Abstracts tagged "rheumatoid arthritis"

Abstract Number: 0515 • ACR Convergence 2021
The Extracellular Sulfatase-2 Inhibitor OKN-007 Abrogates TNF-α-induced Inflammatory Mediators in Human Rheumatoid Arthritis Synovial Fibroblasts
Ruby Siegel, Sang Han and Salah-uddin Ahmed, Washington State University, Spokane, WA
Background/Purpose: Recent unpublished findings from our lab show that the extracellular enzyme sulfatase-2 (Sulf-2) facilitates pro-inflammatory TNF-α signaling which activates rheumatoid arthritis synovial fibroblasts (RASFs).…
Abstract Number: 0579 • ACR Convergence 2021
Predicting Treatment Change in Rheumatoid Arthritis Patients Treated with TNF Inhibitors as First-Line Biologic Agent
Yinzhu Jin¹, Joan Landon¹, Whitney Krueger², Alexander Liede² and Seoyoung Kim³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²AbbVie Global Epidemiology, Chicago, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Patient characteristics including serostatus, body mass index (BMI), and smoking are considered to be associated with their response to disease-modifying anti-rheumatic drugs (DMARD) treatment…
Abstract Number: 0608 • ACR Convergence 2021
Adaptation of a Shared Decision-Making Tool for Early Rheumatoid Arthritis Treatment Decisions with Indigenous Patients
Valerie Umaefulam¹, Terri-Lynn Fox¹, Glen Hazlewood¹, Nick Bansback², Claire Barber¹ and Cheryl Barnabe¹, ¹University of Calgary, Calgary, AB, Canada, ²University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Patient decision aids (PtDA) can enable shared decision-making between patients and healthcare providers. We have previously developed a PtDA for first-line methotrexate-based treatment options…
Abstract Number: 0787 • ACR Convergence 2021
Association of Hemoglobin Levels and Radiographic Progression in the BRASS Registry
Nancy Shadick¹, Owen Hagino², Amy Praestgaard³, Stefano Fiore², Michael Weinblatt⁴ and Gerd Burmester⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Sanofi, Bridgewater, NJ, ³Sanofi, Cambridge, MA, ⁴Brigham and Women’s Hospital, Boston, MA, ⁵Charité University Medicine Berlin, Berlin, Germany
Background/Purpose: To evaluate baseline hemoglobin (Hb) and radiographic progression over time for patients in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) registry.Methods:…
Abstract Number: 0803 • ACR Convergence 2021
Rheumatoid Arthritis Practice Performance (RAPP) Project at 6 Years: Population Medicine (POPMED) Principles and Treat to Target (T2T) Care Yield Dramatic Improvements in Both Outcomes and Access for RA Patients and Productivity for Rheumatologists
William Arnold¹, Erin Arnold¹, David Sikes², Gary Crump³, Kathleen Thomas⁴ and andrew johnson⁵, ¹Arnold Arthritis and Rheumatology, Wilmette, IL, ²Florida Medical Clinic, Wesley Chapel, FL, ³Rheumatology Associates, Louisville, KY, ⁴Community Health Network, Noblesville, IN, ⁵PopMed Solutions, Boyds, MD
Background/Purpose: The RAPP quality improvement project is a voluntary consortium of practicing rheumatologists founded in 2013 by Timothy Harrington MD, MACR. The primary focus is…
Abstract Number: 0821 • ACR Convergence 2021
Baseline Characteristics Predictive of Remission in Patients with RA Following Treatment with IV Abatacept: Post Hoc Analysis of a Real-world Observational Study
Rieke Alten¹, Xavier Mariette², Mauro Galeazzi³, Melanie Chartier⁴, Christiane Rauch⁵, Yedid Elbez⁶ and Karissa Lozenski⁷, ¹Schlosspark-Klinik University, Berlin, Germany, ²Université Paris-Saclay, AP-HP, Hospital Bicêtre, Paris, France, ³University of Siena, Siena, Italy, ⁴Bristol Myers Squibb, Rueil-Malmaison, France, ⁵Bristol Myers Squibb, Munich, Germany, ⁶Deepscover, Puteaux, France, ⁷Bristol Myers Squibb, Princeton, NJ
Background/Purpose: Identifying factors associated with treatment response and remission in patients with RA may assist with therapeutic decision-making. An international observational study evaluated efficacy and…
Abstract Number: 0838 • ACR Convergence 2021
Predictors of Treatment for Inflammatory Arthritis with Immune Modulating Medications (IMM) in US Veterans
Tawnie Braaten¹, shaobo Pei², Anitha Rathod², Gopi Penmetsa³, Kevin Douglas⁴, Jodi Walker⁴, Jerry Clewell⁵ and Jessica Walsh⁶, ¹Salt Lake City Veteran Affairs and University of Utah Medical Center, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT, ³Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ⁴AbbVie Inc., North Chicago, IL, ⁵Abbvie Inc, North Chicago, IL, ⁶Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT
Background/Purpose: Non-treatment and treatment delays contribute to suboptimal symptom control and irreversible joint damage in patients with inflammatory arthritis (IA). This investigations objective was to…
Abstract Number: 0982 • ACR Convergence 2021
B Cells Repertoire Repartition Predicts Response to Methotrexate at 6 and 12 Months in Naïve RA: A Machine Learning Driven Approach
Aurelie Najm¹, Shrutii Sarda², Michelle Toro³, Loni Pickle³, Stephanie Ostresh³, Fraser Morton⁴, Geoffrey Lowman³, Andrew Felton⁵ and Carl Goodyear⁴, ¹Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, South San Francisco-CA, United States, San Francisco, ³Clinical Sequencing Division, Specialty Diagnostics Group, Thermo Fisher Scientific, Carlsbad, CA, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵VP, Platforms, Research & Applied, Specialty Diagnostics Group, South San Francisco, CA
Background/Purpose: The adaptive immune system plays a central role in Rheumatoid Arthritis (RA) pathogenesis. Moreover, the composition of the B cell repertoire and its perturbation…
Abstract Number: 1067 • ACR Convergence 2021
Experiences of Self-Care During the COVID-19 Pandemic Among Individuals with Rheumatoid Arthritis: A Qualitative Study
Jenny Leese¹, Catherine L. Backman¹, Jasmin Ma¹, Cheryl Koehn², Alison Hoens³, Kelly English³, Eileen Davidson⁴, Shanon McQuitty³, James Gavin⁵, Jo Adams⁵, Stephanie Thierren⁶ and Linda Li¹, ¹University of British Columbia, Vancouver, BC, Canada, ²Arthritis Consumer Experts, Vancouver, BC, Canada, ³Arthritis Research Canada Arthritis Patient Advisory Board, Vancouver, BC, Canada, ⁴Arthritis Research Canada Arthritis Patient Advisory Board, Burnaby, BC, Canada, ⁵University of Southampton, Southampton, United Kingdom, ⁶Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: The COVID-19 pandemic poses new challenges for individuals with rheumatoid arthritis (RA) to manage their self-care, such as being physically active, maintaining emotional wellbeing,…
Abstract Number: 1198 • ACR Convergence 2021
Ultrasonography of the Median Nerve in Patients with Rheumatoid Arthritis Under Suspicion of Carpal Tunnel Syndrome
Styliani Tsiami¹, Efthymia Ntasiou², Christos Krogias², Ralf Gold², Jürgen Braun¹, Michael Sarholz³ and Xenofon Baraliakos¹, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, ²St. Josef-Hospital, Bochum and Ruhr-University Bochum, Germany, Bochum, Germany, ³Klinik fuer Rheumatologie, St. Marien-Hospital Vreden, Vreden, Germany
Background/Purpose: Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome and a common extra-articular manifestation of rheumatoid arthritis (RA). Different causes of CTS…
Abstract Number: 1214 • ACR Convergence 2021
Examining the Relationship Between Shared Epitope, ACPA Seropositivity, and Real-World Drug Effectiveness in Patients with Rheumatoid Arthritis
Kristin Wipfler¹, Joshua Baker², Harlan Sayles³, Xue Han⁴, Sang Hee Park⁴, Keith Wittstock⁴, Ted Mikuls³ and Kaleb Michaud³, ¹FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³University of Nebraska Medical Center, Omaha, NE, ⁴Bristol Myers Squibb, Princeton, NJ
Background/Purpose: The shared epitope (SE) is an amino acid sequence motif coded by several HLA-DRB1 alleles that are overrepresented among people with rheumatoid arthritis (RA).…
Abstract Number: 1230 • ACR Convergence 2021
Impact of Serologic Status on Clinical Responses to Upadacitinib or Abatacept in Patients with Rheumatoid Arthritis and Prior Inadequate Response to Biologic DMARDs: Sub-Group Analysis from the Phase 3 SELECT-CHOICE Study
Andrea Rubbert-Roth¹, Jeffrey Sparks², Arnaud Constantin³, Ricardo Xavier⁴, Yanna Song⁵, Jessica Suboticki⁵ and Roy Fleischmann⁶, ¹Kantonspital St Gallen, St.Gallen, Switzerland, ²Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Toulouse University Hospital, Toulouse Cedex 9, France, ⁴Departamento de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁵AbbVie Inc., North Chicago, IL, ⁶University of Texas Southwestern Medical Center, Metroplex Clinical Research Center, Dallas, TX
Background/Purpose: In patients with RA who had a prior inadequate response or intolerance to biologic DMARDs, the oral Janus kinase inhibitor, upadacitinib (UPA), demonstrated superiority…
Abstract Number: 1246 • ACR Convergence 2021
The Effect of Tocilizumab on miR-146a-5p and EMMPRIN/CD147 in Rheumatoid Arthritis Patients
Devy Zisman¹, Mirna Safieh¹, Elina Simanovich¹, Joy Feld², Amalia Kinarty¹, Liron Zisman¹, Tal Gazitt³, Amir Haddad⁴, Muna Elias¹, Itzhak Rosner⁵, Lisa Kaly⁶ and Michal A Rahat⁷, ¹Carmel Medical Center, Haifa, Israel, ²Carmel and Zvulun Medical Centre, Haifa, Israel, ³Carmel Hospital, Haifa, Israel, ⁴Carmel Medical Centre, Haifa, Israel, ⁵Rheumatology Unit, Bnai Zion Medical Center, Haifa, Israel, ⁶Bnei Zion Medical Center, Haifa, Israel, ⁷Carmel Medical Center/Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Background/Purpose: Angiogenesis is an important contributor to the development of rheumatoid arthritis (RA). Tocilizumab (TCZ), an anti-IL-6 receptor antibody used in the treatment of RA…
Abstract Number: 1443 • ACR Convergence 2021
Long-term Effectiveness of Ultra-Low Doses of Rituximab in Rheumatoid Arthritis
Nathan den Broeder¹, Lise Verhoef², Yael De Man³, Marc Kok⁴, Rogier Thurlings⁵, Wilfred van der Weele⁶, Bart van den Bemt⁷, Frank van den Hoogen⁸, Aatke van der Maas⁹ and Alfons den Broeder¹⁰, ¹Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands, ²Sint Maartenskliniek, Nijmegen, Netherlands, ³Ziekenhuisgroep Twente (Hospital Group Twente), Borne, Netherlands, ⁴Maasstad Hospital, Rotterdam, Netherlands, ⁵Radboud University Medical Centre, Nijmegen, Netherlands, ⁶Reade, Amsterdam, Netherlands, ⁷Sint Maartenskliniek; Radboud University Medical Center, Ubbergen, Netherlands, ⁸Sint Maartenskliniek, Ubbergen, Gelderland, Netherlands, ⁹St Maartenskliniek, Nijmegen, Gelderland, Netherlands, ¹⁰Sint Maartenskliniek, Nijmegen, Gelderland, Netherlands
Background/Purpose: The optimal rituximab (RTX) dose for the treatment of rheumatoid arthritis remains unclear. RTX treatment of 1000mg per 6 months and 2000mg per 6…
Abstract Number: 1603 • ACR Convergence 2021
COVID-19 Vaccination Experience in Patients with Rheumatoid Arthritis Treated at the Cleveland VA Medical Center
Sarah Abi Doumeth¹, Laura Silversteyn², Donald Anthony² and Maya Mattar³, ¹University hospitals Cleveland medical center, Cleveland, OH, ²Louis Stokes Cleveland VA Medical Center, Cleveland, OH, ³Louis Stokes VA Medical Center, Mayfield Heights, OH
Background/Purpose: Following the introduction of the COVID-19 vaccines, there has been uncertainty as to whether receiving the COVID-19 vaccine would result in overactivation of the…

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