Abstracts tagged "RNA"

Abstract Number: 0061 • ACR Convergence 2021
Harnessing Spatially-Resolved Gene Expression to Characterize the Transcriptional Landscape of Psoriatic Skin
Rochelle Castillo¹, Ikjot Sidhu¹, Di Yan¹, Piotr Konieczny¹, Rebecca Haberman¹, Brandon Hsieh¹, Andrea Neimann¹, Shruti Naik¹ and Jose Scher², ¹NYU Langone Health, New York, NY, ²New York University School of Medicine, New York, NY
Background/Purpose: The skin is recognized as a window into the immunopathogenic mechanisms in the psoriatic arthritis (PsA) joint. This is evidenced by the fact that…
Abstract Number: 005 • 2020 Pediatric Rheumatology Symposium
Single Cell Sequencing of the Skin to Define Cell Populations of Interest in Localized Scleroderma (LS)
Emily Mirizio ¹, Wei Chen ², Tao Sun ², Tracy Tabib ³, Kaila Schollaert-Fitch ¹, Robert Lafyatis ⁴, Heidi Jacobe ⁵ and Kathryn Torok¹, ¹Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, ²Research Computing Core at Children's Hospital of Pittsburgh, Pittsburgh, ³Univ of Pittsburgh Med Ctr, Pittsburgh, ⁴Univ of Pittsburgh Med Ctr, Pittsburgh, Pittsburgh, ⁵University of Texas Southwestern Medical Ctr, Dallas
Background/Purpose: Scleroderma is an autoimmune disorder involving inflammatory driven fibrosis, which encompasses systemic sclerosis (SSc) and localized scleroderma (LS). LS and SSc share histological characteristics,…
Abstract Number: 776 • 2019 ACR/ARP Annual Meeting
Genetic Signatures Support Inflammation Driven Fibrosis in Localized Scleroderma
Christina Schutt¹, Emily Mirizio ², Claudia Salgado ³, Miguel Reyes-Mugica ³, Kaila L. Schollaert ² and Kathryn Torok ³, ¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, ³UPMC Children's Hospital of Pittsburgh, Pittsburgh
Background/Purpose: Localized scleroderma (LS) is a progressive autoimmune disease of the skin and underlying tissue that is characterized by an initial inflammatory infiltration which is…
Abstract Number: 2101 • 2018 ACR/ARHP Annual Meeting
UV-Induced Skin Inflammation Is Exacerbated in Lupus-Prone Ro60 Knockout Female Mice with Interferon Priming
Masaoki Kawasumi¹, Daiki Rokunohe¹, Xizhang Sun², Lena Tanaka², Sladjana Skopelja-Gardner³, Edward Chiou², Anne Davidson⁴, Sandra L. Wolin⁵ and Keith B. Elkon², ¹Medicine/Dermatology, University of Washington, Seattle, WA, ²Medicine/Rheumatology, University of Washington, Seattle, WA, ³University of Washington, Seattle, WA, ⁴Feinstein Institute for Medical Research, Manhasset, NY, ⁵National Cancer Institute, Frederick, MD
Background/Purpose: Photosensitivity is a major symptom of lupus, and excessive sunlight can cause skin rashes and flares of disease activity in systemic lupus erythematosus (SLE).…
Abstract Number: 2517 • 2018 ACR/ARHP Annual Meeting
The JAK1-Selective Inhibitor Filgotinib Reverses the Disease-Associated Transcriptional Profile Found in the Blood of Patients with Active Rheumatoid Arthritis
Peter C. Taylor¹, Bryan Downie², Luting Zhuo², Yevgeniy Gindin², Jacqueline Tarrant³, Jinfeng Liu², René Galien⁴ and Amer M Mirza⁵, ¹University of Oxford Botnar Research Centre, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ²Bioinformatics, Gilead Sciences Inc., Foster City, CA, ³Gilead Sciences Inc., Foster City, CA, ⁴Galapagos SASU, Romainville, France, ⁵Biomarker Sciences, Gilead Sciences Inc., Foster City, CA
Background/Purpose: Filgotinib (FIL), an oral JAK1- selective inhibitor, has shown good safety and efficacy in active rheumatoid arthritis (RA) patients with inadequate response to MTX…
Abstract Number: 2933 • 2018 ACR/ARHP Annual Meeting
Non-Invasive Tape Sampling Reveals RNA Gene Clusters in Cutaneous Lupus Erythematosus That Discriminate Affected from Unaffected and Healthy Volunteer Skin
Joseph F. Merola¹, Wenting Wang², Carrie Wager³, Stefan Hamann², Xueli Zhang³, Alice Thai², Chris Roberts², Christina Lam⁴, Cristina Musselli², Galina Marsh², Dania Rabah², Catherine Barbey⁵, Nathalie Franchimont² and Taylor L. Reynolds², ¹Clinical Unit for Research Innovation & Trials, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Biogen, Cambridge, MA, ³Formerly of Biogen, Cambridge, MA, ⁴Boston University Medical School, Boston, MA, ⁵Biogen, Zug, Switzerland
Background/Purpose: Punch biopsy, the standard diagnostic and monitoring procedure for patients with cutaneous lupus erythematosus (CLE), impedes patient recruitment and follow up due to risk…
Abstract Number: 2950 • 2018 ACR/ARHP Annual Meeting
10X Genomics-Based Single-Cell RNA-Seq Analysis Identifies a Transcriptional Landscape of Inflammation and Fibrosis in Lupus Nephritis
Hemant Suryawanshi¹, Evan Der², Pavel Morozov¹, Robert M. Clancy³, Beatrice Goilav⁴, H. Michael Belmont³, Peter M. Izmirly⁵, Nicole Bornkamp⁶, Nicole Jordan⁷, Ming Wu³, Judith A. James⁸, Joel M. Guthridge⁹, Soumya Raychaudhuri¹⁰, Jill P. Buyon³, Chaim Putterman² and Thomas Tuschl¹, ¹Howard Hughes Medical Institute and The Rockefeller University, New York, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³NYU School of Medicine, New York, NY, ⁴Division of Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, ⁵Rheumatology, NYU School of Medicine, New York, NY, ⁶Medicine, NYU School of Medicine, New York, NY, ⁷Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Harvard Medical School, Boston, MA
Background/Purpose: Renal histology remains a primary tool for classification and treatment decisions in lupus nephritis (LN). Single-cell RNA-seq (scRNA-seq) analysis may provide mechanistic insights into…
Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting
Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis
Paul Martin¹, James Ding¹, Ben Mulhearn¹, Sebastien Viatte¹ and Stephen Eyre^1,2, ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…
Abstract Number: 924 • 2018 ACR/ARHP Annual Meeting
10X Genomics-Based Single-Cell RNA-Seq and Low Input RNA-Seq Identify a Transcriptional Landscape Supporting Interferon in the Pathogenesis of Autoimmune-Associated Congenital Heart Block
Hemant Suryawanshi¹, Jill P. Buyon², Miao Chang², Thomas Tuschl¹ and Robert M. Clancy², ¹Howard Hughes Medical Institute and The Rockefeller University, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: Towards understanding the molecular mechanisms that link maternal anti-Ro antibodies to the development of conduction system disease in a second trimester fetus, single cell…
Abstract Number: 1119 • 2018 ACR/ARHP Annual Meeting
Genetic Signatures from RNA Sequencing of Pediatric Localized Scleroderma (LS) Skin
Emily Mirizio¹, Roosha Mandal², Qi Yan³, William Horne⁴, Kaila Schollaert-Fitch³ and Kathryn S. Torok⁵, ¹Peds Rheum, University of Pittsburgh Med Ctr, Pittsburgh, PA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of Pittsburgh Med Ctr, Pittsburgh, PA, ⁴Health Sciences Sequencing Core at Children's Hospital of Pittsburgh, Pittsburgh, PA, ⁵Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA
Background/Purpose: Localized scleroderma (LS) is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children.…
Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting
Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Qiong Wu, Quanhu Sheng, Joseph F. Solus, Kasey Vickers, Ryan Allen, Shilin Zhao, Yan Guo, Fei Ye, C Michael Stein and Michelle J. Ormseth, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…
Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting
Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell
Zoya Qaiyum¹, Eric Gracey², Yuchen Yao² and Robert D Inman³, ¹Department of Immunology, University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada
Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…
Abstract Number: 1897 • 2018 ACR/ARHP Annual Meeting
Single Cell RNA Expression in Lupus Nephritis Comparing African-American and Caucasian Patients Identifies Differential Expression of Interferon Pathway
Andrea Fava¹, Yuji Zhang², Nir Hacohen³, Arnon Arazi⁴, Celine C. Berthier⁵, Deepak Rao⁶, Michael Brenner⁷, David Wofsy⁸, Anne Davidson⁹, Matthias Kretzler¹⁰, David Hildeman¹¹, E. Steve Woodle¹², Betty Diamond¹³ and Michelle Petri¹⁴, ¹Departement of Medicine - Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ³Harvard Medical School, Boston, MA, ⁴Broad Institute, Cambridge, MA, ⁵Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Rheumatology, University of California, San Francisco, San Francisco, CA, ⁹Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ¹⁰Division of Nephrology, University of Michigan, Ann Arbor, MI, ¹¹University of Cincinnati, Cincinnati, OH, ¹²University of Cincinnati College of Medicine, Cincinnati, OH, ¹³The Feinstein Institute for Medical Research, Manhasset, NY, ¹⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: African-American (AA) ethnicity is associated with a 3-fold higher risk of developing systemic lupus erythematosus (SLE). In addition, there is an increased risk of…
Abstract Number: 1899 • 2018 ACR/ARHP Annual Meeting
Down-Regulation of RNA Processing Protein CFIm25 Amplifies Skin Fibrosis By up-Regulating Pro-Fibrotic Transcripts/Proteins in Systemic Sclerosis
Tingting Mills¹, Junsuk Ko¹, Jingjing Huang¹, Minghua Wu², Ningyuan Chen¹, Leng Han¹, Yu Xiang¹, Maureen D. Mayes³, Eric Wagner⁴, Michael Blackburn¹ and Shervin Assassi², ¹Department of Biochemistry & Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁴Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX
Background/Purpose: Persistent myofibroblast activation and associated excessive extracellular matrix protein deposition are hallmarks of systemic sclerosis (SSc). However, the mechanisms that account for this excessive fibrotic response remain…
Abstract Number: 1903 • 2018 ACR/ARHP Annual Meeting
Molecular Analysis of a Skin Equivalent Tissue Culture Model System of Systemic Sclerosis Using RNA Sequencing, Epigenetic Assays, Histology, and Immunoassays
Diana M. Toledo¹, Mengqi Huang², Yue Wang², Bhaven K. Mehta², Tammara A. Wood³, Avi Smith⁴, Yolanda Nesbeth⁵, Irena Ivanovska⁶, Brock Christensen⁷, Patricia A. Pioli⁸, Jonathan Garlick⁴ and Michael L. Whitfield⁹, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Tufts University School of Medicine, Boston, MA, ⁵Celdara Medical, LLC, Lebanon, NH, ⁶Celdara Medical, LLC, Hanover, NH, ⁷Geisel School of Medicine at Dartmouth, Hanover, NH, ⁸Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁹Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: The molecular mechanisms of systemic sclerosis (SSc) have been difficult to study outside of patient samples. Mouse models often lack key features of the…

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