ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 983 • 2019 ACR/ARP Annual Meeting

    Fecal Transfer from Mice on High or Low Magnesium Diets Confers Arthritis Protection

    Teresina Laragione1, Carolyn Harris 1 and Percio Gulko 1, 1Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Magnesium (Mg) plays a key role in the immune response. We have previously demonstrated that alterations in the Mg balance by increasing or decreasing…
  • Abstract Number: 1385 • 2019 ACR/ARP Annual Meeting

    Discontinuation of Oral Glucocorticoid After Initiation of Biological DMARDs Due to a Higher Dose of Methotrexate; A Retrospective Observational Study Based on Data from a Japanese Multicenter Registry Study

    Mochihito Suzuki1, Toshihisa Kojima 2, Nobunori Takahashi 2, Shuji Asai 2 and Naoki Ishiguro 2, 1Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Background/Purpose:  In the treatment of rheumatoid arthritis (RA), glucocorticoid that provide anti-inflammatory effects is an important drug. We recommend discontinuing of glucocorticoid as soon as…
  • Abstract Number: 1999 • 2019 ACR/ARP Annual Meeting

    NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion

    Ha-Reum Lee1, Su-Jin Yoo 2, Chan-Geol Park 2, Jinhyun Kim 2, In Seol Yoo 2 and Seong Wook Kang 2, 1Chungnam National University Hospital,, Daejeon, Republic of Korea, 2Chungnam National University Hospital, Daejeon, Republic of Korea

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and…
  • Abstract Number: 2377 • 2019 ACR/ARP Annual Meeting

    Methotrexate Discontinuation and Dose Decreases After Therapy with Tocilizumab: Results from the Corrona Rheumatoid Arthritis Registry

    Dimitrios Pappas1, Taylor Blachley 2, Steve Zlotnick 3, Jennie Best 3, Kelechi Emeanuru 2 and Joel Kremer 4, 1Columbia University, New York, NY, 2Corrona, LLC, Waltham, MA, 3Genentech, Inc., South San Francisco, CA, 4Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY

    Background/Purpose: Methotrexate (MTX) is frequently prescribed with biologic disease-modifying antirheumatic drugs. Evidence has shown that tocilizumab (TCZ) monotherapy is effective in the treatment of patients…
  • Abstract Number: 495 • 2019 ACR/ARP Annual Meeting

    Pre-Rheumatoid Arthritis Diagnosis Prevalence of Commercial CCP Antibody Positivity Increases over Time with Strong Agreement Between Commercial Assays and Positivity Is Predicative of Developing Rheumatoid Arthritis Within 3 Years

    Steven Taylor1, Mark Parish 2, LauraKay Moss 3, Marie Feser 4, Elizabeth Mewshaw 5, Jess Edison 5 and Kevin Deane 4, 1University of Colorado - Denver, Denver, CO, 2University of Colorado Denver, Aurora, CO, 3University of Colorado Denver, Division of Rheumatology, Aurora, CO USA, Aurora, CO, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 5Walter Reed National Military Medical Center, Bethesda, MD

    Background/Purpose: Rheumatoid arthritis (RA) related autoantibodies, in particular antibodies to citrullinated proteins (ACPA), predict likelihood of developing future RA. Indeed, clinical trials for RA prevention…
  • Abstract Number: 531 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Gonadotropin-Releasing Hormone Antagonism in Severe Biologic Refractory Rheumatoid Arthritis

    Anita Kass1, Hans Christian Gulseth 1 and Camilla Zettel 1, 1Betanien Hospital, Skien, Norway

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and additional therapeutic approaches are needed. The improvement of RA disease activity during pregnancy, and flares during the…
  • Abstract Number: 985 • 2019 ACR/ARP Annual Meeting

    Inhibition of Calcium/calmodulin-dependent Protein Kinase IV in Rheumatoid Arthritis: Dual Effect on Th17 Cell Activation and Osteoclastogenesis

    Tomohiro Koga1, Tomohito Sato 2, Yushiro Endo 1, Sosuke Tsuji 1, Ayuko Takatani 1, Toshimasa Shimizu 1, Remi Sumiyoshi 1, Takashi Igawa 1, Shin-ya Kawashiri 1, Naoki Iwamoto 1, Kunihiro Ichinose 1, Mami Tamai 1, Hideki Nakamura 1, Tomoki Origuchi 3, Nobuya Yoshida 4, Masataka Umeda 5, George Tsokos 4 and Atsushi Kawakami 6, 1Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan, 2Nagasaki University, Nagasaki, Japan, 3Nagasaki University School of health sciences, Division of physical therapy, Nagasaki, Japan, 4Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 5Beth Israel Deaconess Medical Center, Boston, MA, 6Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki

    Background/Purpose: Background: CD4 + T cells are important in the pathogenesis of rheumatoid arthritis (RA), and therapies targeting the differentiation of osteoclasts are attracting attention. Calcium/calmodulin-dependent…
  • Abstract Number: 1400 • 2019 ACR/ARP Annual Meeting

    Real Life Retention of Tofacitinib in Patients with Rheumatoid Arthritis

    Aniela Croiteru 1, Merav Lidar 2, Tatiana Reitblat3, Devy Zisman 4, Alexandra Balbir-Gurman 5, Tanya Meshiach 5, Ronit Almog 5 and Ori Elkayam 6, 1Tel Aviv medical center, Tel Aviv, Israel, 2Sheba Medical Center, Ramat Gan, Israel, 3Barzilai Medical Center, Ashkelon, Israel, 4Carmel Hospital and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel, Haifa, Israel, 5Rambam Medical Center, Haifa, Israel, 6Rheumatology Department, Tel Aviv Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel., Tel Aviv, Israel

    Background/Purpose: Tofacitinib (Xeljanz) is an approved treatment for Rheumatoid Arthritis (RA) but data on its use in “real life” are limited.  We sought to analyze…
  • Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting

    Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts

    Samuel Finlay1, Stefano Alivernini 2, Aziza Elmesmari 3, Barbara Tolusso 2, Luca Petricca 2, Clara Di Mario 4, Annunziata Capacci 2, Andrew Filer 5, Gianfranco Ferraccioli 2, Iain McInnes 1, Elisa Gremese 2 and Mariola Kurowska-Stolarska 1, 1Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 3Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 4Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 5Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
  • Abstract Number: 2380 • 2019 ACR/ARP Annual Meeting

    Improving Depression by Joint Surgery in Established Rheumatoid Arthritis; Results from Multicenter Prospective Cohort Study for Evaluation of Joint Surgery on Patient’s Reported Outcome

    Toshihisa Kojima1, Masayo Kojima 2, Hajime Ishikawa 3, Sakae Tanaka 4, Nobuhiko Haga 5, Keiichiro Nishida 6, Masao Yukioka 7, Jun Hashimoto 8, Hisaaki Miyahara 9, Yasuo Niki 10, Tomoatsu Kimura 11, Hiromi Oda 12, Shuji Asai 1, Koji Funahashi 13 and Naoki Ishiguro 1, 1Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Nagoya City University Graduate School of Medicne, Nagoya, Japan, 3Niigata Rheumatic Center, Niigata, Japan, 4University of Tokyo, Tokyo, Japan, 5The University of Tokyo Hospital, Tokyo, Japan, 6Okayama University, Graduate School of Medicine, Okayama, Japan, 7Yukioka Hospital, Osaka, Japan, 8National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan, 9National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan, 10Keio University, School of Medicine, Tokyo, Japan, 11University of Toyama, Faculty of Medicine, Toyama, Japan, 12Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 13Kariya-Toyota General Hosptal, Kariya, Japan

    Background/Purpose: Total management including reconstructive joint surgery and rehabilitation should be needed for further improvements of physical function for long-standing RA patients. In these days,…
  • Abstract Number: 520 • 2018 ACR/ARHP Annual Meeting

    Factors Associated with the Developement of Severe Respiratory Infections in Patients with Rheumatoid Arthritis Included in a Vaccination Program

    Lucia C. Domínguez-Casas1, Paz Rodríguez-Cundín2, Vanesa Calvo-Río3, Nuria Vegas-Revenga3, Virginia Portilla4, F. Antolin2, M. Rebollo-Rodrigo2, Alfonso Corrales1, Diana Prieto Peña3, Monica Calderón Goercke3, Miguel Angel González-Gay1 and Ricardo Blanco1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Preventive Medicine, Preventive Medicine. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain., Santander, Spain, 3Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 4Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Rheumatoid arthritis(RA) patients are at increased risk of infections particularly respiratory infections. These may be augmented due to RA itself and to immunosuppressive durgs,…
  • Abstract Number: 2047 • 2018 ACR/ARHP Annual Meeting

    Synovial Fluid Cytokines /Chemokines and Proteins from the Knees of Symptomatic RA and OA Patients Which Correlate with the Magnitude of the Inflammatory Response As Measured By Synovial Fluid WBC Levels

    Richard Meehan1, Eric Hoffman2, Mary Wolf3, Elizabeth Regan4, Prashant Parmar5, Karin Pacheco6, Jim Crooks7 and Vijaya Knight8, 1MEDICINE, National Jewish Health, Denver, CO, 2Medicine/Rheumatology, National Jewish Health, Denver, CO, 3Pathology Department, National Jewish Health, Denver, CO, 4Medicine, National Jewish Health, Denver, CO, 5Internal Medicine, St Joseph Hospital, Denver, CO, 6MEDICINE/ Occupational Medince, National Jewish Health, Denver, CO, 7Biostatistics, National Jewish Health, Denver, CO, 8Pathology, ADX laboratory, National Jewish Health, Denver, CO

    Background/Purpose: Synovial fluid (SF) provides nutritional support for cartilage and contains numerous catabolic and anabolic cytokines, chemokines and proteins. The precise role of these proteins…
  • Abstract Number: 552 • 2018 ACR/ARHP Annual Meeting

    Drug Tolerability and Discontinuation Reasons of 7 Biologics in 4466 Treatment Courses of Rheumatoid Arthritis -the Answer Cohort Study-

    Kosuke Ebina1, Makoto Hirao2, Motomu Hashimoto3, Wataru Yamamoto4, Akira Onishi5, Toru Hirano6, Ryota Hara7, Masaki Katayama8, Shuzo Yoshida9, Koji Nagai9, Yonsu Son10, Hideki Amuro10, Kengo Akashi11, Koichi Murata3, Kosaku Murakami12, Keiichi Yamamoto13 and Hideki Yoshikawa14, 1Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, 2Orthopaedic Surgery, Osaka University, Graduate School of Medicine, Suita, Japan, 3Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Health Information Management, Kurashiki Sweet Hospital, Okayama, Japan, 5Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan, 7The Center for Rheumatic Diseases, Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan, 8Department of Rheumatology, Osaka Red Cross Hospital, Osaka, Japan, 9Department of Internal Medicine (IV), Osaka Medical College, Osaka, Japan, 10First Department of Internal Medicine, Kansai Medical University, Osaka, Japan, 11Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 12Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 13Department of Medical Statistics, Osaka City University, Osaka, Japan, 14Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita Osaka, Japan

    Background/Purpose: Drug tolerability indicates both the patient’s and doctor’s satisfaction and useful summary measure of overall treatment effectiveness and toxicity. Although more than 5 years…
  • Abstract Number: 2353 • 2018 ACR/ARHP Annual Meeting

    Attitudes and Beliefs Regarding Methotrexate in Patients with Rheumatoid Arthritis: Results from Australian Rheumatology Association Database

    Nieves Leonardo1,2, Susan Lester3,4, Michelle Graham5, Samuel Whittle1,6, Debra Rowett7,8, Rachelle Buchbinder9,10 and Catherine Hill6,11,12, 1Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia, 2Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia, 3Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia, 4Discipline of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia, 5Arthritis Queensland, Queensland, Australia, 6The Queen Elizabeth Hospital, Adelaide, Australia, 7School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 8Drug and Therapeutics Information Service, Southern Adelaide Local Health Network, Adelaide, Australia, 9Cabrini Institute, Victoria, Australia, 10Monash University, Melbourne, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Medicine, The University of Adelaide, Adelaide, Australia

    Background/Purpose: To determine beliefs about methotrexate (MTX) in patients with Rheumatoid Arthritis (RA) in relation to views obtained from a range of information sources.Methods: RA…
  • Abstract Number: 593 • 2018 ACR/ARHP Annual Meeting

    Predictors of Persistence of Biologic Drug Step-Down Strategies in Inflammatory Arthritis: An Observational Study in Clinical Practice up to Seven Years of Follow-up

    Sebastian C Rodriguez-Garcia1, Raul Castellanos-Moreira Sr.1, José Inciarte-Mundo2, M. Victoria Hernández3, Virginia Ruiz-Esquide2, Andrea Cuervo1, Julio Ramírez2, Juan Cañete1, Jose Gomez Puerta1 and Raimon Sanmartí1, 1Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 2Rheumatology, Hospital Clínic de Barcelona, Barcelona, Spain, 3Rheumatology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain

    Background/Purpose: Recommendations and guidelines for the management of Rheumatoid Arthritis (RA) and spondyloarthritis (SpA) with bDMARD include dose-tapering as an adequate option for patients on…
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