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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 0069 • ACR Convergence 2025

    Spatial transcriptomics in rheumatoid arthritis (RA) synovium reveals distinct region-specific fibroblast functions

    Camilla R.L. Machado1, Mina Yao1, David Boyle2, Robert J. Benschop3, James T. Parker3, Wei Wang2 and Gary Firestein1, 1University of California, San Diego, San Diego, CA, 2University of California, San Diego, San Diego, 3Eli Lilly, San Diego

    Background/Purpose: RA synovium displays cellular heterogeneity, with gene expression driving disease pathogenesis. Unbiased cell-specific transcriptomes in RA synovium have previously relied primarily on disaggregated tissues…
  • Abstract Number: 0033 • ACR Convergence 2025

    Development and Internal Validation of Two Human Leukocyte Antigen Genetic Risk Scores for Predicting Rheumatoid Arthritis Progression and Anti-Citrullinated Protein Antibody-Positivity

    Lauren Vanderlinden1, Jun Inamo2, Jennifer Seifert3, V. Michael Holers4, Joel Guthridge5, Kevin Deane6 and Fan Zhang7, 1University of Colorado Anschutz Medical Campus, Monument, CO, 2University of Colorado School of Medicine, Aurora, CO, 3University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 4University of Colorado, Denver, CO, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 7The University of Colorado, Aurora, CO

    Background/Purpose: Human leukocyte antigen (HLA) class II genes play a central role in antigen presentation and immune modulation. The shared epitope (SE) region within HLA-DRB1…
  • Abstract Number: 2641 • ACR Convergence 2025

    Cizutamig, a BCMA T-cell engager: preclinical to clinical translation of design optimization for the treatment of autoimmune diseases

    Ricardo Grieshaber-Bouyer1, Jamie Haddon2, Maria Gabriella Raimondo3, Carlo Tur3, Sebastian Böltz3, Tobias Dashi4, Melanie Hagen5, Andreas Wirsching3, Tobias Rathe4, Xuan Wu6, Peter Wung2, Francis Kim2, Yonghong Zhu6, Ken Song2, Timothy Lu7 and Georg Schett8, 1University Hospital Erlangen, Erlangen, Germany, 2Candid Therapeutics, San Diego, CA, 3Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 5Friedrich-Alexander-University Erlangen-Nuremberg, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 6EpimAb Biotherapeutics, Shanghai, China (People's Republic), 7Candid Therapeutics, San Diego, 8Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany

    Background/Purpose: Emerging data show the potential of T-cell engagers (TCEs) for deep B cell depletion to treat autoimmune diseases. Cizutamig is a purposefully designed BCMAxCD3…
  • Abstract Number: 2348 • ACR Convergence 2025

    Efficacy and safety of dual biological therapy in the treatment of rheumatic diseases: experience from a single highly specialized center.

    Francesco Fulvio Bizzarri1, Luis Alberto Menchén Viso2, Esther Chamorro De Vega3, Ofelia Baniandrés Rodríguez4 and Juan Carlos Nieto2, 1Hospital Universitario Clinico San Cecilio, Granada, Spain, 2Hospital General Universitario Gregorio Marañón, Madrid, Spain, 3Pharmacy department, Hospital General Universitario Gregorio Marañón.Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain, Madrid, Madrid, Spain, 4Hospital General Universitario Gregorio Marañon, Madrid, Spain

    Background/Purpose: Immune‐mediated rheumatic diseases (IMRDs) are chronic inflammatory disorders driven by multiple overlapping immunological pathways. Although biologic DMARD monotherapy has substantially improved outcomes, a subset…
  • Abstract Number: 2275 • ACR Convergence 2025

    Agreement Between Two Rheumatoid Arthritis Response Measures Across b/ts DMARD Treatment Classes in a Large, Prospective Observational Study Supporting the Development and Clinical Validation of a Novel Blood-based Precision Medicine Test

    Peter Taylor1, Jason Carlson2, Shirley Vu2, Signe Fransen3, Diana Abdueva4 and Jeffrey Curtis5, 1University of Oxford, Oxford, United Kingdom, 2Aqtual Inc, Hayward, CA, 3Aqtual, sf, CA, 4Aqtual, Hayward, CA, 5Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL

    Background/Purpose: Contemporary pharmacological management of rheumatoid arthritis (RA) is set within a treat-to-target framework. This requires quantitative, longitudinal assessments of disease activity with a view…
  • Abstract Number: 2258 • ACR Convergence 2025

    Clinical Associations of Pulmonary Hypertension in RA Patients with and without Interstitial Lung Disease

    Sanjita Gowda1, Yuri Matusov2, Amara Seng1, Nunzio Bottini3 and Jon Giles4, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Cedars-Sinai Medical Center, Los Angeles, 3Cedars Sinai Medical Center, Beverly Hills, CA, 4Cedars Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Pulmonary diseases are contributors to the morbidity and mortality of RA. Despite the recent surge in studies of RA-associated interstitial lung disease (RA-ILD), there…
  • Abstract Number: 2241 • ACR Convergence 2025

    RADAR: A Deep Learning Pipeline for Automated Scoring of Joint Damage in Rheumatoid Arthritis Radiographs

    Hugo PENSEC1, Alain SARAUX2, florent garrigues3, yoann le duault1, sandrine jousse4, baptiste quere4, nathan foulquier5, Valerie Devauchelle6 and ikram brahim7, 1CHRU Brest, Brest, France, 2CHU Brest, Brest, France, 3CHU de BREST, Brest, Bretagne, France, 4LBAI, UMR1227, University of Brest, CHU Brest, Brest, France, Brest, France, 5LBAI, UMR1227, Univ Brest, Inserm, Brest, France, Brest, France, 6UBO, Brest, France, 7CHRU, LBAI, UMR1227, Univ Brest, Inserm, LaTIM, UMR 1101, Brest, France, Brest, France

    Background/Purpose: Rheumatoid arthritis (RA) is a persistent inflammatory disorder inducing joint space narrowing and erosion at both hands and feet. Reading of X-ray images remains…
  • Abstract Number: 2208 • ACR Convergence 2025

    Contraception and Pregnancy Experiences of Veterans from Minoritized Populations with Rheumatoid Arthritis

    Catherine Sims1, Yujung Choi2, Abigail Shapiro3, Elizabeth Strawbridge2, Jennifer Gierisch1, Teresa Howard2, Ankoor Shah1 and Karen Goldstein1, 1VA Durham Healthcare System, Duke University, Durham, 2VA Durham Healthcare System, Durham, 3VA Durham Healthcare System, Cleveland

    Background/Purpose: More than 8,500 women Veterans carry a diagnosis of rheumatoid arthritis (RA), however, there are limited data on the reproductive health and experiences of…
  • Abstract Number: 1950 • ACR Convergence 2025

    Pericoronary fat enhancement in rheumatoid arthritis differs from controls and associates with coronary atherosclerosis independently of epicardial fat volume

    Frederik Enevoldsen1, Sarah Ormseth2, Dzenan Masic1, Matthew Budoff3, Ellen-Margrethe Hauge1 and George Karpouzas3, 1Aarhus University, Aarhus, Denmark, 2The Lundquist Institute for Biomedical Innovation, Torrance, CA, 3Harbor-UCLA Medical Center, Torrance, CA

    Background/Purpose: Pericoronary adipose tissue attenuation (PCATa) reflects the composition of the fat directly surrounding the coronary arteries and is associated with coronary wall inflammation. In…
  • Abstract Number: 1885 • ACR Convergence 2025

    Sex-specific Associations of Anthropometrics, Smoking and Eduction with the Risk of Rheumatoid Athritis: A Nested Case-Control Study

    Carl Turesson1, Linnea arvidsson2, Emil Rydell1 and Ulf Bergström3, 1Lund University, Malmö, Sweden, 2Lund University, Malmö, 3Lund University, Malmö, Sweden

    Background/Purpose: Smoking is an established risk factor for rheumatoid arthritis (RA), and there is also evidence for an association with socioeconomic factors. As RA is…
  • Abstract Number: 1702 • ACR Convergence 2025

    Powerful and Accurate Case-Control Analysis of Spatially Resolved Molecular Data in Autoimmune Disease

    Yakir Reshef1, Lakshay Sood1, Michelle Curtis1, Laurie Rumker2, DANIEL STEIN3, Mukta Palshikar1, Saba Nayar4, Andrew Filer5, Anna Helena Jonsson6, ilya Korsunsky7 and Soumya Raychaudhuri7, 1Brigham and Women's Hospital, Boston, 2Broad Institute, Boston, 3Harvard University, Boston, 4University of Birmingham, Birmingham, United Kingdom, 5The University of Birmingham, Birmingham, United Kingdom, 6University of Colorado School of Medicine, Aurora, CO, 7Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoimmune diseases such as rheumatoid arthritis (RA) involve complex spatial organization of immune and stromal cells within inflamed tissues. As spatial molecular profiling methods…
  • Abstract Number: 1645 • ACR Convergence 2025

    A sex-modified association between Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) blood concentration and prevalent arthritis among young and middle-aged US adults

    Queeneth Edwards1, Samuel Mbadu1, Jhy-Charm Soo2 and Jian Zhang2, 1Georgia Southern University, Statesboro, GA, 2Georgia Southern University, statesboro

    Background/Purpose: Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (PFAS), including Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS), are persistent environmental contaminants that may influence inflammatory joint diseases…
  • Abstract Number: 1363 • ACR Convergence 2025

    Evaluation of the Clinical Outcome of Baricitinib in Patients with Rheumatoid Arthritis from Multi-center Collaborative Study in Japan: Sub-analysis for Difficult-to-treat RA.

    Naoki Kondo and Nariaki Hao, Division of Orthopedic Surgery, Niigata University Medical and Dental General Hospital, Niigata, Japan

    Background/Purpose: The aim is to examine the efficacy and safety of baricitinib (BARI) in Japanese rheumatoid arthritis (RA) patients in real clinical practice and is…
  • Abstract Number: 1346 • ACR Convergence 2025

    Preliminary Result of Investigating the Response of Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) Associated SNPs: One Cohort Study

    YU Chen1, Chien-Sheng Wu2, Jacob Shujui Hsu3 and Pei-Lung Chen4, 1Division of Rheumatology, Allergy and Immunology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C. Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., New Taipei City, Taiwan (Republic of China), 2Division of Rheumatology, Allergy and Immunology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C., New Taipei city, Taiwan (Republic of China), 3Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., Taipei city, Taiwan (Republic of China), 4Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., Taipei, Taiwan (Republic of China)

    Background/Purpose: Multiple Single-Nucleotide Polymorphisms (SNPs), including those in the methotrexate and azathioprine metabolic pathways, are associated with poor response to conventional disease-modifying anti-rheumatic drugs (cDMARDs)…
  • Abstract Number: 1328 • ACR Convergence 2025

    Mortality Trends of Hypertension in Patients with Rheumatoid Arthritis in the United States (1999–2020)

    Rameez Qasim1, Khadija Mohib2, Muhammad Ali3, Umm E Aimen Minhas4, Abu-bakr Ahmed5 and Areeba Minhaj6, 1Allama Iqbal Medical College Lahore, Lahore, Pakistan, 2Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, 3Dow International Medical College, Karachi, Sindh, Pakistan, 4Allama Iqbal Medical College, Lahore, Pakistan, 5Kirk Kerkorian School of Medicine, Las Vegas, NV, 6University of South Dakota, sioux falls, SD

    Background/Purpose: Hypertension is highly prevalent among patients with rheumatoid arthritis (RA) and significantly increases the risk of cardiovascular disease (CVD). Despite this established relationship, there…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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