Abstracts tagged "rheumatoid arthritis"

Abstract Number: 0888 • ACR Convergence 2024
Genetically Determined Peptidylglycine Alpha-amidating Monooxygenase (PAM) Mediated Amidation Regulates Tissue Damage by Rheumatoid Arthritis Synovial Fibroblasts
Kevin Sheridan¹, Emma Doris¹, Maria Pimenta¹, Jemma Falkov¹, Matthew Fisher², Munitta Muthana², Denis Shields¹, Richard Mains³, Betty Eipper³, Christopher Buckley⁴ and Anthony Wilson⁵, ¹University College Dublin, Dublin, Ireland, ²University of Sheffield, Sheffield, United Kingdom, ³University of Connecticut, Connecticut, ⁴University of Oxford, Oxford, United Kingdom, ⁵UCD, Dublin, Dublin, Ireland
Background/Purpose: The SNP rs26232 is associated with both risk and severity of rheumatoid arthritis (RA), with the C allele associated with the susceptibility to RA,…
Abstract Number: 0942 • ACR Convergence 2024
An Aged K/BxA Arthritis Mouse Model Develops Features of Interstitial Lung Disease with Pulmonary Fibrosis and Bronchus-Associated T-Cell Aggregates Without a Pulmonary Insult, and Correlates with Worsening Arthritis Scores
Amir Razmjou¹, Richard Watson², Ani Shahbazian³, Jennifer Wang¹ and christina Charles-Schoeman⁴, ¹UCLA, Los Angeles, CA, ²UCLA Medical Center, Los Angeles, CA, ³UCLA, Los Angeles, ⁴UCLA Medical Center, Santa Monica, CA
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a significant extra-articular manifestation of RA with high morbidity/mortality, but the underlying pathogenesis remains poorly understood.…
Abstract Number: 1011 • ACR Convergence 2024
Use of the Shingrix Vaccine Among Patients with Inflammatory Arthritis and Risk of Cardiovascular Events Following Herpes Zoster
Jeffrey Curtis¹, Danielle M Conrad², Whitney S Krueger², Andrew P Gara² and Kevin Winthrop³, ¹FASTER Medicine, Hoover, AL, ²AbbVie, North Chicago, IL, ³School of Medicine, Oregon Health and Science University, Portland, OR
Background/Purpose: The risk of herpes zoster (HZ) is increased in patients with inflammatory arthritis (IA); although the Shingrix vaccine has been available since 2017, its…
Abstract Number: 1052 • ACR Convergence 2024
Challenges and Opportunities in Post-Pandemic Remote Therapeutic Monitoring for Musculoskeletal Disease
Angela Degrassi¹, Jeffrey Curtis², David Curtis¹, Kelly Gavigan¹, Laura Stradford³, Shelley Fritz⁴, Sandeep Sodhi⁵ and Shilpa Venkatachalam⁶, ¹Global Healthy Living Foundation, Upper Nyack, NY, ²University of Alabama at Birmingham, Hoover, AL, ³Global Healthy Living Foundation, Nyack, NY, ⁴Global Healthy Living Foundation, Kalaheo, HI, ⁵Illumination Health, Hoover, AL, ⁶Global Healthy Living Foundation, New York, NY
Background/Purpose: Remote Therapeutic Monitoring (RTM) connects patients to their healthcare provider using a smartphone app with or without a physiologic biosensor device in an insurance-reimbursable…
Abstract Number: 1326 • ACR Convergence 2024
Which Biomarkers Indicate Imminent Progression to Inflammatory Arthritis in High Risk CCP Positive Persons?
Laurence Duquenne¹, Didem Sahin Eroglu², Jianhua Wu³, Kate Harnden¹, Andrea Di Matteo⁴, Lucy Elizabeth Thornton⁵, Rahaymin Chowdhury⁵, Leticia Garcia-Montoya¹, Kulveer Mankia⁶ and Paul Emery⁶, ¹1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, United Kingdom, ²1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Ankara, Turkey, ³1. University of Leeds, Leeds Institute for Data Analytics, Leeds, United Kingdom 2.Wolfson Institute of Population Health/Queen Mary University of London, UK, Leeds, ⁴1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Jesi, Italy, ⁵1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, ⁶University of Leeds, Leeds, United Kingdom
Background/Purpose: A risk stratification model proposed a simple score using 4 biomarkers to identify those at high risk of developing inflammatory arthritis (IA) in primary…
Abstract Number: 1342 • ACR Convergence 2024
Utility of Anti-Carbamylated Antibodies in Early Rheumatoid Arthritis in South Asian Population
chandhu aS¹, Josna Joseph¹, ABHILASHA ARVIND MANWATKAR² and John Mathew³, ¹CMC Vellore, Vellore, Tamil Nadu, India, ²christian medical college, vellore, Tamil Nadu, India, ³Christian Medical college , Vellore , India, Vellore, India
Background/Purpose: Rheumatoid Arthritis (RA) is an autoantibody mediated disease with deforming peripheral arthritis. Autoantibodies widely used are rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA).…
Abstract Number: 1358 • ACR Convergence 2024
A Step Towards Personalised Medicine – Development and Efficacy of Machine Learning Based Smart-Web Application for Prediction of Steroid Induced Hyperglycemia in Patients with Rheumatoid Arthritis and Other Autoimmune Rheumatic Diseases
Manyam Prudhvi Krishna¹, Sandeep Surendran¹, MITHUN CHALAKKARAYIL BHAGAVALDAS², Sundarakrishna Sai³, Sekhar V Easwar¹, Ronith S Kumar³ and Manu Pradeep¹, ¹Amrita Institute of Medical Sciences, Kochi, Kerala, India, ²Amrita Institute of Medical Sciences, ERNAKULAM, Kerala, India, ³Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
Background/Purpose: Steroids play a key role in treating rheumatic diseases due to their anti-inflammatory effects. However, long-term or high-dose use leads to side effects like…
Abstract Number: 1374 • ACR Convergence 2024
Exploring Two Decades of Therapeutic Challenges: A Monocentric Experience in Rheumatoid Arthritis Patients Battling Cancer
Roba Ghossan¹, Elodie Portier², OLIVIER FOGEL³, Sophie Hecquet¹, Astrid Dauchez¹, Omar AL TABAA⁴, Marion THOMAS⁵, Julia Herrou¹, Yannick Allanore⁶ and Jérôme Avouac⁷, ¹COCHIN HOSPITAL, PARIS, France, ²Cochin Hospital, Bry sur Marne, France, ³AP-HP, Paris, France, ⁴APHP - Cochin Hospital, Paris, France, ⁵APHP, Paris, France, ⁶Université Paris Cité, Paris, France, ⁷Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France
Background/Purpose: Managing inflammatory arthritis patients on biologics with a history of cancer remains a complex task in daily rheumatology practice and requires a thoughtful, individualized…
Abstract Number: 1391 • ACR Convergence 2024
Possible Mechanistic Pathways of the Effective “Plants for Joints” Lifestyle and Dietary Intervention for Rheumatoid Arthritis
Carlijn Wagenaar¹, Márcia Pereira², Sylvio Redanz³, Arne Gessner⁴, Wendy Walrabenstein⁵, Martin Kriegel³, Mario Zaiss⁶ and Dirkjan van Schaardenburg⁷, ¹Reade Rheumatology Center, Amsterdam, Netherlands, ²University of Münster, Münster, Germany, ³Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, ⁴Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ⁵Reade Center for Rheumatology and Rehabilitation, Amsterdam, Netherlands, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universittsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, ⁷Amsterdam UMC, Amsterdam, Netherlands
Background/Purpose: The 16-week Plants for Joints (PFJ) intervention, consisting of a whole-food plant-based diet, physical activity, and stress management, significantly reduced 28-joint Disease Activity Score…
Abstract Number: 1659 • ACR Convergence 2024
Shared Lung and Joint T Cell Repertoire in Early Rheumatoid Arthritis Driven by Cigarette Smoking
Koen Venken¹, Matthias Jarlborg¹, Frederik Stevenaert², Thomas Malfait³, Carolien Vlieghe¹, Yann Abraham², Teddy Manuello¹, Tine Decruy¹, Stijn Van Hee¹, Hans Wils², Pieter Peeters², Philippe Carron⁴, Filip Van den Bosch³, Viggo Van Tendeloo², Bart Lambrecht¹, Ruth Wittoek⁵, Peggy Jacques⁶ and Dirk Elewaut⁷, ¹VIB Center for Inflammation Research - Ghent University, Ghent, Belgium, ²Janssen Research and Development, Beerse, Belgium, ³Ghent University Hospital, Ghent, Belgium, ⁴UZ Gent, Gent, Belgium, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium, ⁶University Hospital of GHent, Gent, Belgium, ⁷Ghent University and VIB Center for Inflammation Research, Ghent, Belgium
Background/Purpose: Cigarette smoking has been associated with the production of anti-citrullinated protein antibodies (ACPA) and an increased risk of developing rheumatoid arthritis (RA) in individuals…
Abstract Number: 1724 • ACR Convergence 2024
Performance of a Novel Cardiovascular Risk Calculator in Rheumatoid Arthritis
Tate Johnson¹, Halie Frideres², Punyasha Roul³, Yangyuna Yang¹, Joshua Baker⁴, Sauer brian⁵, grant Cannon⁶, Ted Mikuls¹ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²UNMC Department of Rheumatology, Omaha, NE, ³UNMC, Omaha, NE, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Salt Lake City VA/University of Utah, Salt Lake City, UT, ⁶University of Utah and Salt Lake City VA, Salt Lake City, UT
Background/Purpose: Existing cardiovascular disease (CVD) risk calculators have inadequately estimated CVD risk in people with rheumatoid arthritis (RA). The American Heart Association (AHA) recently developed…
Abstract Number: 1856 • ACR Convergence 2024
Distinct Proliferative and Special Properties of Peripheral Helper T Cells in RA Synovium
Yuki Masuo¹, Akinori Murakami¹, Rinko Akamine¹, Osamu Iri¹, Koichi Murata¹, Kohei Nishitani¹, Hiromu Ito¹, Takayuki Fujii¹, Ryu Watanabe², Takeshi Iwasaki¹, Shinichiro Nakamura¹, Shinichi Kuriyama¹, Yugo Morita¹, Yasuhiro Murakawa¹, Chikashi Terao³, Yukinori Okada⁴, Motomu Hashimoto², Shuichi Matsuda⁵, Hideki Ueno¹ and Hiroyuki Yoshitomi¹, ¹Kyoto University, Kyoto, Japan, ²Osaka Metropolitan University, Osaka, Japan, ³RIKEN, Tokyo, Japan, ⁴The University of Tokyo / Osaka University / RIKEN, Tokyo, Japan, ⁵Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
Background/Purpose: Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that are frequently observed in the target tissues of chronic diseases. In patients with…
Abstract Number: 1936 • ACR Convergence 2024
Referral and Diagnostic Delays of Patients with Chronic Inflammatory Rheumatic Diseases: A Cross-sectional Study in Eight Countries
Nelly Ziade¹, Nizar Ani², avin maroof³, ASAL ADNAN RIDHA⁴, Manal El Rakawi⁵, Chafika Haouichat⁵, Bassel Elzorkany⁶, Sherif Gamal⁷, Mariama Erraoui⁸, Manal Al-Mashaleh⁹, Fatima Alnaimat¹⁰, Basel masri¹¹, fatemah Baron¹², Lina El Kibbi¹³, Krystel Aouad¹⁴, Karen Mechleb¹⁵ and Ihsane Hmamouchi¹⁶, and ARCH ArLAR, ¹Saint-Joseph University, Beirut, Lebanon, ²Baghdad College of Medicine, Baghdad, Iraq, ³University of Kurdistan Hawler, Erbil, Iraq, ⁴Baghdad Teaching Hospital, baghdad, Iraq, ⁵Djillali Bounaama University Hospital, Algiers, Algeria, ⁶Private (BZRC), Cairo, Egypt, ⁷Cairo University, Cairo, Egypt, ⁸Souss Massa Univeristy, Rabat, Morocco, ⁹Royal Medical Services, Amman, Jordan, ¹⁰The University of Jordan, amman, Jordan, ¹¹Jordan Hospital and Medical Center, Amman, Jordan, ¹²Al-Jahra Hospital, Ministry of Health, Kuwait, Kuwait, ¹³Specialized Medical Center, Riyadh, Saudi Arabia, ¹⁴Saint George Hospital University Medical Center, Beirut, Lebanon, ¹⁵Saint Joseph University Beirut, Beirut, Lebanon, ¹⁶Rheumatology Unit, Lalla Aicha Temara Hospital, Temara, Rabat, Morocco
Background/Purpose: Patients with chronic inflammatory rheumatic diseases (CIRDs) may benefit from a critical window of opportunity for early intervention, yet referral delays remain a major…
Abstract Number: 2141 • ACR Convergence 2024
Glucocorticoid Therapy-Associated Bone Fractures Are Associated with Osteoporosis Underscreening in Patients with Rheumatoid Arthritis
Marlene Marte Furment¹ and Andras Perl², ¹SUNY Upstate Medical University, Syracuse, NY, ²SUNY, Syracuse, NY
Background/Purpose: The majority of bone loss happens within 6 months of glucocorticoid treatment. Per the 2022 American College of Rheumatology (ACR) Glucocorticoid-Induced Osteoporosis Guidelines it…
Abstract Number: 2222 • ACR Convergence 2024
Primary Lung Involvement in Early Rheumatoid Arthritis
Martí Aguilar Coll¹, Javier Narvaez-García², Alejandro Robles Pérez¹, Patricio Luburich¹, Vanesa Vicens-Zygmunt³, Gualadalupe Bermudo³, Santiago Bolivar¹, Pol Maymó³, Judith Palacios¹, Monserrat Roig Kim², Laia De Daniel², Maria Molina-Molina³ and Joan Miquel Nolla¹, ¹Bellvitge University Hospital, L'Hospitalet de Llobregat, Catalonia, Spain, ²Hospital Universitario de Bellvitge, Barcelona, Spain, ³Hospital Universitario de Bellvitge., Barcelona, Spain
Background/Purpose: Since there is broad variability within the studies investigating this issue, it is not possible nowadays to reliably establish prevalence and incidence of rheumatoid…

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