Abstracts tagged "Scleroderma"

Abstract Number: 874 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Subcutaneous Tocilizumab in Adults with Systemic Sclerosis: Week 24 Data from a Phase 2/3 Trial
Dinesh Khanna¹, Christopher P. Denton², Jacob M. van Laar³, Angelika Jahreis⁴, Sabrina Cheng⁴, Helen Spotswood⁵, Jeffrey Siegel⁴ and Daniel E. Furst on behalf of FaSScinate Clinical Trial in Patients With SS⁶, ¹University of Michigan Health System, Ann Arbor, MI, ²University College London Medical School, London, United Kingdom, ³University Medical Center Utrecht, Utrecht, Netherlands, ⁴Genentech, South San Francisco, CA, ⁵Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁶University of California, Los Angeles, CA
Background/Purpose: Systemic sclerosis (SSc) is a progressive, debilitating disease with limited treatment options. IL-6 has been implicated in disease pathogenesis.1,2 IL-6 receptor inhibition prevented and…
Abstract Number: 742 • 2014 ACR/ARHP Annual Meeting
Precision of Ultrasound Skin Thickness Measurements: Influence of Examiner and Ultrasound Transducer
Ingeborg A. Sacksen¹, P. Scott Pollock² and Mark H. Wener³, ¹Rheumatology, University of Washington, Seattle, WA, ²Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology & Lab Med, University of Washington, Seattle, WA
Background/Purpose Ultrasound has been used to measure scleroderma skin thickness, but it has not been established that routine clinical ultrasound equipment is adequate. We compared skin…
Abstract Number: 746 • 2014 ACR/ARHP Annual Meeting
Elevated Pentraxin 3 in Patients with Systemic Sclerosis: Associations with Vascular Manifestations and Defective Vasculogenesis
Yuichiro Shirai¹, Yuka Okazaki¹, Yumiko Inoue¹, Yuichi Tamura², Hidekata Yasuoka³, Tsutomu Takeuchi¹ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan
Background/Purpose: Pentraxin 3 (PTX3) is a multi-functional pattern recognition protein involved in inflammation, extracellular matrix deposition, and suppression of neovascularization mediated by fibroblast growth factor-2…
Abstract Number: 734 • 2014 ACR/ARHP Annual Meeting
Lower Socioeconomic Status, Male Gender and Diffuse Scleroderma Are Associated with Worse Survival in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Cohort
Jessica K. Gordon¹, Wei Zhang², Lorinda Chung³, Yan Ma⁴, Virginia D. Steen⁵ and PHAROS Investigators, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ³Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ⁴Research - Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ⁵Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose Lower socioeconomic status (SES) and male gender have been associated with worse survival in idiopathic pulmonary arterial hypertension (PAH). Pulmonary Hypertension Assessment and Recognition…
Abstract Number: 722 • 2014 ACR/ARHP Annual Meeting
Prediction of Improvement in Skin Fibrosis in Diffuse Cutaneous Systemic Sclerosis
Rucsandra Dobrota^1,2, Britta Maurer¹, Nicole Graf³, Carina Mihai², Otylia Kowal-Bielecka⁴, Yannick Allanore⁵ and Oliver Distler on behalf of the EUSTAR investigators and co-authors¹, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ³graf biostatistics, Winterthur, Switzerland, ⁴Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ⁵Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose Improvement of skin fibrosis over time is part of the “natural history” of patients with diffuse cutaneous systemic sclerosis (dcSSc). However, in the individual…
Abstract Number: 3002 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of a Newly Discovered HGF Receptor Carboxy-Terminal Fragment in Systemic Sclerosis
Yuichiro Shirai¹, Ilia Atanelishvili², Tanjina Akter¹, Richard Silver³ and Galina Bogatkevich¹, ¹Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ³Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is an irreversible fibrotic disorder with interstitial lung disease (ILD) being a major complication and leading cause of mortality. African American…
Abstract Number: 2704 • 2014 ACR/ARHP Annual Meeting
Fatigue in Systemic Sclerosis
Didem Uzunaslan¹, Caner Saygin¹, Tufan Torun², Mehmet Ozdemir² and Gulen Hatemi³, ¹University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ²Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey
Background/Purpose: Fatigue is a frequently reported disabling symptom for patients with systemic sclerosis (SSc). It has a major impact on overall quality of life including…
Abstract Number: 2919 • 2013 ACR/ARHP Annual Meeting
The Clinical Utility Of Flow-Mediated Dilation In Systemic Sclerosis
Tracy M. Frech¹, Ashley Walker², Zachary Barrett-Okeefe², Russell Richardson², D. Walter Wray² and Anthony Donato², ¹Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ²University of Utah, Salt Lake, UT
Background/Purpose: In systemic sclerosis (SSc, scleroderma) vasculopathy can result in the end-stage manifestation of a digital ulcer (DU). We hypothesized that bedside flow mediated dilatation…
Abstract Number: 682 • 2013 ACR/ARHP Annual Meeting
Effects Of Extracoporeal Shock Wave Therapy To The Digital Ulcers Of Scleroderma:a Pilot Study
Shinichiro Saito¹, Yukiko Kamogawa², Kyohei Nakamura³, Ryu Watanabe³, Tsuyoshi Shirai², Yoko Fujita⁴, Hiroshi Fujii³, Yuko Shirota⁵, Tomonori Ishii³, Hideo Harigae³, Katsuko Kikuchi⁶ and Yasushi Kawaguchi⁷, ¹Department of hematology and rheumatology, Tohoku University, Sendai, Japan, ²Tohoku University, Sendai, Japan, ³Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ⁴Department of Hematolgy and rheumatolgy, Tohoku University, Sendai, Japan, ⁵Department of Hematology and Rheumatolgy, Tohoku University, Sendai, Japan, ⁶Department of Dermatology, Tohoku University, Sendai, Japan, ⁷Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Vasculopathy, immunological abnormalities and excessive tissue fibrosis are key elements in the pathogenesis of Scleroderma (SSc). In winter, patients often display Raynaud syndrome, which…
Abstract Number: 647 • 2013 ACR/ARHP Annual Meeting
Enhanced Expression of CCR Receptors in Healthy AA and SSc ILD Monocytes
Rebecca Lee¹, Charles Reese², Beth Perry³, Jonathan Heywood², Michael Bonner¹, Richard P. Visconti⁴, Richard M. Silver⁵, Stanley Hoffman³ and Elena Tourkina², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Rheumatology, Medical University of SC, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁵Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC
Background/Purpose: Scleroderma-associated Interstitial Lung Disease (SSc ILD) is more prevalent and more severe in African Americans (AA) than in Caucasian (C) patients, but little is…
Abstract Number: 662 • 2013 ACR/ARHP Annual Meeting
Oxidative Stress-Dependent Activation Of Collagen Synthesis Is Induced In Human Pulmonary Vascular Smooth Muscle Cells By Scleroderma Sera and Predicts Pulmonary Vascular Disease
Francesco Boin¹, Anna Maria Posadino², Annalisa Cossu², Roberta Giordo², Ami A. Shah¹, Gaia Spinetti³, Gian Luca Erre⁴, Costanza Emanueli⁵, Giuseppe Passiu⁴, Fredrick M. Wigley¹ and Gianfranco Pintus², ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Biomedical Sciences, University of Sassari, Sassari, Italy, ³Istitituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Multi Medica, Milan, Italy, ⁴Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Sassari, Sassari, Italy, ⁵Laboratories of Vascular Pathology and Regeneration, University of Bristol, Bristol, United Kingdom
Background/Purpose: Vascular disease is a dominant component of Systemic Sclerosis (SSc) pathogenesis. Hypoxia and oxidative stress have been linked to endothelial injury, intimal hyperplasia and…
Abstract Number: 2625 • 2012 ACR/ARHP Annual Meeting
The Impact of Sexual Difficulties in Women with Scleroderma and Interpersonal Relationships
Tanaka Ngcozana¹, Louise Parker¹, Christopher P. Denton² and Voon Ong³, ¹Centre for Rheumatology and Connective Diseases, UCL Medical School and Royal Free Hosp, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³Department of Rheumatology, UCL Medical School, London, England
Background/Purpose: Sexual problems are common in women with systemic sclerosis (SSc). SSc is a complicated condition linked to a number of complications including sexual dysfunction.…
Abstract Number: 2424 • 2012 ACR/ARHP Annual Meeting
Sleep Disturbances in Systemic Sclerosis: Evidence for the Role of Gastrointestinal Symptoms, Pain, and Pruritus
Katherine Milette¹, Marie Hudson², Annett Koerner¹, Murray Baron³ and Brett D. Thombs⁴, ¹Educational and Counselling Psychology, McGill University, Montreal, QC, Canada, ²Jewish General Hospital, McGill University, Montreal, QC, Canada, ³Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁴Psychiatry, McGill University, Montreal, QC, Canada
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune connective tissue disorder characterized by thickening and fibrosis of the skin and internal organs. There is significant mortality…
Abstract Number: 1512 • 2012 ACR/ARHP Annual Meeting
Bleomycin Delivery by Osmotic Pump: A Superior Model for Human ILD
Rebecca Lee¹, Michael Bonner², Charles Reese², Elena Tourkina³, Zoltan Hajdu², Jing Zhang², Richard Visconti² and Stanley Hoffman², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of SC, Charleston, SC
Background/Purpose: Interstitial lung disease (ILD) represents a group of chronic, progressive, irreversible diseases associated with pulmonary fibrosis, including systemic sclerosis and idiopathic pulmonary fibrosis. In…
Abstract Number: 1488 • 2012 ACR/ARHP Annual Meeting
Prevalence and Risk Factors of Low Bone Mineral Density in Chinese Patients with Systemic Sclerosis: A Case-Control Study
Chi Chiu Mok, Pak To Chan, Kar Li Chan, Ling Yin Ho and Chi Hung To, Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong
Background/Purpose: To study the prevalence and risk factors of low bone mineral density (BMD) in patients with systemic sclerosis (SSc). Methods: Consecutive patients who fulfilled…

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