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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 0306 • ACR Convergence 2021

    Allergic Disorders in Primary Sjögren’s Syndrome Compared with Rheumatoid Arthritis

    Misako Higashida-Konishi1, Keisuke Izumi2, Tatsuya Shimada3, Satoshi Hama4, Mitsuhiro Akiyama5, Hisaji Oshima4 and Yutaka Okano6, 1Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Meguroku, Japan, 2Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 4Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, tokyo, Japan, 5Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Palo Alto, CA, 6Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Kawasaki, Japan

    Background/Purpose: Allergic disorders are occasionally seen in patients with primary Sjögren's syndrome (pSS) [1]. Risk factors are unclear for allergic disorders.We aimed to compare the…
  • Abstract Number: 0322 • ACR Convergence 2021

    Histopathological Changes in Parotid and Labial Salivary Gland Tissue in Primary Sjögren’s Syndrome Patients After Abatacept Treatment

    Uzma Nakshbandi1, Liseth de Wolff2, Frans Kroese1, Silvia Liefers3, Neelanjana Ray4, Gwenny Verstappen1, Fred Spijkervet3, Marleen Nys5, Arjan Vissink6, Robert Wong7, Bert van der vegt3 and Hendrika Bootsma1, 1University Medical Center Groningen, Groningen, Netherlands, 2University Medical Centre Groningen, Groningen, Netherlands, 3University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Bristol-Myers Squibb Company, Lawrenceville, GA, 5Bristol Myers Squibb, Braine-l'Alleud, Belgium, 6University of Groningen, University Medical Center Groningen, Leek, Netherlands, 7Bristol Myers Squibb, Basking Ridge, NJ

    Background/Purpose: In a previous open-label phase II study, we showed that abatacept treatment might inhibit local formation of autoreactive memory B cells in parotid glands…
  • Abstract Number: 0307 • ACR Convergence 2021

    Cerebellar Ataxia in Primary Sjogren’s Syndrome, Is Gluten Sensitivity the Answer?

    Fu Chuen Kon1, Mohammed Akil2, Rachael Kilding2, Kar-Ping Kuet2, Priya Shanmugarajah3, Nigel Hoggard4 and Marios Hadjivassiliou3, 1Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, 2Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, 3Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Royal Hallamshire Hospital, Sheffield United Kingdom, Sheffield, United Kingdom, 4Academic Unit of Radiology, Royal Hallamshire Hospital, Sheffield, United Kingdom

    Background/Purpose: Cerebellar ataxia is an uncommon neurological complication of Primary Sjogren’s Syndrome (PSS), with case reports being the highest level of evidence available. The underlying…
  • Abstract Number: 0323 • ACR Convergence 2021

    Ro Positivity Is an Under‐Recognised Poor Prognostic Marker in Systemic Lupus Erythematosus Patients

    Katie Liao1, Thilinie De Silva1, Julie Bonin2, Rachel Koelmeyer2 and Alberta Hoi3, 1Department of Rheumatology, Monash Health, Melbourne, Australia, 2Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia, 3Department of Rheumatology, Monash Health & Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia

    Background/Purpose: Antibodies to Ro60 (SSA) or Ro52 (SSB) have been described as one of the defining autoantibodies in Sjogren syndrome but they are also commonly…
  • Abstract Number: 0308 • ACR Convergence 2021

    Sleep Disorders and Serum Brain-derived Neurotrophic Factor Levels in Patients with Primary Sjögren’s Syndrome

    Yaxin Han1, Li Long2, Xixi Chen2, Qing Peng2, GUO TANG3, Jiajun Liu2 and Yan Liu2, 1The People's Hospital of Wenjiang,China; Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China;Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), 2Department of Rheumatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), 3Chongqing Bishan People's Hospital, Chongqing, China (People's Republic)

    Background/Purpose: This study aimed to evaluate the sleep quality and its influenced factors in patients with primary Sjögren's syndrome (pSS), and another purpose is to…
  • Abstract Number: 0530 • ACR Convergence 2021

    Dysregulation of IGFI/IGF1R Pathway and IGF1R+3179A/G Polymorphism in Pathogenesis of Sjögren’s Syndrome

    Charalampos Skarlis1, Adrianos Nezos2, Nikolaos Marketos1, Asimina Papanikolaou3, Athanasios Tzioufas4, Michael Koutsilieris1, Haralampos Moutsopoulos5 and Clio Mavragani1, 1National and Kapodistrian University of Athens, Athens, Greece, 2National & Kapodistrian University of Athens, Athens, Greece, 3Department of Haemopathology, "Evangelismos" Hospital, Athens, Greece, Athens, Greece, 4Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 5Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece

    Background/Purpose: Sjӧgren’s syndrome (SS) is an autoimmune exocrinopathy characterized by chronic salivary and lacrimal gland dysfunction. Alterations of Insulin-like growth factor (IGF) pathway has been…
  • Abstract Number: 0002 • ACR Convergence 2021

    Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-cell Mediated Epithelial Sodium Channel Disruption

    Sarah Pringle1, Bas Berkhof1, Martha S. van Ginkel2, Silvia Liefers1, Bert van der vegt2, Fred Spijkervet2, Hendrika Bootsma1, Arjan Vissink1 and Frans Kroese1, 1University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Patients with Sjögren’s syndrome (SS) suffer from significantly reduced saliva production. Saliva is important for oral health. A careful of sodium, chloride, potassium and…
  • Abstract Number: 0309 • ACR Convergence 2021

    Lymphopenia and Leukopenia in Sjogren Syndrome

    Loukas Chatzis1, Ioanna Stergiou2, Vasilis Pezoulas3, Paraskevi Voulgari4, Dimitrios Fotiadis5, Fotini Skopouli6, Haralampos Moutsopoulos7, Michael Voulgarelis1, Athanasios Tzioufas1 and Andreas Goules2, 1Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 2Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, 3Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Ioannina, Greece, Ioannina, Greece, 4Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, 5Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece, Ioannina, Greece, 6Department of Nutrition and Clinical Dietetics, Harokopio University of Athens, Athens, Greece, 7Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece

    Background/Purpose: Peripheral lymphopenia and leukopenia in Sjögren’s syndrome (SS) may suggest systemic disease activity and have been proposed as lymphoma predictors. However, the clinical phenotype…
  • Abstract Number: 0761 • ACR Convergence 2021

    Development of a Symptom Diary for Use in Patients with Sjogren’s Syndrome

    Briana Ndife1, Sheri Fenel2, Sandy Lewis2 and Neetu Agashivala3, 1Novartis, East Hanover, NJ, 2RTI Health Solutions, Research Triangle Park, NC, 3Novartis Pharmaceutical Corporation, East Hanover, NJ

    Background/Purpose: Sjögren’s Syndrome (SS) is a systemic autoimmune disease associated with a wide range of symptoms and long-term complications. While clinical indices are useful in…
  • Abstract Number: 0005 • ACR Convergence 2021

    Maturation and Dysfunction of Autoreactive B Cell Clones in Tissues of Patients with Sjögren’s Syndrome

    Mathijs Broeren1, Giulia Balzaretti2, Jing Wang3, Patricia Groenen1, Barbera van Schaik4, Tim Chataway3, Charlotte Kaffa1, Sander Bervoets1, Konnie Hebeda1, Gergana Bounova5, Ger Pruijn1, Tom Gordon3, Niek De Vries6 and Rogier Thurlings7, 1Radboud University Medical Center, Nijmegen, Netherlands, 2Amsterdam, Netherlands, 3Flinders University, Adelaide, Australia, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Enpicom BV, Den Bosch, Netherlands, 6Amsterdam UMC, Amsterdam, Netherlands, 7Radboud University Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Sjögren's syndrome (SjS) involves chronic inflammation of exocrine glands that can be complicated by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). We…
  • Abstract Number: 0310 • ACR Convergence 2021

    Histopathology, Salivary Flow and Ultrasonography of the Parotid Gland: Three Complementary Measurements in Primary Sjögren’s Syndrome

    Martha S. van Ginkel1, Esther Mossel2, Erlin A. Haacke2, Suzanne Arends3, Silvia Liefers1, Konstantina Delli1, Jolien F. van Nimwegen4, Alja J. Stel5, Fred Spijkervet1, Arjan Vissink6, Bert van der vegt1, Frans Kroese3 and Hendrika Bootsma3, 1University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Center Groningen, Groningen, 3University Medical Center Groningen, Groningen, Netherlands, 4Univeristy of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, 6University of Groningen, University Medical Center Groningen, Leek, Netherlands

    Background/Purpose: Primary Sjögren’s syndrome is a systemic autoimmune disease characterized by dryness of the mouth and eyes. The impact of the disease on salivary glands…
  • Abstract Number: 0839 • ACR Convergence 2021

    Comparative Treatment Effectiveness in Rheumatoid Arthritis with and Without Concomitant Sjögren’s Syndrome – Results from the Swiss Clinical Quality Management Cohort

    Lisa Christ1, Seraphina Kissling2, Ruediger B. Mueller3, Axel Finckh4, Benjamin Fisher5, Britta Maurer1, Burkhard Moeller6 and Florian Kollert1, 1Department of Rheumatology and Immunology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland, 2Statistics and Data Management Group, Swiss Clinical Quality Management Foundation, Zurich, Switzerland, 3Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Switzerland, 4University Hospital of Geneva, Geneve - Vesenaz, Switzerland, 5Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 6Inselspital - University Hospital Bern, Bern, Switzerland

    Background/Purpose: The variety of treatment options in RA contrasts with a lack of personalized medicine. The presence of concomitant SjS might be associated with differerences…
  • Abstract Number: 0165 • ACR Convergence 2021

    Shear-Wave Elastography Evaluation of Major Salivary Glands and Correlation with B-mode Findings in Patients with Primary Sjögren’s Syndrome

    Ana Prata1, Joao Freitas2, Mary Lucy Marques3, Flavio Costa4, Mariana Santiago5, Sara Serra1, Margarida Coutinho1, Tânia Santiago1, João Pedro Lopes Rovisco1 and Jose Pereira da Silva6, 1Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 2Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal, 3Leiden University Medical Center, Leiden, Netherlands, 4Centro Hospitalar de Vila Nova de Gaia/Espinho, Coimbra, Portugal, 5Centro Hospitalar e Universitário de Coimbra, Unknown, Colombia, 6University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal

    Background/Purpose: Salivary-gland ultrasound has recently shown to help in the diagnosis and monitoring of primary Sjögren’s syndrome (pSS)1. Shear-wave elastography (SWE) is a promising tool…
  • Abstract Number: 0311 • ACR Convergence 2021

    Ultra High‐frequency Ultrasound (UHFUS) of Labial Glands in Primary Sjögren’s Syndrome: Serological and Histological Correlations

    Giovanni Fulvio1, Francesco Ferro1, Rossana Izzetti2, Gianmaria Governato1, Silvia Fonzetti1, Gaetano La Rocca1, Valentina Donati3, Davide Caramella4, Marta Mosca5 and Chiara Baldini6, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2University of Pisa, Unit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Pisa, Italy, 3AOUP, Unit of Pathological Anatomy, Pisa, Italy, 4University of Pisa, 3Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, Pisa, Italy, 5Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 6University of Pisa, Pisa, Italy

    Background/Purpose: Last‐generation ultra high‐frequency ultrasound (UHFUS) transducers are highly sensitive tools potentially able to open new avenues for the identification of imaging biomarkers. Recently UHFUS…
  • Abstract Number: 0984 • ACR Convergence 2021

    Human Papillomavirus Infection Increases Risk of Primary Sjogren’s Syndrome: A Population-based Cohort Study over a 15-year Follow-up

    Kevin Sheng-Kai Ma, Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philidelphia, PA

    Background/Purpose: Viral infection has been considered as an exogeneous risk factor for primary Sjogren’s syndrome (pSS). We determined whether human papillomavirus (HPV) infection was associated…
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