ACR Meeting Abstracts

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Abstracts tagged "RNA"

  • Abstract Number: 0061 • ACR Convergence 2021

    Harnessing Spatially-Resolved Gene Expression to Characterize the Transcriptional Landscape of Psoriatic Skin

    Rochelle Castillo1, Ikjot Sidhu1, Di Yan1, Piotr Konieczny1, Rebecca Haberman1, Brandon Hsieh1, Andrea Neimann1, Shruti Naik1 and Jose Scher2, 1NYU Langone Health, New York, NY, 2New York University School of Medicine, New York, NY

    Background/Purpose: The skin is recognized as a window into the immunopathogenic mechanisms in the psoriatic arthritis (PsA) joint. This is evidenced by the fact that…
  • Abstract Number: 005 • 2020 Pediatric Rheumatology Symposium

    Single Cell Sequencing of the Skin to Define Cell Populations of Interest in Localized Scleroderma (LS)

    Emily Mirizio 1, Wei Chen 2, Tao Sun 2, Tracy Tabib 3, Kaila Schollaert-Fitch 1, Robert Lafyatis 4, Heidi Jacobe 5 and Kathryn Torok1, 1Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, 2Research Computing Core at Children's Hospital of Pittsburgh, Pittsburgh, 3Univ of Pittsburgh Med Ctr, Pittsburgh, 4Univ of Pittsburgh Med Ctr, Pittsburgh, Pittsburgh, 5University of Texas Southwestern Medical Ctr, Dallas

    Background/Purpose: Scleroderma is an autoimmune disorder involving inflammatory driven fibrosis, which encompasses systemic sclerosis (SSc) and localized scleroderma (LS).  LS and SSc share histological characteristics,…
  • Abstract Number: 776 • 2019 ACR/ARP Annual Meeting

    Genetic Signatures Support Inflammation Driven Fibrosis in Localized Scleroderma

    Christina Schutt1, Emily Mirizio 2, Claudia Salgado 3, Miguel Reyes-Mugica 3, Kaila L. Schollaert 2 and Kathryn Torok 3, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, 3UPMC Children's Hospital of Pittsburgh, Pittsburgh

    Background/Purpose: Localized scleroderma (LS) is a progressive autoimmune disease of the skin and underlying tissue that is characterized by an initial inflammatory infiltration which is…
  • Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting

    Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis

    Paul Martin1, James Ding1, Ben Mulhearn1, Sebastien Viatte1 and Stephen Eyre1,2, 1Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

    Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…
  • Abstract Number: 924 • 2018 ACR/ARHP Annual Meeting

    10X Genomics-Based Single-Cell RNA-Seq and Low Input RNA-Seq Identify a Transcriptional Landscape Supporting Interferon in the Pathogenesis of Autoimmune-Associated Congenital Heart Block

    Hemant Suryawanshi1, Jill P. Buyon2, Miao Chang2, Thomas Tuschl1 and Robert M. Clancy2, 1Howard Hughes Medical Institute and The Rockefeller University, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: Towards understanding the molecular mechanisms that link maternal anti-Ro antibodies to the development of conduction system disease in a second trimester fetus, single cell…
  • Abstract Number: 1119 • 2018 ACR/ARHP Annual Meeting

    Genetic Signatures from RNA Sequencing of Pediatric Localized Scleroderma (LS) Skin

    Emily Mirizio1, Roosha Mandal2, Qi Yan3, William Horne4, Kaila Schollaert-Fitch3 and Kathryn S. Torok5, 1Peds Rheum, University of Pittsburgh Med Ctr, Pittsburgh, PA, 2Carnegie Mellon University, Pittsburgh, PA, 3University of Pittsburgh Med Ctr, Pittsburgh, PA, 4Health Sciences Sequencing Core at Children's Hospital of Pittsburgh, Pittsburgh, PA, 5Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA

    Background/Purpose: Localized scleroderma (LS) is a progressive disease of the skin and underlying tissue that causes significant functional disability and disfigurement, especially in developing children.…
  • Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting

    Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu, Quanhu Sheng, Joseph F. Solus, Kasey Vickers, Ryan Allen, Shilin Zhao, Yan Guo, Fei Ye, C Michael Stein and Michelle J. Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…
  • Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting

    Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell

    Zoya Qaiyum1, Eric Gracey2, Yuchen Yao2 and Robert D Inman3, 1Department of Immunology, University of Toronto, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada

    Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…
  • Abstract Number: 1897 • 2018 ACR/ARHP Annual Meeting

    Single Cell RNA Expression in Lupus Nephritis Comparing African-American and Caucasian Patients Identifies Differential Expression of Interferon Pathway

    Andrea Fava1, Yuji Zhang2, Nir Hacohen3, Arnon Arazi4, Celine C. Berthier5, Deepak Rao6, Michael Brenner7, David Wofsy8, Anne Davidson9, Matthias Kretzler10, David Hildeman11, E. Steve Woodle12, Betty Diamond13 and Michelle Petri14, 1Departement of Medicine - Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 3Harvard Medical School, Boston, MA, 4Broad Institute, Cambridge, MA, 5Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, 6Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 8Rheumatology, University of California, San Francisco, San Francisco, CA, 9Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 10Division of Nephrology, University of Michigan, Ann Arbor, MI, 11University of Cincinnati, Cincinnati, OH, 12University of Cincinnati College of Medicine, Cincinnati, OH, 13The Feinstein Institute for Medical Research, Manhasset, NY, 14Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: African-American (AA) ethnicity is associated with a 3-fold higher risk of developing systemic lupus erythematosus (SLE). In addition, there is an increased risk of…
  • Abstract Number: 1899 • 2018 ACR/ARHP Annual Meeting

    Down-Regulation of RNA Processing Protein CFIm25 Amplifies Skin Fibrosis By up-Regulating Pro-Fibrotic Transcripts/Proteins in Systemic Sclerosis

    Tingting Mills1, Junsuk Ko1, Jingjing Huang1, Minghua Wu2, Ningyuan Chen1, Leng Han1, Yu Xiang1, Maureen D. Mayes3, Eric Wagner4, Michael Blackburn1 and Shervin Assassi2, 1Department of Biochemistry & Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, 2Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Rheumatology, University of Texas McGovern Medical School, Houston, TX, 4Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX

    Background/Purpose: Persistent myofibroblast activation and associated excessive extracellular matrix protein deposition are hallmarks of systemic sclerosis (SSc). However, the mechanisms that account for this excessive fibrotic response remain…
  • Abstract Number: 1903 • 2018 ACR/ARHP Annual Meeting

    Molecular Analysis of a Skin Equivalent Tissue Culture Model System of Systemic Sclerosis Using RNA Sequencing, Epigenetic Assays, Histology, and Immunoassays

    Diana M. Toledo1, Mengqi Huang2, Yue Wang2, Bhaven K. Mehta2, Tammara A. Wood3, Avi Smith4, Yolanda Nesbeth5, Irena Ivanovska6, Brock Christensen7, Patricia A. Pioli8, Jonathan Garlick4 and Michael L. Whitfield9, 1Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 3Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 4Tufts University School of Medicine, Boston, MA, 5Celdara Medical, LLC, Lebanon, NH, 6Celdara Medical, LLC, Hanover, NH, 7Geisel School of Medicine at Dartmouth, Hanover, NH, 8Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 9Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: The molecular mechanisms of systemic sclerosis (SSc) have been difficult to study outside of patient samples. Mouse models often lack key features of the…
  • Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting

    Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis

    Michelle J. Ormseth1, Quanhu Sheng1, Shilin Zhao1, Joseph F. Solus1, Qiong Wu1, Ryan Allen1, Yan Guo1, Fei Ye1, Marisol Ramirez1, Kasey Vickers1, S. Louis Bridges Jr.2, Jeffrey R. Curtis3 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…
  • Abstract Number: 1967 • 2018 ACR/ARHP Annual Meeting

    Detection of Association of Long Noncoding RNA ATP6V0E2-AS1 Single Nucleotide Polymorphism with Susceptibility to Myeloperoxidase-ANCA Associated Vasculitis Based on Transcriptome Analysis

    Yuka Iwahashi1,2, Aya Kawasaki1,2, Takayo Tsuchiura3, Ken-ei Sada4, Fumio Hirano5,6, Daisuke Tsukui7, Shigeto Kobayashi8, Hidehiro Yamada9, Hiroshi Furukawa1,2,10, Kenji Nagasaka11, Takahiko Sugihara12, Nao Nishida3, Kunihiro Yamagata13, Takayuki Sumida14, Shigeto Tohma10,15, Shoichi Ozaki9, Hiroshi Hashimoto16, Hirofumi Makino17, Yoshihiro Arimura18, Hajime Kono19, Masayoshi Harigai20 and Naoyuki Tsuchiya1,2, 1University of Tsukuba, Graduate School of Comprehensive Human Sciences, Masters' Program in Medical Sciences, Tsukuba, Japan, 2University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, 3Genome Medical Science Project, National Center for Global Health and Medicine, Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 5Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, 6Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, 7Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 8Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 9St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, 10National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, 11Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 12Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 13University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, 14Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 15National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 16Juntendo University School of Medicine, Tokyo, Japan, 17Okayama University Hospital, Okayama, Japan, 18Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, 19Teikyo University School of Medicine, Department of Internal Medicine, Tokyo, Japan, 20Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan

    Background/Purpose: Because of the low prevalence, only three genome-wide association studies, all from the Caucasian populations, have been reported on ANCA-associated vasculitis (AAV) thus far;…
  • Abstract Number: 2018 • 2018 ACR/ARHP Annual Meeting

    Microenvironment Driven Re-Shaping of Pathogenic T Effector and Regulatory Subset in Active Juvenile Idiopathic Arthritic Patients

    Jing Yao Leong1, Pavanish Kumar1, Phyllis Chen2, Joo Guan Yeo2,3, Camillus Chua2, Sharifah Nur Hazirah2, Suzan Saidin1, Thaschawee Arkachaisri2,3, Alessandro Consolaro4, Marco Gattorno5, Alberto Martini6 and Salvatore Albani2, 1Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, 2Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 3KK Women's and Children's Hospital, Singapore, Singapore, 4Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genova, Italy, 5Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genoa, Italy, 6Pediatric Rheumatology International Trial Organization (PRINTO) Coordinating Centre, Genoa, Italy

    Background/Purpose: We have previously identified two CD4 pathogenic circulatory subsets in both T effector (CPLs) and T regulatory (iaTreg) compartments that are both HLA-DR+, antigen…
  • Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting

    Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue

    Javier Rangel-Moreno1, Nida Meednu2, Andrew McDavid3, Linda Callahan4, V. Kaye Thomas4, Jennifer Albrecht2, Edward F. DiCarlo5, Dana Orange6, Susan M. Goodman6, Laura T. Donlin7 and Jennifer Anolik2, 1Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, 4University of Rochester Medical Center, Rochester, NY, 5Laboratory Medicine, Hospital for Special Surgery, New York, NY, 6Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY

    Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…
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