ACR Meeting Abstracts

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Abstracts tagged "SICCA"

  • Abstract Number: 1451 • 2019 ACR/ARP Annual Meeting

    Histological Characteristics in SICCA Syndrome – Clinical and Serological Association

    Maria de Lourdes Flores 1, Gabriela Alejandra Gutierrez-Robles 1, Flavio Cesar Estrada-Gil 1, Miguel Alejandro Davalos-Benitez 1, Jorge Ernesto Garcia-Alvarado 1, Alejandra de Lourdes Farias-Sierra1, Ignacio Garcia-De La Torre 2, Gerardo Orozco-Barocio 1, Carlos Gerardo Riebeling-Navarro 3 and Arnulfo Hernan Nava-Zavala 4, 1HGO SSJ, U de G, PNPC CONACYT, Guadalajara, Mexico, 2Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Jalisco, Mexico, 3UIEC UMAE HP CMN-SXXI IMSS / UNAM, Ciudad de Mexico, Mexico, 4UIB02 UMAE HE CMNO IMSS / HGO SSJ / PIM UAG / PNPC U de G, Guadalajara, Mexico

    Background/Purpose: The xerostomia and/or xerophtalmia (SICCA syndrome: items I and II of 2002 AECG criteria) are conspicuous characteristics of primary Sjögren´s syndrome (pSS). pSS diagnostic…
  • Abstract Number: 1467 • 2019 ACR/ARP Annual Meeting

    Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age

    Noel Agustin Callahuara Goiburu1, Patricia Sasaki 1, Anastasia Secco 2, Catalan Pellet 3, Nadia Riscanevo 4, Janet Flores 5, Francisco Caeiro 5, cristina Amitrano 6, Cecilia Asnal 7, Alejandro Nitsche 8, Carolina Segura Escobar 9, Julia Demarchi 10, Damian Duartes 10, Lida santiago 11, Laura Raiti 12, Vanesa Cruzat 13, Carla Gobbi 14, Paula Alba 15, Silvia Papasidero 16, Sofia Velez 17, Vicente Juarez 18 and Gabriela Salvatierra 19, 1Rivadavia, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 2Hospital Rivadavia, Caba, Buenos Aires, Argentina, 3Rivadavia, CABA, Argentina, 4Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, 5Hospital Privado de Córdoba, Cordoba, Argentina, 6Hospital Aleman, CABA, Argentina, 7Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, 8Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 9Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 10Hospital Británico, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 11OMI, Ciudad Autonoma de Buenos Aires, Argentina, 12Clinica Bessone, Buenos Aires, Buenos Aires, Argentina, 13Clinica Bessone, Buenos Aires, Argentina, 14CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 15UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, 16Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 17Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, 18Hospital Milagros de Salta, Salta, Salta, Argentina, 19IPRI, Santiago del estero, Santiago del Estero, Argentina

    Background/Purpose: Although there is little information, the debut of primary Sjögren's syndrome in adult patients aged less than or equal to 35 years, would be…
  • Abstract Number: 1710 • 2019 ACR/ARP Annual Meeting

    Chemokine and Cytokine Tear Profile of Patients with IgG4-Related Disease

    Eduardo Martin-Nares1, Luis Llorente 1, Guadalupe Lima 1, Diego Hernández-Ramírez 1, Isela Chan-Campos 1, Vanessa Saavedra-González 1 and Gabriela Hernandez-Molina 1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: The lacrimal gland is frequently involved in both IgG4-related disease (IgG4-RD) and Sjögren’s syndrome (SS) and presents with swelling and/or dry eye symptoms. Although…
  • Abstract Number: 1905 • 2019 ACR/ARP Annual Meeting

    Sicca/Sjögren Syndrome Triggered by PD-1/PD-L1 Checkpoint Inhibitors: Data from the International ImmunoCancer Registry (ICIR)

    Manuel Ramos-Casals 1, Alexandre Maria 2, Maria E. Suárez-Almazor 3, Olivier Lambotte 4, Benjamin A. Fisher 5, Gabriela Hernandez-Molina 6, Philippe Guilpain 2, Xerxes Pundole 3, Soledad Retamozo7, Alejandra Flores-Chávez 8, Chiara Baldini 9, Clifton Bingham 10, Pilar Brito-Zerón 11, Jacques-Eric Gottenberg 12, Marie Kostine 13, Timothy R.D. Radstake 14, Thierry Schaeverbeke 15, Hendrik Schulze-Koops 16, Leonard Calabrese 17, Munther A Khamashta 18 and Xavier Mariette 19, 1Department of Autoimmune Diseases, ICMiD. Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX. Department of Medicine, University of Barcelona, Hospital Clínic, Barcelona, Spain., Barcelona, Spain, 2Department of Internal Medicine, Multi-Organic Diseases, Local Referral Center for Autoimmune Diseases, Saint Eloi Hospital- Montpellier-1 University, Montpellier Cedex 5, France, Montpellier, France, 3Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX, 4APHP Médecine Interne/Immunologie Clinique, Hôpital Bicêtre, Paris, France. Université Paris Sud 11 – INSERM U1184 - CEA, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, Fontenay-aux-Roses & Le Kremlin-Bicêtre, France., Paris, France, 5Institute of Inflammation and Ageing, University of Birmingham; and National Institute of Health Research Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, Birmingham, United Kingdom, 6Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 7Instituto De Investigaciones En Ciencias De La Salud, Univ. Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina., Cordoba, Argentina, 8Department of Autoimmune Diseases, ICMiD, Barcelona, Spain., Barcelona, Spain, 9Rheumatology Unit, University of Pisa, Italy., Pisa, Italy, 10Johns Hopkins University, Baltimore, MD, 11Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic. Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona, Spain., Barcelona, Spain, 12Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 13Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, 14Department of Rheumatology/Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Utrecht, Netherlands, 15FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, 16Department of Rheumatology/Clinical Immunology, Ludwig-Maximilians-University Munich, Munich, Germany., Munich, Germany, 17Rheumatologic and Immunologic Disease/Cleveland Clinic, Cleveland, OH, 18King's College London School of Medicine, London, United Kingdom, 19Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France

    Background/Purpose: To analyse the worldwide occurrence of sicca/Sjögren (SjS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer.Methods: The ImmunoCancer…
  • Abstract Number: 351 • 2018 ACR/ARHP Annual Meeting

    Rheumatic Immune-Related Adverse Events in Patients on ANTI-PD-1 Inhibitors: Fasciitis with Myositis Syndrome As a New Rheumatic Complication of Immunotherapy

    Francisco Javier Narváez1, Pablo Juárez2, Judit Lluch2, Jose Antonio Narvaez3, Ramón Palmero4, Xavier Garcia del Muro4, Joan Miquel Nolla2 and Eva Domingo-Domenech5, 1Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, 2Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 3Radiology, Hospital Universitari de Bellvitge, Barcelona, Spain, 4Medical Oncology., Institut Català d'Oncologia. Hospital Duran i Reynals., Barcelona, Spain, 5Hematology, Institut Català d'Oncologia. Hospital Duran i Reynals, Barcelona, Spain

    Background/Purpose: To evaluate the prevalence and type of rheumatic immune-related adverse events (IRAEs) in patients receiving programmed cell death protein-1 (PD-1) inhibitors. Methods: This is…
  • Abstract Number: 1576 • 2018 ACR/ARHP Annual Meeting

    Soluble Semaphorin 4D/CD100 Is Increased in the Saliva of Sjögren’s Syndrome

    Shin Eui Kang1, Jeong Seok Lee2, Ji Soo Park1, Ji Hye Lee2, Jeong Yeon Kim1, Hyun Jung Yoo2, Yun Jong Lee3, Eun Young Lee4, Eun Bong Lee2 and Yeong Wook Song1,5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South)

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration in exocrine organs with dry mouth and dry eyes. Semaphorin 4D (SEMA4D) /…
  • Abstract Number: 574 • 2017 ACR/ARHP Annual Meeting

    Is Elastography a New Tool to Differentiate Sjögren Syndrome to Sicca Syndrome?: Results of the Elsa (elastography of salivary glands) Study

    Sandrine Jousse-Joulin1, luc Bressollette2, thibault depinoy3, guillermo carvajal Alegria3, Divi Cornec4, Thierry Marhadour5, Dewi Guellec6, Valérie Devauchelle-Pensec7 and Alain Saraux8, 1Rheumatology, CHu La cavle Blanche, Brest, France, 2Doppler unit, Cavale Blanche hospital, brest, France, 3rheumatology department, cavale blanche hospital, brest, France, 4CHU Brest, Brest, France, 5Rheumatology, CHU La Cavale Blanche, Brest, France, 6Rheumatology, CHU Brest, Brest, France, 7Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, 8Rheumatology, Brest University Medical School Hospital, Brest, France

    Background/Purpose: Ultrasonography (US) has been developed in salivary glands (SG) and particularly in primary Sjögren syndrome (pSS) for 10 years. However, the training curve is…
  • Abstract Number: 1495 • 2017 ACR/ARHP Annual Meeting

    Longitudinal Changes in EULAR Sjögren’s Syndrome Patient Reported Index  in Routine Clinical Practice

    Ji Hyoun Kim1, You-Jung Ha2, Eun Ha Kang2, Yeong Wook Song3,4 and Yun Jong Lee5, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South), 3WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 4Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 5Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of (South)

    Background/Purpose: This study aimed to investigate the longitudinal changes in EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) and to study clinical features associated with favorable…
  • Abstract Number: 1497 • 2017 ACR/ARHP Annual Meeting

    Clinical and Laboratory Features of Patients with Focal Lymphocytic Sialadenitis on Minor Salivary Gland Biopsy for Sicca Symptoms: A 16 Year Experience

    Bibi Ayesha1, Ruth Fernandez-Ruiz2, Devin Shrock3, Rebecca Tuetken4, Scott Lieberman5, Elizabeth Field6 and Namrata Singh7, 1Internal Medicine and Division of Rheumatology, MD, BRONX, NY, 2Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 3Pathology, MD, Iowa, IA, 4MD, PhD, Iowa, IA, 5Division of Rheumatology, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 6Iowa City VA, Iowa City, IA, 7VA Nebraska-Western Iowa Health Care System and University of Iowa, Omaha, IA

    Background/Purpose: Focal lymphocytic sialadenitis (FLS) on minor salivary gland biopsy (MSGB) is one of the classification criteria for Sjögren's syndrome (SS). As no diagnostic criteria…
  • Abstract Number: 671 • 2016 ACR/ARHP Annual Meeting

    Steered Screening for Sjögren Syndrome in Patients with Sicca Syndrome. Role of Salival Beta-2 Microglogulin

    Janett Riega-Torres1, Amaury Valdés-Mancha2, Celia Sánchez-Domínguez3, Lorena Pérez-Barbosa1, Ana Arana-Guajardo4, David Vega-Morales5 and Mario Alberto Garza-Elizondo1, 1Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, 2Servicio de Reumatología, Departamento de Medicina Interna. Hospital Universitario “Dr. José Eleuterio González”. Universidad Autónoma de Nuevo León, Monterrey, Mexico, 3Departamento de Bioquímica, Facultad de Medicina. Universidad Autónoma de Nuevo León, Monterrey, Mexico, 4Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, 5Universidad Autónoma de Nuevo Léon, Monterrey, Mexico

    Background/Purpose: Sicca Syndrome patients represent a diagnostic challenge for the wide variety of etiologies that can afford it. Beta-2 Microglogulin (B2MG) is a non-glycosylated protein,…
  • Abstract Number: 1516 • 2016 ACR/ARHP Annual Meeting

    Evidence of Labial Salivary Gland Epithelial Cell Activation from Patients with Rheumatoid Arthritis and Sicca Symptomatology

    George Fragoulis1, James Reilly1, Shauna Kerr1, Iain B McInnes2 and Haralampos M. Moutsopoulos3, 1Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, Great Britain, 3Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: In primary Sjögren’s syndrome (pSS), labial minor salivary gland epithelial cells (LMSGEC) inappropriately express various molecules, including B7, HLA-DR, ICAM, as assessed previously by…
  • Abstract Number: 2662 • 2016 ACR/ARHP Annual Meeting

    Effect of Tobacco Smoking on the Clinical, Histopathological, and Serological Manifestations of SjöGren’s Syndrome

    Astrid Rasmussen1, Donald U. Stone2, Dustin Fife3, Michael Brown4, Keith Earley5, Lida Radfar6, C. Erick Kaufman7, David M. Lewis8, Nelson L. Rhodus9, Barbara M. Segal10, Daniel J Wallace11, Michael Weisman12, Swamy Venuturupalli13, Michael T. Brennan14, Christopher J Lessard3, Courtney G. Montgomery15, R. Hal Scofield15 and Kathy L. Sivils15, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, 2King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Pfizer Inc., Groton, CT, 559th Medical Wing, US Air Force, San Antonio, TX, 6Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, 7Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 8Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 9Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 10Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, 11Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 12Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 13Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, 14Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: To assess the prevalence of smoking in patients with Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca), and the association of smoking habits with…
  • Abstract Number: 2684 • 2016 ACR/ARHP Annual Meeting

    Diagnosis of Systemic Diseases in Patients Presenting with Sicca Syndrome Using a Minimally-Invasive Minor Salivary Gland Biopsy: Analysis of 901 Patients

    Soledad Retamozo1,2,3, Pilar Brito-Zerón1,4,5, Alejandro Alvarellos3, Veronica Saurit3, Ana C. Alvarez3, Maria Soledad Fiorentino3, Nadia Benzaquén3, Juan Pablo Pirola3, Diego Baenas3, Maria Jezabel Haye Salinas3, Albert Bove6, Isabel Sánchez-Berná7, César Morcillo8, Francisco Caeiro3 and Manuel Ramos-Casals2,5,9, 1Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 2Sjögren Syndrome Research Group (AGAUR), Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Postgraduate Career of Rheumatology Catholic University of Córdoba, Fundación para las Ciencias Biomédicas de Córdoba (FUCIBICO), Cordoba, Argentina, 4Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain, 5Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 6Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 7Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institutd’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Department of Autoimmune Diseases, ICMiD, Barcelona, Spain, 8Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Spain, Barcelona, Spain, 9Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain

    Background/Purpose: Sicca syndrome is a clinical presentation that is common for several systemic diseases that may infiltrate the exocrine glands. The most frequent disease is…
  • Abstract Number: 3080 • 2016 ACR/ARHP Annual Meeting

    Rheumatologic Consequences of Immunotherapy to Treat Malignancies: The Tip of an Iceberg

    Laura Cappelli1, Anna Kristina Gutierrez2, Alan N. Baer2, Jemima Albayda3, Rebecca L. Manno2, Uzma Haque3, Ami A. Shah3, Evan Lipson4, Karen Bleich5, Julie Brahmer4, Patrick Forde4, Dung Le6, Jarushka Naidoo4 and Clifton Bingham III7, 1Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Johns Hopkins University School of Medicine, Baltimore, MD, 7Johns Hopkins University, Baltimore, MD

    Rheumatologic Consequences of Immunotherapy to Treat Malignancies: The Tip of an Iceberg   Background/Purpose:  Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed…
  • Abstract Number: 1358 • 2015 ACR/ARHP Annual Meeting

    Detection of a Unique Viral Infection in Salivary Glands of Sjögren’s Syndrome Patients and Viral-Mediated Recapitulation of Disease in Vivo

    Melodie Weller1, Matthew Gardner1, Zoe Bogus1, Michael Smith1, Elisa Astorri2, Drew Michael1, Changyu Zheng1, Peter Burbelo3, Paul A. Wilson4, Zhennan Lai1, Bill Swaim1, Beverly Handelman1, Sandra Afione1, Michele Bombardieri2 and John A. Chiorini1, 1Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 3Clinical Dental Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 4National Intramural Database, Division of Enterprise and Custom Applications, Center for Information Technology, National Institutes of Health, Bethesda, MD

    Background/Purpose: A viral infection is thought to be one of the triggers in the development of primary Sjögren’s syndrome (pSS).  Multiple studies have shown stimulation…
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