ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 2169 • ACR Convergence 2024

    Different Trajectories of Patient Reported Outcomes in Patients with RA in a Stable Phase of Disease – an Observational Study

    Paul Studenic1, Nadine Schwab2, Günther Zauner2, Thi Lan Vi Tran3 and Helga Lechner-Radner4, 1Medical University Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria, Vienna, Austria, 2dwh GmbH, simulation services, Vienna, Austria & Institute of Information Systems Engineering, TU Wien, Vienna, Austria, 3Medical University of Vienna, Vienna, Austria, 4Medical University Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria

    Background/Purpose: In patients with rheumatoid arthritis (RA), we often see a disconnect between patient and evaluator perceived disease activity. In this study we aim to…
  • Abstract Number: 2226 • ACR Convergence 2024

    Site-specific Differences in the Association of Non-vertebral Major Osteoporotic Fractures and Rheumatoid Arthritis

    John Chen1, Malini Chandra2, Laura Carbone3, John Schousboe4, Elisha Garcia2 and Joan Lo2, 1Kaiser Permanente Oakland Medical Center, Oakland, CA, 2Kaiser Permanente, Oakland, CA, 3Augusta University, Augusta, GA, 4University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and osteoporosis are both chronic, potentially debilitating conditions that frequently co-occur, affecting millions of people annually. Among those with osteoporosis, RA…
  • Abstract Number: 2242 • ACR Convergence 2024

    A Cross-sectional Study on Predictors of COVID-19 Infection, Admission and Mortality and Effect of Immunomodulating Treatments in Rheumatoid Arthritis

    Mohammad Movahedi1, Elliot Hepworth2, Angela Cesta3, Xiuying Li3, Claire Bombardier4 and Sibel Aydin5, and OBRI investogators, 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2University of Ottawa, Ottawa, ON, Canada, 3UHN, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada, 5Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Background/Purpose: COVID-19 infection frequently leads to a cytokine storm, which has successfully been treated with some immunomodulating therapies according to observational studies. Interestingly, treatments investigated…
  • Abstract Number: 2262 • ACR Convergence 2024

    Window of Opportunity in the Treatment of Rheumatoid Arthritis – Interstitial Lung Disease with Abatacept. National Multicenter Study of 526 Patients

    Ana Serrano-Combarro1, Belén Atienza-Mateo2, Libe Ibarrola Paino3, Ivette Casafont-Sole4, Jesús Loarce5, Juan María Blanco Madrigal6, Santos Castañeda7, Rafaela Ortega-Castro8, Natalia Mena Vázquez9, Nuria Vegas Revenga10, Lucía Domínguez Casas11, Cilia Peralta Ginés12, Miriam Retuerto Guerrero13, Lorena Pérez Albadalejo14, Rubén López Sánchez15, MARIA GUADALUPE MANZANO CANABAL16, Anahy Maria Brandy-Garcia17, Patricia Lopez Viejo18, Gema Bonilla19, Olga Maíz Alonso20, Carmen Carrasco-Cubero21, Marta Garijo Bufort22, Ana Urruticoechea Arana23, Sergi Ordoñez24, Carmen González Montagut25, Andrea García-Valle26, Juan Ramón De Dios27, María Martín López28, Tomás Vázquez Rodríguez29, Delia Fernández-Lozano30, Ignacio Brana Abascal31, Rafael Benito Melero-Gonzalez32, Emilio Giner33, Virginia Ruiz-Esquide34, Clara Ventin Rodriguez35, Marina Rodriguez36, Pablo Andújar-Brazal37, Julia Fernandez Melon23, Lilian M. López-Núñez38, JOSE RAMON LAMUA RIAZUELO39, Anna Pamies Corts40, Carlos Fernández Díaz41, Javier Loricera42, Diego Ferrer43 and Ricardo Blanco-Alonso44, 1Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 3Rheumatology Division, Bisadoa Hospital, Bidasoa, Spain, 4Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 5Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 6Basurto University Hospital, Bilbao, Spain, 7Hospital Universitario de la Princesa, Madrid, Spain, 8Hospital Reina Sofía, Cordoba, Andalucia, Spain, 9IBIMA, Málaga, Andalucia, Spain, 10Hospital Galdakao- Usansolo, Galdakao, Spain, 11Hospital Universitario San Agustín, Avilés, Spain, 12Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, 13Complejo Asistencial Universitario de León, Leon, Spain, 14Hospital Universitario de Jaén, Jaén, Spain, 15Hospital Universitario de Gran Canaria Dr. Negrín, Gran Canaria, Spain, 16CAZA, Salamanca, Spain, 17Hospital Germans Trias i Pujol, Badalona, Spain, 18Hospital Severo Ochoa, Madrid, Madrid, Spain, 19H. Universitario La Paz, Madrid, Spain, 20Hospital Universitario de Donosti, Donosti, Spain, 21Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 22Hospital de Sagunto, Valencia, Spain, 23Hospital Son Espases, Palma, Spain, 24Hospital Universitario Arnau de Vilanova de Lleida, Lleida, Spain, 25Hospital Universitario de Valladolid, Valladolid, Spain, 26Hospital General Río Carrión, Palencia, Spain, 27Osakidetza, Vitoria, Spain, 28General University Hospital of Ciudad Real, Ciudad de México, Spain, 29Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain, 30Hospital Clínico Universitario de Valencia, Valencia, Spain, 31Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, 32CHU Ourense, O Carballino, Spain, 33Hospital Royo Villanova, Teruel, Spain, 34Hospital Clinic de Barcelona, Barcelona, Spain, 35Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 36Hospital Clínico Universitario de Santiago, La Coruna, Spain, 37Hospital Universitario Doctor Peset, Valencia, Spain, 38Hospital Universitari Son Llàtzer, Palma, Spain, 39Hospital Universitario del Henares, Madrid, Spain, 40Hospital Verge de la Cinta, Tortosa, TARRAGONA, Spain, 41Hospital Universitario Santa Lucía, Cartagena, Spain, 42Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 43Division of Pneumology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 44Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a severe complication of rheumatoid arthritis (RA). Abatacept (ABA) has demonstrated efficacy in the treatment of RA-ILD. Our objective…
  • Abstract Number: 2280 • ACR Convergence 2024

    Development of a Blood-based Cell-free DNA Classifier Assay to Predict Biologic and Targeted Synthetic DMARDs Response in Rheumatoid Arthritis Patients (PRIMA-102)

    Peter C. Taylor1, Kevin Lai2, Hsin-Ta Wu2, Jason Carlson2, Diana Abdueva3, Signe Fransen4, Alan Kivitz5, Gordon Lam6 and David Chernoff7, 1University of Oxford, Oxford, United Kingdom, 2Aqtual Inc, Hayward, CA, 3Aqtual Inc., Hayward, CA, 4Aqtual Inc., sf, CA, 5Altoona Center for Clinical Research, Duncansville, PA, 6Arthritis and Osteoporosis Consultants of the Carolinas, Cornelius, NC, 7SetPoint Medical, Sausalito, CA

    Background/Purpose: Matching most beneficial targeted therapy to rheumatoid arthritis (RA) patients with inadequate response or intolerance to current treatment is an important unmet clinical need. The…
  • Abstract Number: 2544 • ACR Convergence 2024

    Spatial Transcriptomics Suggests Synovial Macrophage Niches Are Sexually Dimorphic in a Mouse Inflammatory Arthritis Model

    Richard Bell1, Ruoxi Yuan2, Mary Huang2, Ewurama Cann2, Chao Yang2, Franck Barrat1 and Lionel Ivashkiv1, 1Hospital for Special Surgery, New York, NY, 2HSS, New York, NY

    Background/Purpose: Monocytes and Macrophages (MФ) play a key pathogenic role in Rheumatoid Arthritis (RA), a disease that exhibits female sex bias. Recent work using scRNAseq…
  • Abstract Number: 2672 • ACR Convergence 2024

    Prevention of the Development of Rheumatoid Arthritis by a 1-year Course of Methotrexate in ACPA-negative Arthralgia Patients at Increased Risk for Rheumatoid Arthritis: 4 Year Results of the TREAT EARLIER Trial

    Quirine Dumoulin1, Doortje Krijbolder2, Karen Visser3, Leroy Lard4 and Annette van der Helm-van Mil5, 1Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands, 2Leiden University Medical Centre, Leiden, Netherlands, 3Haga Hospital The Hague, Amsterdam, Netherlands, 4Haaglanden Medical Center The Hague, Leidschendam, Netherlands, 5LUMC, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: Currently, prevention possibilities of developing ACPA-negative rheumatoid arthritis (RA) are unknown. Studying this is challenging because many ACPA-negative at-risk individuals have low risk of…
  • Abstract Number: 0043 • ACR Convergence 2024

    Inflammatory and Angiogenic Serum Profile of Refractory Rheumatoid Arthritis

    Manon Lesturgie-Talarek1, Virginie Gonzalez2, ALICE COMBIER3, Marion THOMAS4, Margaux Boisson5, Sandrine Carves3, Sarah Wanono3, Lucie Poiroux3, Anne Cauvet1, Sophie Hecquet6, Yannick Allanore7 and Jérôme Avouac8, 1Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, 2Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, 3Hôpital Cochin - Université Paris Cité, Paris, France, 4APHP, Paris, France, 5Hôpital Cochin - Université Paris Cité, Paris, 6Cochin Hospital, Paris, France, 7Université Paris Cité, Paris, France, 8Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France

    Background/Purpose: Despite the emergence of new therapies, a considerable proportion of individuals with rheumatoid arthritis (RA) still endure symptoms, giving rise to the concept of…
  • Abstract Number: 0060 • ACR Convergence 2024

    Spectral Cytometry Shows Increased CD56hi NK Cells and New HLA-DR+CD56+ Phenotypes in RA

    Estelle Khairallah1, Haani Qudsi2, Jihad Ben Gabr1, Andras Perl3 and Christian Geier1, 1SUNY Upstate Medical University, Syracuse, NY, 2Norton College of Medicine, Syracuse, NY, 3SUNY, Syracuse, NY

    Background/Purpose: Previous studies of RA patients have shown changes in NK cell populations (as defined by CD56 expression). The nature of these cellular changes remains…
  • Abstract Number: 0147 • ACR Convergence 2024

    Clinical Characteristics and Biomarkers Associated with Detectable High-Sensitivity Cardiac Troponin in Patients with Rheumatoid Arthritis

    Ilana Usiskin1, Mary Jeffway1, Feng Liu1, Nancy Shadick1, Michael Weinblatt2, Brittany Weber3 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 3Brigham and Women's Hospital, DEDHAM, MA

    Background/Purpose: General population-based cardiovascular (CV) risk estimators are known to underestimate CV risk in RA. High-sensitivity cardiac troponin T (hs-cTnT), typically measured during a work-up…
  • Abstract Number: 0228 • ACR Convergence 2024

    Do Imaging Tests Have a Role in Predicting Progression to Rheumatoid Arthritis in People with Clinically Suspect Arthralgia? A Systematic Review & Meta-Analysis

    Ankita Gupta1, Sulaiman Anis2 and Paola de Pablo2, 1Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, 2University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Clinically suspect arthralgia (CSA) has been associated with an increased risk of developing inflammatory arthritis (IA). Subclinical inflammation on imaging tests may help to…
  • Abstract Number: 0419 • ACR Convergence 2024

    Placental Weights of Offspring Born to Women with Rheumatoid Arthritis and Juvenile Idiopathic Arthritis

    Eugenia Chock1, Zeyan Liew2, Lars Henning Pedersen3 and Mette Oestergaard Thunbo3, 1Yale School of Medicine, New Haven, CT, 2Yale Center for Perinatal, Pediatric and Environmental Epidemiology, New Haven, CT, 3Aarhus University, Aarhus, Denmark

    Background/Purpose: Offspring of patients with chronic inflammatory arthritis have almost double the risk of being born small for gestational age. Placental insufficiency is one of…
  • Abstract Number: 0464 • ACR Convergence 2024

    Increases in Paraoxonase-1 Activity over Time Associates with Reduced Risk of Incident Inflammatory Arthritis in an Anti-Citrullinated Protein Antibody-Positive Population

    Amir Razmjou1, Rong Guo2, David Elashoff3, Kevin Deane4, Jill Norris5, Marie Feser6, Jennifer Wang1, Ani Shahbazian2 and christina Charles-Schoeman7, 1UCLA, Los Angeles, CA, 2UCLA, Los Angeles, 3UCLA Department of Medicine Statistics Core, Los Angeles, 4University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 5Colorado School of Public Health, Denver, CO, 6Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 7UCLA Medical Center, Santa Monica, CA

    Background/Purpose: Rheumatoid arthritis (RA) has a well described pre-clinical state, with a continuum of genetic and environmental risk factors leading to the development of systemic…
  • Abstract Number: 0480 • ACR Convergence 2024

    Can’t Sleep, Won’t Sleep: A Systematic Review and Meta-Analysis of Insomnia Prevalence in 70,105 Rheumatoid Arthritis Patients

    Mohamed Abdelsalam1, Mamdouh Ahmed Khairy2, Mohamed Reda Awad3, Aly Alnabawy2, Maryam Taha4 and Mohamed Al-Adl Ali Ali2, 1Rheumatology, Rehabilitation and Physical medicine department - faculty of medicine -Misr University for science and technology, 6th of October, Al Jizah, Egypt, 2Faculty of medicine - Al-Azhar university Cairo branch, Cairo, Egypt, 3Al Azhar University, Cairo, Egypt, Giza, Egypt, 4Faculty of medicine - Ain Shams university, Madinat Nasr, Al Qahirah, Egypt

    Background/Purpose: Insomnia is a significant challenge for rheumatoid arthritis (RA) patients. Chronic pain conditions often exacerbate sleep disturbances, creating a vicious cycle where pain and…
  • Abstract Number: 0498 • ACR Convergence 2024

    ACPA Subtypes, RF Isotypes, and the Risk of Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Jacob Welch1, Yangyuna Yang1, Joshua Baker2, Katherine Wysham3, Dana Ascherman4, Paul Monach5, Gail Kerr6, Andreas Reimold7, grant Cannon8, Gary Kunkel9, William Robinson10, Michael Duryee1, Geoffrey Thiele1, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, 5VA Boston Healthcare System, Boston, MA, 6Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 7Dallas VA Medical Center, Dallas, TX, 8University of Utah and Salt Lake City VA, Salt Lake City, UT, 9University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 10Stanford University, Palo Alto, CA

    Background/Purpose: Interstitial lung disease (ILD) is among the most significant extra-articular manifestations of rheumatoid arthritis (RA), clinically affecting 8-15% of RA patients, and accounting for…
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