Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Systemic sclerosis (SSc) is a well established disease associated with primary biliary cirrhosis (PBC), however original 1980 American College of Rheumatology (ACR) criteria have poor sensitivity, especially for detection of earlier SSc in previous studies. The objective is to evaluate the prevalence of SSc in PBC patients using more sensitive 2001 LeRoy criteria and the recent 2013 ACR/European League Against Rheumatism (EULAR) classification criteria, and secondarily the frequency of individual clinical features.
100 PBC patients without previously diagnosed SSc were recruited over 18 months from a tertiary care gastroenterology clinic. All patients underwent a clinical, biological, and capillaroscopic evaluation. Fulfillment of the three different criteria sets were analyzed.
1% of the PBC patients met the ACR 1980 criteria. 22% met the 2001 LeRoy’s criteria for early SSc and 16% the 2013 ACR/EULAR criteria. Raynaud phenomenon, SSc related antibodies and SSc nailfold capillaroscopy changes were the most prevalent findings with the highest sensitivities to help guide future screening.
Our data show a high prevalence of SSc and possible underestimation of previous studies using the original ACR 1980 criteria. SSc based on newly described criteria may lead to improved detection and increased benefits of earlier treatment in ameliorating SSc related morbidity and mortality.
To cite this abstract in AMA style:Zheng B, Vincent C, Fritzler MJ, Senécal JL, Koenig M, Joyal F. Prevalence of Systemic Sclerosis in Primary Biliary Cirrhosis Using the New ACR/EULAR Classification Criteria [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-systemic-sclerosis-in-primary-biliary-cirrhosis-using-the-new-acreular-classification-criteria/. Accessed October 20, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-systemic-sclerosis-in-primary-biliary-cirrhosis-using-the-new-acreular-classification-criteria/