Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 0306 • ACR Convergence 2021
Allergic Disorders in Primary Sjögren’s Syndrome Compared with Rheumatoid Arthritis
Misako Higashida-Konishi¹, Keisuke Izumi², Tatsuya Shimada³, Satoshi Hama⁴, Mitsuhiro Akiyama⁵, Hisaji Oshima⁴ and Yutaka Okano⁶, ¹Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Meguroku, Japan, ²Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ⁴Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, tokyo, Japan, ⁵Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Palo Alto, CA, ⁶Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Kawasaki, Japan
Background/Purpose: Allergic disorders are occasionally seen in patients with primary Sjögren's syndrome (pSS) [1]. Risk factors are unclear for allergic disorders.We aimed to compare the…
Abstract Number: 0322 • ACR Convergence 2021
Histopathological Changes in Parotid and Labial Salivary Gland Tissue in Primary Sjögren’s Syndrome Patients After Abatacept Treatment
Uzma Nakshbandi¹, Liseth de Wolff², Frans Kroese¹, Silvia Liefers³, Neelanjana Ray⁴, Gwenny Verstappen¹, Fred Spijkervet³, Marleen Nys⁵, Arjan Vissink⁶, Robert Wong⁷, Bert van der vegt³ and Hendrika Bootsma¹, ¹University Medical Center Groningen, Groningen, Netherlands, ²University Medical Centre Groningen, Groningen, Netherlands, ³University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Bristol-Myers Squibb Company, Lawrenceville, GA, ⁵Bristol Myers Squibb, Braine-l'Alleud, Belgium, ⁶University of Groningen, University Medical Center Groningen, Leek, Netherlands, ⁷Bristol Myers Squibb, Basking Ridge, NJ
Background/Purpose: In a previous open-label phase II study, we showed that abatacept treatment might inhibit local formation of autoreactive memory B cells in parotid glands…
Abstract Number: 0307 • ACR Convergence 2021
Cerebellar Ataxia in Primary Sjogren’s Syndrome, Is Gluten Sensitivity the Answer?
Fu Chuen Kon¹, Mohammed Akil², Rachael Kilding², Kar-Ping Kuet², Priya Shanmugarajah³, Nigel Hoggard⁴ and Marios Hadjivassiliou³, ¹Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, ²Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, ³Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Royal Hallamshire Hospital, Sheffield United Kingdom, Sheffield, United Kingdom, ⁴Academic Unit of Radiology, Royal Hallamshire Hospital, Sheffield, United Kingdom
Background/Purpose: Cerebellar ataxia is an uncommon neurological complication of Primary Sjogren’s Syndrome (PSS), with case reports being the highest level of evidence available. The underlying…
Abstract Number: 0323 • ACR Convergence 2021
Ro Positivity Is an Under‐Recognised Poor Prognostic Marker in Systemic Lupus Erythematosus Patients
Katie Liao¹, Thilinie De Silva¹, Julie Bonin², Rachel Koelmeyer² and Alberta Hoi³, ¹Department of Rheumatology, Monash Health, Melbourne, Australia, ²Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia, ³Department of Rheumatology, Monash Health & Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia
Background/Purpose: Antibodies to Ro60 (SSA) or Ro52 (SSB) have been described as one of the defining autoantibodies in Sjogren syndrome but they are also commonly…
Abstract Number: 0308 • ACR Convergence 2021
Sleep Disorders and Serum Brain-derived Neurotrophic Factor Levels in Patients with Primary Sjögren’s Syndrome
Yaxin Han¹, Li Long², Xixi Chen², Qing Peng², GUO TANG³, Jiajun Liu² and Yan Liu², ¹The People's Hospital of Wenjiang,China; Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China；Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), ²Department of Rheumatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), ³Chongqing Bishan People's Hospital, Chongqing, China (People's Republic)
Background/Purpose: This study aimed to evaluate the sleep quality and its influenced factors in patients with primary Sjögren's syndrome (pSS), and another purpose is to…
Abstract Number: 0530 • ACR Convergence 2021
Dysregulation of IGFI/IGF1R Pathway and IGF1R+3179A/G Polymorphism in Pathogenesis of Sjögren’s Syndrome
Charalampos Skarlis¹, Adrianos Nezos², Nikolaos Marketos¹, Asimina Papanikolaou³, Athanasios Tzioufas⁴, Michael Koutsilieris¹, Haralampos Moutsopoulos⁵ and Clio Mavragani¹, ¹National and Kapodistrian University of Athens, Athens, Greece, ²National & Kapodistrian University of Athens, Athens, Greece, ³Department of Haemopathology, "Evangelismos" Hospital, Athens, Greece, Athens, Greece, ⁴Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁵Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece
Background/Purpose: Sjӧgren’s syndrome (SS) is an autoimmune exocrinopathy characterized by chronic salivary and lacrimal gland dysfunction. Alterations of Insulin-like growth factor (IGF) pathway has been…
Abstract Number: 0002 • ACR Convergence 2021
Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-cell Mediated Epithelial Sodium Channel Disruption
Sarah Pringle¹, Bas Berkhof¹, Martha S. van Ginkel², Silvia Liefers¹, Bert van der vegt², Fred Spijkervet², Hendrika Bootsma¹, Arjan Vissink¹ and Frans Kroese¹, ¹University Medical Center Groningen, Groningen, Netherlands, ²University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Patients with Sjögren’s syndrome (SS) suffer from significantly reduced saliva production. Saliva is important for oral health. A careful of sodium, chloride, potassium and…
Abstract Number: 0309 • ACR Convergence 2021
Lymphopenia and Leukopenia in Sjogren Syndrome
Loukas Chatzis¹, Ioanna Stergiou², Vasilis Pezoulas³, Paraskevi Voulgari⁴, Dimitrios Fotiadis⁵, Fotini Skopouli⁶, Haralampos Moutsopoulos⁷, Michael Voulgarelis¹, Athanasios Tzioufas¹ and Andreas Goules², ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ²Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, ³Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Ioannina, Greece, Ioannina, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, ⁵Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece, Ioannina, Greece, ⁶Department of Nutrition and Clinical Dietetics, Harokopio University of Athens, Athens, Greece, ⁷Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece
Background/Purpose: Peripheral lymphopenia and leukopenia in Sjögren’s syndrome (SS) may suggest systemic disease activity and have been proposed as lymphoma predictors. However, the clinical phenotype…
Abstract Number: 0761 • ACR Convergence 2021
Development of a Symptom Diary for Use in Patients with Sjogren’s Syndrome
Briana Ndife¹, Sheri Fenel², Sandy Lewis² and Neetu Agashivala³, ¹Novartis, East Hanover, NJ, ²RTI Health Solutions, Research Triangle Park, NC, ³Novartis Pharmaceutical Corporation, East Hanover, NJ
Background/Purpose: Sjögren’s Syndrome (SS) is a systemic autoimmune disease associated with a wide range of symptoms and long-term complications. While clinical indices are useful in…
Abstract Number: 0005 • ACR Convergence 2021
Maturation and Dysfunction of Autoreactive B Cell Clones in Tissues of Patients with Sjögren’s Syndrome
Mathijs Broeren¹, Giulia Balzaretti², Jing Wang³, Patricia Groenen¹, Barbera van Schaik⁴, Tim Chataway³, Charlotte Kaffa¹, Sander Bervoets¹, Konnie Hebeda¹, Gergana Bounova⁵, Ger Pruijn¹, Tom Gordon³, Niek De Vries⁶ and Rogier Thurlings⁷, ¹Radboud University Medical Center, Nijmegen, Netherlands, ²Amsterdam, Netherlands, ³Flinders University, Adelaide, Australia, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Enpicom BV, Den Bosch, Netherlands, ⁶Amsterdam UMC, Amsterdam, Netherlands, ⁷Radboud University Medical Centre, Nijmegen, Netherlands
Background/Purpose: Sjögren's syndrome (SjS) involves chronic inflammation of exocrine glands that can be complicated by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). We…
Abstract Number: 0310 • ACR Convergence 2021
Histopathology, Salivary Flow and Ultrasonography of the Parotid Gland: Three Complementary Measurements in Primary Sjögren’s Syndrome
Martha S. van Ginkel¹, Esther Mossel², Erlin A. Haacke², Suzanne Arends³, Silvia Liefers¹, Konstantina Delli¹, Jolien F. van Nimwegen⁴, Alja J. Stel⁵, Fred Spijkervet¹, Arjan Vissink⁶, Bert van der vegt¹, Frans Kroese³ and Hendrika Bootsma³, ¹University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²University of Groningen, University Medical Center Groningen, Groningen, ³University Medical Center Groningen, Groningen, Netherlands, ⁴Univeristy of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, ⁶University of Groningen, University Medical Center Groningen, Leek, Netherlands
Background/Purpose: Primary Sjögren’s syndrome is a systemic autoimmune disease characterized by dryness of the mouth and eyes. The impact of the disease on salivary glands…
Abstract Number: 0839 • ACR Convergence 2021
Comparative Treatment Effectiveness in Rheumatoid Arthritis with and Without Concomitant Sjögren’s Syndrome – Results from the Swiss Clinical Quality Management Cohort
Lisa Christ¹, Seraphina Kissling², Ruediger B. Mueller³, Axel Finckh⁴, Benjamin Fisher⁵, Britta Maurer¹, Burkhard Moeller⁶ and Florian Kollert¹, ¹Department of Rheumatology and Immunology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland, ²Statistics and Data Management Group, Swiss Clinical Quality Management Foundation, Zurich, Switzerland, ³Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Switzerland, ⁴University Hospital of Geneva, Geneve - Vesenaz, Switzerland, ⁵Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁶Inselspital - University Hospital Bern, Bern, Switzerland
Background/Purpose: The variety of treatment options in RA contrasts with a lack of personalized medicine. The presence of concomitant SjS might be associated with differerences…
Abstract Number: 0165 • ACR Convergence 2021
Shear-Wave Elastography Evaluation of Major Salivary Glands and Correlation with B-mode Findings in Patients with Primary Sjögren’s Syndrome
Ana Prata¹, Joao Freitas², Mary Lucy Marques³, Flavio Costa⁴, Mariana Santiago⁵, Sara Serra¹, Margarida Coutinho¹, Tânia Santiago¹, João Pedro Lopes Rovisco¹ and Jose Pereira da Silva⁶, ¹Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ²Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Centro Hospitalar de Vila Nova de Gaia/Espinho, Coimbra, Portugal, ⁵Centro Hospitalar e Universitário de Coimbra, Unknown, Colombia, ⁶University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal
Background/Purpose: Salivary-gland ultrasound has recently shown to help in the diagnosis and monitoring of primary Sjögren’s syndrome (pSS)1. Shear-wave elastography (SWE) is a promising tool…
Abstract Number: 0311 • ACR Convergence 2021
Ultra High‐frequency Ultrasound (UHFUS) of Labial Glands in Primary Sjögren’s Syndrome: Serological and Histological Correlations
Giovanni Fulvio¹, Francesco Ferro¹, Rossana Izzetti², Gianmaria Governato¹, Silvia Fonzetti¹, Gaetano La Rocca¹, Valentina Donati³, Davide Caramella⁴, Marta Mosca⁵ and Chiara Baldini⁶, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²University of Pisa, Unit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Pisa, Italy, ³AOUP, Unit of Pathological Anatomy, Pisa, Italy, ⁴University of Pisa, 3Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, Pisa, Italy, ⁵Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁶University of Pisa, Pisa, Italy
Background/Purpose: Last‐generation ultra high‐frequency ultrasound (UHFUS) transducers are highly sensitive tools potentially able to open new avenues for the identification of imaging biomarkers. Recently UHFUS…
Abstract Number: 0984 • ACR Convergence 2021
Human Papillomavirus Infection Increases Risk of Primary Sjogren’s Syndrome: A Population-based Cohort Study over a 15-year Follow-up
Kevin Sheng-Kai Ma, Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philidelphia, PA
Background/Purpose: Viral infection has been considered as an exogeneous risk factor for primary Sjogren’s syndrome (pSS). We determined whether human papillomavirus (HPV) infection was associated…