Abstracts tagged "Scleroderma"

Abstract Number: 1236 • ACR Convergence 2024
A Novel Role for Artificial Intelligence in Detecting Distinctive Scleroderma Facial Features
yossra suliman¹ and daniel Furst², ¹Assiut university hospital, assiut, Egypt, ²Pacific Arthritis Center, Inglewood
Background/Purpose: Scleroderma (SSc) is a rare autoimmune fibrosing disease with high rates of morbidity and mortality. Scleroderma is usually diagnosed by rheumatologists and/or dermatologists. However,…
Abstract Number: 1689 • ACR Convergence 2024
Pulmonary Function Test Reference Equations May Drive Inequitable Classification of Restrictive Lung Disease Severity in Systemic Sclerosis
Kamini Kuchinad¹, Rachel Wallwork², Matthew Lammi³, Christopher Mecoli¹, Julie Paik¹, Fredrick Wigley⁴, Robert Wise¹, Laura Hummers⁵, Ami Shah⁶ and Ji Soo Kim¹, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University, Towson, MD, ³Johns Hopkins University Division of Pulmonary and Critical Care Medicine, Baltimore, MD, ⁴Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, ⁵Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, ⁶Division of Rheumatology, Johns Hopkins University, Ellicott City, MD
Background/Purpose: Black individuals with systemic sclerosis (SSc) have an increased frequency and severity of interstitial lung disease (ILD) as compared to their White counterparts. Pulmonary…
Abstract Number: 1867 • ACR Convergence 2024
RNA Polymerase III Specific CD8+ T Cells at the Interface Between Scleroderma and Cancer
Eleni Tiniakou¹, Mekha Thomas², Ami Shah³, Fredrick Wigley⁴, Livia Casciola-Rosen², Kellie Smith², Antony Rosen² and Erika Darrah², ¹Johns Hopkins University, Lutherville Timonium, MD, ²Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, ⁴Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD
Background/Purpose: Increasing evidence suggests an immunologic link between cancer and autoimmunity. Systemic sclerosis (SSc), offers a unique opportunity to study the evolution of naturally occurring…
Abstract Number: 2465 • ACR Convergence 2024
Subclinical Loss of Lung Volumes in Very Early SSc: Evidence from Two Independent Cohorts in EUSTAR
Vishal Kakkar¹, Stefano Di Donato², Silvia Bellando-Randone³, Riccardo Bixio⁴, Marco Matucci-Cerinic⁵, Yannick Allanore⁶ and Francesco Del Galdo¹, ¹University of Leeds, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK, Leeds, United Kingdom, ³University of Florence, Florence, Florence, Italy, ⁴University of Verona, Verona, Verona, Italy, ⁵University San Raffaele Milano, Milano, Milan, Italy, ⁶Université Paris Cité, Paris, France
Background/Purpose: Interstitial lung disease (ILD) remains as the major driver of mortality in systemic sclerosis (SSc). The literature indicates that at the time of diagnosis…
Abstract Number: 0309 • ACR Convergence 2024
Characteristics and Factors Associated with Treatment Response Among Patients with Eosinophilic Fasciitis: A Systematic Review and Meta-analysis
Omar Hamdan¹, Roa'a Alshajrawi¹, Qais Mussa¹, Yazeed Alajlouni¹, Yazan Dabbah¹, Rawan Fratekh¹, Yousef Al-Mabrouk², Shatha Al-Mabrok² and Ahmad A. Toubasi¹, ¹University of Jordan, Amman, Jordan, ²Mansoura University, Al Mansoura, Egypt
Background/Purpose: To date, data on the clinical features, diagnosis and the treatment of Eosinophilic Fasciitis (EF) patients are mostly derived from individual case reports, with…
Abstract Number: 0706 • ACR Convergence 2024
Single Center Prospective Cohort of Systemic Sclerosis Patients Who Are At-Risk for Pulmonary Hypertension
Carleigh Zahn¹, Scott Visovatti², Rosemary Gedert¹, Suiyuan Huang¹, Victor Moles¹, Amber Young¹, Vallerie McLaughlin¹ and Dinesh Khanna¹, ¹University of Michigan, Ann Arbor, MI, ²The Ohio State University, Columbus
Background/Purpose: Pulmonary hypertension (PH) is a leading cause of mortality in systemic sclerosis (SSc). We launched an IRB approved prospective study (NOVEL) in 2013 at…
Abstract Number: 1244 • ACR Convergence 2024
Creation of a New Patient-reported Outcome for a Combined Response Index for Limited Cutaneous SSc Using the FDA Guidance on Patient Reported Outcome Measures: The CRISTAL PRO
Alain Lescoat¹, Yen Chen², Rosemary Gedert², Neda Kortam², Nadia Vann², David Cella³, Sara Shaunfield⁴, Susan Murphy⁵ and Dinesh Khanna², ¹CHU Rennes - University Rennes 1, Rennes, France, ²University of Michigan, Ann Arbor, MI, ³Northwestern University, Chicago, IL, ⁴Northwestern University, Chicago, ⁵University of Michigan, Plymouth, MI
Background/Purpose: Limited cutaneous systemic sclerosis (lcSSc) is the most frequent subset of scleroderma, yet there is a paucity of outcome measures to assess symptoms that…
Abstract Number: 1692 • ACR Convergence 2024
Single Cell RNA-seq Identifies Circulating Double-negative-2 B-cell Population Associated with Progressive Scleroderma Interstitial Lung Disease
Trinitee Oliver¹, Kim Taylor², Ye Cao³, Takanori Sasaki⁴, Deepak Rao⁵, Nunzio Bottini⁶, Francesco Boin⁶ and Richard Ainsworth⁶, ¹Cedars-Sinai Medical Center, Hawthorne, CA, ²University of California, San Francisco, CA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Brookline, MA, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: B-cell subsets display aberrant function in systemic sclerosis (SSc) pathogenesis and infiltrate the lungs of SSc patients with interstitial lung disease (ILD). B-cells relevance…
Abstract Number: 1914 • ACR Convergence 2024
Racial and Ethnic Differences in the Prevalence of Disease Features in Systemic Sclerosis
Harry Hurley¹, Davina Chen², Xianhong Xie³, Manpreet Parmar⁴ and Bibi Ayesha⁵, ¹Albert Einstein College of Medicine, Maplewood, NJ, ²Montefiore Medical Center, New Rochelle, NY, ³Albert Einstein College of Medicine, Bronx, NY, ⁴Montefiore, Bronx, NY, ⁵Montefiore Medical Center, Metuchen, NJ
Background/Purpose: Systemic sclerosis (SSc) is a chronic, systemic autoimmune disease with a higher prevalence among women and racial/ethnic minority groups in the US. Despite the…
Abstract Number: 2468 • ACR Convergence 2024
Audio-Guided Imagery Positively Impacted Patients with Raynaud’s Phenomenon Associated Connective Tissue Disease
Cristina Padilla¹, Veena Katikineni², Yongseok Park¹, Leigh Freno³, Maureen Laffoon⁴ and Robyn Domsic⁵, ¹University of Pittsburgh, Pittsburgh, PA, ²Providence, Victorville, CA, ³University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴UPMC, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
Background/Purpose: Raynaud’s phenomenon (RP) is characterized as episodic color changes of the digits occurring with exposure to cold environments, sudden temperature decreases, and emotional stress. …
Abstract Number: 0361 • ACR Convergence 2024
Maternal and Fetal Outcomes in Those with Autoimmune Connective Tissue Disease
Nada Alrifai¹, Anushree Puttur², Laith Alhuneafat³, Fares Ghanem⁴, yadhu Dhital², Ahmad Jabri⁵ and David Feinstein⁶, ¹Cooper University Hospital, Cherry Hill, NJ, ²Allegheny Health Network, Pittsburgh, PA, ³University of Minnesota, Minneapolis, MN, ⁴Southern Illinois University, Springfield, IL, ⁵Henry Ford, Detroit, MI, ⁶Cooper University, Camden, NJ
Background/Purpose: Autoimmune connective tissue diseases (CTD) predominantly affect women during their reproductive years. CTDs such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic…
Abstract Number: 0710 • ACR Convergence 2024
High S100A4 Levels Associate with Inflammation and Vasculopathy in Systemic Sclerosis
Adela-Cristina Sarbu¹, Håvard Fretheim², Ladislav Šenolt³, Henriette Didriksen⁴, Cosimo Bruni⁵, Marco Sprecher⁶, Thor Ueland⁷, Jonas Hallén⁸, Rizwan Hussain⁹, Jörg Klingelhöfer¹⁰, Michal Tomcik¹¹, Yannick Allanore¹², Oliver Distler¹³ and Anna-Maria Hoffmann-Vold², ¹University Hospital Zurich, University of Zurich, Department of Rheumatology, Bern, Switzerland, ²Oslo University Hospital, Oslo, Norway, ³Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Oslo University Hospital, Moss, Norway, ⁵University of Zurich, Zurich, Switzerland, ⁶Universitätsspital Zürich (University Hospital Zurich), Zürich, Switzerland, ⁷Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, ⁸Arxx Therapeutics, Oslo, Norway, Oslo, Norway, ⁹Agiana Therapeutics, Oslo, Norway, Oslo, Norway, ¹⁰Calluna Pharma, Oslo, Norway, Oslo, Norway, ¹¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ¹²Université Paris Cité, Paris, France, ¹³Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: S100A4, a member of the S100 protein family, is implicated in various cellular processes. In systemic sclerosis (SSc), S100A4 is believed to contribute to…
Abstract Number: 1559 • ACR Convergence 2024
Vectorcardiography for Identification of Systemic Sclerosis Patients at Risk for Pulmonary Hypertension
S. Ahmed¹, Eva Hoekstra², Katie van der Wouden², Sum-Che Man², Kees Swenne², Madelon Vonk³, Anna-Maria Hoffmann-Vold⁴, Cosimo Bruni⁵, Udo Mulder⁶, Thomas Huizinga⁷, H.W. Vliegen² and Jeska de Vries-Bouwstra², ¹Leiden University Medical Centre, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Oslo University Hospital, Oslo, Norway, ⁵University of Zurich, Zurich, Switzerland, ⁶Universitair Medisch Centrum Groningen, Groningen, Netherlands, ⁷Department of Rheumatology, Leiden University, Leiden, Netherlands
Background/Purpose: Pulmonary hypertension (PH) in SSc causes significant disease burden and requires invasive diagnosis with right heart catheterization (RHC). Comprehensive work-up is needed to identify…
Abstract Number: 1814 • ACR Convergence 2024
Understanding Monocyte Derived Macrophages in the Skin of SSc Patients Through Single Cell Analysis of Blister Fluid Immune Cell Populations
Sandra Lopez Garces¹, Tamara Searle², Siyu Zhang¹, Henry Lopez³, Isra Elhussin⁴, Clayton Yates⁴, David Abraham⁵, Christopher Denton⁶, Bahja Ahmed Abdi¹ and Richard Stratton⁷, ¹University College London, London, United Kingdom, ²Imperial College London, London, United Kingdom, ³Riptide Bioscience Inc, Bethesda, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵UCL, London, United Kingdom, ⁶University College London, Northwood, United Kingdom, ⁷UCL, London, England, United Kingdom
Background/Purpose: Cells of the monocyte-macrophages (Mφ) are key players in the pathogenesis of systemic sclerosis (SSc), contributing to inflammation and fibrosis. To advance beyond the…
Abstract Number: 1920 • ACR Convergence 2024
Admixture Mapping and Gene-Based Analysis Identifies Rare Variants in Genes in the IL-13 and TGFβ Signaling Pathways in African Americans with Systemic Sclerosis
Jordan Hicks¹, Daniel Shriner², Ami Shah³, Maureen Mayes⁴, Ayo P. Doumatey², Amy R. Bentley¹, Robyn Domsic⁵, Thomas Medsger, Jr⁶, Paula Ramos⁷, Richard Silver⁸, Virginia Steen⁹, John Varga¹⁰, Vivien Hsu¹¹, Lesley Ann Saketkoo¹², Dinesh Khanna¹⁰, Elena Schiopu¹³, Jessica Gordon¹⁴, Lindsey Criswell¹⁵, Heather Gladue¹⁶, Chris Derk¹⁷, Elana Bernstein¹⁸, S. Louis Bridges¹⁴, Victoria Shanmugam¹⁹, Lorinda Chung²⁰, Suzanne Kafaja²¹, Reem Jan²², Marcin Trojanowski²³, Avram Goldberg²⁴, Benjamin Korman²⁵, James W. Thomas²⁶, Elaine Remmers²⁷, Adebowale Adeyemo², Charles Rotimi², Fredrick Wigley²⁸, Francesco Boin²⁹, Daniel Kastner³⁰ and Pravitt Gourh³¹, ¹National institute of Health, Bethesda, MD, ²Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, ⁴UTHealth Houston Division of Rheumatology, Houston, TX, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, ⁷Medical University of South Carolina, Charleston, SC, ⁸Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁹Georgetown University School of Medicine, Washington, DC, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Department of Medicine, Rheumatology Division, Rutgers-RWJ Medical School, South Plainfield, NJ, ¹²New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University and Tulane University Medical Schools, New Orleans, LA, ¹³Division of Rheumatology, Medical College of Georgia at Augusta University, Martinez, GA, ¹⁴Division of Rheumatology, Weill Cornell Medical College, New York, NY, ¹⁵Genomics of Autoimmune Rheumatic Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Bethesda, MD, ¹⁶Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, ¹⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁸Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, ¹⁹NIH Office of Autoimmune Disease Research in the Office of Research on Women's Health, National Institutes of Health, Bethesda, MD, Bethesda, MD, ²⁰Stanford University, Woodside, CA, ²¹Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²²Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, ²³Department of Rheumatology, Boston University School of Medicine, Boston, MA, ²⁴NYU Langone Health - NYU Hospital for Joint Diseases, Lake Success, NY, ²⁵University of Rochester, Rochester, NY, ²⁶NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁷Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁸Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, ²⁹Cedars-Sinai Medical Center, Los Angeles, CA, ³⁰National Human Genome Research Institute, Bethesda, MD, ³¹National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD
Background/Purpose: There are significant racial disparities in systemic sclerosis (SSc), with an increased disease burden and worse outcomes among African American (AA) individuals. Reasons for…

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