Abstracts tagged "scleroderma and systemic sclerosis"

Abstract Number: 833 • 2016 ACR/ARHP Annual Meeting
A Small Proportion of Patients with Systemic Sclerosis with Suspected Pulmonary Hypertension Meet the Published Inclusion/Exclusion Criteria for Two Systemic Sclerosis Associated Pulmonary Arterial Hypertension Screening Algorithms– Results from a Single Center Cohort
Amber Young¹, Victor Moles², Vivek Nagaraja³, Scott H. Visovatti⁴, Vallerie McLaughlin⁴ and Dinesh Khanna⁵, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, ³Department of Medicine [Division of Rheumatology], University of Toledo, Toledo, OH, ⁴Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Pulmonary arterial hypertension (PAH) is one of the leading causes of mortality in patients with systemic sclerosis (SSc). Active screening detects SSc-PAH earlier and…
Abstract Number: 1888 • 2015 ACR/ARHP Annual Meeting
There Is a Need for New Systemic Sclerosis Subset Criteria: A Content Analytic Approach
Sindhu Johnson¹, Medha Soowamber², Jaap Fransen³, Dinesh Khanna⁴, Frank H.J. van den Hoogen⁵, Murray Baron⁶, Marco Matucci Cerinic⁷, Christopher P. Denton⁸, Thomas A. Medsger Jr.⁹, Patricia E. Carreira¹⁰, Gabriela Riemekasten¹¹, Jorg HW. Distler¹², Armando Gabrielli¹³, Virginia D. Steen¹⁴, Lorinda Chung¹⁵, Richard Silver¹⁶, John Varga¹⁷, Ulf Müller-Ladner¹⁸, Madelon C. Vonk¹⁹, Ulrich A. Walker²⁰, Frank Wollheim²¹, Ariane L. Herrick²², Daniel E. Furst²³, Lazlo Czirjak²⁴, Otylia Kowal-Bielecka²⁵, Francesco Del Galdo²⁶, Maurizio Cutolo²⁷, Nicolas Hunzelmann²⁸, Charles Murray²⁹, Ivan Foeldvari³⁰, Luc Mouthon³¹, Nemanja Damjanov³², Bashar Kahaleh³³, Tracy M. Frech³⁴, Shervin Assassi³⁵, Lesley Ann Saketkoo³⁶ and Janet E. Pope³⁷, ¹Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ²Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ⁴Medicine, University of Michigan, Ann Arbor, MI, ⁵Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁶Pavillion A, Rm 216, Jewish General Hospital, Montreal, QC, Canada, ⁷Department of BioMedicine, Division of Rheumatology, Transition Unit, University of Florence, Firenze, Italy, ⁸Centre for Rheumatology, Royal Free Hospital, London, United Kingdom, ⁹Medicine/Rheumatology, Univ of Pittsburgh, Pittsburgh, PA, ¹⁰Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Rheumatology, Human medicine, BERLIN, Germany, ¹²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ¹³Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ¹⁴Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹⁶Div Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ¹⁷Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁸Rheumatology, Internal Medicine, Bad Nauheim, Germany, ¹⁹Rheumatology, Rheumatology, Nijmegen, Netherlands, ²⁰Rheumatology, Systemic Sclerosis, Basel, Switzerland, ²¹Rheumatology, Lund University Hospital, Lund, Sweden, ²²Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²⁴University of Pécs Medical Center, Pécs, Hungary, ²⁵Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ²⁶University of Leeds, Leeds, United Kingdom, ²⁷Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²⁸Department of Dermatology, University of Cologne, Cologne, Germany, ²⁹Department of Gastroenterology, Royal Free Hospital, London, United Kingdom, ³⁰Rheumatology, Hamburg, Germany, ³¹Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, ³²Resavska 69, Institute of Rheumatology, Belgrade, Serbia, ³³Medicine/Rheumatology, The University of Toledo, Toledo, OH, ³⁴Div of Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT, ³⁵Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³⁶Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ³⁷University of Western Ontario, London, ON, Canada
Background/Purpose: Systemic sclerosis (SSc) is a family of diseases unified by the presence of immune activation, vasculopathy and fibrosis. The concept of SSc subsets cannot…
Abstract Number: 1889 • 2015 ACR/ARHP Annual Meeting
Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease
Natalie K. Kozij¹, John T. Granton², Philip E. Silkoff³, John Thenganatt⁴, Shobha Chakravorty⁴ and Sindhu R. Johnson⁵, ¹Department of Medicine, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada., Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Medicine, Temple University, Philadelphia, PA, ⁴Respirology, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ⁵Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
Background/Purpose: We evaluated the ability of alveolar and conducting airway nitric oxide (NO) to discriminate between systemic sclerosis (SSc) with and without lung involvement, idiopathic…
Abstract Number: 1901 • 2015 ACR/ARHP Annual Meeting
Association of Serum Adipokines Adipsin, Adiponectin, and Leptin/Adiponectin Ratio with Systemic Sclerosis
Benjamin Korman¹, Roberta Goncalves Marangoni¹, Monique E. Hinchcliff², Sanjiv Shah³, Mary A. Carns⁴, Rosalind Ramsey-Goldman⁵ and John Varga⁶, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University, Chicago, IL, ⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Patients with systemic sclerosis (SSc) display reductions in adipose tissue, particularly intradermal adipose tissue. There are currently no well-validated serum biomarkers in SSc, and…
Abstract Number: 1911 • 2015 ACR/ARHP Annual Meeting
Monocyte Chemoattractant Protein-1 (MCP-1, CCL2) Is a Potential Local Marker of Renal Involvement in Scleroderma
Edward Stern^1,2, Cassandra Hong², Voon H. Ong², Aine Burns¹, Robert Unwin³ and Christopher P. Denton⁴, ¹Nephrology, Royal Free Hospital, London, United Kingdom, ²Rheumatology, UCL Division of Medicine, London, United Kingdom, ³Nephrology, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Renal disease in scleroderma (SSc), including scleroderma renal crisis (SRC), remains a major clinical challenge. Previous studies showed up to 50% of SSc patients…
Abstract Number: 2968 • 2015 ACR/ARHP Annual Meeting
Interrater Reliability of Nailfold Capillaroscopy in Systemic Sclerosis Using Widefield Microscopy
Jessica K. Gordon¹, Meng Zhang², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Dinesh Khanna⁸, Ami A. Shah⁹, Victoria K. Shanmugam^10,11, Virginia D. Steen¹² and Tracy M. Frech¹³, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁰Director, Division of Rheumatology, The George Washington University, Washington, DC, ¹¹Division of Rheumatology, The George Washington University, Washington, DC, ¹²Rheumatology, Georgetown University Medical Center, Washington, DC, ¹³Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: The presence of nailfold capillary (NFC) abnormality is part of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis (SSc). NFC findings include the presence…
Abstract Number: 2978 • 2015 ACR/ARHP Annual Meeting
Longitudinal Assessment of Gastrointestinal Symptoms in the Prospective Registry of Early Systemic Sclerosis Cohort
Tracy M. Frech¹, Maureen Murtaugh², Jessica K. Gordon³, Robyn T. Domsic⁴, Ami A. Shah⁵, Faye N. Hant⁶, Shervin Assassi⁷, Monique E. Hinchcliff⁸, Elana J. Bernstein⁹, Virginia D. Steen¹⁰, Victoria K. Shanmugam^11,12 and Dinesh Khanna¹³, ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake, UT, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁸Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Columbia University, New Yory, NY, ¹⁰Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Director, Division of Rheumatology, The George Washington University, Washington, DC, ¹²Division of Rheumatology, The George Washington University, Washington, DC, ¹³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) is a multicenter incident cohort study of patients with early diffuse cutaneous systemic sclerosis (dcSSc; <…
Abstract Number: 829 • 2015 ACR/ARHP Annual Meeting
Fecal Incontinence and Association with Bowel Dysfunction in Systemic Sclerosis: A Canadian Multicenter Study
Nicolas Richard^1,2, Marie Hudson², Genevieve Gyger², Murray Baron³, Evelyn Sutton⁴, Nader A. Khalidi⁵, Janet E. Pope⁶, Nathalie Carrier¹, Maggie J. Larche⁵, Alexandra Albert⁷, Paul R. Fortin⁷, Carter Thorne⁸, Ariel Masetto⁹ and Canadian Scleroderma Research Group, ¹Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²McGill University, Jewish General Hospital, Montreal, QC, Canada, ³Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁴Rheumatology, Dalhousie University, Nova Scotia Rehabilitation Centre, Halifax, NS, Canada, ⁵McMaster University, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁶Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, ⁷Université Laval, CHU de Québec, Québec, QC, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: Gastrointestinal (GI) tract involvement is a common and serious complication of systemic sclerosis (SSc). However, the prevalence of fecal incontinence (FI) and its relationship…
Abstract Number: 2979 • 2015 ACR/ARHP Annual Meeting
Laser Speckled Imaging and Videomicroscopy Assessment of Sublingual Perfusion in Systemic Sclerosis and Healthy Controls
Mark Sievert¹, Daniel R. Machin², Anthony J. Donato², Maureen Murtaugh³, John D. Pauling⁴, Robyn T. Domsic⁵, Lee S. Shapiro⁶ and Tracy M. Frech⁷, ¹University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³University of Utah, Salt Lake, UT, ⁴Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Steffens Scleroderma Center, Albany, NY, ⁷Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: Our group has previously described the sublingual frenulum abnormalities in systemic sclerosis (SSc, scleroderma). The goal of this project was to assess microvascular abnormalities…
Abstract Number: 831 • 2015 ACR/ARHP Annual Meeting
Mycophenolate Decreases the Frequency of Endoscopic Therapy for Gastric Antral Vascular Ectasia in Patients with Systemic Sclerosis
Tiffany Lin¹, James Bena², Shannon Morrison² and Soumya Chatterjee³, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Gastric antral vascular ectasia (GAVE) is an increasingly recognized cause of upper gastrointestinal bleeding in patients with systemic sclerosis (SSc). These patients may require…
Abstract Number: 2980 • 2015 ACR/ARHP Annual Meeting
Assessment of Sublingual Frenulum Perfusion in Systemic Sclerosis
Tracy M. Frech¹, Daniel R. Machin², Phillip E. Gates², Robyn T. Domsic³, Lee S. Shapiro⁴, John D. Pauling⁵ and Anthony J. Donato², ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Steffens Scleroderma Center, Albany, NY, ⁵Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom
Background/Purpose: SSc is characterized by vasculopathy that precedes fibrosis and progresses to end-stage vascular manifestations such as malnutrition due to gastro-intestinal tract (GIT) involvement. Clinical…
Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting
The Validity and Reliability of Online Obituaries As a Source of Mortality Data
Medha Soowamber¹, John T. Granton², Fatemeh Bavaghar-Zaeimi³ and Sindhu R. Johnson^4,5, ¹Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, ⁴Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁵Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada
Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
Abstract Number: 2986 • 2015 ACR/ARHP Annual Meeting
Systemic Sclerosis Patients on Intensive Care Unit – Reasons for Admission and Determinants of Outcome
Svetlana I. Nihtyanova¹, Francesco Figorilli², Christopher P. Denton³, Banwari Agarwal² and Voon H. Ong¹, ¹Rheumatology, UCL Division of Medicine, London, United Kingdom, ²ITU, Royal Free Hospital, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Little has been published on systemic sclerosis (SSc) patients requiring admission to Intensive Care Unit (ICU) for organ support; published results suggest respiratory failure…
Abstract Number: 841 • 2015 ACR/ARHP Annual Meeting
Prevalence of Systemic Sclerosis in Primary Biliary Cirrhosis Using the New ACR/EULAR Classification Criteria
Boyang Zheng¹, Catherine Vincent², Marvin J. Fritzler³, Jean-Luc Senécal⁴, Martial Koenig⁵ and France Joyal⁵, ¹Division of Internal Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ²Division of Hepatology, Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada, ⁴Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁵Department of Medicine, Division of Internal Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada
Background/Purpose: Systemic sclerosis (SSc) is a well established disease associated with primary biliary cirrhosis (PBC), however original 1980 American College of Rheumatology (ACR) criteria have…
Abstract Number: 2995 • 2015 ACR/ARHP Annual Meeting
Genome Wide Analysis in Scleroderma Renal Crisis: Defining Genetic Risk in Patients with RNA Polymerase III Auto-Antibodies
Maria C Fonseca¹, Sandra Guerra¹, Edward Stern^1,2, Svetlana I. Nihtyanova¹, David Abraham³, Aine Burns², Mark Harber² and Christopher P. Denton⁴, ¹Rheumatology, UCL Division of Medicine, London, United Kingdom, ²Nephrology, Royal Free Hospital, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC) is a severe complication of systemic sclerosis (SSc). Most SSc cases demonstrate a disease-specific antinuclear antibody including anti-RNA polymerase III…

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