Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2359 • 2019 ACR/ARP Annual Meeting
High Body Mass Index Shortens Retention of Tumor Necrosis Factor-α Blocker Treatment in Rheumatoid Arthritis
Ori Elkayam ¹, Merav Lidar ², Tatiana Reitblat ³, Devy Zisman ⁴, Alexandra Balbir-Gurman ⁵, Odelia Kakakian ¹, Tanya Meshiach ⁵, Ronit Almog ⁶ and Ofir Elalouf¹, ¹Tel Aviv Medical Center, Tel Aviv, Israel, ²Rheumatology Unit Sheba Medical Center, Ramat Gan, Israel, ³Barzilai Medical Center, Ashkelon, Israel, ⁴Carmel Medical Center, Haifa, Israel, ⁵Rambam Medical Center, Haifa, Israel, ⁶the7Epidemiology and Biostatistics Unit, Rambam Health Care Campus, Haifa, Israel
Background/Purpose: The primary objective was to evaluate the effect of body mass index (BMI) on tumor necrosis factor α (TNF-α) blockers (including etanercept, infliximab, adalimumab…
Abstract Number: 2386 • 2019 ACR/ARP Annual Meeting
Consensus Statement and Recommendations on Methotrexate Use in Combined Therapy with Biological or Targeted Synthetic Disease Modifying Drugs in Patients with Rheumatoid Arthritis
Jesus Tornero¹, Mercedes Alperi-López ², Ivan Castellvi ³, Juan José de Agustín de Oro ⁴, Alejandro Escudero ⁵, Rosario Garcia-Vicuña ⁶, Miguel Angel González-Gay ⁷, Cristina Hidalgo ⁸, Esteban Rubio ⁹, Raimon Sanmarti ¹⁰, Núria Casamira ¹¹ and Jaime Calvo-Alen ¹², ¹Hospital de Guadalajara, Guadalajara, Spain, ²Hospital Universitario Central de Asturias, Oviedo, Spain, ³Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁴Hospital Universitari Vall d’Hebron, Barcelona, Spain, ⁵IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁶Hospital Universitario de La Princesa, Madrid, Spain, ⁷Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁸Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, ⁹Rheumatology Department, University Hospital Virgen del Rocío, Sevilla, Spain, ¹⁰Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, ¹¹Medical Department, Gebro Pharma S.A., Barcelona, Spain, ¹²Hospital Universitario Araba, Vitoria-Gasteiz, Spain
Background/Purpose: Our aim was to develop recommendations for the management of methotrexate (MTX) when considering the combination with biological (b) or targeted synthetic (ts) disease…
Abstract Number: 2764 • 2019 ACR/ARP Annual Meeting
Medication Necessity and Concerns Beliefs Are Distinct, Interactive Predictors of Treatment Adherence in Rheumatoid Arthritis
George Karpouzas¹, Elizabeth Hernandez ², Lorena Ruiz ³, Vibeke Strand ⁴ and Sarah Ormseth ¹, ¹Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA, ²Harbor-UCLA and Los Angeles Biomedical Institute, Torrance, CA, ³Harbor-UCLA andLos Angeles Biomedical Research Institute, Torrance, ⁴Division of Immunology/Rheumatology, Stanford University, Stanford, CA
Background/Purpose: Medication adherence is instrumental for the successful management of rheumatoid arthritis (RA) to a goal of remission. Awareness of medication necessity and concerns regarding…
Abstract Number: 2858 • 2019 ACR/ARP Annual Meeting
The Role of Bradykinin Receptor B1 and Its New Ligand Soluble CD13 in Rheumatoid Arthritis and Inflammatory Arthritis Mouse Model
Chenyang Lu ¹, Phillip Campbell ¹, Jonatan Hervoso ², Stephanie Rasmussen ², Wenyi Fu ², Jeffrey Ruth ², David Fox ³ and M Amin⁴, ¹the University of Michigan, Ann Arbor, MI, ²the University of Michigan, Ann Arbor, ³University of Michigan, Ann Arbor, ⁴University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disorder characterized by synovial hyperplasia, inflammatory cell infiltration and pannus formation. We have shown that soluble CD13 (sCD13)…
Abstract Number: 16 • 2019 ACR/ARP Annual Meeting
Monoclonal ACPA Promote Synovial Fibroblasts Migration Through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Bence Rethi ¹, Akilan Krishnamurthy ², Vijay Joshua ³, Alexandra Circiumaru ¹, Aase Hensvold ¹, Marianne Engström ⁴, Sergiu-Bogdan Catrina ⁵, Johanna Steen ⁶, Vivianne Malmström ³, Caroline Grönwall ³, Lars Klareskog ⁷, Heidi Wähämaa ¹ and Anca Catrina ⁷, ¹Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, ²Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ⁴Karolinska Institutet and Karolinska University Hospital, Stockholm, ⁵Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁶Stockholm University, Stockholm, ⁷Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) play an important role in rheumatoid arthritis (RA) pathogenesis. ACPAs have different amino acid motif recognition patterns and show cross-reactivity…
Abstract Number: 104 • 2019 ACR/ARP Annual Meeting
Novel, Selective, Orally Active PAD4 Inhibitors for the Treatment of Autoimmune Disorders
Santosh Vishwakarma¹, Gurulingappa Hallur ¹, Himanshu Agrawal ¹, Sharad Singh ¹, Annasaheb Kalange ¹, Seema Chikkur Gangadhar ¹, Shuvranshu PraharaJ ¹, Nafees Ahmad Quresh ¹, Srikanth Kanagal Gopinath ¹, Krishnakumar V ¹, Sameer Mahmood ¹, Rudresh G ¹, Mohd Zainuddin ¹, Rajendra Kristam ¹, Ishtiyaque Ahmad ¹, Ramachandraiah Gosu ¹, Purra Buchi Reddy ¹, N V S K Rao ¹, Saloni Mehra ², Jeyaraj D A ¹, Takeshi Yura ¹, Saravanakumar dhakshinamoorthy ¹, Sriram Rajagopal ¹, Dhanalakshmi Sivanandhan ³ and Sridharan Rajagopal ³, ¹Jubilant Biosys, Bangalore, India, ²Jubilant Chemsys, Noida, India, ³Jubilant Therapeutics, Bangalore, India
Background/Purpose: Citrullination of proteins is catalyzed by a family of enzymes called the peptidylarginine deiminases (PADs). While the citrullinated proteins may have physiological roles in differentiation,…
Abstract Number: 193 • 2019 ACR/ARP Annual Meeting
Diet as a Risk Factor for Rheumatoid Arthritis
Chelsea Guan ¹ and Shazia Beg², ¹University of Central Florida, Orlando, ²University of Central Florida College of Medicine, Orlando
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease affecting the joints that typically affects women more than men. An exact cause has yet…
Abstract Number: 284 • 2019 ACR/ARP Annual Meeting
Impact of Body Mass Index on the Agreement Between Ultrasound- and Clinical Assessments of Disease Activity in Rheumatoid Arthritis : Multicenter and Cross-sectional Study
Gaël Mouterde¹, Federico Manna ², Benoît Le Goff ³, Jean-David Albert ⁴, Sandrine Jousse-Joulin ⁵, Frédérique Gandjbakhch ⁶, Damien Loeuille ⁷, Philippe Gaudin ⁸, Muriel Piperno ⁹, Frédéric Banal ¹⁰, Bénédicte Jamard ¹¹, Carine Salliot ¹², Nicolas Molinari ², Bernard Combe ¹³, Maria-Antonietta D'Agostino ¹⁴ and Cédric Lukas ¹⁵, ¹CHU Montpellier and Univ Montpellier, Montpellier, France, ²Clinical Research and Epidemiology Unit, University Hospital, Montpellier, France, ³Rheumatology Department, CHU de Nantes and INSERM UMR 1238, Faculty of Biology of Nantes, Nantes, France, ⁴Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, ⁵Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ⁶Rheumatology department, Pitié Salpêtrière hospital, APHP and Sorbonne University, Paris, France, ⁷Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France, ⁸Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ⁹Rheumatology Department, Hospices Civils de Lyon, centre hospitalier Lyon Sud, Pierre Bénite, France, ¹⁰Service rhumatologie, hôpital d'instruction des armées Bégin, Saint Mandé, France, ¹¹Department of Rheumatology, Purpan Teaching Hospital, Toulouse, France, ¹²Rheumatology Unit, centre hospitalier regional d'Orleans, Orléans, France, ¹³CHU Montpellier, Montpellier University, Montpellier, France, ¹⁴UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne Billancourt, France, ¹⁵Rheumatology department, CHU Montpellier, Univ Montpellier, Montpellier, France
Background/Purpose: Clinical evaluation of synovitis in rheumatoid arthritis (RA) is difficult in obese (O) and overweight patients, due to the fat pad located around the…
Abstract Number: 449 • 2019 ACR/ARP Annual Meeting
The Course of Disability Related to Function of the Upper Extremities in Early Rheumatoid Arthritis over 10 Years of Follow-up
Maria Rydholm ¹, Ingegerd Wikström ², Maria Mellblom Bengtsson ¹, Sofia Hagel ³, Lennart Jacobsson ⁴ and Carl Turesson², ¹Skåne University Hospital, Malmö, Sweden, ²Lund University, Malmö, Sweden, ³Skåne University Hospital, Lund, Sweden, ⁴Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased disability, in particular due to involvement of the joints of the upper extremities. The Stanford Health Assessment…
Abstract Number: 476 • 2019 ACR/ARP Annual Meeting
Decreased Muscle Mass, a Novel Predicting Indicator for One-year Radiographic Progression in Rheumatoid Arthritis: A Real-world Cohort Study
Jian-Zi Lin ¹, Jian-Da Ma ¹, Qian-Hua Li ¹, Ying-Qian Mo ¹, Li-Juan Yang ¹, Le-Feng Chen ¹, Chu-Tao Chen ¹, Jun-Wei Wang ¹, Dong-Hui Zheng ¹ and Lie Dai¹, ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (People's Republic)
Background/Purpose: Obesity paradox based on body mass index (BMI) in rheumatoid arthritis (RA) remain elusive. Our previous cross-sectional study has reported myopenia is associated with joint…
Abstract Number: 526 • 2019 ACR/ARP Annual Meeting
Factors Influencing Discontinuation in Long-term RA Treatment
Madison Grinnell¹, Sofia Pedro ² and Kaleb Michaud ³, ¹University of Nebraska College of Medicine, OMAHA, NE, ²FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: While medication persistence can act as a substitute metric for effectiveness, few studies have examined real-world patterns of bDMARD persistence by line of treatment…
Abstract Number: 823 • 2019 ACR/ARP Annual Meeting
The Risk of Venous Thromboembolism in Patients with Psoriatic Disease and Rheumatoid Arthritis, a Population-based Study
Lingyi Li¹, Na Lu ¹, Eric Sayre ¹, Hui Xie ², Diane Lacaille ³, John Esdaile ⁴ and J. Antonio Avina-Zubieta ⁵, ¹Arthritis Research Canada, Vancouver, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁵Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Venous thromboembolism (VTE, which includes pulmonary embolism [PE] and deep vein thrombosis [DVT]) is associated with increased morbidity and mortality. Previous studies have shown…
Abstract Number: 930 • 2019 ACR/ARP Annual Meeting
Neurostimulation for Treatment of Drug Refractory Rheumatoid Arthritis: A First-in-Human Study Using a Novel Vagus Nerve Stimulator
Norman Gaylis¹, David Sikes ², Alan Kivitz ³, Diane Horowitz ⁴, Charles Peterfy ⁵, Yaakov Levine ⁶, David Chernoff ⁶ and Mark Genovese ⁷, ¹Arthritis and Rheumatic Disease Specialties, Aventura, FL, ²Florida Medical Clinic, Land O Lakes, FL, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴Northwell Health, Manhasset, NY, ⁵Spire Sciences Inc, Boca Raton, ⁶SetPoint Medical, Valencia, CA, ⁷Stanford University, Stanford, CA
Background/Purpose: The inflammatory reflex is an endogenous neuroimmune circuit that helps regulate innate and adaptive immunity (Annu. Rev. Immunol. 2012; 30:313). Activation of this reflex by…
Abstract Number: 1140 • 2019 ACR/ARP Annual Meeting
The Socioeconomic, Gender, Urban-rural, and Regional Disparities in the Risk of Acute Myocardial Infarction Among RA Patients
Yufei Zheng¹, Hui Xie ², J. Antonio Avina-Zubieta ³, Kia Yazdani ⁴, John Esdaile ⁵ and Diane Lacaille ⁶, ¹Arthritis Research Canada, Richmond, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Richmond, ⁵Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁶Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: To assess socioeconomic (SES), gender, urban-rural, and regional disparities in the risk of acute myocardial infarction (MI) among rheumatoid arthritis patients.Methods: We conducted a…
Abstract Number: 1339 • 2019 ACR/ARP Annual Meeting
Risk of Immunotherapy Related Toxicity in Patients with Rheumatoid Arthritis
Elizaveta Efuni ¹, Samuel Cytryn ², Patrick Boland ² and Sabina Sandigursky³, ¹New York University School of Medicine, New York, NY, ²NYU Langone Health, New York, ³NYU Langone Health, New York, NY
Background/Purpose: Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape in oncology leading to cures in some cancer types. However, patients with pre-existing autoimmune diseases…

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