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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: LB11 • ACR Convergence 2025

    Efficacy and Safety of Telitacicept in Patients with Sjögren’s Disease: Results from a Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Clinical Study

    Dong Xu1, Shangzhu Zhang1, Lin Qiao1, Li Zhang1, Wenxiang Wang2, Lin Li2, Binghua Xiao2, Jing Zhang2, Qing Zuraw3, Jianmin Fang2 and Xiaofeng Zeng1, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China (People's Republic), 2RemeGen Co., Ltd., Rheumatology, Yantai, China (People's Republic), 3Vor Biopharma Inc., Boston

    Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune disease whose pathogenesis is associated with aberrant activation of B-lymphocytes. Telitacicept, a novel fusion protein, dually targets and…
  • Abstract Number: 2449 • ACR Convergence 2025

    Patient Characteristics, Treatment and Prognosis in Patients with Neuromyelitis OpticaSpectrum Disorder Coexisting with Systemic Lupus Erythematosus or Sjögren’s Syndrome: An Analysis Using Japanese Inpatient Database

    Hiroshi Shiba1, Mikio Nakajima2, Kaito Nakamura3, Yusuke Sasabuchi4, Hiroyuki Ohbe5, Yuya Kimura6, Tadahiro Goto7, Hiroki Matsui8, Kiyohide Fushimi9 and Hideo Yasunaga5, 1Suwa central hospital, Chino, Japan, 2Emergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Hiroo, Tokyo, Japan, 3Department of Rheumatology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan, 4Department of Real-world Evidence, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, 5Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, 6Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, 7Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Kanagawa, Japan, 8Department of Clinical Epidemiology and Health Economics, School of Public Health, Bunkyo-ku, Tokyo, Japan, 9Department of Health Policy and Informatics, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

    Background/Purpose: Neuromyelitis optica spectrum disorder (NMOSD) can coexist with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Due to overlapping clinical presentations and the rarity…
  • Abstract Number: 2292 • ACR Convergence 2025

    Safety and Humoral Response to Recombinant Herpes Zoster Vaccine in immunosuppressed Sjögren’s Disease Patients: Results From a Double-Blinded Placebo-Controlled Study

    Sandra G Pasoto1, Talita Ribeiro2, Nadia Emi Aikawa3, Ana C Medeiros-Ribeiro1, Bruno Borges2, Andre Franco4, Henrique Silva2, Eloisa Bonfa5 and Clovis Artur Silva6, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, 3Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, São Paulo, Brazil, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Sao Paulo, Brazil, 5Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, 6University of São Paulo, São Paulo, São Paulo, Brazil

    Background/Purpose: Immunosuppressed Sjögren’s disease (SjD) patients are at increased risk of herpes zoster (HZ). Despite this vulnerability, data on safety and immunogenicity of the recombinant…
  • Abstract Number: 1682 • ACR Convergence 2025

    Sjögren’s Disease Salivary Gland Fibroblast Subsets are Proinflammatory and Aberrantly Promote Pain

    Sara McCoy1, Rachael Bogle2, michele larsen3, Li Chen4, thomas pranzatelli5, Paola Perez6, john chiorini7, Alan Baer8, A. Darise Farris9, Christopher Lessard9, Astrid Rasmussen9, Caroline Shiboski10, Stephen Shiboski10, Alexander Mikesell3, Zachary Campbell3, Alex Tsoi2, Johann Gudjonsson11 and Blake M. Warner12, 1University of Wisconsin–Madison, Madison, WI, 2University of Michigan, Holland, OH, 3University of Wisconsin, Madison, 4University of Michigan, Ann Arbor, 5NIH, Bethesda, 6NIDCR, Bethesda, MD, 7NIH, bethesda, MD, 8Johns Hopkins University School of Medicine, Baltimore, MD, 9Oklahoma Medical Research Foundation, Oklahoma City, OK, 10University of California San Francisco, San Francisco, CA, 11University of Michigan, Ann Arbor, MI, 12National Institutes of Health, Bethesda, MD

    Background/Purpose: Fibroblasts (fb) are increasingly recognized as dynamic signaling hubs in rheumatic disease, yet their contribution to Sjögren Disease (SjD) remains poorly defined. We dissect…
  • Abstract Number: 1393 • ACR Convergence 2025

    Prevalence of Sjögren’s Disease in the United States – A Retrospective Cohort Study Among a Commercially Insured Population (2019-2023)

    Minoti Ganguli, Annie Kilby, Ahva Shahabi and Tsu-Chieh Jay Lin, Amgen Inc., Thousand Oaks, CA

    Background/Purpose: Sjögren’s disease (SjD) is a systemic autoimmune condition characterized by diverse clinical manifestations, which often complicates diagnosis and disease management1. Previous epidemiological estimates of…
  • Abstract Number: 1361 • ACR Convergence 2025

    Efficacy of Telitacicept in the treatment of Connective tissue disease-associated interstitial lung disease: A Potential therapeutic option

    Mingfang Sun1, Xue Chen2, Ying Zhou2, Yanlong Yang2, Fei Xiao2 and huanzi dai2, 1Daping Hospital, chongqing, China (People's Republic), 2Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing, PR China., Chongqing, China (People's Republic)

    Background/Purpose: Connective tissue disease-associated interstitial lung disease(CTD-ILD) represents a significant cause of mortality among patients. Presently, research on treatment options for CTD-ILD is limited, with…
  • Abstract Number: 0512 • ACR Convergence 2025

    Dry Eye Disease Severity and Salivary Gland Biopsy in Patients with Primary Sjögren’s Syndrome

    Karina Palomo-Arnaud1, Janett C. Riega-Torres2, Jose Martinez-Delgado3, Fernando Morales-Wong3, Jesus Mohamed-Hamsho3, Valeria Mata-Riega1, Irma Cantu-Zapata1, Luis Medina-Gomez1, Miguel Betancourt-De la Torre1, Aritze Chong-Amezcua1, Dionicio A. Galarza-Delgado4 and Karim Mohamed-Noriega3, 1Hospital Universitario "Dr. José Eleuterio González", Rheumatology, Monterrey, Nuevo León, Monterrey, Nuevo Leon, Mexico, 2Rheumatology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, 3Hospital Universitario "Dr. José Eleuterio González", Ofthalmology, Monterrey, Nuevo León, Monterrey, Nuevo Leon, Mexico, 4Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico

    Background/Purpose: Dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film. This is commonly observed…
  • Abstract Number: 2398 • ACR Convergence 2025

    Analytical performance of the HEp-2 substrate Diagnostic Kit for ANA as an initial step in the evaluation of a novel Fully Automated IFA Analyzer in a laboratory in England

    Jason Sillitoe1, Ewa Fiorentino-Rozek2, Gerber Gomez3, Christian Fischer3 and Caroline Wilson1, 1North East Innovation Lab, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom, 2Clinical Affairs, AliveDx Suisse SA, Eysins, Vaud, Switzerland, 3Scientific & Medical Affairs, AliveDx Suisse SA, Eysins, Switzerland

    Background/Purpose: Indirect immunofluorescence assay (IFA) on HEp-2 cells (HEp-2 IFA) remains a key tool in the diagnostic work-up of autoimmune connective tissue diseases (CTD). Traditionally…
  • Abstract Number: 2291 • ACR Convergence 2025

    Correlation and Concordance Between the Oxford Grading Scale, Ocular Staining Score, and van BijsterveldScore in the diagnosis of Sjögren’s Disease

    Alejandro Gómez Gómez1, Eric Kirkegaard-Biosca2, Sergio H. Martínez Mateu3, Iago Alvarez Saez4, Natalia Boix- Martí5, Antonio Julià1, Jose Luis Andreu6 and Sara Marsal1, 1Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain, 2Hospital Univetsitari Vall d'Hebron, Ophthalmology Department, Barcelona, Spain, 3IMIDomics, Barcelona, Spain, 4Hospital Univetsitari Vall d'Hebron, Maxilofacial Surgery Department, Barcelona, Spain, 5Hospital Univetsitari Vall d'Hebron, Rheumatology Department, Barcelona, Spain, 6Hospital Universitario Puerta de Hierro, Majadahonda, Spain

    Background/Purpose: Sjögren’s Disease (SjD) is a systemic autoimmune disorder marked by mucosal dryness and ocular surface damage. For diagnosis, the ACR-EULAR 2016 criteria require the…
  • Abstract Number: 1680 • ACR Convergence 2025

    Major salivary gland ultrasonographic features of lymphoma and high lymphoproliferative risk lesions in Sjögren’s Disease: a systematic review

    Alen Zabotti1, Valeria Manfrè1, Maria Teresa Rizzo1, Alessia Nano1, Garifallia Sakellariou2 and Luca Quartuccio1, 1Division of Rheumatology, Department of Medicine (DMED), Academic Hospital "Santa Maria della Misericordia", ASUFC, University of Udine, Udine, Italy, Udine, Italy, 2Department of Internal Medicine and Therapeutics, Università Di Pavia, Pavia, Italy; Istituti Clinici Scientifici Maugeri IRCCS Pavia, Pavia, Italy

    Background/Purpose: Sjögren's disease (SjD) is burdened by significant lymphoproliferative risk. Up to date there is no established consensus on the salivary gland ultrasonographic (SGUS) features…
  • Abstract Number: 1392 • ACR Convergence 2025

    Cancer Mortality in Sjogren’s Disease: Disproportionate Increase in Mortality from Cancers in Sjogren’s Disease Relative to All-Cancers

    Margaret Essien and Ram Singh, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Sjögren's disease (SjD), an autoimmune condition with chronic inflammation in exocrine glands, is associated with increased risks of cancers. The impact of cancer on…
  • Abstract Number: 1223 • ACR Convergence 2025

    Pain and Fibromyalgia Across Autoimmune and Inflammatory Diseases in the AMP AIM Cohort

    Alexis Ogdie1, Astrid Rasmussen2, Dana Orange3, Michelle Petri4, Caroline Shiboski5, Rebecca Haberman6, Mala Masson7, Daniel Goldman4, Peter Izmirly8, Brooke Cohen9, Jennifer Seifert10, Jennifer Anolik11, Wade DeJager12, Alan Baer13, Jill Buyon14 and Yvonne Lee15, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3The Rockefeller University, New York, NY, 4Johns Hopkins University School of Medicine, Timonium, MD, 5University of California San Francisco, San Francisco, CA, 6NYU Langone Health, New York, NY, 7NYU Langone Medical Center- Division of Rheumatology, New York, NY, 8New York University Grossman School of Medicine, New York, NY, 9Yale Physician Associate Program, New Haven, CT, 10University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 11University of Rochester Medical Center, Rochester, NY, 12Oklahoma Medical Research Foundation, Oklahoma City, 13Johns Hopkins University School of Medicine, Baltimore, MD, 14NYU Grossman School of Medicine, New York, NY, 15Northwestern University, Chicago, IL

    Background/Purpose: The Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) network seeks to understand the cellular and molecular interactions that lead to inflammation and…
  • Abstract Number: 0511 • ACR Convergence 2025

    Submandibular Gland Ratio Stratifies Salivary Function and Reveals a Senescence Peak in Anti-SSA Positive Sjögren’s Syndrome

    Chiao-Feng Cheng1, Tseng-Cheng Chen2, Min-Shu Hsieh3, TING-YUAN LAN4, Jui-Hung Kao5, Yu Heng Lin6, Mei-Fang Cheng7, Yi-Chieh Chen8, Hsiao-Sang Chu9, Yi-Min Huang10, Cheng-Hsun Lu11, Ko-Jen Li11, Chieh-Yu Shen1 and Song-Chou Hsieh12, 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 2Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 3Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan, Taipei, Taiwan (Republic of China), 4National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan, 5Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, Taipei, Taiwan (Republic of China), 6Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, Taipei, Taiwan (Republic of China), 7Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 8Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 9Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan., Taipei, Taiwan (Republic of China), 10Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 11National Taiwan University Hospital, Taipei, Taiwan, 12National Taiwan Unuversity Hospital, Taipei City, Taiwan (Republic of China)

    Background/Purpose: In primary Sjögren’s syndrome (pSS), the histologic focus score reflects immune infiltration but does not capture irreversible glandular damage. We evaluated a submandibular gland…
  • Abstract Number: 2397 • ACR Convergence 2025

    Analytical Performance of a Fully Automated Multiplexed Microarray Immunoassay for the Simultaneous Detection of Fifteen Autoantibodies Associated with Connective Tissue Diseases in a Reference Laboratory in Southern France

    Guillaume Nardella1, Gerber Gomez2, Christian Fischer2 and Claire Monat1, 1Inovie Labosud Provence, Specialized Autoimmunity Analyses, Marseille, France, 2Scientific & Medical Affairs, AliveDx Suisse SA, Eysins, Switzerland

    Background/Purpose: Autoantibodies are key diagnostic markers in autoimmune connective tissue diseases (CTD). Conventional testing often requires multiple single-measurand assays, which can be labor-intensive and time-consuming.…
  • Abstract Number: 2290 • ACR Convergence 2025

    Patterns and Predictors of Clinical Improvement in Patients with Sjögren’s Disease: A Longitudinal Analysis of ESSDAI and ESSPRI Improvements

    Alejandro Gómez Gómez1, Sergio H. Martínez Mateu2, Jose Luis Tandaipan3, Monica Fernandez Castro4, Guillermo gonzalez5, Sheila Melchor-Díaz6, Miren Uriarte Ecenarro7, Raúl Menor Almagro8, Paloma Vela Casasempere9, Beatriz Paredes-Romero10, Judit Font-Urgelles11, Paula Estrada-Alarcón12, Sara Manrique-Arija13, Mª Angeles Blazquez Cañamero14, Clara Moriano15, Juan José Alegre-Sancho16, Marina Rodríguez López17, Marta López18, Gema Bonilla19, Rafaela Ortega-Castro20, Sara Maria Rojas Herrera21, Ignacio Braña22, Lilian López-Núñez23, Javier Narváez24, Jose Rosas Gómez de Salazar25, Ruben D. López-Sánchez26, Carles Galisteo Veiga27, Javier Martínez-Ferrin28, Jose Javier Pérez Venegas29, Guadalupe Manzano-Canabal30, Cilia Peralta-Ginés31, Lara Sánchez Bilbao32, José Andrés Román Ivorra33, Rafael Cáliz-Cáliz34, Belén Serrano-Benavente35, Sabela Fernández-Aguado36, Natalia Boix- Martí37, Eric Kirkegaard-Biosca38, Iago Alvarez Saez39, Ares Selles-Rius40, Maribel Pérez41, Juan Cañete42, Sara Marsal1 and Jose Luis Andreu43, 1Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain, 2IMIDomics, Barcelona, Spain, 3Rheumatology. Hospital Universitario de la Santa Creu i Sant Pau, Barcelona, Spain, 4PUERTA DE HIERRO HOSPITAL, Madrid, Spain, 5Hospital Universitario de A Coruña, A Coruña, Spain, 6Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Madrid, 7Hospital Universitario La Princesa, Madrid, Spain, 8Department of Rheumatology, Hospital de Jerez, Spain, Puerto De Santa María, Spain, 9Hospital General Universitario Alicante, Alicante, Comunidad Valenciana, Spain, 10Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, San Sebastian de los Reyes, Spain, 11Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 12Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 13Hospital Regional Universitario Málaga, Malaga, Spain, 14Hospital Ramon y Cajal, Madrid, Spain, 15Hospital León, LEON, Castilla y Leon, Spain, 16Hospital Universitario Doctor Peset, Valencia, Spain, 17Complejo Hospitalario Universitario de Santiago, Rheumatology, Santiago de Compostela., Santiago de Compostela, Spain, 18Complex Hospitalari Universitari Moisés Broggi, Barcelona, Spain, 19Hospital Universitario La Paz, Rheumatology, Madrid, Madrid, Spain, 20Rheumatology service/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ Reina Sofia University Hospital/ University of Cordoba, Spain, Cordoba, Andalucia, Spain, 21Hospital de Mérida, Rheumatology, Badajoz, Badajoz, Spain, 22Hospital Universitario Central de Asturias, Oviedo, Spain, 23Hospital Son Llatzer, Rheumatology, Palma de Mallorca, Palma de Mallorca, Spain, 24Hospital Universitario de Bellvitge, Barcelona, Spain, 25Hospital Marina Baixa, PALMA DE MALLORCA, Spain, 26Hospital Universitario de Gran Canaria Dr. Negrín, Gran Canaria, Spain, 27Hospital Parc Taulí, Rheumatology, Sabadell, Sabadell, Spain, 28Hospital Universitario Virgen de la Arrixaca, Rheumatology, Murcia, Murcia, Spain, 29Virgen Macarena University Hospital, Sevilla, Spain, Sevilla, Spain, 30Hospital Virgen de la Concha (Zamora), Zamora, Spain, 31Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 32Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain, 33Hospital Universitari i Politècnic La Fe, Valencia, Spain, 34Hospital Universitario Virgen de las Nieves, Rheumatology, Granada, Granada, Spain, 35Hospital Gregorio Marañon, Madrid, Spain, 36Hospital Universitario de Pontevedra, Pontevedra, Spain, 37Hospital Univetsitari Vall d'Hebron, Rheumatology Department, Barcelona, Spain, 38Hospital Univetsitari Vall d'Hebron, Ophthalmology Department, Barcelona, Spain, 39Hospital Univetsitari Vall d'Hebron, Maxilofacial Surgery Department, Barcelona, Spain, 40Rheumatology Research Group, Vall d'Hebron University Hospital, Barcelona, Spain, 41IMIDomics, Barcelona, Barcelona, Spain, 42Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 43Hospital Universitario Puerta de Hierro, Majadahonda, Spain

    Background/Purpose: Assessing clinical improvements in Sjögren's Disease (SjD) is challenging. Our objective was to describe patterns of improvement in SjD using ESSDAI and ESSPRI indices…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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