ACR Meeting Abstracts

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Abstracts tagged "Sjögren’s Syndrome"

  • Abstract Number: 1249 • ACR Convergence 2020

    The Impact of Anti-Ro Antibodies on the Pregnancy Outcome in Relation to Maternal Disease Presentation: A Descriptive Analysis of 231 Pregnancies

    Eman Satti1, Nawal Hadwan1, Hadil Ashour1, Rawan Saleh1, Fiaz Alam1, Omar Alsaed1 and Samar Al Emadi1, 1Hamad medical corporation, DOHA, Qatar

    Background/Purpose: Anti-Ro antibody positivity is linked to adverse fetal outcomes like congenital heart block CHB (2%) and neonatal lupus. The incidence of CHB increases to…
  • Abstract Number: 1954 • ACR Convergence 2020

    Genome-wide Association Study of Sjögren’s Syndrome Identifies Ten New Risk Loci

    Bhuwan Khatri1, Tove Ragna Reksten2, Kandice Tessneer3, Astrid Rasmussen1, R. Scofield1, Simon Bowman4, Joel Guthridge1, Judith James5, Lars Ronnblom6, Blake Warner7, Xavier Mariette8, Roald Omdal9, Javier Martin10, Maria Teruel10, Janicke Liaaen Jensen11, Lara Aqrawi11, Øyvind Palm11, Marie Wahren-Herlenius12, Torsten Witte13, Roland Jonsson14, Maureen Rischmueller15, A Darise Farris1, Marta Alarcon-Riquelme10, Wan-Fai Ng16, Kathy Sivils1, Gunnel Nordmark17 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Bergen, Bergen, Norway, 3Oklahoma Medical Research Foundation, Oklahoma City, 4University Hospitals Birmingham, Birmingham, United Kingdom, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 6Uppsala University, Uppsala, Sweden, 7National Institute of Dental and Craniofacial Research, Bethesda, 8Paris-Sud University, Rueil-Malmaison, France, 9University of Oslo, Stavanger, Norway, 10Center for Genomics and Oncological Research (GENYO), Granada, Spain, 11University of Oslo, Oslo, Norway, 12Karolinska Institute, Stockholm, Sweden, 13Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 14Haukeland University Hospital, Bergen, Norway, 15The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 16Newcastle University, Gateshead, United Kingdom, 17Uppsala University, Copenhagen S, Sweden

    Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity, and 10 published genetic susceptibility loci. Our genome-wide…
  • Abstract Number: 1250 • ACR Convergence 2020

    Early Sjögren Antibodies: Potential Biomarker for Abnormal Minor Labial Salivary Gland Biopsy in Juvenile Sjögren’s Syndrome

    Akaluck Thatayatikom1, Sthorn Thatayatikom1, Indraneel Bhattacharyya2, Melissa Elder1, Renee Modica1 and Seunghee Cha2, 1Department of Pediatrics, University of Florida, Gainesville, FL, 2College of Dentistry, University of Florida, Gainesville, FL

    Background/Purpose: Juvenile Sjögren’s Syndrome (jSS) is a perplexing systemic autoimmune disease in children presenting with positive autoantibodies, glandular, and/ or extraglandular symptoms. In pediatric practice,…
  • Abstract Number: 1956 • ACR Convergence 2020

    Dysregulated Expression of the Long Non-coding RNA, LINC01871, Implicated in Sjögren’s Syndrome Pathogenesis

    Michelle Joachims1, Bhuwan Khatri1, Kandice Tessneer2, Anna Stolarczyk1, Graham Wiley1, Astrid Rasmussen1, Joel Guthridge1, Judith James3, R. Scofield1, Kathy Sivils1, Indra Adrianto4 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 4Henry Ford Health System, Detroit, MI

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammatory destruction of the exocrine glands. Long non-coding RNAs (lncRNAs) are a functionally diverse class…
  • Abstract Number: 1251 • ACR Convergence 2020

    Assessing the Construct Validity of the Novel OMERACT Ultrasound Scoring System for Salivary Glands Target Lesions by Comparison with MRI in Patients with Sjögren’s Syndrome – An OMERACT Ultrasound Working Group Exercise

    Nevsun Inanc1, Sandrine Jousse-Joulin2, Kerem Abacar3, Çagatay Cimşit4, Canan Cimşit4, Maria D’Agostino5, Esperanza Naredo6, Alojzija Hocevar7, Stephanie Finzel8, Lene Terslev9, Annamaria Iagnocco10, Petra Hanova11, Wolfgang Schmidt12, Gonca Mumcu13 and George A. Bruyn14, 1Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, 2Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, 3Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 4Marmara University School of Medicine, Radiology, Istanbul, Istanbul, Turkey, 5Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, 6Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, 7University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 8Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 10Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 11Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 12Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, 13Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, 14Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands

    Background/Purpose: Imaging techniques such as salivary gland ultrasound and magnetic resonance imaging (MRI) are able to diagnose primary Sjögren syndrome (pSS) patients with high sensitivity…
  • Abstract Number: 1957 • ACR Convergence 2020

    A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland

    Ilya Korsunsky1, Kevin Wei2, Mathilde Pohin3, Edy Kim4, Jason Turner5, Saba Nayar6, Benjamin Fisher7, Karim Raza8, Matthias Friedrich9, Jennifer Marshall5, Adam Croft5, Mark Coles10, Andreas Frei11, Andrew Filer12, Francesca Barone5, Kara Lassen11, Fiona Powrie10, Christopher Buckley13, Michael Brenner2 and Soumya Raychaudhuri14, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, Oxford, United Kingdom, 4Brigham and Women’s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, MA, 5Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 6Institute for Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 7University Hospitals Birmingham NHS Foundation Trust-Birmingham, Birmingham, United Kingdom, 8Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, 9Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, 10Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 11Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland, 12Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 13University of Birmingham, Birmingham, United Kingdom, 14Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Pro-inflammatory fibroblasts have been independently implicated in the pathogenesis of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), interstitial lung disease (ILD), and Sjogren’s syndrome…
  • Abstract Number: 1252 • ACR Convergence 2020

    Ultrasound-guided Parotid Gland Biopsy in Cadavers Performed by Rheumatologists – an OMERACT Ultrasound Working Group Study

    Nevsun Inanc1, Sandrine Jousse-Joulin2, Kerem Abacar3, Leyla Cinel4, Maria D’Agostino5, Esperanza Naredo6, Alojzija Hocevar7, Stephanie Finzel8, Lene Terslev9, Annamaria Iagnocco10, Petra Hanova11, Wolfgang Schmidt12, Gonca Mumcu13, Ümit S. Şehirli14 and George A. Bruyn15, 1Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, 2Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, 3Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 4Marmara University, School of Medicine, Division of Pathology, Istanbul, Turkey, 5Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, 6Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, 7University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 8Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 10Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 11Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 12Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, 13Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, 14Marmara University, School of Medicine, Anatomy, Istanbul, Turkey, 15Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands

    Background/Purpose: With the diagnostic capability of the parotid gland biopsy similar to minor salivary gland biopsy in Sjögren’s syndrome, the parotid gland biopsy may also…
  • Abstract Number: 0037 • ACR Convergence 2020

    Lipoprotein-associated Phospholipase A2: A New Biomarker for Lymphoma Development in Sjögren’s Syndrome

    Adrianos Nezos1, Eleni Kotsifaki1, Charalampos Skarlis2, Konstantinos Markakis1, Haralampos Moutsopoulos3, Michael Koutsilieris1, Clio Mavragani1 and Anna Psarrou1, 1National & Kapodistrian University of Athens, Athens, Greece, 2National &Kapodistrian University of Athens, Athens, Greece, 3National & Kapodistrian University of Athens/ Academy of Athens, Athens, Greece

    Background/Purpose: B-cell non-Hodgkin's lymphoma (B-NHL) is one of the major complications of primary Sjögren’s syndrome (SS). Chronic inflammation and macrophages in SS minor salivary glands…
  • Abstract Number: 1253 • ACR Convergence 2020

    Re-evaluation of the Extent of Lymphocytic Infiltration May Improve the Diagnostic Accuracy of Lip Biopsy in Primary Sjögren’s Syndrome (pSS)

    Chiara Baldini1, Francesco Ferro1, Gianmaria Governato1, Giovanni Fulvio2, Elena Elefante3, Marta Mosca1, Stefano Bombardieri1 and Valentina Donati4, 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 2Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 3Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa; Department of Medical Biotechnology, University of Siena, Pisa, Italy, 4Pathology Unit, AOUP, Pisa

    Background/Purpose: Focus score (FS) remains the key element for the histological diagnosis of pSS; nonetheless, additional parameters have been proposed for clinical trials including the…
  • Abstract Number: 0091 • ACR Convergence 2020

    Helicobacter Pylori Infection, Autoimmune Disease and Paraproteinemia Influence the Presentation of a Cohort of 150 Pernicious Anemia Patients Diagnosed in a Rheumatology Clinic

    Michael Lovy1, Norma Daniela Aguirre Vega1 and Crystal Escobar1, 1Desert Oasis Healthcare, Palm Springs, CA

    Background/Purpose: The most familiar presentation of pernicious anemia is an elderly Northern European woman with hematologic and neurologic manifestations.  More recently the influence of Helicobacter…
  • Abstract Number: 1254 • ACR Convergence 2020

    Lack of Efficacy of Early Treatment with Hydroxychloroquine in a Group of Hispanics with Primary Sjögren’s Syndrome

    Ariana González-Meléndez1, Patricia Jordán-González1, Ricardo Gago-Piñero1, Noemí Varela-Rosario1, Naydi Pérez-Ríos1 and Luis Vilá1, 1University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

    Background/Purpose: Treatment of primary Sjögren’s syndrome (pSS) with hydroxychloroquine (HCQ) has been evaluated in the past but with conflicting results regarding its efficacy. While earlier…
  • Abstract Number: 0293 • ACR Convergence 2020

    Contraction of the Stool Taxa Clostridia Is Associated with the Development of Clinical Disease Among Anti-Ro+ Mothers of Children with Neonatal Lupus

    Robert Clancy1, Miranda Marion2, Peter Izmirly3, Mala Masson4, Hannah Ainsworth2, Timothy Howard5, Jill Buyon6 and Carl Langefeld7, 1NYU School of Medicine, New York, 2Wake Forest School of Medicine, Winston-Salem, 3Department of Medicine, New York University School of Medicine, New York, NY, 4New York University School of Medicine, New York, 5Wake Forest School of Medicine, Winston-Salem, NC, 6Department of Medicine, NYU School of Medicine, New York, NY, 7Wake Forest School of Medicine, Winston Salem, NC

    Background/Purpose: Anti-Ro autoantibody production often precedes the development of systemic lupus erythematosus (SLE) or Sjögren’s syndrome (SS) by years. Anti-Ro+ mothers of children with manifestations…
  • Abstract Number: 1255 • ACR Convergence 2020

    Sjӧgren’s Syndrome Minor Salivary Gland Mesenchymal Stromal Cells Derived Deploy Intact Immune Plasticity and Display Myofibroblast-Like Properties

    Sara McCoy1, Jayeeta Giri1, Rahul Das1, Pradyut Paul1, Andrea Pennati1, Maxwell Parker1, Yun Liang1 and Jacques Galipeau1, 1University of Wisconsin, Madison

    Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is the second most common systemic autoimmune disease with hallmark features of severe ocular and oral sicca, leading to reduced…
  • Abstract Number: 0449 • ACR Convergence 2020

    Cytotoxic T Cells with a Chronic Antigen Exposure Phenotype Drive Immune Checkpoint Inhibitor Sicca

    Blake Warner1, Billel Gasmi2, David Kleiner3, Paola Perez Riveros4, Daniel Barber5, Shunsuke Sakai5 and Alan Baer6, 1National Institute of Dental and Craniofacial Research, Bethesda, 2National Cancer Institute, Bethesda, MD, 3National Cancer Institute, Bethesda, 4National Institute of Dental and Craniofacial Research, Bethesda, MD, 5National Institute of Allergy and Infectious Disease, Bethesda, MD, 6Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Immune checkpoint inhibitors (ICI) have advanced the field of cancer therapeutics. By blocking the negative co-stimulation of T cells, ICI augment the anti-tumor immune…
  • Abstract Number: 1256 • ACR Convergence 2020

    Mast Cells Contribute to the Development of Sialadenitis Associated with Sjögren’s Syndrome via Inducing Tissue Fibrosis by TGFβ Production

    Shinjiro Kaieda1, Kyoko Fujimoto1 and Hiroaki Ida1, 1Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis in…
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