ACR Meeting Abstracts

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Abstracts tagged "scleroderma and systemic sclerosis"

  • Abstract Number: 853 • 2012 ACR/ARHP Annual Meeting

    Systemic Sclerosis Classification Criteria: Developing Methods for Multi-Criteria Decision Analysis

    Sindhu R. Johnson1, Raymond P. Naden2, Jaap Fransen3, Frank H.J. van den Hoogen4, Janet E. Pope5, Murray Baron6, Alan G. Tyndall7, Marco Matucci-Cerinic8 and Dinesh Khanna on behalf of ACR/EULAR Classification Criteria SSc9, 1Dept of Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 2Auckland City Hospital, Auckland, New Zealand, Austria, 3Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 5Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, 6Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 7Rheumatology, University of Basel, Basel, Switzerland, 8Medicine, Univ Florence, Firenze, Italy, 9Div of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Classification criteria for systemic sclerosis (SSc) are being developed. Twenty-three candidate criteria have been identified, but need to be reduced. The objectives of this…
  • Abstract Number: 1470 • 2012 ACR/ARHP Annual Meeting

    Clinical Features Associated with Anti-Th/to in Non-Scleroderma Patients – Sine Scleroderma?

    Ann D. Chauffe1, Minoru Satoh1, Angela Ceribelli2, Edward K.L. Chan2, Yi Li1, Eric S. Sobel3, Westley H. Reeves4 and Michael R. Bubb1, 1Medicine, University of Florida, Gainesville, FL, 2Oral Biology, University of Florida, Gainesville, FL, 3Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, 4Rheumatology & Clinical Imm, University of Florida, Gainesville, FL

    Background/Purpose: Autoantibodies in scleroderma (systemic sclerosis, SSc) such as anti-topoisomerase I (Scl-70), RNA polymerase III, centromere, U3RNP/fibrillarin, and Th/To are associated with a unique subset…
  • Abstract Number: 1464 • 2012 ACR/ARHP Annual Meeting

    Comparison of Baseline Characteristics of the Combined Response Index for Systemic Sclerosis (CRISS) Cohort to Patients Enrolled in Clinical Trials of Diffuse Systemic Sclerosis

    Heather Gladue1, Daniel Furst2, Veronica Berrocal3, James R. Seibold4, Peter A. Merkel5, Maureen D. Mayes6, Kristine Phillips7, Robert W. Simms8, Shervin Assassi9, Philip J. Clements10, Paul Maranian11 and Dinesh Khanna12, 1University of Michigan, Ann Arbor, MI, 2David Geffen School of Medicine, Div of Rheumatology, University of California at Los Angeles, Los Angeles, CA, 3Div of Rheumatology, University of Michigan, Ann Arbor, MI, 4Scleroderma Research Consultants LLC, Avon, CT, 5University of Pennsylvania, Philadelphia, PA, 6Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 7Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 8Rheumatology, Boston University School of Medicine, Boston, MA, 9Rheumatology, Univ of Texas Health Science Houston, Houston, TX, 10University of California, Los Angeles, Department of Medicine, Los Angeles, CA, 11Division of Rheumatology, UCLA Medical School, Los Angeles, CA, 12Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Randomized clinical trials (RCTs) of treatment of diffuse systemic sclerosis (dcSSc) would benefit from a composite index that predicted efficacy better than current standard…
  • Abstract Number: 1505 • 2012 ACR/ARHP Annual Meeting

    Inactivation of Tankyrases Ameliorates Canonical Wnt Signaling and Prevents Experimental Fibrosis

    Alfiya Distler1, Lisa Deloch2, Jingang Huang2, Clara Dees2, Neng Yu Lin2, Christian Beyer3, Oliver Distler4, Georg A. Schett5 and Joerg HW Distler1, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Systemic sclerosis (SSc) is characterized by aberrant activation of fibroblasts with increased release of extracellular matrix components. Canonical Wnt signaling has recently emerged as…
  • Abstract Number: 1712 • 2012 ACR/ARHP Annual Meeting

    The Submaximal Heart and Pulmonary Evaluation: A Novel Noninvasive Test to Identify Pulmonary Hypertension in Patients with Systemic Sclerosis

    Elana J. Bernstein1, Jessica K. Gordon2, Robert F. Spiera2, Lisa A. Mandl2 and Evelyn M. Horn3, 1Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Cardiology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY

    Background/Purpose: Pulmonary hypertension (PH), defined as a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg on right heart catheterization (RHC), is a leading cause of…
  • Abstract Number: 1805 • 2012 ACR/ARHP Annual Meeting

    The Pro-Fibrotic Cytokines IL-33 and IL-13 Modulates Dermal Fibrosis Via the A2A Adenosine Receptor

    Ross C. Radusky1, Jessica L. Feig2, Bruce N. Cronstein3, Andrew G. Franks Jr.4 and Edwin SL Chan1, 1Medicine, New York University School of Medicine, New York, NY, 2Medicine. Department of Translational Medicine, New York University School of Medicine, New York, NY, 3Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY, 4Dermatology & Medicine (Rheumatology), New York University, New York, NY

    Background/Purpose: We have previously demonstrated that the nucleoside adenosine mediates collagen production and induce dermal fibrosis in in vitro and in vivo models. IL–13 expression…
  • Abstract Number: 2295 • 2012 ACR/ARHP Annual Meeting

    Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells in Vitro

    Zhaodong Li1, Peter J. Wermuth2, Bryan Benn2, Michael P. Lisanti3 and Sergio A. Jimenez2, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 3Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Recent studies demonstrated that the phenotypic transition of endothelial cells (EC) into activated mesenchymal cells, a process known an endothelial-to-mesenchymal transition (EndoMT), may be…
  • Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting

    Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study

    Lara Bossini-Castillo1, Jose Ezequiel Martin2, Carmen Pilar Simeon3, Lorenzo Beretta4, Olga Y. Gorlova5, Madelon C. Vonk6, Patricia Carreira7, the Spanish Scleroderma Group8, Annemie Schuerwegh9, Alexandre Voskuyl10, Anna-Maria Hoffmann-Vold11, Roger Hesselstrand12, Annika Nordin13, Claudio Lunardi14, Jaap Van Laar15, Paul Shiels16, Ariane Herrick17, Jane Worthington18, Carmen Fonseca19, Christopher P. Denton19, Shervin Assassi20, Bobby P.C. Koeleman21, Maureen D. Mayes22, T.R.D.J. Radstake23 and Javier Martin1, 1Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 2Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 3Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, 4Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 5Department of Epidemiology, UT M. D. Anderson Cancer Center, Houston, TX, 6Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 7Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 8Granada, Spain, 9Leids Univ Medisch Centrum, Leiden, Netherlands, 10Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 11Rheumatology, Oslo University Hospital, Oslo, Norway, 12Rheumatology, Lund University, Lund, Sweden, 13Department of Rheumatology, Karolinska Institute, Stockholm, Sweden, 14Department of Medicine, Università degli Studi di Verona, Verona, Italy, 15Rheumatology, Leiden University Hospital, Leiden, Netherlands, 16University of Glasgow, Glasgow, United Kingdom, 17Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, 18Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 19Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 20Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 22Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 23Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…
  • Abstract Number: 2422 • 2012 ACR/ARHP Annual Meeting

    Sexual Activity and Sexual Functioning Among Women with Systemic Sclerosis Compared to Women From a Population Sample

    Brooke Levis1, Andrea Burri2, Marie Hudson3, Murray Baron4 and Brett D. Thombs5, 1Epidemiology, McGill University, Montreal, QC, Canada, 2Twin Research and Genetic Epidemiology, King's College, London, United Kingdom, 3Jewish General Hospital, McGill University, Montreal, QC, Canada, 4Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 5Psychiatry, McGill University, Montreal, QC, Canada

    Background/Purpose: Systemic sclerosis (SSc), or scleroderma, is a chronic, multi-system, connective tissue disorder characterized by thickening and fibrosis of the skin and internal organ involvement.…
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