ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 861 • 2017 ACR/ARHP Annual Meeting

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice

    Sho Sendo1, Jun Saegusa1, Hirotaka Yamada2, Yoshihide Ichise2, Ikuko Naka3, Yo Ueda2, Takaichi Okano2, Soshi Takahashi4, Kengo Akashi5, Akira Onishi6 and Akio Morinobu4, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 4Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Department of Rheumatology and Clinical Immnology, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department for Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    CD11b+Gr1dim tolerogenic Dendritic Cell-like Cells Suppress the Progression of Interstitial Lung Disease in SKG Mice Background/Purpose: SKG mice develop interstitial lung disease (ILD) resembling rheumatoid arthritis-associated…
  • Abstract Number: 1326 • 2017 ACR/ARHP Annual Meeting

    Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

    Lingshu Zhang1,2, Pingfang Song2, Xiaowei Zhang2, Christina Metea2, Matthew Schleisman2, Lisa Karstens2, Eric Leung2, Jun Zhang3, Qiang Xu2,4, Yi Liu5, Mark Asquith2 and Cong-Qiu Chu6,7, 1Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, 2Oregon Health & Science University, Portland, OR, 3MD Anderson Cancer Center, Houston, TX, 4Guangzhou University of Chinese Medicine, Guangzhou, China, 5Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China, 6Rheumatology, Oregon Health & Science University, Portland, OR, 7Rheumatology, VA Portland Health Care System, Portland, OR

    Background/Purpose: Acarbose, an alpha-glucosidase inhibitor anti-diabetic drug exhibited anti-arthritic effects. The mechanism that acarbose exerts its anti-arthritic effects is not fully understood. Since > 90%…
  • Abstract Number: 1331 • 2017 ACR/ARHP Annual Meeting

    A Pathogenic Role of Porphyomonas Gingivalis Fimbriae (FimA) in Periodontitis-Associated Rheumatoid Arthritis

    Ji-Won Kim1, Jennifer Lee2, Yeon-Sik Hong3, Sung-Hwan Park2 and Ji Hyeon Ju2, 1Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: Periodontitis induced by oral pathogen Porphyromonas gingivalis (Pg) has been suggested to be associated with rheumatoid arthritis (RA). Pg peptidyl arginine deiminase -mediated citrullination…
  • Abstract Number: 1392 • 2017 ACR/ARHP Annual Meeting

    Effect Size Comparison of Ultrasound Measures in Rheumatoid Arthritis

    Veena K. Ranganath1, David Elashoff2, Jenny Brook3, Ami Ben-Artzi4, Geraldine Navarro5, Lynnette Avedikian-Tatosyan6, George Karpouzas7, William Martin5, Tanaz A. Kermani5, Soo Choi5 and Gurjit S. Kaeley8, 1Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, 2David Geffen School of Medicine,, University of California, Los Angeles, Los Angeles, CA, 3Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 4Medicine, Cedars, Beverly Hills, CA, 5Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 6Healthcare Partners, Los Angeles, CA, 7Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 8Rheumatology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL

    Background/Purpose: Currently there are several outcome metrics used for the assessment and quantification of musculoskeletal (MSK) ultrasound inflammatory burden in rheumatoid arthritis (RA). This study…
  • Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting

    Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jeong Yeon Kim1, Shin Eui Kang1, Ji Seok Yoo3, Yong Nam Lee3, Dong Goo Lee3, Ji Soo Park1, Eun Bong Lee4, Eun Young Lee4 and Yeong Wook Song2,5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), 3Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
  • Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting

    Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis

    Aurélie Najm1,2, Benoît Le Goff MD PhD2,3, Frédéric Blanchard1, Jérome Amiaud4, Céline Charrier5 and Veit Krenn6, 1INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, 2Rheumatology, Nantes University Hospital, Nantes, France, 3UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 4UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 5UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 6Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany

    Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
  • Abstract Number: 2436 • 2017 ACR/ARHP Annual Meeting

    MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis

    Yuan-hao Wu1,2, Wei Liu1, Lei Zhang3, Bin Xue3, Yi Wang3, Xiao-ya Liu3, Yang Ji4, Ran Duan3, Yue Cai3 and Bo Zhang3, 1Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China, 3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, 4The 272nd Hospital of Chinese People's Liberation Army, Tianjin, China

    Background/Purpose: To investigate the role of miR-146a in the activation of toll-like receptor-4 (TLR4)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and…
  • Abstract Number: 2704 • 2017 ACR/ARHP Annual Meeting

    Skin Migratory Dendritic Cells Targeted and Tolerized By Calcitriol-Peptide Liposomes Supress Antigen-Specific Autoreactive T Cell Expansion and Memory Differentiation to Regulate Autoimmune Arthritis

    Ryan Galea1,2, Hendrik Nel1,2, Meghna Talekar1,2, Suzanne Cole3, Karyn Cochlin4, Shannon Hitchcock5, Bijun Zeng1,2, Suman Yekollu1,2, Jamie Rossjohn6, Hugh Reid7, Ravi Malaviya5, Dave Shealy8, Brendan O'Sullivan1,2 and Ranjeny Thomas1,2, 1Dendright Pty Ltd, Brisbane, Australia, 2University of Queensland Diamantina Institute, Brisbane, Australia, 3Immunology, Janssen Research and Development, Spring House, PA, 4Immunology, Janssen Research and Development, Springhouse, PA, 5Janssen Research and Development, Springhouse, PA, 6Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, 7Monash University, Melbourne, Australia, 8Janssen Research and Development, Spring House, PA

    Background/Purpose: Current treatments to control autoimmune arthritis and vasculitis use broadly immunosuppressive drugs, associated with undesirable side effects. Antigen-specific immunological tolerance strategies are preferable to…
  • Abstract Number: 61 • 2017 ACR/ARHP Annual Meeting

    Resolution of Systemic Joint Inflammatory Processes and Regeneration of Existing Bone Damage upon TNF Blockade As Monitored By In Vivo Multimodal PET-CT Imaging in Progressed Experimental Arthritis

    Silvia Hayer1, Markus Zeilinger2,3, Volker Weiss3,4, Markus Seibt5, Birgit Niederreiter1, Tetyana Shvets6, Monika Dumanic6, Florian Pichler6, Marcus Hacker6, Josef S. Smolen7, Kurt Redlich8 and Markus Mitterhauser6, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Faulty of Engineering, University of Applied Sciences, Winer Neustadt, Austria, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Faculty of Engineering, University of Applied Sciences, Wiener Neustadt, Austria, 5Department Internal Medicine III, Division Rheumatology, Medical University of Vienna, Vienna, Austria, 6Medical University of Vienna, Vienna, Austria, 7Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 8Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: To use in vivo multimodal [18F]FDG (fluoro-D-glucose, tracer for inflammation) and [18F]Sodium Fluoride (bone tracer) positron emission tomography/computed tomography (PET-CT) imaging for the monitoring…
  • Abstract Number: 2869 • 2017 ACR/ARHP Annual Meeting

    Significant Decrease of T-Cells but Not Macrophages in the Synovium of Patients with Active Rheumatoid Arthritis after Treatment with Tocilizumab

    Katerina Chatzidionysiou1, Marianne Engström1, Erik af Klint1, Aase Hensvold1 and Anca I Catrina2, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Tocilizumab (TCZ) is an anti-IL6R monoclonal antibody approved for the treatment of Rheumatoid Arthritis (RA). There is limited data on synovial tissue histology changes.…
  • Abstract Number: 171 • 2017 ACR/ARHP Annual Meeting

    Finding Transcriptional Regulators Central to RA with Transcriptomics of IL17 Dose Response, Time Series, and siRNA Silencing in Stromal Cells

    Kamil Slowikowski1, Hung Nguyen2, Gerald Watts2, Fumitaka Mizoguchi3, Erika H. Noss4, Michael Brenner5 and Soumya Raychaudhuri6, 1Harvard University, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 4Division of Rheumatology, University of Washington, Seattle, WA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by immune cell infiltration into the synovial membrane of the joint, where they engage stromal cells such as synovial…
  • Abstract Number: 2913 • 2017 ACR/ARHP Annual Meeting

    the Periodontal Pathogen Aggregatibacter Actinomycetemcomitans Is Associated with Subclinical Coronary Atherosclerosis in Rheumatoid Arthritis

    Jon T. Giles1, Jesper Reinholdt2, Joan Bathon3, Felipe Andrade4 and Maximilian F. Konig5, 1Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, 2Department of Biomedicine, Aarhus University, Aarhus, Denmark, 3Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 4Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The oral pathogen Aggregatibacter actinomycetemcomitans (Aa) generates citrullinated proteins targeted by autoantibodies in RA through its pore-forming toxin leukotoxin A (LtxA).  Aa-derived LtxA is…
  • Abstract Number: 394 • 2017 ACR/ARHP Annual Meeting

    Female Tumor Necrosis Factor Transgenic Mice Have More Severe Arthritis Than Males and Supporessed Levels of Bifidobacterium Pseudolongum in Their Gut Microbiome

    Emily Wu1, Richard Bell2, Alex Grier3, Steven Gill4, Edward Schwarz5 and Homaira Rahimi6, 1Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 2Center for Musculoskelatal Research, University of Rochester, Rochester, NY, 3Rochester Genomics Center, University of Rochester, Rochester, NY, 4Genomics Research Center, University of Rochester, Rochester, NY, 5Orthopedeatrics, University of Rochester, Rochester, NY, 6Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) has an increased prevalence and severity in women compared to men, yet the underlying etiology of this sexual dimorphism is unknown.…
  • Abstract Number: 2963 • 2017 ACR/ARHP Annual Meeting

    Sirukumab Improves Synovial Vascularity As Measured By Power Doppler Sonography in Rheumatoid Arthritis Patients from As Early As Week 4 in a Phase 3 Trial

    Bidisha Dasgupta1, Kristen Sweet1, Dick DeVries2, Benjamin Hsu1, Ian Gourley1, Matthew Loza1 and Peter C. Taylor3, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Biologics Europe, Leiden, Netherlands, 3Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Ultrasound (US) is an established non-invasive tool for sensitively assessing disease activity at the individual‐joint level in rheumatoid arthritis (RA). Synovial thickness is detectable…
  • Abstract Number: 1447 • 2016 ACR/ARHP Annual Meeting

    Therapeutic Blockade of Interleukin-6 Trans-Signalling Restores Vascular Function in Murine Collagen Induced Arthritis

    Ruth Davies1, Jessica O Williams2, Katie Sime2, Ellyn Hughes2, Lauren A. Jordan2, Charlotte Rawlings2, Derek Lang3, Stefan Rose-John4, Simon A. Jones5, Anwen S. Williams2 and Ernest H. Choy6,7, 1CREATE Centre, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 2Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom, 3Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, 4Institute of Biochemistry, Christian Albrechts University, Kiel, Germany, 5Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, 6Section of Rheumatology, Cardiff University, Cardiff, Great Britain, 7CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom

    Background/Purpose: Mortality is increased in rheumatoid arthritis (RA), mainly due to cardiovascular disease (CVD). While molecular mechanisms underlining this clinical observation are unknown, systemic elevations…
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