Abstracts tagged "rheumatoid arthritis"

Abstract Number: 2848 • 2019 ACR/ARP Annual Meeting
Semiquantitative Assessment of Synovial Inflammation on US-Guided Synovial Membrane Biopsy Is Contingent to Disease Phase, Autoimmune Profile and Treatment Response in Rheumatoid Arthritis: Large Single Center Experience (SYNGem Cohort)
Stefano Alivernini¹, Barbara Tolusso ¹, Marco Gessi ², Maria Rita Gigante ¹, Luca Petricca ¹, Clara Di Mario ³, Simone Perniola ¹, Anna Laura Fedele ¹, Giusy Peluso ⁴, Laura Bui ², Annunziata Capacci ¹, Francesco Federico ², Gianfranco Ferraccioli ³ and Elisa Gremese ¹, ¹Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ²Division of Pathology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ³Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, ⁴Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy, Italy
Background/Purpose: Ultrasound (US)-guided minimally-invasive Synovial Tissue (ST) biopsy is a well tolerated procedure for basic and translational studies on chronic inflammatory joint diseases as Rheumatoid…
Abstract Number: 44 • 2019 ACR/ARP Annual Meeting
Validation of New Genes Identified in a Molecular Bayesian Network of Rheumatoid Arthritis Synovitis
Teresina Laragione¹, Carolyn Harris ¹, Wenhui Wang ¹, Jun Zhu ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: We have previously identified new key regulators of Rheumatoid arthritis (RA) synovial pathology using a systems biology approach that combined RA gene expression datasets,…
Abstract Number: 518 • 2019 ACR/ARP Annual Meeting
Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biological DMARDs: Results at 60 Weeks
Mark Genovese¹, Bernard Combe ², Stephen Hall ³, Andrea Rubbert-Roth ⁴, Sheng Zhong ⁵, Sebastian Meerwein ⁶, Aileen Pangan ⁷ and Roy Fleischmann ⁸, ¹Stanford University, Stanford, CA, ²CHU Montpellier, Montpellier University, Montpellier, France, ³Monash University and Emeritus Research, Melbourne, Australia, ⁴Kantonsspital St. Gallen, St Gallen, Switzerland, ⁵AbbVie Inc., North Chicago, IL, USA, North Chicago, IL, ⁶AbbVie GmbH Co. KG, Ludwigshafen, Germany, Wiesbaden, Germany, ⁷AbbVie Inc., North Chicago, ⁸Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: In patients (pts) with active rheumatoid arthritis (RA) and inadequate response or intolerance to bDMARDs, treatment with upadacitinib (UPA), a JAK1-selective inhibitor resulted in…
Abstract Number: 977 • 2019 ACR/ARP Annual Meeting
Conditional Deletion of MKL1 Inhibits Osteoclast Formation and Bone Erosions in Collagen Induced Arthritis Mice
Wenfeng Tan¹, Aishu Luo ¹, Yong Xu ², Shiyu Lin ³, Miaojia Zhang ⁴ and Fang Wang ³, ¹the First Affiliated Hospital of Nanjing Medical University, Nanjing, China (People's Republic), ²Nanjing Medical University, NANJING, China (People's Republic), ³the First Affiliated Hospital of Nanjing Medical University, Nanjing, ⁴the First Affiliated Hospital of Nanjing Medical University, Najing, China (People's Republic)
Background/Purpose: Excessively osteoclasts (OCs) activation play an essential role in bone erosions in rheumatoid arthritis (RA). Thus, controlling OCs would be an effective strategy to…
Abstract Number: 1340 • 2019 ACR/ARP Annual Meeting
Patterns of Sustained Remission and Subsequent DMARD Tapering in Early Rheumatoid Arthritis: Data from the Canadian Early Arthritis Cohort
Maria Powell¹, Vivian Bykerk ², Orit Schieir ³, Marie-France Valois ⁴, Susan J. Bartlett ⁵, Louis Bessette ⁶, Gilles Boire ⁷, Carol Hitchon ⁸, Edward Keystone ⁹, Janet Pope ¹⁰, Carter Thorne ¹¹, Diane Tin ¹² and Glen Hazlewood ¹, ¹University of Calgary, Calgary, AB, Canada, ²Hospital for Special Surgery, New York City, NY, ³University of Toronto Dalla Lana School of Public Health, Toronto, ON, Canada, ⁴McGill University, Montreal, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Laval University, Quebec City, QC, Canada, ⁷Sherbrooke University, Sherbrooke, QC, Canada, ⁸University of Manitoba, Winnipeg, Canada, ⁹Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹⁰Western University, London, ON, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Southlake Regional Health Centre, Newmarket, Canada
Background/Purpose: Rheumatoid arthritis (RA) treatment emphasizes aggressive titration of disease-modifying antirheumatic drugs (DMARDs) with the goal of achieving disease remission. This often includes the use…
Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting
Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis
Izumi Kurata¹, Isao Matsumoto ¹, Natsuko Mikami ¹, Ayako Ohyama ¹, Atsumu Osada ¹, Yuya Kondo ¹, Hiroto Tsuboi ¹ and Takayuki Sumida ¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
Abstract Number: 2298 • 2019 ACR/ARP Annual Meeting
Interstitial Lung Disease Is Associated with Distinct Fine Specificities of Anti-Carbamylated Peptide/Protein Antibodies in Rheumatoid Arthritis
Raul Castellanos-Moreira¹, Sebastian Rodriguez-Garcia ², Virginia Ruiz-Esquide ³, Fernanda Hernández-González ⁴, Marcelo Sánchez ⁵, José Ramírez ⁶, Mariana Benegas ⁵, Carmen Lucena-Pozo ⁴, Carlos Agustí ⁴, Marc Boada ⁷, Odette Viñas ⁸, Estíbaliz Ruiz ⁸, Sergio Prieto-González ⁹, Jose Gomez-Puerta ¹, Jacobo Sellares ⁴, Juan Cañete ¹, Isabel Haro ¹⁰ and Raimon Sanmarti ¹, ¹Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, ²Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, ³Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, ⁴Department of Pneumology, Hospital Clínic, Barcelona, Barcelona, Spain, ⁵Department of Radiodiagnosis, Hospital Clínic, Barcelona, Barcelona, Spain, ⁶Department of Pathological Anatomy, Hospital Clínic, Barcelona, Barcelona, Spain, ⁷Department of Thoracic Surgery, Hospital Clínic, Barcelona, Barcelona, Spain, ⁸Department of Immunology, Hospital Clínic, Barcelona, Barcelona, Spain, ⁹Department of Systemic Autoimmune Diseases Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁰Unit of Synthesis and Biomedical Applications of Peptides, IQAC CSIC, Barcelona, Barcelona, Spain
Background/Purpose: Interstitial lung disease (ILD) is a common and severe complication of rheumatoid arthritis (RA). It has been associated with the presence of ACPA. Anti-carbamylated…
Abstract Number: 2861 • 2019 ACR/ARP Annual Meeting
Lung-Related Factors Are Associated with Transitions from Systemic Anti-CCP Antibody Positivity to Classified RA
Ashley Visser ¹, Marie Feser ², Chelsie Fleischer ³, Laura Lenis-Charry ¹, Justin August ¹, Elizabeth Bemis ⁴, Jill Norris ⁵, V. Michael Holers ⁶, Kevin Deane ² and M. Kristen Demoruelle⁷, ¹University of Colorado Denver, Aurora, ²University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO USA, Aurora, ⁴University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, ⁵Colorado School of Public Health, Aurora, ⁶University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁷University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora
Background/Purpose: Systemic autoimmunity associated with RA precedes the onset of inflammatory arthritis (IA) by several years. In particular, the presence of systemic anti-cyclic citrullinated peptide…
Abstract Number: 48 • 2019 ACR/ARP Annual Meeting
Phenotype-based Clustering Along with Analysis of Molecular Profile Might Help to Define Precise CV-risk Profiles in RA Patients
Chary Lopez-Pedrera¹, Nuria Barbarroja ², Maria Luque-Tevar ¹, Patricia Ruiz-Limon ³, Laura Pérez-Sanchez ⁴, Sara Remuzgo-Martínez ⁵, Alejandro Ibañez-Costa ¹, Alejandra Patiño-Trives ¹, Ivan Arias de la Rosa ⁶, Maria del Carmen Abalos-Aguilera ¹, Andres Delgado-Campos ⁷, Rafaela Ortega ¹, Raquel López-Mejías ⁵, M Angeles Aguirre ⁸, Alejandro Escudero ⁷, Eduardo Collantes-Estevez ⁶, Miguel A. González-Gay ⁹ and Carlos Perez-Sanchez ¹⁰, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, ³Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain, Málaga, Spain, ⁴MIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁶University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁷IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁸IMIBIC/Reina Sofia Hospital/University of Cordoba,, Córdoba, Spain, ⁹Hospital Universitario Marqués de Valdecilla. IDIVAL. Universidad de Cantabria., Cantabria, Spain, ¹⁰Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain
Background/Purpose: 1. To identify and characterize specific immunological, inflammatory and epigenetic determinants involved in the enhanced cardiovascular (CV)-risk present in Rheumatoid Arthritis (RA) patients. 2.…
Abstract Number: 521 • 2019 ACR/ARP Annual Meeting
Discontinuation of Disease Modifying Drugs Due to Inefficacy in Patients with Incident Rheumatoid Arthritis
Zulema Rosales Rosado¹, pia Lois ¹, Arkaitz Mucientes Ruiz ¹, Esperanza Pato Cour ¹, Dalifer Freites Nuñez ², Juan Angel Jover Jover ¹, lydia Abasolo Alcazar ¹ and Leticia León ³, ¹HOSPITAL CLINICO SAN CARLOS, MADRID, Spain, ²Hospital Clínico San Carlos, MADRID, Spain, ³Fundación para la Investigación Biomedica, Madrid, Madrid, Spain
Background/Purpose: The treatment of Rheumatoid Arthritis (RA) has undergone a big change in the last two decades with the Disease Modifying Drugs (DMARDs). These drugs…
Abstract Number: 978 • 2019 ACR/ARP Annual Meeting
Light Mediated Therapeutics in Arthritis
Victoria Wickenheisser¹, Emily Rabjohns ², Emilia Zywot ³, Natalia Orlova ³, Christina Marvin ³, Song Ding ⁴, David Lawrence ⁴ and Teresa Tarrant ⁵, ¹Duke University School of Medicine, Durham, ²Department of Rheumatology, Duke University Hospital, Durham, NC, ³UNC Department of Chemistry, Chapel Hill, NC, ⁴Division of Medicinal Chemistry and Chemical Biology The UNC Eshelman School of Pharmacy at UNC, Chapel Hill, NC, ⁵Department of Medicine Division of Rheumatology and Immunology, Duke University Hospital, Durham, NC
Background/Purpose: Rheumatoid arthritis (RA) therapies are constrained by the failure to deliver sufficient quantities of drug to the inflamed site, systemic side effects, and the…
Abstract Number: 1355 • 2019 ACR/ARP Annual Meeting
A Comparison of Clinical Improvement Following a Major Therapeutic Change Utilizing Updated Treatment Thresholds Defined by Three Different Disease Activity Measures
Grant Cannon¹, Wei Chen ¹, JIncheng Shen ², Neil Accortt ³, David Collier ⁴ and Brian Sauer ¹, ¹Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ²Univeristy of Utah, Salt Lake City, UT, ³Amgen, Thousand Oaks, CA, ⁴Amgen Inc., Thousand Oaks, CA
Background/Purpose: Despite ACR recommendations to initiate a major therapeutic change (MTC) in rheumatoid arthritis (RA) patients with moderate/severe disease activity, our recent work has shown…
Abstract Number: 1803 • 2019 ACR/ARP Annual Meeting
Performance of the RABBIT Infection Score in a Prospective Multicenter Cohort of Rheumatoid Arthritis Patients from Argentina
Rodrigo Garcia Salinas¹, Maria Alicia Lazaro ², Santiago Scarafia ³, Alejandra Cusa ², Nieves Capozzi ⁴, Luciana Casalla ⁴, Lucia Zarate ⁴, Maria de la Vega ⁵, Maria Correa ⁶, Gustavo Casado ⁷, Silvia Papasidero ⁸, Oscar Rillo ⁹, Nevil Alejandro Muñoz ¹⁰, Mariana Benegas ¹¹, Karin Kirmayr ¹², Maria Paula Girard Bosch ¹³, Maria Victoria Martire ¹⁴ and Ramiro Gomez ¹⁵, ¹Hospital Italiano de La Plata, La plata, Buenos Aires, Argentina, ²IARI, Buenos Aires, ³Hospital Municipal "San Cayetano", Buenos Aires, Buenos Aires, Argentina, ⁴Hospital Posadas, Buenos Aires, ⁵CEIM Investigaciones Medicas, Buenos Aires, Argentina, ⁶Consultorios Reumatológicos Pampa, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ⁷Hospital Militar Central, Buenos Aires, ⁸Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ⁹Hospital Pirovano, Buenos Aires, ¹⁰Hospital Ramos Mejia, Buenos Aires, ¹¹Sanatorio Mendez, Buenos Aires, ¹²Hospital Zonal Bariloche, Bariloche, ¹³Instituto Médico Platense, La Plata, ¹⁴Hospital San Martín. Instituto Médico Platense, La Plata, ¹⁵Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: The biologics therapies in rheumatoid arthritis (RA) implies a well-known risk of infection. It is of utterly importance to count with predictive models to…
Abstract Number: 2301 • 2019 ACR/ARP Annual Meeting
Profile of Renal Function in Patient Suffering from Rheumatoid Arthritis
Denis Choquette¹, Louis Bessette ², Loïc Choquette Sauvageau ³, Isabelle Ferdinand ³, Boulos Haraoui ³, Frédéric Massicotte ³, Jean-Pierre Pelletier ⁴, Jean-Pierre Raynauld ⁵, Marie-Anaïs Rémillard ³, Diane Sauvageau ³, Edith Villeneuve ⁶ and Louis Coupal ³, ¹Institut de Recherche en Rhumatologie de Montréal, University of Montreal, Québec, Canada., Montreal, QC, Canada, ²Centre de l'Ostéoporose et de Rhumatologie de Québec, Québec, QC, Canada, ³Institut de Recherche en Rhumatologie de Montréal, Montréal, QC, Canada, ⁴University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁵Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ⁶Institut de Recherche en Rhumatologie de Montréal, Montreal, QC, Canada
Background/Purpose: Many medications used in the treatment of rheumatoid arthritis (RA) impact renal function. Some of these may be contraindicated in the presence of a…
Abstract Number: 2871 • 2019 ACR/ARP Annual Meeting
Advances in Treatment of Rheumatoid Arthritis: ACPA-positive Patients Benefited More Than ACPA-negative Patients; 25 Year Results of a Longitudinal Cohort Study
Xanthe ME Matthijssen¹, Ellis Niemantsverdriet ², Thomas Huizinga ² and Annette van der Helm-van Mil ³, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The last 25 years, treatment of rheumatoid arthritis (RA) has changed considerably. Although clinically relevant joint damage has become infrequent, it is less established…

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