ACR Meeting Abstracts

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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 0443 • ACR Convergence 2024

    Significance of anti-Ro52 Antibody in Pregnancy Complicated with Anti-SS-A Antibody Positive Rheumatic Disease Patients

    Hiromi Shimada1, Rina Mino2, taichi miyagi3, Yusuke Ushio4, Koichi Sugihara5, Mao Mizusaki2, Hayamasa yamaguchi2, Naoto Manabe2, Shusaku Nakashima1 and Hiroaki Dobashi1, 1Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, 2Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Japan, 3Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, kidagun, Japan, 4Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, 5Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa Prefecture, Japan

    Background/Purpose: Anti-SS-A antibodies are associated with neonatal lupus erythematosus and congenital heart block (CHB). Ro/SS-A autoantigen is comprised of 52kDa Ro (Ro52) and 60kDa Ro…
  • Abstract Number: 1413 • ACR Convergence 2024

    Pilot Trial of Ustekinumab for Primary Sjogren’s Syndrome

    Ummara Shah1 and Andrea Coca2, 1University of Rochester, Webster, NY, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Sjogren’s Syndrome (SS) is a chronic autoimmune disease characterized by keratoconjunctivitis sicca and xerostomia. Currently there is no approved systemic treatment for primary SS. …
  • Abstract Number: 1429 • ACR Convergence 2024

    Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren’s Disease

    Andre Franco1, Igor Murai2, Thomas Yang2, Valeria Caparbo3, Virginia Bonoldi2, Diogo Domiciano1, Lissiane Guedes2, Sandra Pasoto1, Camille Figueiredo3 and Rosa M R Pereira3, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina da USP, São Paulo, SP, Brazil, 3Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil

    Background/Purpose: Sjögren's disease (SjD) is a chronic multisystem autoimmune condition characterized by sicca syndrome and inflammatory arthralgia, more common in women. Bone involvement can result…
  • Abstract Number: 2291 • ACR Convergence 2024

    The Relationship of the ESSDAI to Health-Related Quality of Life in People Living with Sjogren’s Disease

    Dana DiRenzo1, Chadwick Johr1, Nora Sandorfi1, Sara McCoy2 and Thomas Grader-Beck3, 1University of Pennsylvania, Philadelphia, PA, 2University of Wisconsin, Middleton, WI, 3Johns Hopkins, Baltimore, MD

    Background/Purpose: Historically, Heath Related Quality of Life (HRQL) in Sjogren’s Disease (SjD) has been measured by the EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI), which…
  • Abstract Number: 2307 • ACR Convergence 2024

    Deep Spatial Profiling Unveils Dominant Double Negative B Cells in Severe Forms of Sjögren’s Syndrome

    Loukas chatzis1, Patrice Hemon2, Yvonne Scuiller3, Andreas Goules4, Divi Cornec5, Athanasios Tzioufas6 and Jacques-Olivier Pers3, 1Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 2LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, 3LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, France, 4GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 5Service de Rhumatologie, CHU de Brest, Brest, France, 6LAIKO HOSPITAL, Athens, Greece

    Background/Purpose: Imaging mass cytometry (IMC) is a powerful high throughput technique that enables in-situ multiparametric analysis of a single fixed tissue section while preserving spatial…
  • Abstract Number: 0451 • ACR Convergence 2024

    Macrophages and Interferon Upregulation in Placentas from Patients with Systemic Lupus Erythematosus, Primary Sjögren’s Disease and Antiphospholipid Syndrome

    Juan J. Fierro1, Mirthe Schoots1, Silvia Liefers1, Berber Doornbos-van der Meer2, Gilles Diercks1, Hendrika Bootsma3, Jelmer R. Prins1, Johanna Westra1 and Karina de Leeuw4, 1University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 2University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 4University Medical Center Groningen, Groningen, Groningen, Netherlands

    Background/Purpose: SLE, primary Sjögren’s disease (pSjD) and APS are systemic rheumatic diseases (SRD) that mainly affect women of childbearing age and have been associated with…
  • Abstract Number: 1414 • ACR Convergence 2024

    Evidence-Based Guidelines for Sjögren’s Disease Peripheral Nervous System Manifestations

    Robert Fox1, Anahita Deboo2, Matthew Baker3, Stamatina Danielides4, Eduardo de Sousa5, Julie Frantsve Hawley6, Brent Goodman7, Katherine Hammitt6, Jennifer King8, Matt Makara6, Steven Mandel9, Ghaith Noaiseh10, Pantelis Pavlakis11, George Sarka12, Arun Varadhachary13, Daniel Wallace14, Robert Hal Scofield15, Nancy Carteron16 and Steven Carsons17, 1Rheumatology Clinic, San Diego, CA, 2Temple University, Philadelphia, 3Stanford University, Menlo Park, CA, 4Vcu, Glen Allen, VA, 5Mercy, Moore, OK, 6Sjogren's Foundation, Reston, VA, 7Mayo Clinic, Scottsdale, AZ, 8UCLA, Los Angeles, CA, 9Hofstra, Hempstead, 10University of Kansas Medical Center, Kansas City, KS, 11Hospital for Special Surgery, New York, NY, 12UCLA, Laguna Hills, CA, 13Washington University in St. Louis, St. Louis, MO, 14Cedars Sinai Medical Center, Studio City, CA, 15Oklahoma Medical Research Foundation, Oklahoma City, OK, 16University of California, Berkeley & San Francisco, Angwin, CA, 17NYU Long Island School of Medicine, Mineola, NY

    Background/Purpose: Peripheral Nervous System (PNS) manifestations occur frequently in Sjögren’s disease and can encompass mononeuropathy, polyneuropathy, and autonomic neuropathy. Guidance is needed for rheumatologists, neurologists,…
  • Abstract Number: 1430 • ACR Convergence 2024

    C57BL/6.NOD-Aec1Aec2 Mice Recapitulate Sjögren’s Serology Better Than NOD.B10Sn-H2b Models and JAK Inhibitor Treatment Improves Immunoglobulins and Salivary Gland Inflammation but Not Salivary Flow in Sjögren’s Mice

    Sara McCoy1 and Ilya Gurevic2, 1University of Wisconsin, Middleton, WI, 2University of Wisconsin, Madison

    Background/Purpose: Sjögren’s disease (SjD) is a systemic autoimmune disease in which interferons (IFNs) are believed to play a major role/ JAK inhibitors (JAKinibs) block IFN…
  • Abstract Number: 2292 • ACR Convergence 2024

    Fibroblasts with High Expression of CD74 Promote Lymphocytes Infiltration in Salivary Gland in Sjӧgren’s Disease

    Xinwei zhang1, Yixuan Li1, Hongyan Qian1, Chaoqiong Deng1, Shiju Chen1, Guixiu Shi2 and Yuan Liu1, 1xiamen university, xiamen, China (People's Republic), 2xiamen university, xiamen

    Background/Purpose: Sjӧgren's disease (SjD) is characterized by persistent focal infiltration of B- and T lymphocytes in the exocrine gland, mainly salivary gland. Though it is…
  • Abstract Number: 2308 • ACR Convergence 2024

    Characterization of Damage in a Primary Sjogren’s Syndrome Cohort

    Ana Mafalda Abrantes1, Pedro Gaspar2 and David Isenberg3, 1Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Lisbon, Portugal, 2Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Povoa de Santa Iria, Portugal, 3University College London, London, United Kingdom

    Background/Purpose: Damage is irreversible and represents a permanent loss in organ function. Outcome measures are critical for minimizing and prevent damage acquisition. There are two…
  • Abstract Number: 0777 • ACR Convergence 2024

    Rheumatoid Factor B Cell Clones Proliferate Predominantly as Atypical Memory B Cells in Reactive Cervical Lymph Node Follicles Compared to Extrafollicular Sites in Affected Salivary Glands of SjS Patients

    Theodoros Ioannis Papadimitriou1, Jing Jing Wang2, Xuehui He3, Sidney van der Zade4, Massis Krekorian5, Prashant Singh6, Erik Dik5, Ger Pruijn5, Tom Gordon2, Hans Koenen7, Martijn Huijnen8 and Rogier Thurlings1, 1Radboudumc, Department of Rheumatology, Nijmegen, Gelderland, Netherlands, 2Flinders University, Adeleide, Australia, 3Radboudumc, Nijmegen, Netherlands, 4Radboudumc, Amsterdam, Netherlands, 5Radboudumc, Nijmegen, Gelderland, Netherlands, 6Radboudumc, Department of Medical BioSciences, Nijmegen, Netherlands, 7Radboudumc, Department of Medical Immunology, Nijmegen, Gelderland, Netherlands, 8Radboudumc, Department of Medical BioSciences, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Sjögren’s syndrome (SjS) is a chronic inflammatory disorder, characterized by formation of autoantibodies. Over time rheumatoid factor (RF) clones can give rise to cryoglobulinemic…
  • Abstract Number: 1415 • ACR Convergence 2024

    Metformin Improves Salivary Gland Infiltration and Objective Measures of Dry Eyes in Sjögren’s Disease: A Retrospective Observational Study

    Astrid Rasmussen1, Alan Baer2, Thomas Grader-Beck3, Margaret Beach4, Blake M. Warner5, Christopher Lessard1, A. Darise Farris1 and Robert Hal Scofield1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins, Baltimore, MD, 4NIH/NIDCR, Arlington, VA, 5National Institutes of Health, Bethesda, MD

    Background/Purpose: Metformin (Met) is a widely used, first-line antidiabetic drug with AMPK-dependent anti-inflammatory and immunomodulatory effects. In in vitro studies and human trials in SLE…
  • Abstract Number: 1432 • ACR Convergence 2024

    Diagnostic Performance of Mayor Salivary Gland Ultrasound for Diagnosis of Sjögren’s Syndrome in Routine Clinical Practice

    Carmen Raya-Santos1, José Miguel Senabre2, José Antonio Bernal3, Rocío Gallego Campuzano4, Lara Pons-Canet2, Ana Pons-Bas2, Juan Carlos Cortes4, Gregorio Santos-Soler5 and José Rosas-Gómez de Salazar6, 1Hospital Marina Baixa, Villajoyosa (Alicante), Spain, 2Hospital Marina Baixa, Villajoyosa, Spain, 3Hospital Marina Baixa (Villajoyosa), Alicante, Spain, 4Hospital Marina Baixa, Villajoyosa, Comunidad Valenciana, Spain, 5Hospital Marina Baixa, Villajoyosa, 6Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain

    Background/Purpose: Major salivary glands ultrasound (SGU) is a promising tool in the diagnosis of Sjögren syndrome (SS) and has demonstrated good sensitivity and specificity in…
  • Abstract Number: 2293 • ACR Convergence 2024

    Altered Expression of the MicroRNA Biogenesis Machinery Components Correlates with Inflammatory Parameters in Salivary Glands of Patient with Sjögren’s Disease

    Sergio Aguilera1, Patricia Carvajal2, Isabel Castro2, María-José Barrera3, Sergio González4, Claudio Molina3 and María-Julieta González2, 1Clinica Indisa, Santiago, Chile, 2Universidad de Chile, Santiago, Chile, 3Universidad San Sebastián, Santiago, Chile, 4Universidad Mayor, Santiago, Chile

    Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level (by translational blocking or mRNA degradation). The…
  • Abstract Number: 2309 • ACR Convergence 2024

    Damage Accrual Predicts the Development of Lymphoma in Primary Sjogren’s Syndrome

    Ana Mafalda Abrantes1, Pedro Gaspar2 and David Isenberg3, 1Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Lisbon, Portugal, 2Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Povoa de Santa Iria, Portugal, 3University College London, London, United Kingdom

    Background/Purpose: Primary Sjogren Syndrome (pSS) is an autoimmune disease affecting primarily exocrine glands. Over a quarter of patients have systemic involvement, which includes the development…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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