ACR Meeting Abstracts

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Abstracts tagged "scleroderma and systemic sclerosis"

  • Abstract Number: 974 • 2016 ACR/ARHP Annual Meeting

    Diffuse Scleroderma, Male Sex, and Myopathy Are Associated with Severe Gastrointestinal Dysmotility in Scleroderma

    Zsuzsanna McMahan1, Livia Casciola-Rosen2 and Fredrick M. Wigley3, 1Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Despite the fact that up to 90% of scleroderma (SSc) patients are affected by gastrointestinal (GI) dysmotility, features associated with severe GI disease are…
  • Abstract Number: 2968 • 2015 ACR/ARHP Annual Meeting

    Interrater Reliability of Nailfold Capillaroscopy in Systemic Sclerosis Using Widefield Microscopy

    Jessica K. Gordon1, Meng Zhang2, Shervin Assassi3, Elana J. Bernstein4, Robyn T. Domsic5, Faye N. Hant6, Monique E. Hinchcliff7, Dinesh Khanna8, Ami A. Shah9, Victoria K. Shanmugam10,11, Virginia D. Steen12 and Tracy M. Frech13, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, 3Rheumatology, University of Texas Medical School at Houston, Houston, TX, 4Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 5Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Dept of Medicine, Medical University of South Carolina, Charleston, SC, 7Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 8Division of Rheumatology, University of Michigan, Ann Arbor, MI, 9Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 10Director, Division of Rheumatology, The George Washington University, Washington, DC, 11Division of Rheumatology, The George Washington University, Washington, DC, 12Rheumatology, Georgetown University Medical Center, Washington, DC, 13Div of Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: The presence of nailfold capillary (NFC) abnormality is part of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis (SSc).  NFC findings include the presence…
  • Abstract Number: 2978 • 2015 ACR/ARHP Annual Meeting

    Longitudinal Assessment of Gastrointestinal Symptoms in the Prospective Registry of Early Systemic Sclerosis Cohort

    Tracy M. Frech1, Maureen Murtaugh2, Jessica K. Gordon3, Robyn T. Domsic4, Ami A. Shah5, Faye N. Hant6, Shervin Assassi7, Monique E. Hinchcliff8, Elana J. Bernstein9, Virginia D. Steen10, Victoria K. Shanmugam11,12 and Dinesh Khanna13, 1Div of Rheumatology, University of Utah, Salt Lake City, UT, 2University of Utah, Salt Lake, UT, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 5Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Dept of Medicine, Medical University of South Carolina, Charleston, SC, 7Rheumatology, University of Texas Medical School at Houston, Houston, TX, 8Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 9Columbia University, New Yory, NY, 10Rheumatology, Georgetown University Medical Center, Washington, DC, 11Director, Division of Rheumatology, The George Washington University, Washington, DC, 12Division of Rheumatology, The George Washington University, Washington, DC, 13Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) is a multicenter incident cohort study of patients with early diffuse cutaneous systemic sclerosis (dcSSc; <…
  • Abstract Number: 829 • 2015 ACR/ARHP Annual Meeting

    Fecal Incontinence and Association with Bowel Dysfunction in Systemic Sclerosis: A Canadian Multicenter Study

    Nicolas Richard1,2, Marie Hudson2, Genevieve Gyger2, Murray Baron3, Evelyn Sutton4, Nader A. Khalidi5, Janet E. Pope6, Nathalie Carrier1, Maggie J. Larche5, Alexandra Albert7, Paul R. Fortin7, Carter Thorne8, Ariel Masetto9 and Canadian Scleroderma Research Group, 1Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 2McGill University, Jewish General Hospital, Montreal, QC, Canada, 3Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 4Rheumatology, Dalhousie University, Nova Scotia Rehabilitation Centre, Halifax, NS, Canada, 5McMaster University, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 6Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, 7Université Laval, CHU de Québec, Québec, QC, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

    Background/Purpose: Gastrointestinal (GI) tract involvement is a common and serious complication of systemic sclerosis (SSc). However, the prevalence of fecal incontinence (FI) and its relationship…
  • Abstract Number: 2979 • 2015 ACR/ARHP Annual Meeting

    Laser Speckled Imaging and Videomicroscopy Assessment of Sublingual Perfusion in Systemic Sclerosis and Healthy Controls

    Mark Sievert1, Daniel R. Machin2, Anthony J. Donato2, Maureen Murtaugh3, John D. Pauling4, Robyn T. Domsic5, Lee S. Shapiro6 and Tracy M. Frech7, 1University of Utah, Salt Lake City, UT, 2University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, 3University of Utah, Salt Lake, UT, 4Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom, 5Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Steffens Scleroderma Center, Albany, NY, 7Div of Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: Our group has previously described the sublingual frenulum abnormalities in systemic sclerosis (SSc, scleroderma).   The goal of this project was to assess microvascular abnormalities…
  • Abstract Number: 831 • 2015 ACR/ARHP Annual Meeting

    Mycophenolate Decreases the Frequency of Endoscopic Therapy for Gastric Antral Vascular Ectasia in Patients with Systemic Sclerosis

    Tiffany Lin1, James Bena2, Shannon Morrison2 and Soumya Chatterjee3, 1Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 2Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Gastric antral vascular ectasia (GAVE) is an increasingly recognized cause of upper gastrointestinal bleeding in patients with systemic sclerosis (SSc).  These patients may require…
  • Abstract Number: 2980 • 2015 ACR/ARHP Annual Meeting

    Assessment of Sublingual Frenulum Perfusion in Systemic Sclerosis

    Tracy M. Frech1, Daniel R. Machin2, Phillip E. Gates2, Robyn T. Domsic3, Lee S. Shapiro4, John D. Pauling5 and Anthony J. Donato2, 1Div of Rheumatology, University of Utah, Salt Lake City, UT, 2University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, 3Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Steffens Scleroderma Center, Albany, NY, 5Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom

    Background/Purpose: SSc is characterized by vasculopathy that precedes fibrosis and progresses to end-stage vascular manifestations such as malnutrition due to gastro-intestinal tract (GIT) involvement. Clinical…
  • Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting

    The Validity and Reliability of Online Obituaries As a Source of Mortality Data

    Medha Soowamber1, John T. Granton2, Fatemeh Bavaghar-Zaeimi3 and Sindhu R. Johnson4,5, 1Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, 2Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, 3Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, 4Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 5Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
  • Abstract Number: 2986 • 2015 ACR/ARHP Annual Meeting

    Systemic Sclerosis Patients on Intensive Care Unit – Reasons for Admission and Determinants of Outcome

    Svetlana I. Nihtyanova1, Francesco Figorilli2, Christopher P. Denton3, Banwari Agarwal2 and Voon H. Ong1, 1Rheumatology, UCL Division of Medicine, London, United Kingdom, 2ITU, Royal Free Hospital, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose: Little has been published on systemic sclerosis (SSc) patients requiring admission to Intensive Care Unit (ICU) for organ support; published results suggest respiratory failure…
  • Abstract Number: 841 • 2015 ACR/ARHP Annual Meeting

    Prevalence of Systemic Sclerosis in Primary Biliary Cirrhosis Using the New ACR/EULAR Classification Criteria

    Boyang Zheng1, Catherine Vincent2, Marvin J. Fritzler3, Jean-Luc Senécal4, Martial Koenig5 and France Joyal5, 1Division of Internal Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, 2Division of Hepatology, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, 3Medicine, University of Calgary, Calgary, AB, Canada, 4Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 5Department of Medicine, Division of Internal Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada

    Background/Purpose: Systemic sclerosis (SSc) is a well established disease associated with primary biliary cirrhosis (PBC), however original 1980 American College of Rheumatology (ACR) criteria have…
  • Abstract Number: 2995 • 2015 ACR/ARHP Annual Meeting

    Genome Wide Analysis in Scleroderma Renal Crisis: Defining Genetic Risk in Patients with RNA Polymerase III Auto-Antibodies

    Maria C Fonseca1, Sandra Guerra1, Edward Stern1,2, Svetlana I. Nihtyanova1, David Abraham3, Aine Burns2, Mark Harber2 and Christopher P. Denton4, 1Rheumatology, UCL Division of Medicine, London, United Kingdom, 2Nephrology, Royal Free Hospital, London, United Kingdom, 3Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC) is a severe complication of systemic sclerosis (SSc). Most SSc cases demonstrate a disease-specific antinuclear antibody including anti-RNA polymerase III…
  • Abstract Number: 845 • 2015 ACR/ARHP Annual Meeting

    Modelling of Longitudinal Changes in Lung Function in Patients with Systemic Sclerosis and Their Association with Development of Pulmonary Hypertension

    Svetlana I. Nihtyanova1, Voon H. Ong1 and Christopher P. Denton2, 1Rheumatology, UCL Division of Medicine, London, United Kingdom, 2Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose: The majority of published models for prediction of PH use cross-sectional data, while studies exploring the use of repeated measurements of lung function tests…
  • Abstract Number: 3006 • 2015 ACR/ARHP Annual Meeting

    Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation

    Shadia Nada1, Omar Oraibi2, Farouk Abu Alhana2, Nawaf Almeshal2, Yongqing Wang2, Nezam Altorok3 and Bashar Kahaleh4, 1Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, 2The University of Toledo, Toledo, OH, 3Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, 4Medicine/Rheumatology, The University of Toledo, Toledo, OH

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction, vascular injury, and activation of fibroblasts leading to organ fibrosis. The precise etiology…
  • Abstract Number: 849 • 2015 ACR/ARHP Annual Meeting

    A Computational Tool for Individualized Prognosis of Percent of Predicted Forced Vital Capacity Trajectories in Systemic Sclerosis

    Peter Schulam1, Colin Ligon2, Robert Wise3, Laura K. Hummers4, Fredrick M. Wigley5 and Suchi Saria1,6, 1Department of Computer Science, Johns Hopkins University, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, 6Departments of Biostatistics, and Health Policy and Management, Bloomberg School of Public Health, Baltimore, MD

    Background/Purpose: Interstitial lung disease (ILD) is a common cause of mortality in systemic sclerosis (Ssc). Decreased forced vital capacity (FVC) in Ssc-ILD is associated with…
  • Abstract Number: 3007 • 2015 ACR/ARHP Annual Meeting

    Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis

    Yongqing Wang1, John Sun1, Shadia Nada2, Nezam Altorok3 and Bashar Kahaleh4, 1The University of Toledo, Toledo, OH, 2Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, 3Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, 4Medicine/Rheumatology, The University of Toledo, Toledo, OH

    Background/Purpose: Enhanced cold sensitivity is an early and consistent phenomenon in scleroderma (SSc). We previously demonstrated increased expression of the transient receptor potential melastatine 8…
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