Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1346 • ACR Convergence 2024
Early Diagnosis of Rheumatoid Arthritis: Role of Joint Ultrasound Assessment
Cristina Corrales Selaya¹, Carmen Secada Gómez², Sabela Fernandez-Aguado³, Isla Morante-bolado⁴, Montserrat Santos-gomez⁵, Sara Alonso-Castro⁶, Virginia Portilla-González⁷, Ricardo Blanco-Alonso⁸, Javier Rueda Gotor⁴ and alfonso Corrales-Martínez⁹, ¹Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³Hospital Universitario Montecelo, Pontevedra, Galicia, Spain, ⁴Hospital Sierrallana, Torrelavega, Cantabria, Spain, ⁵Hospital universitario Central de Asturias, Oviedo, Asturias, Spain, ⁶Hospital Universitario Central de Asturias., Oviedo, Asturias, Spain, ⁷Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ⁸Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, ⁹Hospital Universitario Marques de Valdecilla, Santander, Spain
Background/Purpose: Early diagnosis of Rheumatoid Arthritis (RA) is essential to establish treatment to improve long-term disease outcomes. Musculoskeletal ultrasound (US) is able to detect subclinical…
Abstract Number: 1362 • ACR Convergence 2024
Comparative Effectiveness of Upadacitinib versus Other JAK Inhibitors in Patients with Rheumatoid Arthritis in a Global Real-World Setting
Peter C. Taylor¹, Aditi Kadakia², Jack Milligan³, Sander Strengholt², Oliver Howell³, Pankaj Patel², Sophie Barlow³ and Roberto Caporali⁴, ¹University of Oxford, Oxford, United Kingdom, ²AbbVie Inc., North Chicago, IL, ³Adelphi Real World, Bollington, United Kingdom, ⁴Department of Clinical Sciences and Community Health, University of Milan, and Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Milan, Italy
Background/Purpose: Network meta-analyses of phase 3 clinical trial data involving JAK inhibitor (JAKi)-treated patients with RA and an inadequate response to conventional synthetic DMARDs showed…
Abstract Number: 1378 • ACR Convergence 2024
Tocilizumab Effect on the Three Pathways of the Complement System in Patients with Rheumatoid Arthritis
Marta Hernández-Díaz¹, Iván Ferraz-Amaro², Sergio Santos-Concepción³, Javier Castro³, Vanesa Hernandez⁴, Beatriz Tejera Segura⁵, Cristina Luna⁶, Esmeralda Delgado-Frías² and Federico Diaz-González², ¹Hospital Universitario de Canarias, SANTA CRUZ DE TENERIFE, Spain, ²Hospital Universitario de Canarias, La Laguna, Spain, ³Universidad de La Laguna, La Laguna, Spain, ⁴Rheumatology department. Hospital Universitario de Canarias, La Laguna, Spain, ⁵Rheumatology Department. Hospital Universitario Insular de Gran Canaria, Las palmas, Spain, ⁶Hospital Universitario Nuestra Señora de La Candelaria, Santa Cruz, Spain
Background/Purpose: Tocilizumab (TCZ) is used in diseases characterized by markedly elevated inflammatory markers and elevated pro-inflammatory cytokines like rheumatoid arthritis (RA), juvenile idiopathic arthritis and…
Abstract Number: 1395 • ACR Convergence 2024
Effects of Butyrate Supplementation in Modulation of Gut Microbiome and Its Metabolites in New Onset Rheumatoid Arthritis
Rebecca Blank¹, Alba Boix-Amoros², Erin Reilly³, Kevin Bu⁴, Ian Cunningham⁵, Renuka Nayak⁶, Andrew Patterson⁷, Jose Clemente⁴ and Jose Scher⁸, ¹NYU, New York, NY, ²Icahn School of Medicine, New York, NY, ³Penn State, State Park, PA, ⁴Icahn School of Medicine at Mount Sinai, New York, NY, ⁵NYU Langone Health, New York, NY, ⁶University of California, San Francisco (UCSF), San Francisco, CA, ⁷Penn State University, State College, PA, ⁸New York University School of Medicine, New York, NY
Background/Purpose: The gut microbiome and its metabolites are dysregulated in RA and other immune-mediated inflammatory diseases. However, the significance of this observation and its implications…
Abstract Number: 1663 • ACR Convergence 2024
Notch—mediated Fibrogenic Activation Is a Spatial Determinant of RA Treatment Response
Kartik Bhamidipati¹, Ce Gao¹, Ksenia Anufrieva², Shideh Kazerounian³, Roopa Madhu⁴, Miles Tran¹, Vikram Khedgikar¹, Sonia Presti¹, Anna Helena Jonsson⁵, ilya Korsunsky¹ and Kevin Wei⁶, ¹Brigham and Women's Hospital, Boston, MA, ²BWH, Cambridge, MA, ³Brigham & Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital, Brookline, MA, ⁵University of Colorado School of Medicine, Aurora, CO, ⁶Brigham and Women's Hospital at Harvard Medical School, Boston, MA
Background/Purpose: In RA, poor treatment response has been linked to a fibroid synovial tissue phenotype, characterized by lack of immune cell infiltration and an expansion…
Abstract Number: 1745 • ACR Convergence 2024
Use of Statins and Its Association with Major Adverse Cardiovascular Outcomes with Tofacitinib versus TNF Inhibitors in a Risk-Enriched Population of Patients with Rheumatoid Arthritis
Jon Giles¹, christina Charles-Schoeman², Maya H. Buch³, Maxime Dougados⁴, Zoltan Szekanecz⁵, Ted Mikuls⁶, Steven R Ytterberg⁷, Gary G Koch⁸, Kenneth Kwok⁹, Mary Jane Cadatal¹⁰, Sujatha Menon¹¹, Yan Chen¹², Annette M Diehl¹², Jose L Rivas¹³, Arne Yndestad¹⁴ and Deepak L Bhatt¹⁵, ¹Cedars Sinai Medical Center, Los Angeles, CA, ²UCLA Medical Center, Santa Monica, CA, ³Division of Musculoskeletal & Dermatological Sciences, University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, ⁴Université de Paris; Department of Rheumatology, Hôpital Cochin; Assistance Publique-Hôpitaux de Paris; and INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France, ⁵Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ⁶University of Nebraska Medical Center, Omaha, NE, ⁷Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁸Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁹Pfizer Inc, New York, NY, ¹⁰Pfizer Inc, Manila, Philippines, ¹¹Pfizer Inc, Groton, CT, ¹²Pfizer Inc, Collegeville, PA, ¹³Pfizer SLU, Madrid, Spain, ¹⁴Pfizer Inc, Oslo, Norway, ¹⁵Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: ORAL Surveillance (NCT02092467; a post-authorization safety study of tofacitinib 5 and 10 mg twice daily [BID] vs TNF inhibitors [TNFi]) found higher incidence of…
Abstract Number: 1877 • ACR Convergence 2024
Trends in Rheumatoid Arthritis Incidence, Prevalence, DALY and Death Rates (1991-2021) in the United States: A Comprehensive Analysis of State-Level Disparities
Aviraag Vijaya Prakash¹, Vishwas Hosur Ravishankar², Aishwarya Sudheer¹ and Paramarajan Piranavan³, ¹Saint Vincent Hospital, Department of Internal Medicine, Worcester, MA, ²St Vincents Hospital, Worcester, MA, ³University of Kentucky, Division of Rheumatology, Lexington, KY
Background/Purpose: Rheumatoid Arthritis (RA) exhibits varied epidemiological patterns across states in the United States, influencing disability-adjusted life years (DALYs), incidence rates, prevalence, and mortality. This…
Abstract Number: 1959 • ACR Convergence 2024
A 3-arm, Randomized, Open-label, Parallel Active Controlled, Multicentre International Study to Compare the Response of Ultrasound-assessed Synovitis to Baricitinib, Alone and Combined with Methotrexate versus Etanercept in Rheumatoid Arthritis Patients
ESPERANZA NAREDO¹, Otto Olivas-Vergara², Pablo E. Borges², Sheila Recuero-Díaz², Fernando Saraiva³, Joana Martinho³, Filipa Costa³, Catarina Tenazinha³, Margarida Monteiro³, Ana Teresa Melo³, Ana Rodriguez-García⁴, Carlos A. Guillén-Astete⁵, Boris A. Blanco-Cáceres⁴, Alina L. Boteanu⁴, Antonio Mera-Varela⁶, Eva Pérez Pampín⁶, Yolanda López Golán⁶, Cristina Campos Fernández⁷, Jorge Juan Fragío Gíl⁷, roxana gonzalez mazarío⁷, Juan José De Agustín⁸, Gustavo Añez Sturchio⁹, Luis Coronel Tarancon⁸, Esther Vicente-rabaneda¹⁰, Santos Castañeda¹⁰, Irene Llorente-Cubas¹⁰, Maria S. Stoenoiu¹¹, NZEUSSEU TOUKAP Adrien¹², Ilaria Padovano¹³, Helene Gouze¹³, Ariane Leboime¹³, Maxime Breban¹⁴, Jaqueline Uson¹⁵, Virginia Villaverde¹⁶, Martina Steiner¹⁷, Cristina Vergara Dangond¹⁷, Maria Beatriz Paredes Romero¹⁷, Santiago Muñoz Fernández¹⁸, Carolina Pérez-García¹⁹, Juan Antonio Meraz-Ostiz¹⁹, Stephanie Finzel²⁰, Anna-Maria Kanne²¹, Aránzazu Mediero²², Carmen Herencia²³, Gabriel Herrero-Beaumont²⁴ and Raquel Largo²², ¹Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ²Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, ³Rheumatology Department, Unidade Local de Saúde de Santa Maria. Rheumatology Research Unit, Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal, ⁴Rheumatology Department. Ramón y Cajal University Hospital, Madrid, Spain, ⁵Rheumatology Department. Ramon y Cajal University Hospital, Madrid, Spain, ⁶Department of Rheumatology. Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain, ⁷Department of Rheumatology. Hospital General Universitario de Valencia, Valencia, Spain, ⁸Image and Technics Unit, Department of Rheumatology. Hospital Universitari Vall d’Hebron, Barcelona, Spain, ⁹Department of Rheumatology. Hospital Arnau de Vilanova, Lleida, Spain, ¹⁰Hospital Universitario de La Princesa, Madrid, Spain, ¹¹Cliniques Universitaires Saint-Luc, Brussels, Belgium, ¹²Institut de Recherche Expérimentale et Clinique, Cliniques universitaires Saint-Luc, Université catholique de Louvain, St.-Lambrechts-Woluwe, Belgium, ¹³Departement of Rheumatology, Hopital Ambroise Paré, Boulogne-Billancourt, Spain, ¹⁴Departement of Rheumatology, Hopital Ambroise Paré, Departement of Rheumatology, Hopital Ambroise Paré, Spain, ¹⁵Department of Rheumatology, Hospital Universitario de Móstoles. University Rey Juan Carlos, Madrid, Spain, ¹⁶Department of Rheumatology, Hospital Universitario de Móstoles, Madrid, Spain, ¹⁷Department of Rheumatology. Hospital Universitario Infanta Sofía., Madrid, Spain, ¹⁸Hospital Universitario Infanta Sofía. Universidad Europea de Madrid, Madrid, Spain, ¹⁹Department of Rheumatology, Hospital del Mar of Barcelona, Barcelona, Spain, ²⁰Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, DE, Freiburg im Breisgau, Germany, ²¹Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany, ²²Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz, Madrid, Spain, ²³Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz, M, Spain, ²⁴Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain
Background/Purpose: To demonstrate non-inferiority of the response of musculoskeletal ultrasound (MSKUS)-assessed synovitis to baricitinib, alone and plus MTX vs. etanercept plus MTX in patients with…
Abstract Number: 2169 • ACR Convergence 2024
Different Trajectories of Patient Reported Outcomes in Patients with RA in a Stable Phase of Disease – an Observational Study
Paul Studenic¹, Nadine Schwab², Günther Zauner², Thi Lan Vi Tran³ and Helga Lechner-Radner⁴, ¹Medical University Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria, Vienna, Austria, ²dwh GmbH, simulation services, Vienna, Austria & Institute of Information Systems Engineering, TU Wien, Vienna, Austria, ³Medical University of Vienna, Vienna, Austria, ⁴Medical University Vienna, Department of Internal Medicine III, Division of Rheumatology, Vienna, Austria
Background/Purpose: In patients with rheumatoid arthritis (RA), we often see a disconnect between patient and evaluator perceived disease activity. In this study we aim to…
Abstract Number: 2226 • ACR Convergence 2024
Site-specific Differences in the Association of Non-vertebral Major Osteoporotic Fractures and Rheumatoid Arthritis
John Chen¹, Malini Chandra², Laura Carbone³, John Schousboe⁴, Elisha Garcia² and Joan Lo², ¹Kaiser Permanente Oakland Medical Center, Oakland, CA, ²Kaiser Permanente, Oakland, CA, ³Augusta University, Augusta, GA, ⁴University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) and osteoporosis are both chronic, potentially debilitating conditions that frequently co-occur, affecting millions of people annually. Among those with osteoporosis, RA…
Abstract Number: 2242 • ACR Convergence 2024
A Cross-sectional Study on Predictors of COVID-19 Infection, Admission and Mortality and Effect of Immunomodulating Treatments in Rheumatoid Arthritis
Mohammad Movahedi¹, Elliot Hepworth², Angela Cesta³, Xiuying Li³, Claire Bombardier⁴ and Sibel Aydin⁵, and OBRI investogators, ¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²University of Ottawa, Ottawa, ON, Canada, ³UHN, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Ottawa Hospital Research Institute, Ottawa, ON, Canada
Background/Purpose: COVID-19 infection frequently leads to a cytokine storm, which has successfully been treated with some immunomodulating therapies according to observational studies. Interestingly, treatments investigated…
Abstract Number: 2262 • ACR Convergence 2024
Window of Opportunity in the Treatment of Rheumatoid Arthritis – Interstitial Lung Disease with Abatacept. National Multicenter Study of 526 Patients
Ana Serrano-Combarro¹, Belén Atienza-Mateo², Libe Ibarrola Paino³, Ivette Casafont-Sole⁴, Jesús Loarce⁵, Juan María Blanco Madrigal⁶, Santos Castañeda⁷, Rafaela Ortega-Castro⁸, Natalia Mena Vázquez⁹, Nuria Vegas Revenga¹⁰, Lucía Domínguez Casas¹¹, Cilia Peralta Ginés¹², Miriam Retuerto Guerrero¹³, Lorena Pérez Albadalejo¹⁴, Rubén López Sánchez¹⁵, MARIA GUADALUPE MANZANO CANABAL¹⁶, Anahy Maria Brandy-Garcia¹⁷, Patricia Lopez Viejo¹⁸, Gema Bonilla¹⁹, Olga Maíz Alonso²⁰, Carmen Carrasco-Cubero²¹, Marta Garijo Bufort²², Ana Urruticoechea Arana²³, Sergi Ordoñez²⁴, Carmen González Montagut²⁵, Andrea García-Valle²⁶, Juan Ramón De Dios²⁷, María Martín López²⁸, Tomás Vázquez Rodríguez²⁹, Delia Fernández-Lozano³⁰, Ignacio Brana Abascal³¹, Rafael Benito Melero-Gonzalez³², Emilio Giner³³, Virginia Ruiz-Esquide³⁴, Clara Ventin Rodriguez³⁵, Marina Rodriguez³⁶, Pablo Andújar-Brazal³⁷, Julia Fernandez Melon²³, Lilian M. López-Núñez³⁸, JOSE RAMON LAMUA RIAZUELO³⁹, Anna Pamies Corts⁴⁰, Carlos Fernández Díaz⁴¹, Javier Loricera⁴², Diego Ferrer⁴³ and Ricardo Blanco-Alonso⁴⁴, ¹Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, ²Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, ³Rheumatology Division, Bisadoa Hospital, Bidasoa, Spain, ⁴Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵Ramón y Cajal University Hospital, Madrid, Madrid, Spain, ⁶Basurto University Hospital, Bilbao, Spain, ⁷Hospital Universitario de la Princesa, Madrid, Spain, ⁸Hospital Reina Sofía, Cordoba, Andalucia, Spain, ⁹IBIMA, Málaga, Andalucia, Spain, ¹⁰Hospital Galdakao- Usansolo, Galdakao, Spain, ¹¹Hospital Universitario San Agustín, Avilés, Spain, ¹²Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, ¹³Complejo Asistencial Universitario de León, Leon, Spain, ¹⁴Hospital Universitario de Jaén, Jaén, Spain, ¹⁵Hospital Universitario de Gran Canaria Dr. Negrín, Gran Canaria, Spain, ¹⁶CAZA, Salamanca, Spain, ¹⁷Hospital Germans Trias i Pujol, Badalona, Spain, ¹⁸Hospital Severo Ochoa, Madrid, Madrid, Spain, ¹⁹H. Universitario La Paz, Madrid, Spain, ²⁰Hospital Universitario de Donosti, Donosti, Spain, ²¹Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, ²²Hospital de Sagunto, Valencia, Spain, ²³Hospital Son Espases, Palma, Spain, ²⁴Hospital Universitario Arnau de Vilanova de Lleida, Lleida, Spain, ²⁵Hospital Universitario de Valladolid, Valladolid, Spain, ²⁶Hospital General Río Carrión, Palencia, Spain, ²⁷Osakidetza, Vitoria, Spain, ²⁸General University Hospital of Ciudad Real, Ciudad de México, Spain, ²⁹Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain, ³⁰Hospital Clínico Universitario de Valencia, Valencia, Spain, ³¹Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, ³²CHU Ourense, O Carballino, Spain, ³³Hospital Royo Villanova, Teruel, Spain, ³⁴Hospital Clinic de Barcelona, Barcelona, Spain, ³⁵Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ³⁶Hospital Clínico Universitario de Santiago, La Coruna, Spain, ³⁷Hospital Universitario Doctor Peset, Valencia, Spain, ³⁸Hospital Universitari Son Llàtzer, Palma, Spain, ³⁹Hospital Universitario del Henares, Madrid, Spain, ⁴⁰Hospital Verge de la Cinta, Tortosa, TARRAGONA, Spain, ⁴¹Hospital Universitario Santa Lucía, Cartagena, Spain, ⁴²Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁴³Division of Pneumology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴⁴Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain
Background/Purpose: Interstitial lung disease (ILD) is a severe complication of rheumatoid arthritis (RA). Abatacept (ABA) has demonstrated efficacy in the treatment of RA-ILD. Our objective…
Abstract Number: 2280 • ACR Convergence 2024
Development of a Blood-based Cell-free DNA Classifier Assay to Predict Biologic and Targeted Synthetic DMARDs Response in Rheumatoid Arthritis Patients (PRIMA-102)
Peter C. Taylor¹, Kevin Lai², Hsin-Ta Wu², Jason Carlson², Diana Abdueva³, Signe Fransen⁴, Alan Kivitz⁵, Gordon Lam⁶ and David Chernoff⁷, ¹University of Oxford, Oxford, United Kingdom, ²Aqtual Inc, Hayward, CA, ³Aqtual Inc., Hayward, CA, ⁴Aqtual Inc., sf, CA, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶Arthritis and Osteoporosis Consultants of the Carolinas, Cornelius, NC, ⁷SetPoint Medical, Sausalito, CA
Background/Purpose: Matching most beneficial targeted therapy to rheumatoid arthritis (RA) patients with inadequate response or intolerance to current treatment is an important unmet clinical need. The…
Abstract Number: 2544 • ACR Convergence 2024
Spatial Transcriptomics Suggests Synovial Macrophage Niches Are Sexually Dimorphic in a Mouse Inflammatory Arthritis Model
Richard Bell¹, Ruoxi Yuan², Mary Huang², Ewurama Cann², Chao Yang², Franck Barrat¹ and Lionel Ivashkiv¹, ¹Hospital for Special Surgery, New York, NY, ²HSS, New York, NY
Background/Purpose: Monocytes and Macrophages (MФ) play a key pathogenic role in Rheumatoid Arthritis (RA), a disease that exhibits female sex bias. Recent work using scRNAseq…
Abstract Number: 2672 • ACR Convergence 2024
Prevention of the Development of Rheumatoid Arthritis by a 1-year Course of Methotrexate in ACPA-negative Arthralgia Patients at Increased Risk for Rheumatoid Arthritis: 4 Year Results of the TREAT EARLIER Trial
Quirine Dumoulin¹, Doortje Krijbolder², Karen Visser³, Leroy Lard⁴ and Annette van der Helm-van Mil⁵, ¹Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Haga Hospital The Hague, Amsterdam, Netherlands, ⁴Haaglanden Medical Center The Hague, Leidschendam, Netherlands, ⁵LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Currently, prevention possibilities of developing ACPA-negative rheumatoid arthritis (RA) are unknown. Studying this is challenging because many ACPA-negative at-risk individuals have low risk of…

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