Abstract Number: 0061 • ACR Convergence 2021
Harnessing Spatially-Resolved Gene Expression to Characterize the Transcriptional Landscape of Psoriatic Skin
Background/Purpose: The skin is recognized as a window into the immunopathogenic mechanisms in the psoriatic arthritis (PsA) joint. This is evidenced by the fact that…Abstract Number: 005 • 2020 Pediatric Rheumatology Symposium
Single Cell Sequencing of the Skin to Define Cell Populations of Interest in Localized Scleroderma (LS)
Background/Purpose: Scleroderma is an autoimmune disorder involving inflammatory driven fibrosis, which encompasses systemic sclerosis (SSc) and localized scleroderma (LS). LS and SSc share histological characteristics,…Abstract Number: 776 • 2019 ACR/ARP Annual Meeting
Genetic Signatures Support Inflammation Driven Fibrosis in Localized Scleroderma
Background/Purpose: Localized scleroderma (LS) is a progressive autoimmune disease of the skin and underlying tissue that is characterized by an initial inflammatory infiltration which is…Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting
Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis
Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…Abstract Number: 924 • 2018 ACR/ARHP Annual Meeting
10X Genomics-Based Single-Cell RNA-Seq and Low Input RNA-Seq Identify a Transcriptional Landscape Supporting Interferon in the Pathogenesis of Autoimmune-Associated Congenital Heart Block
Background/Purpose: Towards understanding the molecular mechanisms that link maternal anti-Ro antibodies to the development of conduction system disease in a second trimester fetus, single cell…Abstract Number: 1119 • 2018 ACR/ARHP Annual Meeting
Genetic Signatures from RNA Sequencing of Pediatric Localized Scleroderma (LS) Skin
Background/Purpose: Localized scleroderma (LS) is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children.…Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting
Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting
Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell
Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…Abstract Number: 1897 • 2018 ACR/ARHP Annual Meeting
Single Cell RNA Expression in Lupus Nephritis Comparing African-American and Caucasian Patients Identifies Differential Expression of Interferon Pathway
Background/Purpose: African-American (AA) ethnicity is associated with a 3-fold higher risk of developing systemic lupus erythematosus (SLE). In addition, there is an increased risk of…Abstract Number: 1899 • 2018 ACR/ARHP Annual Meeting
Down-Regulation of RNA Processing Protein CFIm25 Amplifies Skin Fibrosis By up-Regulating Pro-Fibrotic Transcripts/Proteins in Systemic Sclerosis
Background/Purpose: Persistent myofibroblast activation and associated excessive extracellular matrix protein deposition are hallmarks of systemic sclerosis (SSc). However, the mechanisms that account for this excessive fibrotic response remain…Abstract Number: 1903 • 2018 ACR/ARHP Annual Meeting
Molecular Analysis of a Skin Equivalent Tissue Culture Model System of Systemic Sclerosis Using RNA Sequencing, Epigenetic Assays, Histology, and Immunoassays
Background/Purpose: The molecular mechanisms of systemic sclerosis (SSc) have been difficult to study outside of patient samples. Mouse models often lack key features of the…Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting
Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis
Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…Abstract Number: 1967 • 2018 ACR/ARHP Annual Meeting
Detection of Association of Long Noncoding RNA ATP6V0E2-AS1 Single Nucleotide Polymorphism with Susceptibility to Myeloperoxidase-ANCA Associated Vasculitis Based on Transcriptome Analysis
Background/Purpose: Because of the low prevalence, only three genome-wide association studies, all from the Caucasian populations, have been reported on ANCA-associated vasculitis (AAV) thus far;…Abstract Number: 2018 • 2018 ACR/ARHP Annual Meeting
Microenvironment Driven Re-Shaping of Pathogenic T Effector and Regulatory Subset in Active Juvenile Idiopathic Arthritic Patients
Background/Purpose: We have previously identified two CD4 pathogenic circulatory subsets in both T effector (CPLs) and T regulatory (iaTreg) compartments that are both HLA-DR+, antigen…Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting
Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue
Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…
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