ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 1729 • ACR Convergence 2022

    SLAMF4+ CCR5+ Effector Memory CD4+ T Cells Are Polyfunctional, Resistant to Exhaustion, and Expanded in Rheumatoid Arthritis

    Mégane Lacaud1, Houda-Ghozlane Bouzidi1, Magali Breckler2, Delphine Lemeiter2, Johanna Sigaux3, Luca Semerano4, Marie-Christophe Boissier5, Natacha Bessis6 and Jerome Biton7, 1Sorbonne Paris Nord University, Inserm U1125, Bobigny, France, 2Sorbonne Paris Nord University, Inserm UMR1125, Bobigny, France, 3Avicenne Hospital, Sorbonne Paris Nord University, Inserm UMR1125, Bobigny, France, 4Hopital Avicenne - AP-HP, Sorbonne Paris Nord University, INSERM UMR1125, Bobigny Cedex, France, 5INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, 6INSERM 1125 and University Sorbonne Paris Nord, Bobigny, France, 7INSERM UMR 1125, Sorbonne Paris Nord University, Bobigny, France

    Background/Purpose: CD4+ Foxp3- conventional T cells (Tconv) play a key role in the inflammatory process involved in rheumatoid arthritis (RA). Usually, chronic stimulation of T…
  • Abstract Number: 1765 • ACR Convergence 2022

    Safety of the Recombinant Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis Treated with JAKi Drugs

    Ana Pons1, José Rosas1, José Miguel Senabre2, JC Cortés-Quiroz1, Carmen Raya-Santos2, Gregorio Santos-Soler2, Lara Pons2, Marisa Lorente2, José Antonio Bernal3, Xavier Barber4 and José Alberto Garciía-Gómez4, 1Rheumatology Department, Hospital Marina Baixa, Villajoyosa, Spain, 2Hospital Marina Baixa, Villajoyosa, Spain, 3Hospital Marina Baixa (Villajoyosa), Alicante, Spain, 4CIO Miguel Hernández University Elche, Alicante, Spain

    Background/Purpose: Patients receiving treatment with JAK inhibitor drugs (JAKi) have an increased risk of developing herpes zoster (HZ). A new recombinant vaccine effective against HZ…
  • Abstract Number: 1956 • ACR Convergence 2022

    Functional Disabilities in Hands Precede Those in Feet in Patients Progressing from Clinically Suspect Arthralgia to Rheumatoid Arthritis; A Longitudinal Observational Study

    Sarah J.H. Khidir1, Bastiaan van Dijk2, Marloes Verstappen1, Elise van Mulligen3 and Annette van der Helm-van Mil4, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Centre (LUMC), Leiden, Netherlands, 3Erasmus Medical Center, Leiden University Medical Center, Rotterdam, Netherlands, 4Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: In the pre-arthritis phase of Rheumatoid Arthritis (RA), symptoms resulting in physical disabilities already occur. It is unknown whether functional disabilities start in hands…
  • Abstract Number: 1973 • ACR Convergence 2022

    Association Between Activity Limitations, Sleep Disturbance, Pain Sensitivity, Pain Intensity, and Widespread Pain in Adults with Rheumatoid Arthritis

    Burcu Aydemir1, Jing Song2, Lutfiyya Muhammad3, Daniela Grimaldi1, Kathryn Reid1, Phyllis Zee1, Rowland Chang4 and Yvonne Lee1, 1Northwestern University, Chicago, IL, 2Northwestern University, Evanston, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL, 4Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Despite treatment with strong immunosuppressive medications, more than half of patients with rheumatoid arthritis (RA) still report pain. Pain can spread from joint sites…
  • Abstract Number: 1991 • ACR Convergence 2022

    Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation

    Siba Raychaudhuri1, Smriti Raychaudhuri2 and Heike Wulff3, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, 2VA Medical Center, Sacramento, CA, 3UC Davis, Davis, CA

    Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1.…
  • Abstract Number: 2007 • ACR Convergence 2022

    Rheumatoid Arthritis Associated Lymphoproliferative Disorders: Current Features and It’s Changing Pattern Due to the Influence of Anti-rheumatic Drugs

    Yoshihiko Hoshida1, Atsuko Tsujii2, Shiro Ohshima2, Yukihiko Saeki2, Masato Yagita3, Tomoya Miyamura4, Masao Katayama5, Yasushi Hiramatsu6, Hisaji Oshima7, Toshihiko Murayama8, Shinji Higa9, Fuminori Hirano10, Kenji Ichikawa11, Noriyuki Chiba12, Takao Sugiyama13, Atsushi Ihata14, Akiko Mitsuo15, Hiroshi Tsutani16, Koichiro Takahi17, Akira Okamoto18, Shigeru Yoshizawa19, Yasuo Suenaga20, Shunsuke Mori21, Shoichi Nagakura22, Norie Yoshikawa23, Atsuhisa Ueda24, Shouhei Nagaoka25, Keigo Setoguchi26, Shoji Sugii27, Asami Abe28, Toshiaki Sugaya29, Masahiro Koseto30, Yasuo Kunugiza31, Norishige Iizuka32, Ryosuke Yoshihara33, Tomoaki Fujisaki34, Hiroyuki Sugahara35, Ikuo Saito36, Kazuya Kuraoka37, Norihiro Teramoto38, Masahiro Ito39, Kenichi Taguchi40, Yuko Minami41, Shinji Naito42, Mitsuharu Nomoto43, Kazuyoshi Saito44, Kiyoshi Matsui45, Yasuhiko Tomita46, Hiroshi Furukawa47 and Shigeto Tohma48, 1Department of Pathology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, 2Department of Rheumatology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, 3Division of Inflammation and Immunity, Tazuke-Kofukai Medical Research Institute Kitano Hospital, Osaka, Osaka, Japan, 4Department of Rheumatology, NHO Kyushu Medical Center, Fukuoka, Japan, 5Department of Rheumatology, NHO Nagoya Medical Center, Nagoya, Japan, 6Department of Hematology and Oncology, Japanese Red Cross Society Himeji Hospital, Himeji, Japan, 7National Hospital Organization Tokyo Medical Center, Meguroku, Japan, 8Department of Pathology, NHO Kumamoto Medical Center, Kumamoto, Kumamoto, Japan, 9Division of Rheumatology, Daini Osaka Police Hospital, Osaka, Osaka, Japan, 10Department of Rheumatology, NHO Asahikawa Medical Center, Asahikawa, Hokkaido, Japan, 11Department of Rheumatology, NHO Hokkaido Medical Center, Sapporo, Japan, 12epartment of Rheumatology, NHO Morioka Medical Center, Morioka, Japan, 13Department of Rheumatology, NHO Shimoshizu Hospital, SIkaido, Chiba, Japan, 14Department of Rheumatology, NHO Yokohama Medical Center, Yokohama, Japan, 15Department of Rheumatology, NHO Disaster Medical Center, Tachikawa, Japan, 16Department of Rheumatology, NHO Awara Hospital, Awara, Fukui, Japan, 17Department of Rheumatology, NHO Osaka Toneyama Medical Center, Toyonaka, Japan, 18Department of Rheumatology, NHO Himeji Medical Center, Himeji, Japan, 19Department of Rheumatology, NHO Fukuoka Hospital, Fukuoka, Japan, 20Department of Rheumatology, NHO Beppu Medical Center, Beppu, Oita, Japan, 21Department of Rheumatology, NHO Kumamoto Saishun Medical Center, Goshi, Japan, 22Department of Hematology, NHO Kumamoto Minami Hospital, Ushiro, Japan, 23Department of Rheumatology, NHO Miyakonojo Medical Center, Miyakonojo, Japan, 24Department of Rheumatology, Yokohama City University, Yokohama, Japan, 25Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan, 26Department of Systemic immunological diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan, 27Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan, 28Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 29Department of Rheumatology, Fuchu Hospital, Izumi, Japan, 30Department of Laboratory Medicine and Internal Medicine (Clinical Immunology), Nippon Life Hospital, Osaka, Osaka, Japan, 31Department of Orthopedics, JCHO Hoshigaoka Medical Center, Hirakata, Japan, 32Department of Pathology, Kishiwada City Hospital, Kishiwada, Japan, 33Department of Rheumatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan, 34Department of Hematology, Matsuyama Red Cross Hospital, Matsuyama, Japan, 35Department of Hematology, Sumitomo Hospital, Osaka, Osaka, Japan, 36Department of Pathology, NHO Sagamihara Hospital, Sagamihara, Kanagawa, Japan, 37Department of Diagnostic Pathology, NHO Kure Medical Center /Chugoku Cancer Center, Kure, Hiroshima, Japan, 38Department of Pathology, NHO Shikoku Cancer Center, Matsuyama, Japan, 39Department of Pathology, NHO Nagasaki Medical Center, Nagasaki, Japan, 40Department of Pathology, NHO Kyushu Cancer Center, Fukuoka, Japan, 41Department of Pathology, NHO Ibarakihigashi Hospital, Nakagun, Japan, 42Department of Pathology, NHO Ureshino Medical Center, Ureshino, Japan, 43Department of Pathology, NHO, Kagoshima Medical Center, Kagoshima, Japan, 44First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 45Hyogo College of Medicine, Nishinomiya, Japan, 46Department of Pathology, International University of Health and Welfare, Narita, Japan, 47Department of Rheumatology, NHO Tokyo National Hospital, Tokyo, Japan, 48National Hospital Organization Tokyo National Hospital, Dallas, TX

    Background/Purpose: The effect of antirheumatic drugs on the development of lymphoproliferative disorders (LPDs) in rheumatoid arthritis (RA) patients remains unclear. The current study aimed to…
  • Abstract Number: 2188 • ACR Convergence 2022

    The Effect of Group-based Cognitive Behavioral Therapy for Insomnia in People with Rheumatoid Arthritis: A Randomized Controlled Trial

    Kristine Latocha1, Katrine Loeppenthin2, Mikkel Østergaard3, poul jennum4, Merete L Hetland5, Henrik Rogind6, Tine Lundbak6, Julie Midtgaard7, Robin Christensen8 and Bente Esbensen5, 1Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark, 2Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 3Rigshospitalet, University of Copenhagen, Glostrup, Denmark, 4Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen University Hospital - Rigshospitalet, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, 5Rigshospitalet, Glostrup, Denmark, 6Center for Rheumatology and Spine Diseases, Copenhagen University Hospital -Rigshospitalet, Glostrup, Denmark, 7Mental Health Centre Glostrup, University of Copenhagen, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 8Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark

    Background/Purpose: Insomnia is highly prevalent in people with rheumatoid arthritis (RA) and may exacerbate symptoms and burdens, such as fatigue, depressive symptoms, and pain (1).…
  • Abstract Number: 2252 • ACR Convergence 2022

    Higher Matrix Metalloproteinase Levels Are Predictive of Incident Interstitial Lung Disease Among a Cohort of US Veterans with Rheumatoid Arthritis

    Brent Luedders1, Dana Ascherman2, Joshua Baker3, Michael Duryee1, Yangyuna Yang1, Punyasha Roul4, Katherine Wysham5, Paul Monach6, Andreas Reimold7, Gail Kerr8, Gary Kunkel9, Grant Cannon10, Jill Poole1, Geoffrey Thiele1, Ted Mikuls11 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pennsylvania, Philadelphia, PA, 4UNMC, Omaha, NE, 5VA Puget Sound/University of Washington, Seattle, WA, 6VA Boston Healthcare System, Boston, MA, 7University of Texas Southwestern Medical Center, Dallas, TX, 8Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 9University of Utah, Salt Lake City, UT, 10Retired, Salt Lake City, UT, 11Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Matrix metalloproteinases (MMPs) degrade extracellular matrix and have been implicated to play a role in a number of fibrotic processes. Specifically, MMPs have been…
  • Abstract Number: 0065 • ACR Convergence 2022

    Rheumatoid Arthritis Clinical Care Pathway Implementation: A Step Towards Improved Outcomes and Value-Based Care

    Tarun Sharma1, paul lebovitz1, chetan rajput2, Lori Mcaninch3, ellen Kraemer3, izabela Stanescu3, adam dore1, joseph ahearn3 and Susan Manzi4, 1Allegheny Health Network, Pittsburgh, PA, 2Highmark Health, Pittsburgh, 3Allegheny Health Network, Pittsburgh, 4Allegheny Health Network, Lupus Center of Excellence, Wexford, PA

    Background/Purpose: Care transformation in a chronic illness like RA requires delivery of health care services through a patient-centric care model. Within an integrated delivery and…
  • Abstract Number: 0129 • ACR Convergence 2022

    Effectiveness of Golimumab in the Treatment of Patients with Active Rheumatoid Arthritis, Psoriatic Arthritis, or Axial Spondyloarthritis Who Failed Initial TNFα Therapy: A Pooled Analysis of European Prospective Observational Studies (the GO BEYOND Program)

    Marinella Govoni1, Anastas Batalov2, Dimitrios Boumpas3, Salvatore D'Angelo4, Filip De Keyser5, Rene-Marc Flipo6, Herbert Kellner7, Hermine Leroi8 and Ahmed Khalifa9, 1MSD Italy, Cento, Italy, 2Medical University of Plovdiv, Plovdiv, Bulgaria, 3National and Kapodistrian University of Athens, Heraklion, Greece, 4Rheumatology Department of Lucania - San Carlo Hospital of Potenza, Potenza, Italy, 5Department of Rheumatology, Ghent University Hospital, Maldegem, Belgium, 6CHU Lille, Boulogne-Billancourt, France, 7Schwerpunktpraxis für Rheumatologie und Gastroenterologie, Munich, Germany, 8MSD Belgium, Woluwe-Saint-Lambert, Belgium, 9MSD Sharp & Dohme GmbH, Germany, Kriens, Switzerland

    Background/Purpose: Patients with inflammatory arthritis often experience secondary non-response to a first-line tumor necrosis factor alpha inhibitor (TNFαi). GO-BEYOND is a study program comprised of…
  • Abstract Number: 0244 • ACR Convergence 2022

    Identification of Novel Response Predictors via Cardiovascular Biomarker Proteomic Analysis of Serum Samples from Patients with Early, Seropositive RA Treated with Abatacept or Adalimumab

    Yicong Li1, Chun Wu2, Michael Maldonado2, Peter Schafer2, S. Louis Bridges, Jr.3, William Rigby4, Vivian Bykerk3, Jane Buckner5 and Jinqi Liu2, 1Parexel International, Durham, NC, 2Bristol Myers Squibb, Princeton, NJ, 3Hospital for Special Surgery, New York, NY, 4Dartmouth Hitchcock Medical Center, Lebanon, PA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: Effective RA therapies should not only improve joint signs and symptoms, but also mitigate additional disease-related consequences, such as the increased risk of cardiovascular…
  • Abstract Number: 0260 • ACR Convergence 2022

    Impacts of Poor Prognostic Factors in Rheumatoid Arthritis on Clinical Outcomes and Treatment Choices from an Observational Cohort of Korean Patients with Rheumatoid Arthritis

    You-Jung Ha1, Seunghwan Shin2, SE RIM CHOI3, Eun Ha Kang1 and Yun Jong Lee1, 1Seoul National University Bundang Hospital, Seongnam, Republic of Korea, 2Lunit Inc, Seoul, Republic of Korea, 3Seoul National University Hospital, Seoul, Republic of Korea

    Background/Purpose: The primary target for the treatment of rheumatoid arthritis (RA) is achieving remission or low disease activity with proper use of DMARD. Besides controlling…
  • Abstract Number: 0277 • ACR Convergence 2022

    Malignancy Events in the Filgotinib Rheumatoid Arthritis and Ulcerative Colitis Clinical Development Programs

    Xavier Mariette1, Sandrine Aspeslagh2, Richard Moriggl3, Vijay Rajendran4, Christine Rudolph5, Paul Van Hoek5, Nadia Verbruggen5, Christopher Watson6, Sven Borchmann7 and Andreas Stallmach8, 1Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 2UZ Brussel, Brussels, Belgium, 3University of Veterinary Medicine, Vienna, Austria, 4Galapagos NV, Gent, Belgium, 5Galapagos NV, Mechelen, Belgium, 6Galapagos Biotech Ltd, Cambridge, United Kingdom, 7Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, 8Department of Internal Medicine IV, Jena University Hospital, Jena, Germany

    Background/Purpose: Filgotinib (FIL) is a preferential oral Janus kinase (JAK) 1 inhibitor, approved for the treatment of RA and ulcerative colitis (UC) in Europe, the…
  • Abstract Number: 0294 • ACR Convergence 2022

    Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biologic DMARDs: Results Through 5 Years from the SELECT-BEYOND Study

    Roy Fleischmann1, Sebastian Meerwein2, Christina Charles-Schoeman3, BERNARD COMBE4, Stephen Hall5, Nasser Khan6, Kyle Carter7, Heidi Camp8 and Andrea Rubbert-Roth9, 1Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 2AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, 3Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA, 4Montpellier University, Montpellier, France, 5Emeritus Research and Monash University, Melbourne, Australia, 6AbbVie, Inc., Abbott Park, IL, 7AbbVie, Inc., North Chicago, IL, 8Abbvie, Winnetka, IL, 9Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland

    Background/Purpose: To evaluate the long-term efficacy and safety of upadacitinib (UPA) over 5 yrs among patients with rheumatoid arthritis (RA) in a long-term extension (LTE)…
  • Abstract Number: 0312 • ACR Convergence 2022

    Dose-dependent Suppression of T Cell-Dependent Antibody Response in Healthy Volunteers by KPL-404, an Anti-CD40 Monoclonal Antibody, Supports Phase 2 Study in Patients with Rheumatoid Arthritis

    Lara Pupim1, Gerd Burmester2, Fang Fang1, Alan Kivitz3, Moses Njenga1, Costantino Pitzalis4, Jay Chatfield1, Anastassia Papandrikopoulou1, Manoj Samant1, Steve Schmitz1, Madeline Spiers1, Eben Tessari1, John Ziemniak1 and John F. Paolini5, 1Kiniksa, Lexington, MA, 2Charité University Medicine Berlin, Berlin, Germany, 3Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 4Queen Mary University of London, London, United Kingdom, 5Kiniksa Pharmaceuticals, Lexington, MA

    Background/Purpose: An unmet need remains in patients with failure and/or inadequate response (IR) to biological disease-modifying antirheumatic drugs (bDMARD-IR) and/or Janus kinase inhibitors (JAKi-IR). The…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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