ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 2238 • ACR Convergence 2024

    The Effect of Inflammation on Cardiovascular Risk in Rheumatoid Arthritis Varies According to Sex and Anticitrullinated Protein Antibody Status

    George Karpouzas1, Piet Van RIel2, Elena Myasoedova3, Miguel Angel Gonzalez-Gay4, alfonso Corrales-Martínez5, Solbritt Rantapaa-Dahlqvist6, Petros Sfikakis7, Patrick Dessein8, Linda Tsang9, Carol Hitchon10, Hani El Gabalawy11, Virginia Pascual Ramos12, Irazu Contreras Yanez13, Iris Jazmín Colunga Pedraza14, Dionicio Galarza-Delgado15, jose Ramon Azpiri-Lopez16, Anne Grete Semb17, Durga P Misra18, Patrick Durez19, Brian Bridal Logstrup20, Ellen Margrethe Hauge21, George Kitas22 and Sarah Ormseth23, and ATACC-RA, 1Harbor-UCLA Medical Center, Torrance, CA, 2Radboud University Medical Center, Nijmegen, Netherlands, 3Mayo Clinic, Rochester, MN, 4University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 5Hospital Universitario Marques de Valdecilla, Santander, Spain, 6Umeå University, Umeå, Sweden, 7Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens. Centre of New Biotechnologies and Precision Medicine (CNBPM), School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 8University of Witwatersrand, Johannesburg, South Africa, 9University of Witwatersrand, Johanessburg, South Africa, 10University of Mannitoba, Winnipeg, Canada, 11University of Mannitoba, Winnipeg, MB, Canada, 12Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Federal District, Mexico, 13Instituto Nacional de las Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 14Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 15UANL Hospital Universitario, Monterrey, Nuevo León, Mexico, 16Division of Cardiology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 17Diakonhjemmet Hospital, Oslo, Norway, 18Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 19UCLouvain, Louvain, Belgium, 20University of Aarhus, Aarhus, Denmark, 21Aarhus Universitetshospital, Aarhus, Denmark, 22The Dudley Group NHS Foundation Trust, Birmingham, United Kingdom, 23The Lundquist Institute, Torrance, CA

    Background/Purpose: Disease activity associated with cardiovascular (CV) risk in rheumatoid arthritis (RA). Females with RA exhibit higher disease activity than males. Yet, males with RA…
  • Abstract Number: 2257 • ACR Convergence 2024

    Comparison of the Safety and Effectiveness of Originator Rituximab (Mabthera®) versus Biosimilar (Riximyo®) in Rheumatoid Arthritis: A Retrospective Unicentric Analysis

    Barbara Bayeh1, Fanny Neira1, Karina Bonfiglioli1, Nadia Aikawa2, ANA PAULA ASSAD1, Renata Miossi1, Fernando Souza3, Carlos Emilio Insfran Echauri1, Henrique Giardini1, Emily Figueiredo Neves Yuki1, Henrique Carriço Da Silva1, Andre Franco1, Diogo Domiciano1, Julio Moraes4, Eloisa Bonfa1, Carla Goncalves Schahin Saad3, Ana Cristina Medeiros-Ribeiro5 and Andrea Shimabuco3, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil, 3Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Jundiai, Brazil, 5Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Jose Dos Campos, Brazil

    Background/Purpose: Immunobiological drugs emerged as a revolutionary option for treating inflammatory chronic rheumatic diseases, particularly rheumatoid arthritis (RA). However, the extremely high costs associated with…
  • Abstract Number: 2276 • ACR Convergence 2024

    Use of Methotrexate and TNF-α Inhibitors in Patients with Rheumatoid Arthritis-associated Interstitial Lung Disease: A Survey of Rheumatologists

    Elizabeth Park1, Rabia Iqbal2, Elana Bernstein3 and Jon Giles4, 1Columbia University Medical Center, New York, NY, 2Columbia University Irving Medical Center, Brooklyn, NY, 3Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 4Cedars Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Interstitial lung disease (ILD) is among the most common extra-articular manifestations of RA, with symptomatic disease prevalent in approximately 10% of patients.1 Patients with…
  • Abstract Number: 2539 • ACR Convergence 2024

    Telocytes Integrated into Mast Cells and Joint-Draining Lymphatic Vessels Potentially Regulate Lymphatic Clearance

    Yue Peng1, H. Mark Kenney2, Karen Bentley1, Lianping Xing3, Benjamin Korman4, Christopher Ritchlin5 and Edward Schwarz1, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Henrietta, NY, 3University of Rochester School of Medicine and Dentistry, Webster, NY, 4University of Rochester, Rochester, NY, 5Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Rheumatoid arthritis (RA) patients and TNF-transgenic mice have lymphatic dysfunction (1). Recently, we showed mast cells involvement, as genetic ablation and drug inhibition decreased…
  • Abstract Number: 2636 • ACR Convergence 2024

    Multi-centre Validation of a Serum Protein Biomarker Signature (RAPsA Dx), Which Discriminates Psoriatic Arthritis (PsA) from Rheumatoid Arthritis (RA)

    Stephen Pennington1, Ruoyi Zhou2, Jonathan Brady2, Bruna Wundervald2, Andrew Parnell3, Ciarán Duffy2, Robert Perryman2, James Waddington4, Neil McHugh5, Deepak Jadon6, David Simon7, Filippo Fagni8, Georg Schett9, Fraser Morton10, Aurelie Najm10, Stefan Siebert11, Laura Coates12 and Oliver FitzGerald13, 1UCD, Dublin, Dublin, Ireland, 2Atturos, DUBLIN, Dublin, Ireland, 3NUIM, Maynooth, Ireland, 4Agilent, Manchester, United Kingdom, 5University of Bath, Bath, United Kingdom, 6Cambridge University, Cambridge, United Kingdom, 7Charité - Universittsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Deutsches Zentrum für Immuntherapie (DZI), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 9Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 10University of Glasgow, Glasgow, United Kingdom, 11School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 12University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 13UCD, Dublin 6, Dublin, Ireland

    Background/Purpose: In a previous study, we reported the discovery and evaluation of a serum protein (22 peptide) signature (RAPsA Dx) which, when using random forest machine…
  • Abstract Number: 0040 • ACR Convergence 2024

    Targeting Complement Factor B (CFB) via a Novel siRNA Therapy (AZD6912) to Treat Inflammatory Arthritis

    Gary Sims1, Mia Collins2, Natalie Pursell3, Teneema Kuriakose1, Fanyi Jiang4, Kristi Moore5, Lucie Bertrand5, Melissa Lasaro5, Jessica Neisen6, Scott Manetz7, Gabriel Wong8, Patrick Riley5, Iain McInnes9, Kyriakos Konstantinidis10 and David Close8, 1Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 3Dicerna, Lexington, 4Translation and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 5Alexion, AstraZeneca Rare Disease, New Haven, CT, 6Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 7Clinical Pharmacology and Safety Science, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 8Early Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 9University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 10Projects, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: New precision medicine guided therapies targeting alternate disease driving processes are required to improve clinical outcomes in RA. The complement pathway has long been…
  • Abstract Number: 0057 • ACR Convergence 2024

    Flow Cytometry of Cells Within Induced Sputum from Individuals At-Risk for RA Reveals Relative Expansion of Small Macrophages

    Hideto Takada1, Brian Hattel2, Marie Feser3, LauraKay Moss2, Yuko Okamoto4, Mark Gillespie5, Adam Savage5, Troy Torgerson6, V. Michael Holers7, Kevin Deane8 and Kristen Demoruelle9, 1Tokyo Women's Medical University, Denver, CO, 2University of Colorado Anschutz Medical Campus, Denver, CO, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Tokyo Women's Medical University Division of Rheumatology, Shinjyuku-ku, Tokyo, Japan, 5Allen Institute for Immunology, Seattle, WA, 6Allen Institute for Immunology, Enumclaw, WA, 7University of Colorado, Denver, CO, 8University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 9University of Colorado Anschutz Medical Campus, Golden, CO

    Background/Purpose: Serum elevations of ACPA in the absence of inflammatory arthritis is a well-established risk factor for the future development of clinical RA. The lung…
  • Abstract Number: 0140 • ACR Convergence 2024

    Estimation of 10-year Cardiovascular (CV) Risk and Traditional CV Risk Factors Distribution in Patients with Rheumatoid Arthritis from Three Italian Macro-areas

    Fabiola Atzeni1, Fabio Cacciapaglia2, Elena Bartoloni Bocci3, Matteo Piga4, Garifallia Sakellariou5, Ombretta Viapiana6, Alessandro Giollo7, SIMONE PARISI8, Maria Sole Chimenti9, Ennio Giulio Favalli10, Addolorata Corrado11, Eleonora Celletti12, Ivan Giovannini13, Serena Guiducci14, Elisa Gremese15, Andreina Manfredi16, Francesca Romana Spinelli17 and Gian Luca Erre18, and "Cardiovascular Obesity and Rheumatic DISeaases" Study Group of the Italian Society of Rheumatology, 1University of Messina, Italy, Messina, Italy, 2Rheumatology Unit DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 3Rheumatology Unit. Department of Medicine, Perugia, Perugia, Italy, 4Rheumatology Unit - Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy, 5Department of Internal Medicine and Medical Therapy, University of Pavia, and Istituti Clinici Scientifici Maugeri IRCCS Pavia,, Pavia, Italy, 6Rheumatology Unit, University of Verona, Verona, Italy, 7Azienda Ospedale Università Padova, Padova, Padua, Italy, 8Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, TURIN, Italy, 9Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata, Roma, Italy, 10ASST Gaetano Pini-CTO, Milan, Lombardia, Italy, 11Rheumatology Unit, University of Foggia, Foggia, Italy, 12Medical Clinic, SS. Annunziata Hospital of Chieti, Department of Medicine and Science of Aging, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy, 13Azienda Sanitaria Universitaria Friuli Centrale, Udine, Udine, Italy, 14University of Florence, Pistoia, Italy, 15Catholic University of the Sacred Heart, Rome, Rome, Italy, 16University of Modena and Reggio Emilia, Modena, 17Sapienza University of Rome, Rome - Italy, Roma, Rome, Italy, 18Rheumatology Unit - University of Sassari, Sassari, Italy

    Background/Purpose: Geographic origins can significantly impact people’s health, particularly in Italy, where regional health disparities are among the most pronounced [1]. Rheumatoid arthritis (RA) is…
  • Abstract Number: 0222 • ACR Convergence 2024

    The Prediction of Response to Advanced Therapies on a Joint Level in Rheumatoid Arthritis: The Interpretation of Tenderness and Doppler Ultrasound

    Ricardo Sabido-Sauri1, Seyyid Bilal Acikgoz2, Ummugulsum Gazel1, Ozun Bayindir Tsechelidis3, Sylvia Sangwa4, Catherine Ivory5, Elliot Hepworth1 and Sibel Aydin6, 1University of Ottawa, Ottawa, ON, Canada, 2University of Ottawa, Rheumatology, Ottawa, ON, Canada, 3Ottawa University, Ottawa, ON, Canada, 4The Ottawa Hospital Research Institute, Ottawa, Canada, 5The Ottawa Hospital, Ottawa, ON, Canada, 6University of Ottawa - Ottawa, Ottawa, ON, Canada

    Background/Purpose: There are discrepancies between physical examination and Ultrasound (US) in detecting inflammation in Rheumatoid Arthritis (RA). In this study, we aimed to understand, according…
  • Abstract Number: 0364 • ACR Convergence 2024

    Exploring 24-Hour Temporal Trends in Symptoms and Treatment of Rheumatic Disease Through Google Search Trends

    Insa Mannstadt1, J. Alex B. Gibbons2 and Bella Mehta3, 1Columbia University VP&S, New York, NY, 2Columbia University Vagelos College of Physicians & Surgeons, New York, NY, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: Symptoms of rheumatic diseases such as joint stiffness and pain are known to peak in the early morning hours. In the digital age, tracking…
  • Abstract Number: 0461 • ACR Convergence 2024

    Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis

    ivan Ferraz-Amaro1, Maria Garcia-Gonzalez2, Fuensanta Gomez-Bernal3, Juan Carlos Quevedo-Abeledo4 and Miguel Angel Gonzalez-Gay5, 1Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 2Hospital Universitario de Canarias, SC Tenerife, Canarias, Spain, 3Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 4Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 5University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain

    Background/Purpose: The complement (C) system has been implicated in the etiopathogenesis of rheumatoid arthritis (RA). We aimed to examine the correlation between an in-depth evaluation…
  • Abstract Number: 0477 • ACR Convergence 2024

    The Global Prevalence of Interstitial Lung Disease in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis

    Hari Prasanna1, Charles Inderjeeth2, Johannes Nossent3 and KHALID ALMUTAIRI4, 1University of Western Australia, Perth, Western Australia, Australia, 2SCGH and OPH Group & University of Western Australia, Perth, Western Australia, Australia, 3University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia, 4The University of Western Australia, Perth, Western Australia, Australia

    Background/Purpose: Interstitial lung disease (ILD) is a common manifestation of rheumatoid arthritis (RA) that severely impacts the health outcomes of RA patients. Despite this, the…
  • Abstract Number: 0495 • ACR Convergence 2024

    Correlation Between Triglyceride/Glucose Index and Functional Capacity in Rheumatoid Arthritis Patients

    Yelitza Cecilia Velarde Mejia1, Manuel Ugarte-Gil2, Risto Perich3, Cesar Pastor4, Graciela Alarcon5 and RV, Gamboa-Cardenas6, 1Hncase, Arequipa, Peru, 2Universidad Cientifica del Sur, Lima, Lima, Peru, 3Hospital Almenara, Lima, Peru, 4UNMSM, LIMA, Peru, 5The University of Alabama at Birmingham, Oakland, CA, 6Universidad Científica del Sur, Lima, Lima, Peru

    Background/Purpose: The triglyceride/glucose index (TGI) is a metabolic marker associated with insulin resistance and cardiovascular risk. In patients with Rheumatoid Arthritis (RA), chronic inflammation and…
  • Abstract Number: 0511 • ACR Convergence 2024

    Do High Rheumatoid Factor Levels Impact Response to Certolizumab Pegol in Patients with Inadequately Controlled Rheumatoid Arthritis? A Post Hoc Analysis of a Phase 3b Trial

    Josef Smolen1, Ted Mikuls2, James Galloway3, Ulf Müller-Ladner4, Jeffrey Curtis5, Motomu Hashimoto6, Tsutomu Takeuchi7, Ernest Choy8, Yoshiya Tanaka9, Carlos Cara10, Bernard Lauwerys11, Nicola Tilt12, Baran Ufuktepe13 and Peter C. Taylor14, 1Medical University of Vienna, Vienna, Austria, 2University of Nebraska Medical Center, Omaha, NE, 3Centre for Rheumatic Diseases, King's College London, London, United Kingdom, 4Justus-Liebig University Giessen, Bad Nauheim, Germany, 5University of Alabama at Birmingham, Hoover, AL, 6Osaka Metropolitan University, Osaka, Japan, 7Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 8Cardiff University School of Medicine, Cardiff, United Kingdom, 9Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 10UCB Pharma, Madrid, Spain, 11UCB Pharma, Brussels, Belgium, 12UCB Pharma, Slough, United Kingdom, 13UCB Pharma, Istanbul, Turkey, 14University of Oxford, Oxford, United Kingdom

    Background/Purpose: In pts with RA, high RF levels are associated with poor prognosis, higher disease activity, and decreased response to monoclonal antibodies targeting tumor necrosis…
  • Abstract Number: 0529 • ACR Convergence 2024

    Discontinuation of Targeted Disease-Modifying Antirheumatic Agents in Older Patients with Rheumatoid Arthritis: Retrospective Analysis of Medicare Data

    Yinan Huang1, Shadi Bazzazzadehgan2, Sebastian Bruera3 and Sandeep Agarwal3, 1University of Mississippi School of Pharmacy, Oxford, MS, 2University of Mississippi School of Pharmacy, Oxford, 3Baylor College of Medicine, Houston

    Background/Purpose: Individuals with rheumatoid arthritis (RA) may discontinue b/tsDMARDs due to treatment failure, adverse events or costs. Little is known about b/tsDMARDs discontinuation among Medicare…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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