ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 3148 • 2016 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase 2 Is Required for Tumor Necrosis Factor Alpha Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation

    Mandar Bawadekar1, Daeun Shim1, Ryan Rebernick1, Chloe Peyton1, Chad J. Johnson2, Thomas F. Warner3, Dres Damgaard4, Claus Henrik Nielsen5, Anthony P. Nicholas6, Ger JM Pruijn7, Jeniel E. Nett8 and Miriam A. Shelef1,9, 1Department of Medicine, Division of Rheumatology, University of Wisconsin-Madison, Madison, WI, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, 3Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 4Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 5Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 6Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, 7Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands, 8Medicine and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 9William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: The presence of anti-citrullinated protein antibodies in rheumatoid arthritis points to a potential role for citrullination in disease pathogenesis. Peptidylarginine deiminases (PADs) catalyze the…
  • Abstract Number: 1111 • 2016 ACR/ARHP Annual Meeting

    Huntingtin Interactin Protein 1 (HIP1) Regulates Receptor Tyrosine Kinases Mediated Activity and Cell Invasiness in Fibroblast-like Synoviocytes

    Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is a new arthritis severity gene recently identified in the Pristane and Collagen-induced arthritis (PIA, CIA) quantitative trait locus Cia25/Pia42…
  • Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting

    KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Mark Tanner1, Redwan Huq1, Rajeev Tajhya1, Michael Pennington2, Teresina Laragione3, Pércio Gulko4 and Christine Beeton5, 1Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, 2Peptides International, Louisville, KY, 3Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
  • Abstract Number: 1436 • 2016 ACR/ARHP Annual Meeting

    TAS8274, a Highly Selective Janus Kinase 3 Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis

    Hiroaki Hayashi, Takafumi Harada, Shunsuke Demizu, Fumito Tatsuzawa, Ken Sato, Morihiro Mitsuya, Kenji Tanaka, Kazuhiko Yonekura, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose:   The family of Janus kinases (JAKs) plays important roles in signaling pathway mediated by various cytokine receptors. An aberrant activation of JAK-STAT signaling…
  • Abstract Number: 1447 • 2016 ACR/ARHP Annual Meeting

    Therapeutic Blockade of Interleukin-6 Trans-Signalling Restores Vascular Function in Murine Collagen Induced Arthritis

    Ruth Davies1, Jessica O Williams2, Katie Sime2, Ellyn Hughes2, Lauren A. Jordan2, Charlotte Rawlings2, Derek Lang3, Stefan Rose-John4, Simon A. Jones5, Anwen S. Williams2 and Ernest H. Choy6,7, 1CREATE Centre, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 2Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 3Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, 4Institute of Biochemistry, Christian Albrechts University, Kiel, Germany, 5Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, 6Section of Rheumatology, Cardiff University, Cardiff, Great Britain, 7CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom

    Background/Purpose: Mortality is increased in rheumatoid arthritis (RA), mainly due to cardiovascular disease (CVD). While molecular mechanisms underlining this clinical observation are unknown, systemic elevations…
  • Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting

    Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis

    Soshi Takahashi1, Jun Saegusa2, Ikuko Naka3, Kosaku Tsuda3, Takaichi Okano4, Kengo Akashi3, Sho Sendo2, Yo Ueda3, Akira Onishi5, Yoshinori Kogata2 and Akio Morinobu2, 1Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Kobe University Graduate School of Medicine, Kobe, Japan, 4Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
  • Abstract Number: 1462 • 2016 ACR/ARHP Annual Meeting

    Magnesium Is a New Mediator Arthritis Severity and Joint Damage

    Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose:  Given the effects of magnesium supplementation in suppressing components of the innate immunity in short-term studies, we examined the effect of dietary magnesium modifications…
  • Abstract Number: 1617 • 2016 ACR/ARHP Annual Meeting

    Treatment with Sirukumab, an Anti-IL6 Cytokine Monoclonal Antibody, Improves Fatigue and Health-Related Physical and Emotional Well Being in Patients with Active Rheumatoid Arthritis Refractory to Conventional or Biologic Therapy: Results of 2 Global, Placebo-Controlled, Phase 3 Trials

    Clifton Bingham III1, Yoshiya Tanaka2, George Karpouzas3, Tsutomu Takeuchi4, Daniel Aletaha5, Carter Thorne6, Shihong Sheng7, Weichun Xu7, Ravi Rao8, Kaiyin Fei7, Benjamin Hsu7, Prasheen Agarwal7, Sharon Popik7, Regina Kurrasch9, Steve Peterson7, Rita Ganguly9, Chenglong Han7 and Kelly McQuarrie7, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 4Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 5Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6University of Toronto and Southlake Regional Health Centre, Newmarket, ON, Canada, 7Janssen Research & Development, LLC, Spring House, PA, 8GSK Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom, 9GlaxoSmithKline, Collegeville, PA

    Background/Purpose: Patients (pts) with rheumatoid arthritis (RA) often experience both substantial fatigue and a decline in their health-related physical and emotional well-being. Sirukumab is a…
  • Abstract Number: 1651 • 2016 ACR/ARHP Annual Meeting

    A Case Series on Patients on Tofacitinib in Combination with a Biologic

    Nashla Barroso1 and Daniel E. Furst2, 1Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2David Geffen School of Medicine at UCLA, Los Angeles, CA

    Background/Purpose: Although there have been significant advances in the treatment of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). patients can experience a lack of or…
  • Abstract Number: 2174 • 2016 ACR/ARHP Annual Meeting

    Effect of Anti-Rheumatic Treatment on Selenium Levels in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

    Gia Deyab1, Ingrid Hokstad2, Milada Cvancarova Småstuen3, Stefan Agewall4, Jon Elling Whist5 and Ivana Hollan5,6,7,8, 1Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, 2Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, 3Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, 4University of Oslo, Oslo, Norway, 5Innlandet Hospital Trust, Lillehammer, Norway, 6Brigham and Women’s Hospital, Boston, MA, 7Harvard Medical School, Boston, MA, 8Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway

    Background/Purpose: The cause of the increased cardiovascular risk in inflammatory rheumatic diseases (IRDs) is still unclear. Intriguingly, selenium-deficiency, which might be caused by poor diet or…
  • Abstract Number: 140 • 2016 ACR/ARHP Annual Meeting

    Relationship Between the Prevalence of Subclinical Tenosynovitis and Therapy in Patients with RA in Clinical Remission: Results from Italian Society of Rheumatology Study Group

    Simone Parisi1, Greta Carrara2, Carlo Alberto Scirè3,4, Alberto Batticciotto5, Emanuela Bellis6, Marco Canzoni7, Orazio De Lucia8, Ilaria Farina9, Carlo Venditti10, Annamaria Iagnocco11,12 and Georgios Filippou13, 1Department of Rheumatology, University Hospital Città Della Salute e della Scienza di Torino, Turin, Italy, 2Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy, 3Epidemiology Unit -Italian Society for Rheumatology, Milano, Italy, 4Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, 5Rheumatology, L. Sacco University Hospital, Milano, Italy, 6Rheumatology, Ospedale Mauriziano, Turin, Italy, 7A.O. Sant'Andrea, Rome, Italy, 8Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, 9Rheumatology Unit AOU S.Anna, Ferrara, Italy, 10A.O. Rummo, Benevento, Italy, 11Sapienza University of Rome, Rome, Italy, 12Sapienza University of Rome, Italy, Roma, Italy, 13University of Siena, Siena, Italy

    Background/Purpose: This study is a sub-analysis of the data from the patient cohort of STARTER (The Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission)…
  • Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting

    Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint

    Chrong-Reen Wang1, Shih-Yao Chen1, Ai-Li Shiau2, Ming-Fei Liu1 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, 2Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose:   Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
  • Abstract Number: 2581 • 2016 ACR/ARHP Annual Meeting

    Tripterygium Wilfordii Hook F Applied Topically in Patients with Active Rheumatoid Arthritis

    Juan Jiao1, Hai-bo Yin2, Xiao-po Tang2, Xun Gong2 and Quan Jiang1, 1Rheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, 2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China

    Background/Purpose:  Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herb, is widely used in China for treating Rheumatoid Arthritis (RA), but limited only for eldly…
  • Abstract Number: 458 • 2016 ACR/ARHP Annual Meeting

    The TAM Receptors Axl and Mer Play a Protective Role in a Temporal and Spatial Manner in Inflammatory Arthritis

    Claire E.J. Waterborg1, Paqui G. Través2, Silke Beermann1, Marije I. Koenders1, Greg Lemke2 and Fons A.J. van de Loo1, 1Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, 2Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA

    Background/Purpose:  Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in selective, anatomically distinct synovial joints. The innate immune system…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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