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Abstract Number: 3026

The Efficacy and Safety of Low Dose IL-2 Therapy in over-Treated Patients with Rheumatoid Arthritis: A Preliminary Study

Sheng-Xiao Zhang1, Miao Miao2, Xiao-Qing Liu2, Xiao-Wen Ma2, Xiao-Yan Wu2 and Xiao-Feng Li1, 1Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, 2The Second Hospital of Shanxi Medical University, Taiyuan, China

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: rheumatoid arthritis, treatment

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Session Information

Date: Tuesday, November 15, 2016

Session Title: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy III: Small Molecules and Early Intervention

Session Type: ACR Concurrent Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: Current therapy for rheumatoid arthritis (RA) often leads to excessive immunosuppression induced by glucocorticoids and DMARDs. Low-dose Interleukin 2 (IL-2) has been showed to induce Treg cell expansion and activation, which is expected to control the development of RA. We studied the clinical efficacy and safety of IL-2 treatment in RA.

Methods: Total 41 RA patients with low Treg cells, who had been treated with glucocorticoids and DMARDs for over 6 months, were divided into two groups randomly. Patients in Non-IL-2 group (n=15) were still given traditional glucocorticoids and DMARDs treatment. Patients in IL-2 group (n=26) were not only given traditional treatment, but also injected subcutaneously IL-2 at 50 WIU per day for a 5 day course. The demographic features, clinical manifestations and laboratory indicators were compared before and after the treatment.

Results: There was no difference between Non-IL-2 group and IL-2 group in gender, age and course of the disease (P>0.05). The ratios of Th1/Th2 and Th17/Treg were significant correlated with ESR, the number of tender or swollen joints and DAS28-ESR (P<0.05) in all two groups of patients. After IL-2 treatment, the number of Th17 cells (16.51±19.06 vs 19.00±11.38, P=0.01) or Treg cells (18.67±14.08 vs 78.55±44.67, P=0.001) were significantly increased. Due to increased Treg cells were much more than the Th17, leading to a decrease in their ratio (1.36±1.49 vs 0.28±0.20, P=0.024). Before the IL-2 treatment, there was no difference in clinical manifestations between two groups (P>0.05), but in IL-2 group, there was a significantly decrease after the treatment in the number of tender joints (3.73±2.79 vs 0.94±1.00, P=0.001) or swollen joints (1.40±1.64 vs 0.42±0.70, P=0.011) and DAS28-ESR (3.60±0.96 vs 2.85±0.67, P=0.005). There was no difference in blood routine, liver and renal functions both before and after the treatment between two groups (P>0.05).

Conclusion: IL-2 can effectively up-regulate the level of Treg as well as that of Th17 to some degree and maintain the balance of Th17 and Treg cells. IL-2 subcutaneous injection combined with traditional antirheumatic drugs may help for RA patients’ symptoms remission without over-treatment and evaluated side effect. IL-2 could be used as a novel therapeutic candidate for RA treatment but long term benefits of IL-2 therapy are required to further study.


Disclosure: S. X. Zhang, None; M. Miao, None; X. Q. Liu, None; X. W. Ma, None; X. Y. Wu, None; X. F. Li, National Natural Science Foundation of China (no. 81301532/H0603) and the Shanxi Scholarship council of China (no. 2013-118), 2.

To cite this abstract in AMA style:

Zhang SX, Miao M, Liu XQ, Ma XW, Wu XY, Li XF. The Efficacy and Safety of Low Dose IL-2 Therapy in over-Treated Patients with Rheumatoid Arthritis: A Preliminary Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-efficacy-and-safety-of-low-dose-il-2-therapy-in-over-treated-patients-with-rheumatoid-arthritis-a-preliminary-study/. Accessed February 2, 2023.
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