Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1991 • ACR Convergence 2022
Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation
Siba Raychaudhuri¹, Smriti Raychaudhuri² and Heike Wulff³, ¹UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, ²VA Medical Center, Sacramento, CA, ³UC Davis, Davis, CA
Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1.…
Abstract Number: 2007 • ACR Convergence 2022
Rheumatoid Arthritis Associated Lymphoproliferative Disorders: Current Features and It’s Changing Pattern Due to the Influence of Anti-rheumatic Drugs
Yoshihiko Hoshida¹, Atsuko Tsujii², Shiro Ohshima², Yukihiko Saeki², Masato Yagita³, Tomoya Miyamura⁴, Masao Katayama⁵, Yasushi Hiramatsu⁶, Hisaji Oshima⁷, Toshihiko Murayama⁸, Shinji Higa⁹, Fuminori Hirano¹⁰, Kenji Ichikawa¹¹, Noriyuki Chiba¹², Takao Sugiyama¹³, Atsushi Ihata¹⁴, Akiko Mitsuo¹⁵, Hiroshi Tsutani¹⁶, Koichiro Takahi¹⁷, Akira Okamoto¹⁸, Shigeru Yoshizawa¹⁹, Yasuo Suenaga²⁰, Shunsuke Mori²¹, Shoichi Nagakura²², Norie Yoshikawa²³, Atsuhisa Ueda²⁴, Shouhei Nagaoka²⁵, Keigo Setoguchi²⁶, Shoji Sugii²⁷, Asami Abe²⁸, Toshiaki Sugaya²⁹, Masahiro Koseto³⁰, Yasuo Kunugiza³¹, Norishige Iizuka³², Ryosuke Yoshihara³³, Tomoaki Fujisaki³⁴, Hiroyuki Sugahara³⁵, Ikuo Saito³⁶, Kazuya Kuraoka³⁷, Norihiro Teramoto³⁸, Masahiro Ito³⁹, Kenichi Taguchi⁴⁰, Yuko Minami⁴¹, Shinji Naito⁴², Mitsuharu Nomoto⁴³, Kazuyoshi Saito⁴⁴, Kiyoshi Matsui⁴⁵, Yasuhiko Tomita⁴⁶, Hiroshi Furukawa⁴⁷ and Shigeto Tohma⁴⁸, ¹Department of Pathology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, ²Department of Rheumatology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, ³Division of Inflammation and Immunity, Tazuke-Kofukai Medical Research Institute Kitano Hospital, Osaka, Osaka, Japan, ⁴Department of Rheumatology, NHO Kyushu Medical Center, Fukuoka, Japan, ⁵Department of Rheumatology, NHO Nagoya Medical Center, Nagoya, Japan, ⁶Department of Hematology and Oncology, Japanese Red Cross Society Himeji Hospital, Himeji, Japan, ⁷National Hospital Organization Tokyo Medical Center, Meguroku, Japan, ⁸Department of Pathology, NHO Kumamoto Medical Center, Kumamoto, Kumamoto, Japan, ⁹Division of Rheumatology, Daini Osaka Police Hospital, Osaka, Osaka, Japan, ¹⁰Department of Rheumatology, NHO Asahikawa Medical Center, Asahikawa, Hokkaido, Japan, ¹¹Department of Rheumatology, NHO Hokkaido Medical Center, Sapporo, Japan, ¹²epartment of Rheumatology, NHO Morioka Medical Center, Morioka, Japan, ¹³Department of Rheumatology, NHO Shimoshizu Hospital, SIkaido, Chiba, Japan, ¹⁴Department of Rheumatology, NHO Yokohama Medical Center, Yokohama, Japan, ¹⁵Department of Rheumatology, NHO Disaster Medical Center, Tachikawa, Japan, ¹⁶Department of Rheumatology, NHO Awara Hospital, Awara, Fukui, Japan, ¹⁷Department of Rheumatology, NHO Osaka Toneyama Medical Center, Toyonaka, Japan, ¹⁸Department of Rheumatology, NHO Himeji Medical Center, Himeji, Japan, ¹⁹Department of Rheumatology, NHO Fukuoka Hospital, Fukuoka, Japan, ²⁰Department of Rheumatology, NHO Beppu Medical Center, Beppu, Oita, Japan, ²¹Department of Rheumatology, NHO Kumamoto Saishun Medical Center, Goshi, Japan, ²²Department of Hematology, NHO Kumamoto Minami Hospital, Ushiro, Japan, ²³Department of Rheumatology, NHO Miyakonojo Medical Center, Miyakonojo, Japan, ²⁴Department of Rheumatology, Yokohama City University, Yokohama, Japan, ²⁵Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan, ²⁶Department of Systemic immunological diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan, ²⁷Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan, ²⁸Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ²⁹Department of Rheumatology, Fuchu Hospital, Izumi, Japan, ³⁰Department of Laboratory Medicine and Internal Medicine (Clinical Immunology), Nippon Life Hospital, Osaka, Osaka, Japan, ³¹Department of Orthopedics, JCHO Hoshigaoka Medical Center, Hirakata, Japan, ³²Department of Pathology, Kishiwada City Hospital, Kishiwada, Japan, ³³Department of Rheumatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan, ³⁴Department of Hematology, Matsuyama Red Cross Hospital, Matsuyama, Japan, ³⁵Department of Hematology, Sumitomo Hospital, Osaka, Osaka, Japan, ³⁶Department of Pathology, NHO Sagamihara Hospital, Sagamihara, Kanagawa, Japan, ³⁷Department of Diagnostic Pathology, NHO Kure Medical Center /Chugoku Cancer Center, Kure, Hiroshima, Japan, ³⁸Department of Pathology, NHO Shikoku Cancer Center, Matsuyama, Japan, ³⁹Department of Pathology, NHO Nagasaki Medical Center, Nagasaki, Japan, ⁴⁰Department of Pathology, NHO Kyushu Cancer Center, Fukuoka, Japan, ⁴¹Department of Pathology, NHO Ibarakihigashi Hospital, Nakagun, Japan, ⁴²Department of Pathology, NHO Ureshino Medical Center, Ureshino, Japan, ⁴³Department of Pathology, NHO, Kagoshima Medical Center, Kagoshima, Japan, ⁴⁴First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, ⁴⁵Hyogo College of Medicine, Nishinomiya, Japan, ⁴⁶Department of Pathology, International University of Health and Welfare, Narita, Japan, ⁴⁷Department of Rheumatology, NHO Tokyo National Hospital, Tokyo, Japan, ⁴⁸National Hospital Organization Tokyo National Hospital, Dallas, TX
Background/Purpose: The effect of antirheumatic drugs on the development of lymphoproliferative disorders (LPDs) in rheumatoid arthritis (RA) patients remains unclear. The current study aimed to…
Abstract Number: 2188 • ACR Convergence 2022
The Effect of Group-based Cognitive Behavioral Therapy for Insomnia in People with Rheumatoid Arthritis: A Randomized Controlled Trial
Kristine Latocha¹, Katrine Loeppenthin², Mikkel Østergaard³, poul jennum⁴, Merete L Hetland⁵, Henrik Rogind⁶, Tine Lundbak⁶, Julie Midtgaard⁷, Robin Christensen⁸ and Bente Esbensen⁵, ¹Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark, ²Department of Oncology, Copenhagen University Hospital - Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ³Rigshospitalet, University of Copenhagen, Glostrup, Denmark, ⁴Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen University Hospital - Rigshospitalet, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, ⁵Rigshospitalet, Glostrup, Denmark, ⁶Center for Rheumatology and Spine Diseases, Copenhagen University Hospital -Rigshospitalet, Glostrup, Denmark, ⁷Mental Health Centre Glostrup, University of Copenhagen, Glostrup,Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ⁸Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark
Background/Purpose: Insomnia is highly prevalent in people with rheumatoid arthritis (RA) and may exacerbate symptoms and burdens, such as fatigue, depressive symptoms, and pain (1).…
Abstract Number: 2252 • ACR Convergence 2022
Higher Matrix Metalloproteinase Levels Are Predictive of Incident Interstitial Lung Disease Among a Cohort of US Veterans with Rheumatoid Arthritis
Brent Luedders¹, Dana Ascherman², Joshua Baker³, Michael Duryee¹, Yangyuna Yang¹, Punyasha Roul⁴, Katherine Wysham⁵, Paul Monach⁶, Andreas Reimold⁷, Gail Kerr⁸, Gary Kunkel⁹, Grant Cannon¹⁰, Jill Poole¹, Geoffrey Thiele¹, Ted Mikuls¹¹ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pittsburgh, Pittsburgh, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴UNMC, Omaha, NE, ⁵VA Puget Sound/University of Washington, Seattle, WA, ⁶VA Boston Healthcare System, Boston, MA, ⁷University of Texas Southwestern Medical Center, Dallas, TX, ⁸Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ⁹University of Utah, Salt Lake City, UT, ¹⁰Retired, Salt Lake City, UT, ¹¹Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Matrix metalloproteinases (MMPs) degrade extracellular matrix and have been implicated to play a role in a number of fibrotic processes. Specifically, MMPs have been…
Abstract Number: 0065 • ACR Convergence 2022
Rheumatoid Arthritis Clinical Care Pathway Implementation: A Step Towards Improved Outcomes and Value-Based Care
Tarun Sharma¹, paul lebovitz¹, chetan rajput², Lori Mcaninch³, ellen Kraemer³, izabela Stanescu³, adam dore¹, joseph ahearn³ and Susan Manzi⁴, ¹Allegheny Health Network, Pittsburgh, PA, ²Highmark Health, Pittsburgh, ³Allegheny Health Network, Pittsburgh, ⁴Allegheny Health Network, Lupus Center of Excellence, Wexford, PA
Background/Purpose: Care transformation in a chronic illness like RA requires delivery of health care services through a patient-centric care model. Within an integrated delivery and…
Abstract Number: 0129 • ACR Convergence 2022
Effectiveness of Golimumab in the Treatment of Patients with Active Rheumatoid Arthritis, Psoriatic Arthritis, or Axial Spondyloarthritis Who Failed Initial TNFα Therapy: A Pooled Analysis of European Prospective Observational Studies (the GO BEYOND Program)
Marinella Govoni¹, Anastas Batalov², Dimitrios Boumpas³, Salvatore D'Angelo⁴, Filip De Keyser⁵, Rene-Marc Flipo⁶, Herbert Kellner⁷, Hermine Leroi⁸ and Ahmed Khalifa⁹, ¹MSD Italy, Cento, Italy, ²Medical University of Plovdiv, Plovdiv, Bulgaria, ³National and Kapodistrian University of Athens, Heraklion, Greece, ⁴Rheumatology Department of Lucania - San Carlo Hospital of Potenza, Potenza, Italy, ⁵Department of Rheumatology, Ghent University Hospital, Maldegem, Belgium, ⁶CHU Lille, Boulogne-Billancourt, France, ⁷Schwerpunktpraxis für Rheumatologie und Gastroenterologie, Munich, Germany, ⁸MSD Belgium, Woluwe-Saint-Lambert, Belgium, ⁹MSD Sharp & Dohme GmbH, Germany, Kriens, Switzerland
Background/Purpose: Patients with inflammatory arthritis often experience secondary non-response to a first-line tumor necrosis factor alpha inhibitor (TNFαi). GO-BEYOND is a study program comprised of…
Abstract Number: 0244 • ACR Convergence 2022
Identification of Novel Response Predictors via Cardiovascular Biomarker Proteomic Analysis of Serum Samples from Patients with Early, Seropositive RA Treated with Abatacept or Adalimumab
Yicong Li¹, Chun Wu², Michael Maldonado², Peter Schafer², S. Louis Bridges, Jr.³, William Rigby⁴, Vivian Bykerk³, Jane Buckner⁵ and Jinqi Liu², ¹Parexel International, Durham, NC, ²Bristol Myers Squibb, Princeton, NJ, ³Hospital for Special Surgery, New York, NY, ⁴Dartmouth Hitchcock Medical Center, Lebanon, PA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: Effective RA therapies should not only improve joint signs and symptoms, but also mitigate additional disease-related consequences, such as the increased risk of cardiovascular…
Abstract Number: 0260 • ACR Convergence 2022
Impacts of Poor Prognostic Factors in Rheumatoid Arthritis on Clinical Outcomes and Treatment Choices from an Observational Cohort of Korean Patients with Rheumatoid Arthritis
You-Jung Ha¹, Seunghwan Shin², SE RIM CHOI³, Eun Ha Kang¹ and Yun Jong Lee¹, ¹Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ²Lunit Inc, Seoul, Republic of Korea, ³Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: The primary target for the treatment of rheumatoid arthritis (RA) is achieving remission or low disease activity with proper use of DMARD. Besides controlling…
Abstract Number: 0277 • ACR Convergence 2022
Malignancy Events in the Filgotinib Rheumatoid Arthritis and Ulcerative Colitis Clinical Development Programs
Xavier Mariette¹, Sandrine Aspeslagh², Richard Moriggl³, Vijay Rajendran⁴, Christine Rudolph⁵, Paul Van Hoek⁵, Nadia Verbruggen⁵, Christopher Watson⁶, Sven Borchmann⁷ and Andreas Stallmach⁸, ¹Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, ²UZ Brussel, Brussels, Belgium, ³University of Veterinary Medicine, Vienna, Austria, ⁴Galapagos NV, Gent, Belgium, ⁵Galapagos NV, Mechelen, Belgium, ⁶Galapagos Biotech Ltd, Cambridge, United Kingdom, ⁷Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, ⁸Department of Internal Medicine IV, Jena University Hospital, Jena, Germany
Background/Purpose: Filgotinib (FIL) is a preferential oral Janus kinase (JAK) 1 inhibitor, approved for the treatment of RA and ulcerative colitis (UC) in Europe, the…
Abstract Number: 0294 • ACR Convergence 2022
Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biologic DMARDs: Results Through 5 Years from the SELECT-BEYOND Study
Roy Fleischmann¹, Sebastian Meerwein², Christina Charles-Schoeman³, BERNARD COMBE⁴, Stephen Hall⁵, Nasser Khan⁶, Kyle Carter⁷, Heidi Camp⁸ and Andrea Rubbert-Roth⁹, ¹Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, ²AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, ³Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA, ⁴Montpellier University, Montpellier, France, ⁵Emeritus Research and Monash University, Melbourne, Australia, ⁶AbbVie, Inc., Abbott Park, IL, ⁷AbbVie, Inc., North Chicago, IL, ⁸Abbvie, Winnetka, IL, ⁹Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland
Background/Purpose: To evaluate the long-term efficacy and safety of upadacitinib (UPA) over 5 yrs among patients with rheumatoid arthritis (RA) in a long-term extension (LTE)…
Abstract Number: 0312 • ACR Convergence 2022
Dose-dependent Suppression of T Cell-Dependent Antibody Response in Healthy Volunteers by KPL-404, an Anti-CD40 Monoclonal Antibody, Supports Phase 2 Study in Patients with Rheumatoid Arthritis
Lara Pupim¹, Gerd Burmester², Fang Fang¹, Alan Kivitz³, Moses Njenga¹, Costantino Pitzalis⁴, Jay Chatfield¹, Anastassia Papandrikopoulou¹, Manoj Samant¹, Steve Schmitz¹, Madeline Spiers¹, Eben Tessari¹, John Ziemniak¹ and John F. Paolini⁵, ¹Kiniksa, Lexington, MA, ²Charité University Medicine Berlin, Berlin, Germany, ³Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, ⁴Queen Mary University of London, London, United Kingdom, ⁵Kiniksa Pharmaceuticals, Lexington, MA
Background/Purpose: An unmet need remains in patients with failure and/or inadequate response (IR) to biological disease-modifying antirheumatic drugs (bDMARD-IR) and/or Janus kinase inhibitors (JAKi-IR). The…
Abstract Number: 0534 • ACR Convergence 2022
Synovial Transcriptomic Profiles Correlate with Disease Activity in Early Untreated Rheumatoid Arthritis
Clément Triaille¹, Tatiana Sokolova¹, Stéphanie de Montjoye¹, Adrien NZEUSSEU TOUKAP², Laurent Meric de Bellefon¹, Axelle Loriot³, pierre coulie⁴, Bernard Lauwerys¹, Patrick Durez⁵ and Nisha Limaye⁶, ¹Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, ²Cliniques Universitaires Saint-Luc, Brussels, Belgium, ³Computational Biology, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium, ⁴de Duve Institute, Université Catholique de Louvain, Brussels, Belgium, ⁵Institute de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint-Luc - Université Catholique de Louvain (UCL), Brussels, Belgium, ⁶Genetics of Autoimmune Diseases and Cancer, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium
Background/Purpose: Synovitis is the common feature across all individuals with a diagnosis of rheumatoid arthritis (RA). Yet, cellular and transcriptomic alterations occuring in RA synovium…
Abstract Number: 0592 • ACR Convergence 2022
Autoantibodies Targeting Malondialdehyde-modifications Are Potential Mediators of Inflammation and Bone Loss in RA, Acting via Macrophage and Osteoclast Regulatory Pathways
Jitong Sun¹, Koji Sakuraba², Akilan Krishnamurthy³, Xiaowei Zheng³, Marcelo Gomes Afonso³, Cheng Xu³, Bing Peng³, Per-Johan Jakobsson³, Marianne Engström³, Fredrik Wermeling³, Sergiu Catrina³, Caroline Grönwall³, Anca Catrina³ and Bence Réthi³, ¹Karolinska Institutet, Solna, Sweden, ²Karolinska Institutet and Karolinska University Hospital, Fukuoka, Japan, ³Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Proteins subjected to post-translational modifications, such as citrullination, carbamylation, acetylation, malondialdehyde (MDA) or malondialdehyde/acetaldehyde (MDA/MAA) modification are targeted by autoantibodies in seropositive rheumatoid arthritis…
Abstract Number: 0608 • ACR Convergence 2022
Wnt Pathway Regulators R-spondin 3 and Dickkopf-related Protein 3 Demarcate a Transcriptional Gradient That Drives Synovial Fibroblast Inflammatory Pathology in Rheumatoid Arthritis
Alisa Mueller¹, Angela Zou², SABA NAYAR³, Emily Taylor³, Triin Major³, David H Gardner³, Gerald FM Watts¹, Adam Croft³, Roche Fibroblast Network Consortium⁴, Andrew Filer³, Christopher Buckley⁵, Kevin Wei⁶, ilya Korsunsky¹, Soumya Raychaudhuri¹ and Michael Brenner⁷, ¹Brigham and Women's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³University of Birmingham, Birmingham, United Kingdom, ⁴Roche, Basel, Switzerland, ⁵University of Oxford, Oxford, United Kingdom, ⁶Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Synovial fibroblasts are key players in rheumatoid arthritis (RA) where they secrete inflammatory cytokines and directly instigate cartilage and bone destruction. However, most treatments…
Abstract Number: 0626 • ACR Convergence 2022
Elucidating the Expression and Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Human Rheumatoid Arthritis Synovial Fibroblasts and a Rat Adjuvant-induced Arthritis Model
Meena Afroze Shanta¹, Farheen Sultan Shaikh², Bhanupriya Madarampalli³ and Salahuddin Ahmed², ¹College of Pharmacy and Pharmaceutical Science, Washington State University, Spokane, WA, ²Washington State University, Spokane, WA, ³University of Washington, Bellevue, WA
Background/Purpose: Proprotein convertase subtilisin/Kexin type-9 (PCSK9) is the most recognized serine protease for its pathological role in cardiovascular diseases, however, its role in inflammatory diseases,…

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