitario Puerta de Hierro Majadahonda., Boadilla del Monte, Spain, 2Fundacion Española de Reumatología, Madrid, Spain, 3Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain, 4Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, 5Facultad de Medicina. Universidad de Cantabria, Santander, Cantabria, Spain, 6Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain, 7Department of Rheumatology, Hospital Jerez de la Frontera, Jerez de la Frontera, Spain, 8Hospital Gregorio Marañón, Madrid, Madrid, Spain, 9Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10Hospital Universitario de Toledo, Toledo, Spain, 11Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 12H La Princesa, Madrid, Spain, 13Complejo Hospitalario de Zamora, Zamora, Castilla y Leon, Spain, 14Hospital Universitario de Bellvitge, Barcelona, Spain, 15H Universitario de Canarias, La Laguna- Tenerife, Canarias, Spain, 16Hospital Universitario Parc Taulí, Sabadell, Spain, 17H Madrid Norte SanChinarro, Madrid, Spain, 18Hospital General Universitario Alicante, Alicante, Spain, 19Hospital Universitario Príncipe de Asturias, Alcalá De Henares, Madrid, Spain, 20Gob Canarias, Tenerife, Canarias, Spain, 21H Infanta Sofia, Madrid, Spain, 22HOSPITAL SIERRALLANA, CANTABRIA, Spain, 2312 de Octubre University Hospital, Madrid, Spain, 24Galicia Health Service (SERGAS), Vigo, Spain, 25Hospital de L’Hospitalet, Barcelona, Spain, 26Hospital León, LEON, Spain, 27Hospital Ramon y Cajal, Madrid, Madrid, Spain, 28Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 29H de Albacete, Albacete, Spain, 30H de Donostia, Donostia-San Sebasti, Spain, 31Hospital Universitario Virgen de Valme, Sevilla, Spain, 32Spanish Society of Rheumatology, Madrid, Spain, 33Sociedad Española de Reumatología, Madrid, Spain, 34Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain

    Background/Purpose: It remains debated if patients with Sjögren´s disease (SjD) have a greater mortality risk. The objective of our study was to determine the magnitude…
  • Abstract Number: 2530 • ACR Convergence 2024

    Single-cell Multi-omics Analysis of Reactive Lymph Nodes, Affected Tissues, and Blood Reveals a Naive-like CD4+TRAIL+ T Cell Population That Differentially Directs Effector Anti-nuclear Antigen Reactive Responses in Patients with Sjogren’s Syndrome and Systemic Sclerosis

    Theodoros Ioannis Papadimitriou1, Prashant Singh2, Arjan van Caam3, Madelon Vonk4, Irene E. van der Horst-Bruinsma5, Peter van der kraan3, Erik Aarntzen6, Martijn Huijnen7, Hans Koenen8 and Rogier Thurlings1, 1Radboudumc, Department of Rheumatology, Nijmegen, Gelderland, Netherlands, 2Radboudumc, Department of Medical BioSciences, Nijmegen, Netherlands, 3Radboudumc, Department of Rheumatology, Nijmegen, Netherlands, 4Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, 6Radboudumc, Department of Medical Imaging, Nijmegen, Netherlands, 7Radboudumc, Department of Medical BioSciences, Nijmegen, Gelderland, Netherlands, 8Radboudumc, Department of Medical Immunology, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Recognition of self-peptides by autoreactive CD4+ T-cells is central to the disruption of immune tolerance. Although systemic autoimmune diseases such as Sjogren’s syndrome (SjS)…
  • Abstract Number: 1130 • ACR Convergence 2024

    Safety of Bispecific T-cell Engager Therapy in Autoimmune Disease

    Melanie Hagen1, Laura Bucci1, Sebastian Boeltz2, Danae-Mona Noethling2, Tobias Rothe2, Maria Gabriella Raimondo1, Carlo Tur1, Andreas Wirsching1, Jochen Wacker1, Aline Bozec1, Georg Schett3 and Ricardo Grieshaber-Bouyer1, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 3Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: B-cells and plasma cells are key drivers of systemic autoimmune diseases (AID). Recent data demonstrated preliminary safety and efficacy of using the CD3xCD19 bispecific…
  • Abstract Number: 1420 • ACR Convergence 2024

    Alignment Between Rheumatology and Neurology of Nomenclature for Peripheral Nervous System Neuropathies

    Ghaith Noaiseh1, George Sarka2, Anahita Deboo3, Arun Varadhachary4, Robert Fox5, Matthew Baker6, Stamatina Danielides7, Eduardo de Sousa8, Julie Frantsve Hawley9, Brent Goodman10, Katherine Hammitt9, Jennifer King11, Steven Mandel12, Pantelis Pavlakis13, Daniel Wallace14, Robert Hal Scofield15, Nancy Carteron16 and Steven Carsons17, 1University of Kansas Medical Center, Kansas City, KS, 2UCLA, Laguna Hills, CA, 3Temple University, Philadelphia, 4Washington University in St. Louis, St. Louis, MO, 5Rheumatology Clinic, San Diego, CA, 6Stanford University, Menlo Park, CA, 7Vcu, Glen Allen, VA, 8Mercy, Moore, OK, 9Sjogren's Foundation, Reston, VA, 10Mayo Clinic, Scottsdale, AZ, 11UCLA, Los Angeles, CA, 12Hofstra, Hempstead, 13Hospital for Special Surgery, New York, NY, 14Cedars Sinai Medical Center, Studio City, CA, 15Oklahoma Medical Research Foundation, Oklahoma City, OK, 16University of California, Berkeley & San Francisco, Angwin, CA, 17NYU Long Island School of Medicine, Mineola, NY

    Background/Purpose: The Sjögren’s Foundation Clinical Practice Guidelines for Peripheral Nervous System (PNS) diagnosis, management and treatment in Sjögren’s brought to the fore a major issue…
  • Abstract Number: 1866 • ACR Convergence 2024

    Identification of Sjögren’s Disease-Associated CD4+ T Cell Receptor (TCR) Motifs and Repertoire Landscape Through TCR Deep Sequencing

    Ananth Aditya Jupudi1, Michelle L. Joachims2, Christina Lawrence2, Charmaine Lopez-Davis2, Bhuwan Khatri2, Astrid Rasmussen2, Kiely Grundahl2, Robert Hal Scofield2, Judith James2, Joel Guthridge2, Christopher Lessard2, Linda F. Thompson2 and A. Darise Farris2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjögren’s disease (SjD) is a chronic rheumatic autoimmune disorder characterized by focal lymphocytic infiltration of the lacrimal and salivary glands (SG). CD4+ T cells…
  • Abstract Number: 2298 • ACR Convergence 2024

    Fibroblast-driven Ttek Activation May Drive Acinar Cell Dysfunction in Sjögren’s Disease, Prior to Lymphocytic Infiltration

    Ting Yang1, Rick Wilbrink1, Janneke Terpstra1, Silvia Liefers2, Arjan Vissink1, Fred Spijkervet1, Hendrika Bootsma3, Frans Kroese4 and Sarah Pringle4, 1UMCG, Groningen, Netherlands, 2University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Lymphocytic infiltration of the salivary glands (SGs) represents one hallmark of the autoimmune conditions Sjögren’s Disease (SjD). It is becoming apparent however that loss…
  • Abstract Number: 2537 • ACR Convergence 2024

    Sjögren’s Disease and Non-Sjögren’s Sicca Patient Subsets Exhibit Cell Type-specific Transcriptional Dysregulations That May Identify Early Molecular Predictors of Disease Transition

    James Li1, Chuang Li2, Bhuwan Khatri2, Anna Stolarczyk2, Kandice Tessneer2, Astrid Rasmussen2, Joel Guthridge2, Judith James2, Robert Hal Scofield2, He Li3, A. Darise Farris2, Kathy Sivils4 and Christopher Lessard2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 4Johnson & Johnson Innovative Medicine, Edmond, OK

    Background/Purpose: Sjögren's disease (SjD) is an autoimmune disorder characterized by inflammatory destruction of the exocrine glands. SjD heterogeneity has been described through the presence or…
  • Abstract Number: 1247 • ACR Convergence 2024

    Pre- and Post-Diagnosis Comparison of the Patient Experience of Sjögren’s Syndrome (SS): A Linguistic Analysis of Global Social Media Conversations

    Sarah N. Ali1, Dorothee Oberdhan1, Michelle M. Richardson1, Jordan Amorelli2, Amanda Martini2 and Jennifer Dandy2, 1Otsuka Pharmaceutical Development and Commercialization, Inc., Princeton, NJ, 2Real Chemistry, New York, NY

    Background/Purpose: Patients with Sjögren’s Syndrome (SS) often undergo a prolonged and complex path to diagnosis and experience symptom, disease and treatment burdens with multiple co-morbid…
  • Abstract Number: 1421 • ACR Convergence 2024

    Differential Impact of B-cell Targeted Monotherapy and Combination Regimen on the Peripheral Blood Transcriptome of Adults with Active Sjögren Disease

    Coziana Ciurtin1, Lucia Martin-Gutierrez1, John Casement2, Kyle Thompson3, Fai Ng4, Andre van Maurik5 and Elizabeth Jury1, 1University College London, London, United Kingdom, 2Newcastle University, Newcastle, United Kingdom, 3Newcastle University, Newcastle, England, United Kingdom, 4Newcastle University, Newcastle upon Tyne, England, United Kingdom, 5Precision Medicine, GlaxoSmithKline, Stevenage, United Kingdom

    Background/Purpose: Sjögren disease (SD) is characterised by B-cell hyperactivity associated with increased levels of B-lymphocyte stimulator (BlyS), but there are no effective biologic treatments for…
  • Abstract Number: 1889 • ACR Convergence 2024

    Prevalence of Physician-Diagnosed versus Clinically Confirmed Primary Sjögren’s Syndrome (SS) Among Adults in the United States

    Cynthia J. Willey1, Sarah N. Ali2 and Rieke Alten3, 1College of Pharmacy, University of Rhode Island, Kingston, RI, 2Otsuka Pharmaceutical Development and Commercialization, Inc., Princeton, NJ, 3Schlosspark Klinik, University Medicine Berlin, Berlin, Germany

    Background/Purpose: Sjögren’s Syndrome (SS) is a systemic autoimmune disorder characterized by inflammation of salivary and lachrymal glands. The clinical spectrum is variable as slow progressive…
  • Abstract Number: 2299 • ACR Convergence 2024

    Clinical and Serological Characteristics of Sjögren’s Disease-related Lymphocytic Interstitial Pneumonia: A Large Multicenter Study

    Gaetano La Rocca1, Francesco Ferro2, Marco Sebastiani3, Andreina Manfredi4, Caterina Vacchi5, Elena Bartoloni Bocci6, Martina Nicchi7, Fabiola Atzeni8, Francesca Cracò9, Serena Guiducci10, Laura Cometi11, Luca Quartuccio12, Elena Treppo12, Valeria manfrè13, Marta Mosca1 and Chiara Baldini1, and Italian Study group on Lung iNvolvement in rheumatic Diseases (ISLaND), 1University of Pisa, Department of Clinical and Experimental Medicine - Rheumatology Unit, Pisa, Italy, 2Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 3Rheumatology Unit, Azienda USL of Piacenza and University of Parma, Parma, Italy, 4University of Modena and Reggio Emilia, Modena, 5University of Modena and Reggio Emilia, Modena, Italy, 6Rheumatology Unit. Department of Medicine, Perugia, Perugia, Italy, 7Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, 8University of Messina, Italy, Messina, Italy, 9University of Messina, Messina, Italy, 10University of Florence, Pistoia, Italy, 11University of Florence, Florence, Italy, 12Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, Udine, Italy, 13University of Udine, Udine

    Background/Purpose: Interstitial Lung Disease (ILD) in patients with Primary Sjögren’s Disease (SjD) is very heterogeneous in terms of pathophysiologic mechanisms, clinical course, radiologic and histologic…
  • Abstract Number: 2629 • ACR Convergence 2024

    Deciphering Salivary Gland Inflammation in Sjögren’s Syndrome Reveals Shared and Autoantibody-Specific Immune Cell Heterogeneity

    Jun Inamo1, Masaru Takeshita2, Katsuya Suzuki2, Kazuyuki Tsunoda2, Satoshi Usuda2, Junko Kuramoto2, Tsutomu Takeuchi3 and Yuko Kaneko4, 1University of Colorado School of Medicine, Aurora, CO, 2Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 3Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 4Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JP, Shinjuku-ku, Tokyo, Japan

    Background/Purpose: Sjögren's syndrome (SS) is an autoimmune disease characterized by progressive immune cell-mediated destruction of the exocrine glands. SS patients have distinct clinical phenotypes based…
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