ACR Meeting Abstracts

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Abstracts tagged "Sjögren’s Syndrome"

  • Abstract Number: 1245 • ACR Convergence 2020

    Smoking Might Reduce Odds of Sjӧgren’s Syndrome Among Rheumatoid Arthritis Patients

    Sara McCoy1 and Christie Bartels2, 1University of Wisconsin, Madison, 2University of Wisconsin School of Medicine and Public Health, Department of Medicine, Division of Rheumatology, Madison, WI

    Background/Purpose: Smoking increases the risk of many rheumatic disease, including rheumatoid arthritis (RA). Previous studies have identified that current smoking might reduce the risk of…
  • Abstract Number: 1505 • ACR Convergence 2020

    Antibodies Binding Ro/SSA and Muscarinic 3 Receptor in Sjogren’s Syndrome

    R. Scofield1, Syed Quadri2, Valerie Harris2, Biji Kurien2 and Kristi Keolsch2, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome is characterized by exocrine gland dysfunction and autoantibody production.  Some data suggest autoantibodies binding the muscarinic 3 receptor (M3R) mediate poor function…
  • Abstract Number: 1246 • ACR Convergence 2020

    Sjogren’s Syndrome and Its Risk of Cervical Lesions

    Kelly Corbitt1, Isis Lopez2 and Schartess Culpepper3, 1Jackson Memorial Hospital/University of Miami Internal Medicine Residency Program, Miami, 2Baylor College of Medicine Rheumatology Fellowship Program, Miami, 3University of Miami Hospital System, Miami

    Background/Purpose: Sjogren’s syndrome is chronic inflammatory disease that results in lacrimal and salivary dysfunction and can include extra-glandular manifestations. While it is well established that…
  • Abstract Number: 1506 • ACR Convergence 2020

    Correction of Sjögren’s Syndrome Fluid Secretion Deficits in Salivary Gland Acinar Cells by Aquaporin-1 Gene Transfer

    Paola Perez1, Blake Warner2, Sandra Wainer1, Youngmi Ji1, Thomas Pranzatelli1 and Jay Chiorini1, 1Nidcr, National Institute of Health, Bethesda, MD, 2National Institute of Dental and Craniofacial Research, Bethesda

    Background/Purpose: The hallmark clinical complaints in Sjögren’s syndrome (SS) are dry mouth and dry eyes related to salivary and lacrimal glands dysfunction. Reduced salivation reflects…
  • Abstract Number: 1247 • ACR Convergence 2020

    Features of Childhood Sjogren’s Syndrome: A Literature Review Based Cohort

    Achille Marino1, Micol Romano2, Teresa Giani3, Carla Gaggiano4, Stefania Costi5, Revika Singh6, Jay Mehta7, Scott Lieberman8 and Rolando Cimaz9, 1Department of Pediatrics, Desio Hospital, Milan, 2ASST Gaetano Pini-CTO Institute, Milan, Italy, Milan, Italy, 3AOU Meyer, Florence, Italy, 4Department of Pediatrics, University of Siena, Siena, Italy, Siena, Italy, 5University of Milan, Milan, Italy, Milan, Italy, 6Northwestern University, Evanston, IL, 7Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, USA, Philadelphia, PA, 8Department of Pediatrics, University of Iowa, Iowa City, US, Iowa City, IA, 9ASST Gaetano Pini-CTO Institute and Università degli Studi di Milano, Milan, Italy, Milan, Italy

    Background/Purpose: Sjogren’s syndrome (SS) is an autoimmune chronic disease characterized by inflammation of exocrine glands, but it can affect other organs as well.This study aims…
  • Abstract Number: 1611 • ACR Convergence 2020

    Documentation of Pregnancy Counseling in SSA-Positive Patients of Childbearing Potential: A Cross-Sectional Study

    Heinrich-Karl Greenblatt1 and Elena Weinstein1, 1University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Systemic lupus erythematosus (SLE) and primary Sjogren's Syndrome (SS) are highly associated with anti-SSA (anti-Ro) seropositivity. Anti-SSA autoantibodies may cross the placenta, causing a…
  • Abstract Number: 1248 • ACR Convergence 2020

    Patients Seropositive for La/SSB Without Ro/SSA Differ from Those Displaying La/SSB with Ro/SSA in a Single Center Sjogren’s Cohort

    Rana Mongroo1, Samira Chowdhury2 and Steven Carsons2, 1Mount Sinai South Nassau Hospital, Mineola, NY, 2NYU Winthrop Hospital, Mineola, NY

    Background/Purpose: Sjögren’s disease (SS) is characterized by the presence of antibodies against protein-small RNP complexes designated Ro/SSA and La/SSB. Both are included in the 2002…
  • Abstract Number: 1917 • ACR Convergence 2020

    In Myositis Patients, Sjögren’s Syndrome Is Associated with Inclusion Body Myositis and with anti-cN1A Antibody Independently of the Myositis Subgroups

    Dan Lévy1, Benoit Nespola2, Margherita Giannini3, Renaud Felten4, Francois Severac3, Coralie Varoquier3, Marina Rinagel3, Anne-Sophie Korganow5, Vincent Poindron5, Thierry Martin5, Julien Campagne6, Hassam Chereih7, Bastien Bouldoires8, Baptiste Hervier9, Cédric Lenormand3, Emmanuel Chatelus3, Laurent Arnaud10, Bernard Gény3, Jean Sibilia4, Jacques-Eric Gottenberg11 and Alain Meyer12, 1CHU Strasbourg, CH, 2Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 3CHU Strasbourg, Strasbourg, 4Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, 5Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 6Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 7CH Pontarlier, Pontarlier, 8HP Colmar, Colmar, 9APHP Paris, Paris, 10Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, 11Strasbourg University Hospital, Strasbourg, France, 12Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, Alsace, France

    Background/Purpose: Myositis are characterized by weakness and muscle inflammation. They encompass heterogeneous conditions, which include dermatomyositis (DM), inclusion body myositis (IBM) and polymyositis (PM) according…
  • Abstract Number: 1249 • ACR Convergence 2020

    The Impact of Anti-Ro Antibodies on the Pregnancy Outcome in Relation to Maternal Disease Presentation: A Descriptive Analysis of 231 Pregnancies

    Eman Satti1, Nawal Hadwan1, Hadil Ashour1, Rawan Saleh1, Fiaz Alam1, Omar Alsaed1 and Samar Al Emadi1, 1Hamad medical corporation, DOHA, Qatar

    Background/Purpose: Anti-Ro antibody positivity is linked to adverse fetal outcomes like congenital heart block CHB (2%) and neonatal lupus. The incidence of CHB increases to…
  • Abstract Number: 1954 • ACR Convergence 2020

    Genome-wide Association Study of Sjögren’s Syndrome Identifies Ten New Risk Loci

    Bhuwan Khatri1, Tove Ragna Reksten2, Kandice Tessneer3, Astrid Rasmussen1, R. Scofield1, Simon Bowman4, Joel Guthridge1, Judith James5, Lars Ronnblom6, Blake Warner7, Xavier Mariette8, Roald Omdal9, Javier Martin10, Maria Teruel10, Janicke Liaaen Jensen11, Lara Aqrawi11, Øyvind Palm11, Marie Wahren-Herlenius12, Torsten Witte13, Roland Jonsson14, Maureen Rischmueller15, A Darise Farris1, Marta Alarcon-Riquelme10, Wan-Fai Ng16, Kathy Sivils1, Gunnel Nordmark17 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Bergen, Bergen, Norway, 3Oklahoma Medical Research Foundation, Oklahoma City, 4University Hospitals Birmingham, Birmingham, United Kingdom, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 6Uppsala University, Uppsala, Sweden, 7National Institute of Dental and Craniofacial Research, Bethesda, 8Paris-Sud University, Rueil-Malmaison, France, 9University of Oslo, Stavanger, Norway, 10Center for Genomics and Oncological Research (GENYO), Granada, Spain, 11University of Oslo, Oslo, Norway, 12Karolinska Institute, Stockholm, Sweden, 13Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 14Haukeland University Hospital, Bergen, Norway, 15The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 16Newcastle University, Gateshead, United Kingdom, 17Uppsala University, Copenhagen S, Sweden

    Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity, and 10 published genetic susceptibility loci. Our genome-wide…
  • Abstract Number: 1250 • ACR Convergence 2020

    Early Sjögren Antibodies: Potential Biomarker for Abnormal Minor Labial Salivary Gland Biopsy in Juvenile Sjögren’s Syndrome

    Akaluck Thatayatikom1, Sthorn Thatayatikom1, Indraneel Bhattacharyya2, Melissa Elder1, Renee Modica1 and Seunghee Cha2, 1Department of Pediatrics, University of Florida, Gainesville, FL, 2College of Dentistry, University of Florida, Gainesville, FL

    Background/Purpose: Juvenile Sjögren’s Syndrome (jSS) is a perplexing systemic autoimmune disease in children presenting with positive autoantibodies, glandular, and/ or extraglandular symptoms. In pediatric practice,…
  • Abstract Number: 1956 • ACR Convergence 2020

    Dysregulated Expression of the Long Non-coding RNA, LINC01871, Implicated in Sjögren’s Syndrome Pathogenesis

    Michelle Joachims1, Bhuwan Khatri1, Kandice Tessneer2, Anna Stolarczyk1, Graham Wiley1, Astrid Rasmussen1, Joel Guthridge1, Judith James3, R. Scofield1, Kathy Sivils1, Indra Adrianto4 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 4Henry Ford Health System, Detroit, MI

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammatory destruction of the exocrine glands. Long non-coding RNAs (lncRNAs) are a functionally diverse class…
  • Abstract Number: 1251 • ACR Convergence 2020

    Assessing the Construct Validity of the Novel OMERACT Ultrasound Scoring System for Salivary Glands Target Lesions by Comparison with MRI in Patients with Sjögren’s Syndrome – An OMERACT Ultrasound Working Group Exercise

    Nevsun Inanc1, Sandrine Jousse-Joulin2, Kerem Abacar3, Çagatay Cimşit4, Canan Cimşit4, Maria D’Agostino5, Esperanza Naredo6, Alojzija Hocevar7, Stephanie Finzel8, Lene Terslev9, Annamaria Iagnocco10, Petra Hanova11, Wolfgang Schmidt12, Gonca Mumcu13 and George A. Bruyn14, 1Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, 2Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, 3Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 4Marmara University School of Medicine, Radiology, Istanbul, Istanbul, Turkey, 5Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, 6Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, 7University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 8Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 10Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 11Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 12Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, 13Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, 14Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands

    Background/Purpose: Imaging techniques such as salivary gland ultrasound and magnetic resonance imaging (MRI) are able to diagnose primary Sjögren syndrome (pSS) patients with high sensitivity…
  • Abstract Number: 1957 • ACR Convergence 2020

    A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland

    Ilya Korsunsky1, Kevin Wei2, Mathilde Pohin3, Edy Kim4, Jason Turner5, Saba Nayar6, Benjamin Fisher7, Karim Raza8, Matthias Friedrich9, Jennifer Marshall5, Adam Croft5, Mark Coles10, Andreas Frei11, Andrew Filer12, Francesca Barone5, Kara Lassen11, Fiona Powrie10, Christopher Buckley13, Michael Brenner2 and Soumya Raychaudhuri14, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, Oxford, United Kingdom, 4Brigham and Women’s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, MA, 5Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 6Institute for Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 7University Hospitals Birmingham NHS Foundation Trust-Birmingham, Birmingham, United Kingdom, 8Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, 9Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, 10Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 11Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland, 12Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 13University of Birmingham, Birmingham, United Kingdom, 14Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Pro-inflammatory fibroblasts have been independently implicated in the pathogenesis of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), interstitial lung disease (ILD), and Sjogren’s syndrome…
  • Abstract Number: 1252 • ACR Convergence 2020

    Ultrasound-guided Parotid Gland Biopsy in Cadavers Performed by Rheumatologists – an OMERACT Ultrasound Working Group Study

    Nevsun Inanc1, Sandrine Jousse-Joulin2, Kerem Abacar3, Leyla Cinel4, Maria D’Agostino5, Esperanza Naredo6, Alojzija Hocevar7, Stephanie Finzel8, Lene Terslev9, Annamaria Iagnocco10, Petra Hanova11, Wolfgang Schmidt12, Gonca Mumcu13, Ümit S. Şehirli14 and George A. Bruyn15, 1Marmara University, School of Medicine, Division of Rheumatology, istanbul, Turkey, 2Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, 3Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 4Marmara University, School of Medicine, Division of Pathology, Istanbul, Turkey, 5Université Versailles Saint Quentin, Ambroise Paré Hospital, Paris, France, 6Department of Rheumatology, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz and Universidad Autónoma de Madrid, Madrid, Spain, 7University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 8Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 10Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 11Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 12Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch, Berlin, Germany, 13Marmara University School of Health Sciences, Health Management, Istanbul, Istanbul, Turkey, 14Marmara University, School of Medicine, Anatomy, Istanbul, Turkey, 15Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands

    Background/Purpose: With the diagnostic capability of the parotid gland biopsy similar to minor salivary gland biopsy in Sjögren’s syndrome, the parotid gland biopsy may also…
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