Abstracts tagged "Scleroderma"

Abstract Number: 0811 • ACR Convergence 2025
SSc Skin Cell Atlas: a Scalable Web Portal for scRNA-Seq Analysis
Helen Jarnagin¹, Zhiyun Gong¹, Rachael Bogle², Alex Tsoi², Rezvan Parvizi³, Madeline Morrisson⁴, Dinesh Khanna⁵, Johann Gudjonsson⁵ and Michael Whitfield⁶, ¹Dartmouth College, Lebanon, NH, ²University of Michigan, Holland, OH, ³Dartmouth, lebanon, NH, ⁴Geisel School of Medicine at Dartmouth College, Hanover, NH, ⁵University of Michigan, Ann Arbor, MI, ⁶Geisel School of Medicine, Lebanon, NH
Background/Purpose: Despite the recent popularity and utility of modern high-resolution sequencing technologies, leveraging publicly available single-cell studies remains hampered by the need for substantial computational…
Abstract Number: 2503 • ACR Convergence 2025
Validation of a Composite Biomarker Score To Predict Modified Rodnan Skin Score: Insight From Autologous Stem Cell Transplantation International Scleroderma trial
stefano rodolfi¹, kristina clark², bahja Ahmed Abdi¹, medha kanitkar³, Voon H. Ong³, Alexandre Voskuijl⁴, Jeska de Vries-Bouwstra⁵, Jacob M. van Laar⁶, Christopher Denton⁷ and julia Spierings⁸, ¹University College London, London, United Kingdom, ²Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶UMC Utrecht, Utrecht, Netherlands, ⁷University College London, UK, London, United Kingdom, ⁸Department of Rheumatology & Clinical Immunology, University Medical Center, Ultrecht, The Netherlands, Utrecht, Netherlands
Background/Purpose: Skin fibrosis is a cardinal manifestation of diffuse cutaneous systemic sclerosis (dcSSc) and is routinely measured via the modified Rodnan skin score (mRSS); however,…
Abstract Number: 1874 • ACR Convergence 2025
Neutrophil Extracellular Trap-Rich Systemic Sclerosis Plasma Promotes Microvascular Endothelial Cell Proliferation and Migration: Implications for Aberrant Angiogenesis
Wenying Liang¹, James St. Clair¹, Pei-Suen Tsou², John Varga², Jason S. Knight², Dinesh Khanna² and Ramadan Ali³, ¹University of Michigan, Ann arbor, ²University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arobr, MI
Background/Purpose: Systemic sclerosis (SSc, also known as scleroderma) is a systemic disease characterized by fibrosis, autoimmunity, and vasculopathy. Neutrophil extracellular traps (NETs) are web‐like chromatin…
Abstract Number: 1560 • ACR Convergence 2025
Longitudinal assessment of circulating fibroblast activation protein in systemic sclerosis-associated interstitial lung disease
Bo Broens¹, Conny van der Laken¹, Iris Simons¹, Tamara Dekker¹, Jan Willem Duitman¹ and Alexandre Voskuijl², ¹Amsterdam UMC, Amsterdam, Netherlands, ²Amsterdam University Medical Center, Amsterdam, Netherlands
Background/Purpose: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is difficult to manage due to the heterogeneous disease course. There is a high need for biomarkers to…
Abstract Number: 0701 • ACR Convergence 2025
Exploring Calcinosis On Hand X-Rays In Systemic Sclerosis: a Mayo Clinic Cohort
Maximiliano Diaz Menindez¹, Simran Ravindra Nimal², Michael Pham², Caroyln Harvey³, Leroy W. Griffing² and Vivek Nagaraja², ¹Mayo Clinic School of Graduate Medical Education, Phoenix, AZ, ²Mayo Clinic, Scottsdale, AZ, ³Mayo Clinic, Phoenix, AZ
Background/Purpose: Calcinosis is a vexing manifestation in patients with systemic sclerosis (SSc) with a variable prevalence among cohorts. Up to 86% of calcinosis cases are…
Abstract Number: 0249 • ACR Convergence 2025
Obesity as a possible confusion factor in the scleroderma pattern
Eva Álvarez Andrés¹, Marta Novella-Navarro², Paloma García de la Peña Lefebvre³, Eugenio de Miguel² and Paz Collado Ramos⁴, ¹Hospital Severo Ochoa de Madrid, Madrid, Spain, ²Hospital Universitario La Paz, Madrid, Spain, ³Facultad ciencias de la Salud HM de la UCJC, Madrid, Spain, ⁴Department of Rheumatology, Hospital Universitario Severo Ochoa, Madrid, Spain,, MADRID, Madrid, Spain
Background/Purpose: The 2023 EULAR criteria for systemic sclerosis reaffirm the diagnostic value of nailfold videocapillaroscopy (NVC), particularly the presence of giant capillaries and capillary loss…
Abstract Number: 2499 • ACR Convergence 2025
Concomitant Anti-Ro/SSA Antibodies in Systemic Sclerosis Patients is Associated with Risks Beyond Dryness
Rachael Gordon¹, Leah Wunsch², Maureen Lauffoon¹, Thomas Medsger, Jr³ and Robyn Domsic¹, ¹University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, Verona, PA
Background/Purpose: Sjogren’s disease (SjD) is a common systemic autoimmune disorder characterized by progressive inflammation of the exocrine glands, resulting in dry eyes and dry mouth.…
Abstract Number: 1871 • ACR Convergence 2025
Examining the impact of ETV2 on altered endothelial phenotype in systemic sclerosis
Elio Carmona¹, Alyssa Rosek², Neha Khanna², Dinesh Khanna³, Amr Sawalha⁴ and Pei-Suen Tsou³, ¹Division of Pediatric Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Pittsburgh, ²Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, ³University of Michigan, Ann Arbor, MI, ⁴University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Our prior research demonstrated that epigenetic modifications are central to the pathogenesis of scleroderma (SSc)1. Using ATAC-seq, we found that chromatin accessibility was significantly…
Abstract Number: 1554 • ACR Convergence 2025
Demographic, Clinical, and Mortality Trends in Scleroderma Patients with Gastric Antral Vascular Ectasia (GAVE): A National Inpatient Analysis
Akanksha Sharma¹, Veera Durga Vaishnavi Kurra² and Neev Mehta³, ¹UPMC Mercy hospital, Pittsburgh, PA, Pittsburgh, PA, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Lahey Hospital and Medical Center, Burlington, MA
Background/Purpose: Gastric antral vascular ectasia (GAVE), commonly known as “watermelon stomach,” is a rare but potentially severe gastrointestinal manifestation in systemic sclerosis (SSc). Despite its…
Abstract Number: 0699 • ACR Convergence 2025
A Retrospective Comparison of Transplant Outcomes in Patients with and without Systemic Sclerosis
Lilit Grigoryan, Sumbal Wajid, Giovanni Faddoul and Swati Mehta, Albany medical center, Albany, NY
Background/Purpose: Scleroderma renal crisis (SRC) is one of the life threatening complications of systemic sclerosis (SSc). Up to 20-50% require long term dialysis and subsequently…
Abstract Number: 0245 • ACR Convergence 2025
Predictors of Arterial Stiffness in Connective Tissue Diseases: Insights from the Lupus Extended Autoimmune Phenotype (LEAP) Cohort Study
cristiana Sieiro¹, Sarah Dyball², Ellen Bruce³, Ben Parker⁴ and Ian Bruce⁵, ¹Univrsity of Manchester, Manchester, United Kingdom, ²University of Manchester, Manchester, United Kingdom, ³Manchester University NHS FT, The Kellgren Centre of Rheumatology, Manchester, United Kingdom, Manchester, ⁴NIHR Manchester CRF, Manchester Royal Infirmary, Manchester, United Kingdom, ⁵Centre for Public Health, Faculty of Medicine, Health and Life Sciences, Queen's University, Belfast, Manchester, United Kingdom
Background/Purpose: Connective tissue diseases (CTDs), including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjögren’s disease (SjD), are associated with an increased risk of cardiovascular…
Abstract Number: 0174 • ACR Convergence 2024
A Nationwide Analysis of Gender and Racial Disparities in Patients with Systemic Sclerosis and Acute Coronary Syndrome
Omair Khan¹, Kundan Jana², Azka Naeem², Syed Mujtaba Baqir², Marlon Rivera Boadla², Muhammad Hashim khan² and Vijay Shetty², ¹Maimonides Medical Center, Council Bluffs, IA, ²Maimonides Medical Center, Brooklyn, NY
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune condition characterized by widespread skin fibrosis and/or end-organ damage. Previous studies have reported variable outcomes of the disease…
Abstract Number: 0705 • ACR Convergence 2024
Identification of Risk Factors for Incident Cardiomyopathy in Patients with Systemic Sclerosis
Ji Soo Kim¹, Rachel Wallwork¹, Carrie Richardson², Adrianne Woods³, Monica Mukherjee⁴, Steven Hsu⁴, Julie Paik¹, Christopher Mecoli¹, Laura Hummers⁵, Fredrick Wigley⁶, Scott Zeger¹ and Ami Shah⁷, ¹Johns Hopkins University, Baltimore, MD, ²Northwestern University, Chicago, ³Johns Hopkins University Division of Rheumatology, Baltimore, MD, ⁴Johns Hopkins University Division of Cardiology, Baltimore, MD, ⁵Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, ⁶Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, ⁷Division of Rheumatology, Johns Hopkins University, Ellicott City, MD
Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) is one of the leading causes of scleroderma-associated death. There are limited data examining risk factors for incident…
Abstract Number: 1236 • ACR Convergence 2024
A Novel Role for Artificial Intelligence in Detecting Distinctive Scleroderma Facial Features
yossra suliman¹ and daniel Furst², ¹Assiut university hospital, assiut, Egypt, ²Pacific Arthritis Center, Inglewood
Background/Purpose: Scleroderma (SSc) is a rare autoimmune fibrosing disease with high rates of morbidity and mortality. Scleroderma is usually diagnosed by rheumatologists and/or dermatologists. However,…
Abstract Number: 1689 • ACR Convergence 2024
Pulmonary Function Test Reference Equations May Drive Inequitable Classification of Restrictive Lung Disease Severity in Systemic Sclerosis
Kamini Kuchinad¹, Rachel Wallwork², Matthew Lammi³, Christopher Mecoli¹, Julie Paik¹, Fredrick Wigley⁴, Robert Wise¹, Laura Hummers⁵, Ami Shah⁶ and Ji Soo Kim¹, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University, Towson, MD, ³Johns Hopkins University Division of Pulmonary and Critical Care Medicine, Baltimore, MD, ⁴Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, ⁵Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, ⁶Division of Rheumatology, Johns Hopkins University, Ellicott City, MD
Background/Purpose: Black individuals with systemic sclerosis (SSc) have an increased frequency and severity of interstitial lung disease (ILD) as compared to their White counterparts. Pulmonary…

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